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P20336

- RAB3A_HUMAN

UniProt

P20336 - RAB3A_HUMAN

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Protein
Ras-related protein Rab-3A
Gene
RAB3A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 368GTP By similarity
Nucleotide bindingi48 – 547GTP By similarity
Nucleotide bindingi77 – 815GTP By similarity
Nucleotide bindingi135 – 1384GTP By similarity

GO - Molecular functioni

  1. ATPase activator activity Source: Ensembl
  2. GTP binding Source: UniProtKB-KW
  3. GTPase activity Source: UniProtKB
  4. protein binding Source: UniProtKB

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. axonogenesis Source: Ensembl
  3. glutamate secretion Source: Reactome
  4. lung development Source: Ensembl
  5. maintenance of presynaptic active zone structure Source: Ensembl
  6. mitochondrion organization Source: Ensembl
  7. neuromuscular synaptic transmission Source: Ensembl
  8. neurotransmitter secretion Source: Reactome
  9. post-embryonic development Source: Ensembl
  10. protein transport Source: UniProtKB-KW
  11. regulation of synaptic vesicle fusion to presynaptic membrane Source: Ensembl
  12. respiratory system process Source: Ensembl
  13. response to electrical stimulus Source: Ensembl
  14. sensory perception of touch Source: Ensembl
  15. small GTPase mediated signal transduction Source: InterPro
  16. synaptic transmission Source: Reactome
  17. synaptic vesicle exocytosis Source: Ensembl
  18. synaptic vesicle maturation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_15293. Dopamine Neurotransmitter Release Cycle.
REACT_15309. Acetylcholine Neurotransmitter Release Cycle.
REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
REACT_15425. Serotonin Neurotransmitter Release Cycle.
REACT_23947. GABA synthesis, release, reuptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3A
Gene namesi
Name:RAB3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:9777. RAB3A.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. clathrin-sculpted acetylcholine transport vesicle membrane Source: Reactome
  3. clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane Source: Reactome
  4. clathrin-sculpted glutamate transport vesicle membrane Source: Reactome
  5. clathrin-sculpted monoamine transport vesicle membrane Source: Reactome
  6. cytosol Source: Ensembl
  7. plasma membrane Source: Reactome
  8. protein complex Source: Ensembl
  9. synaptic vesicle Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Ras-related protein Rab-3A
PRO_0000121076Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi218 – 2181S-geranylgeranyl cysteine2 Publications
Modified residuei220 – 2201Cysteine methyl ester1 Publication
Lipidationi220 – 2201S-geranylgeranyl cysteine2 Publications

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP20336.
PaxDbiP20336.
PRIDEiP20336.

PTM databases

PhosphoSiteiP20336.

Expressioni

Tissue specificityi

Specifically expressed in brain.

Gene expression databases

ArrayExpressiP20336.
BgeeiP20336.
CleanExiHS_RAB3A.
GenevestigatoriP20336.

Organism-specific databases

HPAiCAB009949.
HPA003160.

Interactioni

Subunit structurei

Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A and RPH3AL. Interacts with the exocyst complex through SEC15. Binds SYTL4 and RIMS1. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3 By similarity.

Protein-protein interaction databases

BioGridi111802. 23 interactions.
IntActiP20336. 4 interactions.
MINTiMINT-3009239.
STRINGi9606.ENSP00000222256.

Structurei

3D structure databases

ProteinModelPortaliP20336.
SMRiP20336. Positions 18-186.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 599Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP20336.
KOiK07882.
OMAiQLTEQPA.
OrthoDBiEOG7JQBPC.
PhylomeDBiP20336.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20336-1 [UniParc]FASTAAdd to Basket

« Hide

MASATDSRYG QKESSDQNFD YMFKILIIGN SSVGKTSFLF RYADDSFTPA    50
FVSTVGIDFK VKTIYRNDKR IKLQIWDTAG QERYRTITTA YYRGAMGFIL 100
MYDITNEESF NAVQDWSTQI KTYSWDNAQV LLVGNKCDME DERVVSSERG 150
RQLADHLGFE FFEASAKDNI NVKQTFERLV DVICEKMSES LDTADPAVTG 200
AKQGPQLSDQ QVPPHQDCAC 220
Length:220
Mass (Da):24,984
Last modified:February 1, 1991 - v1
Checksum:i08B59F8C9BD2EB40
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701R → K in AAF67748. 1 Publication
Sequence conflicti180 – 1801V → E in AAF67748. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28210 mRNA. Translation: AAA60242.1.
AF157809
, AF157806, AF157807, AF157808 Genomic DNA. Translation: AAD46811.1.
AF254795 mRNA. Translation: AAF67748.1.
AF498931 mRNA. Translation: AAM21079.1.
AK289559 mRNA. Translation: BAF82248.1.
AC068499 Genomic DNA. Translation: AAF67385.1.
CH471106 Genomic DNA. Translation: EAW84672.1.
BC011782 mRNA. Translation: AAH11782.1.
CCDSiCCDS12372.1.
PIRiC34323.
RefSeqiNP_002857.1. NM_002866.4.
UniGeneiHs.27744.

Genome annotation databases

EnsembliENST00000222256; ENSP00000222256; ENSG00000105649.
GeneIDi5864.
KEGGihsa:5864.
UCSCiuc002nie.2. human.

Polymorphism databases

DMDMi131801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28210 mRNA. Translation: AAA60242.1 .
AF157809
, AF157806 , AF157807 , AF157808 Genomic DNA. Translation: AAD46811.1 .
AF254795 mRNA. Translation: AAF67748.1 .
AF498931 mRNA. Translation: AAM21079.1 .
AK289559 mRNA. Translation: BAF82248.1 .
AC068499 Genomic DNA. Translation: AAF67385.1 .
CH471106 Genomic DNA. Translation: EAW84672.1 .
BC011782 mRNA. Translation: AAH11782.1 .
CCDSi CCDS12372.1.
PIRi C34323.
RefSeqi NP_002857.1. NM_002866.4.
UniGenei Hs.27744.

3D structure databases

ProteinModelPortali P20336.
SMRi P20336. Positions 18-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111802. 23 interactions.
IntActi P20336. 4 interactions.
MINTi MINT-3009239.
STRINGi 9606.ENSP00000222256.

PTM databases

PhosphoSitei P20336.

Polymorphism databases

DMDMi 131801.

Proteomic databases

MaxQBi P20336.
PaxDbi P20336.
PRIDEi P20336.

Protocols and materials databases

DNASUi 5864.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222256 ; ENSP00000222256 ; ENSG00000105649 .
GeneIDi 5864.
KEGGi hsa:5864.
UCSCi uc002nie.2. human.

Organism-specific databases

CTDi 5864.
GeneCardsi GC19M018307.
HGNCi HGNC:9777. RAB3A.
HPAi CAB009949.
HPA003160.
MIMi 179490. gene.
neXtProti NX_P20336.
PharmGKBi PA34132.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P20336.
KOi K07882.
OMAi QLTEQPA.
OrthoDBi EOG7JQBPC.
PhylomeDBi P20336.
TreeFami TF313199.

Enzyme and pathway databases

Reactomei REACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_15293. Dopamine Neurotransmitter Release Cycle.
REACT_15309. Acetylcholine Neurotransmitter Release Cycle.
REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
REACT_15425. Serotonin Neurotransmitter Release Cycle.
REACT_23947. GABA synthesis, release, reuptake and degradation.

Miscellaneous databases

GeneWikii RAB3A.
GenomeRNAii 5864.
NextBioi 22774.
PROi P20336.
SOURCEi Search...

Gene expression databases

ArrayExpressi P20336.
Bgeei P20336.
CleanExi HS_RAB3A.
Genevestigatori P20336.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion."
    Zahraoui A., Touchot N., Chardin P., Tavitian A.
    J. Biol. Chem. 264:12394-12401(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND."
    Sullivan M., Olsen A.S., Houslay M.D.
    Cell. Signal. 11:735-742(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Functional cloning and characterization of human fetal brain cDNAs."
    Liu Y., Li J., He J.J.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  9. Cited for: ISOPRENYLATION AT CYS-218 AND CYS-220, METHYLATION AT CYS-220.
  10. "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A."
    Farnsworth C.C., Seabra M.C., Ericsson L.H., Gelb M.H., Glomset J.A.
    Proc. Natl. Acad. Sci. U.S.A. 91:11963-11967(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: ISOPRENYLATION AT CYS-218 AND CYS-220, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiRAB3A_HUMAN
AccessioniPrimary (citable) accession number: P20336
Secondary accession number(s): A8K0J4, Q9NYE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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