ID   TNR9_MOUSE              Reviewed;         256 AA.
AC   P20334;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   14-OCT-2015, entry version 135.
DE   RecName: Full=Tumor necrosis factor receptor superfamily member 9;
DE   AltName: Full=4-1BB ligand receptor;
DE   AltName: Full=T-cell antigen 4-1BB;
DE   AltName: CD_antigen=CD137;
DE   Flags: Precursor;
GN   Name=Tnfrsf9; Synonyms=Cd137, Ila, Ly63;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2784565; DOI=10.1073/pnas.86.6.1963;
RA   Kwon B.S., Weissman S.M.;
RT   "cDNA sequences of two inducible T-cell genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:1963-1967(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BALB/c;
RX   PubMed=8133039;
RA   Kwon B.S., Kozak C.A., Kim K.K., Pickard R.T.;
RT   "Genomic organization and chromosomal localization of the T-cell
RT   antigen 4-1BB.";
RL   J. Immunol. 152:2256-2262(1994).
RN   [3]
RP   CHARACTERIZATION, AND PROTEIN SEQUENCE OF 24-29.
RX   PubMed=7678621;
RA   Pollok K.E., Kim Y.-J., Zhou Z., Hurtado J., Kin K.K., Pickard R.T.,
RA   Kwon B.S.;
RT   "Inducible T cell antigen 4-1BB. Analysis of expression and
RT   function.";
RL   J. Immunol. 150:771-781(1993).
CC   -!- FUNCTION: Receptor for TNFSF9/4-1BBL. Possibly active during T
CC       cell activation.
CC   -!- SUBUNIT: Principally a homodimer, but also found as a monomer.
CC       Associates with p56-LCK. Interacts with TRAF1, TRAF2 and TRAF3 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- TISSUE SPECIFICITY: Expressed on the surface of activated T-cells.
CC   -!- INDUCTION: Optimal by PMA and ionomycin.
CC   -!- SIMILARITY: Contains 4 TNFR-Cys repeats. {ECO:0000305}.
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DR   EMBL; J04492; AAA40167.1; -; mRNA.
DR   EMBL; U02567; AAA93113.1; -; Genomic_DNA.
DR   CCDS; CCDS18976.1; -.
DR   PIR; B32393; B32393.
DR   RefSeq; NP_001070977.1; NM_001077509.1.
DR   RefSeq; NP_035742.1; NM_011612.2.
DR   RefSeq; XP_011248530.1; XM_011250228.1.
DR   UniGene; Mm.244187; -.
DR   PDB; 1D0J; X-ray; 2.50 A; G/H/I/J/K=231-236.
DR   PDBsum; 1D0J; -.
DR   ProteinModelPortal; P20334; -.
DR   SMR; P20334; 28-158.
DR   BioGrid; 204254; 1.
DR   DIP; DIP-1154N; -.
DR   IntAct; P20334; 5.
DR   MINT; MINT-4138174; -.
DR   STRING; 10090.ENSMUSP00000030808; -.
DR   PhosphoSite; P20334; -.
DR   PaxDb; P20334; -.
DR   PRIDE; P20334; -.
DR   GeneID; 21942; -.
DR   UCSC; uc008vya.1; mouse.
DR   CTD; 3604; -.
DR   MGI; MGI:1101059; Tnfrsf9.
DR   eggNOG; NOG44848; -.
DR   HOGENOM; HOG000033708; -.
DR   HOVERGEN; HBG000021; -.
DR   InParanoid; P20334; -.
DR   OMA; WTNCSLD; -.
DR   PhylomeDB; P20334; -.
DR   TreeFam; TF336151; -.
DR   ChiTaRS; Tnfrsf9; mouse.
DR   EvolutionaryTrace; P20334; -.
DR   NextBio; 301576; -.
DR   PRO; PR:P20334; -.
DR   Proteomes; UP000000589; Unplaced.
DR   Bgee; P20334; -.
DR   ExpressionAtlas; P20334; baseline.
DR   Genevisible; P20334; MM.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004872; F:receptor activity; IPI:MGI.
DR   GO; GO:2001180; P:negative regulation of interleukin-10 secretion; IMP:MGI.
DR   GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IMP:MGI.
DR   GO; GO:0070207; P:protein homotrimerization; IDA:MGI.
DR   GO; GO:0042127; P:regulation of cell proliferation; IDA:MGI.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR020413; TNFR_9.
DR   Pfam; PF00020; TNFR_c6; 1.
DR   PRINTS; PR01924; TNFACTORR9.
DR   SMART; SM00208; TNFR; 2.
DR   PROSITE; PS00652; TNFR_NGFR_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Direct protein sequencing;
KW   Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW   Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     23       {ECO:0000269|PubMed:7678621}.
FT   CHAIN        24    256       Tumor necrosis factor receptor
FT                                superfamily member 9.
FT                                /FTId=PRO_0000034578.
FT   TOPO_DOM     24    187       Extracellular. {ECO:0000255}.
FT   TRANSMEM    188    208       Helical. {ECO:0000255}.
FT   TOPO_DOM    209    256       Cytoplasmic. {ECO:0000255}.
FT   REPEAT       24     45       TNFR-Cys 1.
FT   REPEAT       46     85       TNFR-Cys 2.
FT   REPEAT       86    117       TNFR-Cys 3.
FT   REPEAT      118    159       TNFR-Cys 4.
FT   CARBOHYD    128    128       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    138    138       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     28     37       {ECO:0000250}.
FT   DISULFID     31     44       {ECO:0000250}.
FT   DISULFID     47     61       {ECO:0000250}.
FT   DISULFID     64     77       {ECO:0000250}.
FT   DISULFID     67     85       {ECO:0000250}.
FT   DISULFID     87     93       {ECO:0000250}.
FT   DISULFID     98    105       {ECO:0000250}.
FT   DISULFID    101    116       {ECO:0000250}.
FT   DISULFID    119    133       {ECO:0000250}.
FT   DISULFID    139    158       {ECO:0000250}.
SQ   SEQUENCE   256 AA;  27598 MW;  93A10D03C60813C4 CRC64;
     MGNNCYNVVV IVLLLVGCEK VGAVQNSCDN CQPGTFCRKY NPVCKSCPPS TFSSIGGQPN
     CNICRVCAGY FRFKKFCSST HNAECECIEG FHCLGPQCTR CEKDCRPGQE LTKQGCKTCS
     LGTFNDQNGT GVCRPWTNCS LDGRSVLKTG TTEKDVVCGP PVVSFSPSTT ISVTPEGGPG
     GHSLQVLTLF LALTSALLLA LIFITLLFSV LKWIRKKFPH IFKQPFKKTT GAAQEEDACS
     CRCPQEEEGG GGGYEL
//