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Protein

Tumor necrosis factor receptor superfamily member 9

Gene

Tnfrsf9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

GO - Molecular functioni

  • cytokine binding Source: MGI
  • receptor activity Source: MGI
  • tumor necrosis factor-activated receptor activity Source: GO_Central

GO - Biological processi

  • apoptotic signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • multicellular organism development Source: GO_Central
  • negative regulation of cell proliferation Source: InterPro
  • negative regulation of interleukin-10 secretion Source: MGI
  • negative regulation of interleukin-12 secretion Source: MGI
  • protein homotrimerization Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • regulation of cell proliferation Source: MGI
  • response to lipopolysaccharide Source: GO_Central

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 9
Alternative name(s):
4-1BB ligand receptor
T-cell antigen 4-1BB
CD_antigen: CD137
Gene namesi
Name:Tnfrsf9
Synonyms:Cd137, Ila, Ly63
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1101059 Tnfrsf9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 187ExtracellularSequence analysisAdd BLAST164
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 256CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000003457824 – 256Tumor necrosis factor receptor superfamily member 9Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 37By similarity
Disulfide bondi31 ↔ 44By similarity
Disulfide bondi47 ↔ 61By similarity
Disulfide bondi64 ↔ 77By similarity
Disulfide bondi67 ↔ 85By similarity
Disulfide bondi87 ↔ 93By similarity
Disulfide bondi98 ↔ 105By similarity
Disulfide bondi101 ↔ 116By similarity
Disulfide bondi119 ↔ 133By similarity
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi139 ↔ 158By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP20334
PaxDbiP20334
PeptideAtlasiP20334
PRIDEiP20334

PTM databases

PhosphoSitePlusiP20334

Expressioni

Tissue specificityi

Expressed on the surface of activated T-cells.

Inductioni

Optimal by PMA and ionomycin.

Gene expression databases

BgeeiENSMUSG00000028965
ExpressionAtlasiP20334 baseline and differential
GenevisibleiP20334 MM

Interactioni

Subunit structurei

Principally a homodimer, but also found as a monomer. Associates with p56-LCK. Interacts with TRAF1, TRAF2 and TRAF3 (By similarity).By similarity

GO - Molecular functioni

  • cytokine binding Source: MGI

Protein-protein interaction databases

BioGridi204254, 1 interactor
DIPiDIP-1154N
IntActiP20334, 5 interactors
MINTiP20334
STRINGi10090.ENSMUSP00000030808

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 30Combined sources3
Beta strandi35 – 38Combined sources4
Beta strandi41 – 46Combined sources6
Beta strandi54 – 56Combined sources3
Beta strandi58 – 60Combined sources3
Beta strandi71 – 75Combined sources5
Beta strandi79 – 81Combined sources3
Beta strandi84 – 87Combined sources4
Beta strandi91 – 95Combined sources5
Beta strandi100 – 103Combined sources4
Beta strandi109 – 112Combined sources4
Beta strandi115 – 118Combined sources4
Beta strandi127 – 130Combined sources4
Turni139 – 143Combined sources5
Beta strandi144 – 148Combined sources5
Beta strandi152 – 154Combined sources3
Beta strandi157 – 160Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D0JX-ray2.50G/H/I/J/K231-236[»]
5WI8X-ray2.95A/B/C/D24-160[»]
5WIWX-ray2.30A/B24-160[»]
5WJFX-ray2.60A/B24-160[»]
ProteinModelPortaliP20334
SMRiP20334
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20334

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 45TNFR-Cys 1Add BLAST22
Repeati46 – 85TNFR-Cys 2Add BLAST40
Repeati86 – 117TNFR-Cys 3Add BLAST32
Repeati118 – 159TNFR-Cys 4Add BLAST42

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW3N Eukaryota
ENOG41129F9 LUCA
GeneTreeiENSGT00730000111279
HOGENOMiHOG000033708
HOVERGENiHBG000021
InParanoidiP20334
KOiK05146
OMAiFKQPFMR
OrthoDBiEOG091G03XW
PhylomeDBiP20334
TreeFamiTF336151

Family and domain databases

CDDicd13410 TNFRSF9, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020413 TNFR_9
IPR034020 TNFRSF9_N
PANTHERiPTHR23097:SF136 PTHR23097:SF136, 1 hit
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01924 TNFACTORR9
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNNCYNVVV IVLLLVGCEK VGAVQNSCDN CQPGTFCRKY NPVCKSCPPS
60 70 80 90 100
TFSSIGGQPN CNICRVCAGY FRFKKFCSST HNAECECIEG FHCLGPQCTR
110 120 130 140 150
CEKDCRPGQE LTKQGCKTCS LGTFNDQNGT GVCRPWTNCS LDGRSVLKTG
160 170 180 190 200
TTEKDVVCGP PVVSFSPSTT ISVTPEGGPG GHSLQVLTLF LALTSALLLA
210 220 230 240 250
LIFITLLFSV LKWIRKKFPH IFKQPFKKTT GAAQEEDACS CRCPQEEEGG

GGGYEL
Length:256
Mass (Da):27,598
Last modified:February 1, 1991 - v1
Checksum:i93A10D03C60813C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04492 mRNA Translation: AAA40167.1
U02567 Genomic DNA Translation: AAA93113.1
CCDSiCCDS18976.1
PIRiB32393
RefSeqiNP_001070977.1, NM_001077509.1
NP_035742.1, NM_011612.2
XP_011248530.1, XM_011250228.2
UniGeneiMm.244187

Genome annotation databases

EnsembliENSMUST00000030808; ENSMUSP00000030808; ENSMUSG00000028965
ENSMUST00000105671; ENSMUSP00000101296; ENSMUSG00000028965
ENSMUST00000116257; ENSMUSP00000111961; ENSMUSG00000028965
GeneIDi21942
KEGGimmu:21942
UCSCiuc008vya.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTNR9_MOUSE
AccessioniPrimary (citable) accession number: P20334
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 28, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health