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Protein

Tumor necrosis factor receptor superfamily member 9

Gene

Tnfrsf9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

GO - Molecular functioni

  • cytokine binding Source: MGI
  • receptor activity Source: MGI
  • tumor necrosis factor-activated receptor activity Source: GO_Central

GO - Biological processi

  • extrinsic apoptotic signaling pathway via death domain receptors Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • multicellular organism development Source: GO_Central
  • negative regulation of interleukin-10 secretion Source: MGI
  • negative regulation of interleukin-12 secretion Source: MGI
  • protein homotrimerization Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • regulation of cell proliferation Source: MGI
  • response to lipopolysaccharide Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 9
Alternative name(s):
4-1BB ligand receptor
T-cell antigen 4-1BB
CD_antigen: CD137
Gene namesi
Name:Tnfrsf9
Synonyms:Cd137, Ila, Ly63
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1101059. Tnfrsf9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 187164ExtracellularSequence analysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST
Topological domaini209 – 25648CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • extracellular space Source: MGI
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 256233Tumor necrosis factor receptor superfamily member 9PRO_0000034578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 37By similarity
Disulfide bondi31 ↔ 44By similarity
Disulfide bondi47 ↔ 61By similarity
Disulfide bondi64 ↔ 77By similarity
Disulfide bondi67 ↔ 85By similarity
Disulfide bondi87 ↔ 93By similarity
Disulfide bondi98 ↔ 105By similarity
Disulfide bondi101 ↔ 116By similarity
Disulfide bondi119 ↔ 133By similarity
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi139 ↔ 158By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP20334.
PaxDbiP20334.
PeptideAtlasiP20334.
PRIDEiP20334.

PTM databases

PhosphoSiteiP20334.

Expressioni

Tissue specificityi

Expressed on the surface of activated T-cells.

Inductioni

Optimal by PMA and ionomycin.

Gene expression databases

BgeeiENSMUSG00000028965.
ExpressionAtlasiP20334. baseline and differential.
GenevisibleiP20334. MM.

Interactioni

Subunit structurei

Principally a homodimer, but also found as a monomer. Associates with p56-LCK. Interacts with TRAF1, TRAF2 and TRAF3 (By similarity).By similarity

GO - Molecular functioni

  • cytokine binding Source: MGI

Protein-protein interaction databases

BioGridi204254. 1 interaction.
DIPiDIP-1154N.
IntActiP20334. 5 interactions.
MINTiMINT-4138174.
STRINGi10090.ENSMUSP00000030808.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D0JX-ray2.50G/H/I/J/K231-236[»]
ProteinModelPortaliP20334.
SMRiP20334. Positions 28-158.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20334.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 4522TNFR-Cys 1Add
BLAST
Repeati46 – 8540TNFR-Cys 2Add
BLAST
Repeati86 – 11732TNFR-Cys 3Add
BLAST
Repeati118 – 15942TNFR-Cys 4Add
BLAST

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW3N. Eukaryota.
ENOG41129F9. LUCA.
HOGENOMiHOG000033708.
HOVERGENiHBG000021.
InParanoidiP20334.
KOiK05146.
OMAiWTNCSLD.
OrthoDBiEOG091G03XW.
PhylomeDBiP20334.
TreeFamiTF336151.

Family and domain databases

CDDicd13410. TNFRSF9. 1 hit.
InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020413. TNFR_9.
[Graphical view]
PANTHERiPTHR23097:SF136. PTHR23097:SF136. 2 hits.
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01924. TNFACTORR9.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNNCYNVVV IVLLLVGCEK VGAVQNSCDN CQPGTFCRKY NPVCKSCPPS
60 70 80 90 100
TFSSIGGQPN CNICRVCAGY FRFKKFCSST HNAECECIEG FHCLGPQCTR
110 120 130 140 150
CEKDCRPGQE LTKQGCKTCS LGTFNDQNGT GVCRPWTNCS LDGRSVLKTG
160 170 180 190 200
TTEKDVVCGP PVVSFSPSTT ISVTPEGGPG GHSLQVLTLF LALTSALLLA
210 220 230 240 250
LIFITLLFSV LKWIRKKFPH IFKQPFKKTT GAAQEEDACS CRCPQEEEGG

GGGYEL
Length:256
Mass (Da):27,598
Last modified:February 1, 1991 - v1
Checksum:i93A10D03C60813C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04492 mRNA. Translation: AAA40167.1.
U02567 Genomic DNA. Translation: AAA93113.1.
CCDSiCCDS18976.1.
PIRiB32393.
RefSeqiNP_001070977.1. NM_001077509.1.
NP_035742.1. NM_011612.2.
XP_011248530.1. XM_011250228.1.
UniGeneiMm.244187.

Genome annotation databases

EnsembliENSMUST00000030808; ENSMUSP00000030808; ENSMUSG00000028965.
ENSMUST00000105671; ENSMUSP00000101296; ENSMUSG00000028965.
ENSMUST00000116257; ENSMUSP00000111961; ENSMUSG00000028965.
GeneIDi21942.
KEGGimmu:21942.
UCSCiuc008vya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04492 mRNA. Translation: AAA40167.1.
U02567 Genomic DNA. Translation: AAA93113.1.
CCDSiCCDS18976.1.
PIRiB32393.
RefSeqiNP_001070977.1. NM_001077509.1.
NP_035742.1. NM_011612.2.
XP_011248530.1. XM_011250228.1.
UniGeneiMm.244187.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D0JX-ray2.50G/H/I/J/K231-236[»]
ProteinModelPortaliP20334.
SMRiP20334. Positions 28-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204254. 1 interaction.
DIPiDIP-1154N.
IntActiP20334. 5 interactions.
MINTiMINT-4138174.
STRINGi10090.ENSMUSP00000030808.

PTM databases

PhosphoSiteiP20334.

Proteomic databases

EPDiP20334.
PaxDbiP20334.
PeptideAtlasiP20334.
PRIDEiP20334.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030808; ENSMUSP00000030808; ENSMUSG00000028965.
ENSMUST00000105671; ENSMUSP00000101296; ENSMUSG00000028965.
ENSMUST00000116257; ENSMUSP00000111961; ENSMUSG00000028965.
GeneIDi21942.
KEGGimmu:21942.
UCSCiuc008vya.1. mouse.

Organism-specific databases

CTDi3604.
MGIiMGI:1101059. Tnfrsf9.

Phylogenomic databases

eggNOGiENOG410IW3N. Eukaryota.
ENOG41129F9. LUCA.
HOGENOMiHOG000033708.
HOVERGENiHBG000021.
InParanoidiP20334.
KOiK05146.
OMAiWTNCSLD.
OrthoDBiEOG091G03XW.
PhylomeDBiP20334.
TreeFamiTF336151.

Miscellaneous databases

ChiTaRSiTnfrsf9. mouse.
EvolutionaryTraceiP20334.
PROiP20334.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028965.
ExpressionAtlasiP20334. baseline and differential.
GenevisibleiP20334. MM.

Family and domain databases

CDDicd13410. TNFRSF9. 1 hit.
InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020413. TNFR_9.
[Graphical view]
PANTHERiPTHR23097:SF136. PTHR23097:SF136. 2 hits.
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01924. TNFACTORR9.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR9_MOUSE
AccessioniPrimary (citable) accession number: P20334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.