ID   CNTF_RAT                Reviewed;         200 AA.
AC   P20294;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   24-JAN-2024, entry version 151.
DE   RecName: Full=Ciliary neurotrophic factor;
DE            Short=CNTF;
GN   Name=Cntf;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=2594085; DOI=10.1038/342920a0;
RA   Stoeckli K.A., Lottspeich F., Sendtner M., Masiakowski P., Carroll P.,
RA   Goetz R., Lindholm D., Thoenen H.;
RT   "Molecular cloning, expression and regional distribution of rat ciliary
RT   neurotrophic factor.";
RL   Nature 342:920-923(1989).
CC   -!- FUNCTION: CNTF is a survival factor for various neuronal cell types.
CC       Seems to prevent the degeneration of motor axons after axotomy.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Nervous system.
CC   -!- SIMILARITY: Belongs to the CNTF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X17457; CAA35500.1; -; mRNA.
DR   PIR; S08144; UNRTCF.
DR   RefSeq; NP_037298.1; NM_013166.1.
DR   AlphaFoldDB; P20294; -.
DR   SMR; P20294; -.
DR   STRING; 10116.ENSRNOP00000016690; -.
DR   PhosphoSitePlus; P20294; -.
DR   PaxDb; 10116-ENSRNOP00000016690; -.
DR   Ensembl; ENSRNOT00055017589; ENSRNOP00055014154; ENSRNOG00055010397.
DR   GeneID; 25707; -.
DR   KEGG; rno:25707; -.
DR   UCSC; RGD:2370; rat.
DR   AGR; RGD:2370; -.
DR   CTD; 1270; -.
DR   RGD; 2370; Cntf.
DR   eggNOG; ENOG502S4XX; Eukaryota.
DR   InParanoid; P20294; -.
DR   OrthoDB; 4215903at2759; -.
DR   PhylomeDB; P20294; -.
DR   Reactome; R-RNO-6788467; IL-6-type cytokine receptor ligand interactions.
DR   PRO; PR:P20294; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0030424; C:axon; IDA:RGD.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0097386; C:glial cell projection; IDA:RGD.
DR   GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR   GO; GO:0032838; C:plasma membrane bounded cell projection cytoplasm; IDA:RGD.
DR   GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; IPI:RGD.
DR   GO; GO:0005125; F:cytokine activity; IDA:RGD.
DR   GO; GO:0008083; F:growth factor activity; ISO:RGD.
DR   GO; GO:0005138; F:interleukin-6 receptor binding; ISO:RGD.
DR   GO; GO:0044877; F:protein-containing complex binding; IPI:RGD.
DR   GO; GO:0048143; P:astrocyte activation; IDA:RGD.
DR   GO; GO:0031103; P:axon regeneration; IDA:UniProtKB.
DR   GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; ISO:RGD.
DR   GO; GO:0060081; P:membrane hyperpolarization; IDA:RGD.
DR   GO; GO:0048644; P:muscle organ morphogenesis; ISO:RGD.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IDA:RGD.
DR   GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; ISO:RGD.
DR   GO; GO:0007399; P:nervous system development; IDA:RGD.
DR   GO; GO:0048666; P:neuron development; ISO:RGD.
DR   GO; GO:0048680; P:positive regulation of axon regeneration; IDA:RGD.
DR   GO; GO:0030307; P:positive regulation of cell growth; IDA:RGD.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   GO; GO:0046887; P:positive regulation of hormone secretion; IDA:RGD.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:RGD.
DR   GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IDA:RGD.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IDA:RGD.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:RGD.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IDA:RGD.
DR   GO; GO:0060075; P:regulation of resting membrane potential; IDA:RGD.
DR   GO; GO:0046668; P:regulation of retinal cell programmed cell death; ISO:RGD.
DR   GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
DR   GO; GO:0009642; P:response to light intensity; IEP:RGD.
DR   GO; GO:0060221; P:retinal rod cell differentiation; ISO:RGD.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000151; Ciliary_neurotrophic_fac_CNTF.
DR   PANTHER; PTHR15196; CILIARY NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR15196:SF0; CILIARY NEUROTROPHIC FACTOR; 1.
DR   Pfam; PF01110; CNTF; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Differentiation;
KW   Direct protein sequencing; Growth factor; Neurogenesis; Reference proteome.
FT   CHAIN           1..200
FT                   /note="Ciliary neurotrophic factor"
FT                   /id="PRO_0000149523"
SQ   SEQUENCE   200 AA;  22854 MW;  FC95A25FE1A1DE3D CRC64;
     MAFAEQTPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNINL DSVDGVPVAS
     TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP TEGDFHQAIH TLMLQVSAFA
     YQLEELMVLL EQKIPENEAD GMPATVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRVIS
     SHQMGISALE SHYGAKDKQM
//