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Protein

Ciliary neurotrophic factor

Gene

Cntf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

GO - Molecular functioni

  • ciliary neurotrophic factor receptor binding Source: RGD
  • cytokine activity Source: RGD
  • growth factor activity Source: RGD
  • interleukin-6 receptor binding Source: RGD

GO - Biological processi

  • astrocyte activation Source: RGD
  • ciliary neurotrophic factor-mediated signaling pathway Source: RGD
  • growth Source: InterPro
  • JAK-STAT cascade Source: RGD
  • membrane hyperpolarization Source: RGD
  • muscle organ morphogenesis Source: RGD
  • negative regulation of neuron apoptotic process Source: RGD
  • negative regulation of neuron death Source: RGD
  • negative regulation of photoreceptor cell differentiation Source: RGD
  • nervous system development Source: RGD
  • neuron development Source: RGD
  • positive regulation of axon extension involved in regeneration Source: CAFA
  • positive regulation of axon regeneration Source: RGD
  • positive regulation of cell growth Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of hormone secretion Source: RGD
  • positive regulation of JAK-STAT cascade Source: RGD
  • positive regulation of MAPK cascade Source: RGD
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: RGD
  • positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
  • protein heterooligomerization Source: RGD
  • regulation of resting membrane potential Source: RGD
  • regulation of retinal cell programmed cell death Source: RGD
  • response to electrical stimulus Source: RGD
  • response to light intensity Source: RGD

Keywordsi

Molecular functionDevelopmental protein, Growth factor
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor
Short name:
CNTF
Gene namesi
Name:Cntf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2370. Cntf.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001495231 – 200Ciliary neurotrophic factorAdd BLAST200

Proteomic databases

PaxDbiP20294.

Expressioni

Tissue specificityi

Nervous system.

Interactioni

GO - Molecular functioni

  • ciliary neurotrophic factor receptor binding Source: RGD
  • cytokine activity Source: RGD
  • growth factor activity Source: RGD
  • interleukin-6 receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016690.

Structurei

3D structure databases

ProteinModelPortaliP20294.
SMRiP20294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CNTF family.Curated

Phylogenomic databases

eggNOGiENOG410IGEN. Eukaryota.
ENOG410YYIH. LUCA.
HOGENOMiHOG000059605.
HOVERGENiHBG005362.
InParanoidiP20294.
KOiK05420.
PhylomeDBiP20294.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
PfamiView protein in Pfam
PF01110. CNTF. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

P20294-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFAEQTPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNINL
60 70 80 90 100
DSVDGVPVAS TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP
110 120 130 140 150
TEGDFHQAIH TLMLQVSAFA YQLEELMVLL EQKIPENEAD GMPATVGDGG
160 170 180 190 200
LFEKKLWGLK VLQELSQWTV RSIHDLRVIS SHQMGISALE SHYGAKDKQM
Length:200
Mass (Da):22,854
Last modified:February 1, 1991 - v1
Checksum:iFC95A25FE1A1DE3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17457 mRNA. Translation: CAA35500.1.
PIRiS08144. UNRTCF.
RefSeqiNP_037298.1. NM_013166.1.
UniGeneiRn.6067.

Genome annotation databases

GeneIDi25707.
KEGGirno:25707.
UCSCiRGD:2370. rat.

Similar proteinsi

Entry informationi

Entry nameiCNTF_RAT
AccessioniPrimary (citable) accession number: P20294
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 22, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families