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P20294

- CNTF_RAT

UniProt

P20294 - CNTF_RAT

Protein

Ciliary neurotrophic factor

Gene

Cntf

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

    GO - Molecular functioni

    1. ciliary neurotrophic factor receptor binding Source: RGD
    2. cytokine activity Source: RGD
    3. growth factor activity Source: RGD

    GO - Biological processi

    1. astrocyte activation Source: RGD
    2. growth Source: InterPro
    3. JAK-STAT cascade Source: RGD
    4. membrane hyperpolarization Source: RGD
    5. negative regulation of neuron apoptotic process Source: RGD
    6. negative regulation of neuron death Source: RGD
    7. nervous system development Source: RGD
    8. positive regulation of axon regeneration Source: RGD
    9. positive regulation of cell growth Source: RGD
    10. positive regulation of cell proliferation Source: RGD
    11. positive regulation of hormone secretion Source: RGD
    12. positive regulation of JAK-STAT cascade Source: RGD
    13. positive regulation of MAPK cascade Source: RGD
    14. positive regulation of phosphatidylinositol 3-kinase signaling Source: RGD
    15. positive regulation of tyrosine phosphorylation of Stat3 protein Source: RGD
    16. protein heterooligomerization Source: RGD
    17. regulation of resting membrane potential Source: RGD
    18. response to electrical stimulus Source: RGD
    19. response to light intensity Source: RGD

    Keywords - Molecular functioni

    Developmental protein, Growth factor

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ciliary neurotrophic factor
    Short name:
    CNTF
    Gene namesi
    Name:Cntf
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2370. Cntf.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: RGD
    2. cell projection cytoplasm Source: RGD
    3. cytosol Source: RGD
    4. neuronal cell body Source: RGD
    5. nucleus Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Ciliary neurotrophic factorPRO_0000149523Add
    BLAST

    Expressioni

    Tissue specificityi

    Nervous system.

    Gene expression databases

    GenevestigatoriP20294.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016690.

    Structurei

    3D structure databases

    ProteinModelPortaliP20294.
    SMRiP20294. Positions 12-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CNTF family.Curated

    Phylogenomic databases

    eggNOGiNOG114783.
    HOGENOMiHOG000059605.
    HOVERGENiHBG005362.
    InParanoidiP20294.
    KOiK05420.
    PhylomeDBiP20294.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000151. Ciliary_neurotrophic_fac_CNTF.
    [Graphical view]
    PfamiPF01110. CNTF. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P20294-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFAEQTPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNINL    50
    DSVDGVPVAS TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP 100
    TEGDFHQAIH TLMLQVSAFA YQLEELMVLL EQKIPENEAD GMPATVGDGG 150
    LFEKKLWGLK VLQELSQWTV RSIHDLRVIS SHQMGISALE SHYGAKDKQM 200
    Length:200
    Mass (Da):22,854
    Last modified:February 1, 1991 - v1
    Checksum:iFC95A25FE1A1DE3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17457 mRNA. Translation: CAA35500.1.
    PIRiS08144. UNRTCF.
    RefSeqiNP_037298.1. NM_013166.1.
    UniGeneiRn.6067.

    Genome annotation databases

    GeneIDi25707.
    KEGGirno:25707.
    UCSCiRGD:2370. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17457 mRNA. Translation: CAA35500.1 .
    PIRi S08144. UNRTCF.
    RefSeqi NP_037298.1. NM_013166.1.
    UniGenei Rn.6067.

    3D structure databases

    ProteinModelPortali P20294.
    SMRi P20294. Positions 12-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016690.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25707.
    KEGGi rno:25707.
    UCSCi RGD:2370. rat.

    Organism-specific databases

    CTDi 1270.
    RGDi 2370. Cntf.

    Phylogenomic databases

    eggNOGi NOG114783.
    HOGENOMi HOG000059605.
    HOVERGENi HBG005362.
    InParanoidi P20294.
    KOi K05420.
    PhylomeDBi P20294.

    Miscellaneous databases

    NextBioi 607759.

    Gene expression databases

    Genevestigatori P20294.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000151. Ciliary_neurotrophic_fac_CNTF.
    [Graphical view ]
    Pfami PF01110. CNTF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor."
      Stoeckli K.A., Lottspeich F., Sendtner M., Masiakowski P., Carroll P., Goetz R., Lindholm D., Thoenen H.
      Nature 342:920-923(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiCNTF_RAT
    AccessioniPrimary (citable) accession number: P20294
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3