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P20294 (CNTF_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ciliary neurotrophic factor

Short name=CNTF
Gene names
Name:Cntf
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

Subcellular location

Cytoplasm.

Tissue specificity

Nervous system.

Sequence similarities

Belongs to the CNTF family.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentCytoplasm
   Molecular functionDevelopmental protein
Growth factor
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processJAK-STAT cascade

Inferred from direct assay PubMed 15342787. Source: RGD

astrocyte activation

Inferred from direct assay PubMed 11771938. Source: RGD

growth

Inferred from electronic annotation. Source: InterPro

membrane hyperpolarization

Inferred from direct assay PubMed 15831538. Source: RGD

negative regulation of neuron apoptotic process

Inferred from direct assay PubMed 15574731. Source: RGD

negative regulation of neuron death

Inferred from direct assay PubMed 14725620. Source: RGD

nervous system development

Inferred from direct assay PubMed 11932952. Source: RGD

positive regulation of JAK-STAT cascade

Inferred from direct assay PubMed 15574731. Source: RGD

positive regulation of MAPK cascade

Inferred from direct assay PubMed 15574731. Source: RGD

positive regulation of axon regeneration

Inferred from direct assay PubMed 15574731. Source: RGD

positive regulation of cell growth

Inferred from direct assay PubMed 11771938. Source: RGD

positive regulation of cell proliferation

Inferred from direct assay PubMed 15831538. Source: RGD

positive regulation of hormone secretion

Inferred from direct assay PubMed 11771938. Source: RGD

positive regulation of phosphatidylinositol 3-kinase signaling

Inferred from direct assay PubMed 15574731. Source: RGD

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from direct assay PubMed 14725620. Source: RGD

protein heterooligomerization

Inferred from physical interaction PubMed 8385113. Source: RGD

regulation of resting membrane potential

Inferred from direct assay PubMed 15831538. Source: RGD

   Cellular_componentaxon

Inferred from direct assay PubMed 12849744. Source: RGD

cell projection cytoplasm

Inferred from direct assay PubMed 12849744. Source: RGD

cytosol

Inferred from direct assay Ref.1. Source: RGD

neuronal cell body

Inferred from direct assay PubMed 12849744. Source: RGD

nucleus

Inferred from direct assay PubMed 12849744. Source: RGD

   Molecular_functionciliary neurotrophic factor receptor binding

Inferred from physical interaction PubMed 1648265. Source: RGD

cytokine activity

Inferred from direct assay PubMed 8385113. Source: RGD

growth factor activity

Traceable author statement PubMed 12040055. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Ciliary neurotrophic factor
PRO_0000149523

Sequences

Sequence LengthMass (Da)Tools
P20294 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: FC95A25FE1A1DE3D

FASTA20022,854
        10         20         30         40         50         60 
MAFAEQTPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNINL DSVDGVPVAS 

        70         80         90        100        110        120 
TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP TEGDFHQAIH TLMLQVSAFA 

       130        140        150        160        170        180 
YQLEELMVLL EQKIPENEAD GMPATVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRVIS 

       190        200 
SHQMGISALE SHYGAKDKQM 

« Hide

References

[1]"Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor."
Stoeckli K.A., Lottspeich F., Sendtner M., Masiakowski P., Carroll P., Goetz R., Lindholm D., Thoenen H.
Nature 342:920-923(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17457 mRNA. Translation: CAA35500.1.
PIRUNRTCF. S08144.
RefSeqNP_037298.1. NM_013166.1.
UniGeneRn.6067.

3D structure databases

ProteinModelPortalP20294.
SMRP20294. Positions 12-186.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000016690.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25707.
KEGGrno:25707.
UCSCRGD:2370. rat.

Organism-specific databases

CTD1270.
RGD2370. Cntf.

Phylogenomic databases

eggNOGNOG114783.
HOGENOMHOG000059605.
HOVERGENHBG005362.
InParanoidP20294.
KOK05420.
PhylomeDBP20294.

Gene expression databases

GenevestigatorP20294.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
[Graphical view]
PfamPF01110. CNTF. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio607759.

Entry information

Entry nameCNTF_RAT
AccessionPrimary (citable) accession number: P20294
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families