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Protein

Ciliary neurotrophic factor

Gene

Cntf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

GO - Molecular functioni

  • ciliary neurotrophic factor receptor binding Source: RGD
  • cytokine activity Source: RGD
  • growth factor activity Source: RGD

GO - Biological processi

  • astrocyte activation Source: RGD
  • growth Source: InterPro
  • JAK-STAT cascade Source: RGD
  • membrane hyperpolarization Source: RGD
  • negative regulation of neuron apoptotic process Source: RGD
  • negative regulation of neuron death Source: RGD
  • nervous system development Source: RGD
  • positive regulation of axon regeneration Source: RGD
  • positive regulation of cell growth Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of hormone secretion Source: RGD
  • positive regulation of JAK-STAT cascade Source: RGD
  • positive regulation of MAPK cascade Source: RGD
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: RGD
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: RGD
  • protein heterooligomerization Source: RGD
  • regulation of resting membrane potential Source: RGD
  • response to electrical stimulus Source: RGD
  • response to light intensity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor
Short name:
CNTF
Gene namesi
Name:Cntf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2370. Cntf.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • cell projection cytoplasm Source: RGD
  • cytosol Source: RGD
  • neuronal cell body Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Ciliary neurotrophic factorPRO_0000149523Add
BLAST

Expressioni

Tissue specificityi

Nervous system.

Gene expression databases

GenevisibleiP20294. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016690.

Structurei

3D structure databases

ProteinModelPortaliP20294.
SMRiP20294. Positions 12-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CNTF family.Curated

Phylogenomic databases

eggNOGiNOG114783.
HOGENOMiHOG000059605.
HOVERGENiHBG005362.
InParanoidiP20294.
KOiK05420.
PhylomeDBiP20294.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
[Graphical view]
PfamiPF01110. CNTF. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

P20294-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFAEQTPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNINL
60 70 80 90 100
DSVDGVPVAS TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP
110 120 130 140 150
TEGDFHQAIH TLMLQVSAFA YQLEELMVLL EQKIPENEAD GMPATVGDGG
160 170 180 190 200
LFEKKLWGLK VLQELSQWTV RSIHDLRVIS SHQMGISALE SHYGAKDKQM
Length:200
Mass (Da):22,854
Last modified:February 1, 1991 - v1
Checksum:iFC95A25FE1A1DE3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17457 mRNA. Translation: CAA35500.1.
PIRiS08144. UNRTCF.
RefSeqiNP_037298.1. NM_013166.1.
UniGeneiRn.6067.

Genome annotation databases

GeneIDi25707.
KEGGirno:25707.
UCSCiRGD:2370. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17457 mRNA. Translation: CAA35500.1.
PIRiS08144. UNRTCF.
RefSeqiNP_037298.1. NM_013166.1.
UniGeneiRn.6067.

3D structure databases

ProteinModelPortaliP20294.
SMRiP20294. Positions 12-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25707.
KEGGirno:25707.
UCSCiRGD:2370. rat.

Organism-specific databases

CTDi1270.
RGDi2370. Cntf.

Phylogenomic databases

eggNOGiNOG114783.
HOGENOMiHOG000059605.
HOVERGENiHBG005362.
InParanoidiP20294.
KOiK05420.
PhylomeDBiP20294.

Miscellaneous databases

NextBioi607759.
PROiP20294.

Gene expression databases

GenevisibleiP20294. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
[Graphical view]
PfamiPF01110. CNTF. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor."
    Stoeckli K.A., Lottspeich F., Sendtner M., Masiakowski P., Carroll P., Goetz R., Lindholm D., Thoenen H.
    Nature 342:920-923(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiCNTF_RAT
AccessioniPrimary (citable) accession number: P20294
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 24, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.