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P20273

- CD22_HUMAN

UniProt

P20273 - CD22_HUMAN

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Protein
B-cell receptor CD22
Gene
CD22, SIGLEC2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Sialic acid By similarity

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. cell adhesion Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell receptor CD22
Alternative name(s):
B-lymphocyte cell adhesion molecule
Short name:
BL-CAM
Sialic acid-binding Ig-like lectin 2
Short name:
Siglec-2
T-cell surface antigen Leu-14
CD_antigen: CD22
Gene namesi
Name:CD22
Synonyms:SIGLEC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:1643. CD22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 687668Extracellular Reviewed prediction
Add
BLAST
Transmembranei688 – 70619Helical; Reviewed prediction
Add
BLAST
Topological domaini707 – 847141Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 847828B-cell receptor CD22
PRO_0000014873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 167 By similarity
Disulfide bondi44 ↔ 102 By similarity
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi101 – 1011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi161 ↔ 219 By similarity
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi265 ↔ 309 By similarity
Disulfide bondi353 ↔ 396 By similarity
Glycosylationi363 – 3631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi442 ↔ 484 By similarity
Glycosylationi445 – 4451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi448 – 4481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi479 – 4791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi529 ↔ 571 By similarity
Glycosylationi574 – 5741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi616 ↔ 659 By similarity
Glycosylationi634 – 6341N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
Phosphorylated on tyrosine residues by LYN By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP20273.
PaxDbiP20273.
PRIDEiP20273.

PTM databases

PhosphoSiteiP20273.

Expressioni

Tissue specificityi

B-lymphocytes.

Gene expression databases

ArrayExpressiP20273.
BgeeiP20273.
GenevestigatoriP20273.

Organism-specific databases

HPAiCAB002418.
HPA024353.

Interactioni

Subunit structurei

Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation By similarity. May form a complex with INPP5D/SHIP, GRB2 and SHC1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LYNP079482EBI-78277,EBI-79452
PLCG1P191742EBI-78277,EBI-79387
PTPN6P293504EBI-78277,EBI-78260
SYKP434054EBI-78277,EBI-78302

Protein-protein interaction databases

BioGridi107371. 11 interactions.
IntActiP20273. 7 interactions.
MINTiMINT-3009156.

Structurei

3D structure databases

ProteinModelPortaliP20273.
SMRiP20273. Positions 36-677.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 138119Ig-like V-type
Add
BLAST
Domaini143 – 23593Ig-like C2-type 1
Add
BLAST
Domaini242 – 32685Ig-like C2-type 2
Add
BLAST
Domaini331 – 41686Ig-like C2-type 3
Add
BLAST
Domaini419 – 50082Ig-like C2-type 4
Add
BLAST
Domaini505 – 58278Ig-like C2-type 5
Add
BLAST
Domaini593 – 67684Ig-like C2-type 6
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi760 – 7656ITIM motif 1
Motifi794 – 7996ITIM motif 2
Motifi820 – 8256ITIM motif 3
Motifi840 – 8456ITIM motif 4

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287433.
HOVERGENiHBG005272.
InParanoidiP20273.
KOiK06467.
OMAiPTNYTWY.
OrthoDBiEOG7VHSWK.
PhylomeDBiP20273.
TreeFamiTF334827.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform CD22-beta (identifier: P20273-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD    50
GDLESFILFH NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK 100
NCTLSIHPVH LNDSGQLGLR MESKTEKWME RIHLNVSERP FPPHIQLPPE 150
IQESQEVTLT CLLNFSCYGY PIQLQWLLEG VPMRQAAVTS TSLTIKSVFT 200
RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH TPKLEIKVTP 250
SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT 300
KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE 350
FLCMSLANPL PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN 400
ILGTGQRGPG AELDVQYPPK KVTTVIQNPM PIREGDTVTL SCNYNSSNPS 450
VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT TIACAACNSW CSWASPVALN 500
VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ FFWEKNGRLL 550
GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM 600
SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK 650
VQHSGAYWCQ GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI 700
LAICGLKLQR RWKRTQSQQG LQENSSGQSF FVRNKKVRRA PLSEGPHSLG 750
CYNPMMEDGI SYTTLRFPEM NIPRTGDAES SEMQRPPPDC DDTVTYSALH 800
KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV DYVILKH 847
Length:847
Mass (Da):95,348
Last modified:July 15, 1999 - v2
Checksum:i38EB0BE4220ACA2D
GO
Isoform CD22-alpha (identifier: P20273-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-417: Missing.

Show »
Length:670
Mass (Da):75,799
Checksum:i04F241A74FF61471
GO
Isoform 3 (identifier: P20273-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-417: Missing.

Note: No experimental confirmation available.

Show »
Length:759
Mass (Da):85,675
Checksum:i18C7BFA0D4C94AE5
GO
Isoform 4 (identifier: P20273-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     737-751: VRRAPLSEGPHSLGC → RCRVLRDAETSPGLR
     752-847: Missing.

Note: Gene prediction based on EST data.

Show »
Length:751
Mass (Da):84,480
Checksum:i1DA8314C562A6D00
GO
Isoform 5 (identifier: P20273-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MHL → MSL
     4-175: Missing.

Note: No experimental confirmation available.

Show »
Length:675
Mass (Da):75,354
Checksum:iE0969BC34AC17057
GO

Sequence cautioni

The sequence CAA36988.1 differs from that shown. Reason: Frameshift at position 806.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341A → T.1 Publication
Corresponds to variant rs201453271 [ dbSNP | Ensembl ].
VAR_014133
Natural varianti152 – 1521Q → E Observed with a marginally higher frequency in patients with systemic lupus erythematosus. 1 Publication
VAR_003913
Natural varianti203 – 2031E → K.1 Publication
VAR_014134
Natural varianti551 – 5511G → R.
Corresponds to variant rs35715143 [ dbSNP | Ensembl ].
VAR_049903
Natural varianti639 – 6391Y → H.1 Publication
Corresponds to variant rs1058407 [ dbSNP | Ensembl ].
VAR_014135
Natural varianti664 – 6641S → G.1 Publication
Corresponds to variant rs17719289 [ dbSNP | Ensembl ].
VAR_003914
Natural varianti669 – 6691R → C.1 Publication
VAR_003915
Natural varianti745 – 7451G → D.1 Publication
Corresponds to variant rs10406069 [ dbSNP | Ensembl ].
VAR_003916

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 33MHL → MSL in isoform 5.
VSP_054619
Alternative sequencei4 – 175172Missing in isoform 5.
VSP_054620Add
BLAST
Alternative sequencei241 – 417177Missing in isoform CD22-alpha.
VSP_002531Add
BLAST
Alternative sequencei330 – 41788Missing in isoform 3.
VSP_045363Add
BLAST
Alternative sequencei737 – 75115VRRAP…HSLGC → RCRVLRDAETSPGLR in isoform 4.
VSP_047223Add
BLAST
Alternative sequencei752 – 84796Missing in isoform 4.
VSP_047224Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti486 – 4861A → R in CAA42006. 1 Publication
Sequence conflicti788 – 7892PD → RT in CAA42006. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62631 Genomic DNA. Translation: AAB06448.1.
U62631 Genomic DNA. Translation: AAB06449.1.
X59350 mRNA. Translation: CAA42006.1.
X52785 mRNA. Translation: CAA36988.1. Frameshift.
AK225625 mRNA. No translation available.
AC002132 Genomic DNA. No translation available.
BC109306 mRNA. Translation: AAI09307.1.
AB012995 Genomic DNA. Translation: BAA36564.1.
AB012996 Genomic DNA. Translation: BAA36565.1.
AB012997 Genomic DNA. Translation: BAA36566.1.
AB012998 Genomic DNA. Translation: BAA36567.1.
AB012999 Genomic DNA. Translation: BAA36568.1.
AB013000 Genomic DNA. Translation: BAA36569.1.
AB013002 Genomic DNA. Translation: BAA36571.1.
AB013003 Genomic DNA. Translation: BAA36572.1.
AB013004 Genomic DNA. Translation: BAA36573.1.
AB013006 Genomic DNA. Translation: BAA36575.1.
CCDSiCCDS12457.1. [P20273-1]
CCDS54247.1. [P20273-4]
CCDS54248.1. [P20273-3]
CCDS54249.1. [P20273-2]
CCDS62634.1. [P20273-5]
PIRiA35648.
RefSeqiNP_001172028.1. NM_001185099.1. [P20273-3]
NP_001172029.1. NM_001185100.1. [P20273-4]
NP_001172030.1. NM_001185101.1. [P20273-2]
NP_001265346.1. NM_001278417.1. [P20273-5]
NP_001762.2. NM_001771.3. [P20273-1]
UniGeneiHs.579691.

Genome annotation databases

EnsembliENST00000085219; ENSP00000085219; ENSG00000012124. [P20273-1]
ENST00000341773; ENSP00000339349; ENSG00000012124. [P20273-2]
ENST00000419549; ENSP00000403822; ENSG00000012124.
ENST00000536635; ENSP00000442279; ENSG00000012124. [P20273-3]
ENST00000544992; ENSP00000441237; ENSG00000012124. [P20273-4]
ENST00000594250; ENSP00000469984; ENSG00000012124. [P20273-2]
GeneIDi933.
KEGGihsa:933.
UCSCiuc002nzb.4. human. [P20273-2]
uc010edt.3. human. [P20273-1]

Polymorphism databases

DMDMi6166019.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-2 [3 Fc Domains]

Functional Glycomics Gateway - Glycan Binding

Siglec-2

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62631 Genomic DNA. Translation: AAB06448.1 .
U62631 Genomic DNA. Translation: AAB06449.1 .
X59350 mRNA. Translation: CAA42006.1 .
X52785 mRNA. Translation: CAA36988.1 . Frameshift.
AK225625 mRNA. No translation available.
AC002132 Genomic DNA. No translation available.
BC109306 mRNA. Translation: AAI09307.1 .
AB012995 Genomic DNA. Translation: BAA36564.1 .
AB012996 Genomic DNA. Translation: BAA36565.1 .
AB012997 Genomic DNA. Translation: BAA36566.1 .
AB012998 Genomic DNA. Translation: BAA36567.1 .
AB012999 Genomic DNA. Translation: BAA36568.1 .
AB013000 Genomic DNA. Translation: BAA36569.1 .
AB013002 Genomic DNA. Translation: BAA36571.1 .
AB013003 Genomic DNA. Translation: BAA36572.1 .
AB013004 Genomic DNA. Translation: BAA36573.1 .
AB013006 Genomic DNA. Translation: BAA36575.1 .
CCDSi CCDS12457.1. [P20273-1 ]
CCDS54247.1. [P20273-4 ]
CCDS54248.1. [P20273-3 ]
CCDS54249.1. [P20273-2 ]
CCDS62634.1. [P20273-5 ]
PIRi A35648.
RefSeqi NP_001172028.1. NM_001185099.1. [P20273-3 ]
NP_001172029.1. NM_001185100.1. [P20273-4 ]
NP_001172030.1. NM_001185101.1. [P20273-2 ]
NP_001265346.1. NM_001278417.1. [P20273-5 ]
NP_001762.2. NM_001771.3. [P20273-1 ]
UniGenei Hs.579691.

3D structure databases

ProteinModelPortali P20273.
SMRi P20273. Positions 36-677.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107371. 11 interactions.
IntActi P20273. 7 interactions.
MINTi MINT-3009156.

Chemistry

BindingDBi P20273.
ChEMBLi CHEMBL3218.
DrugBanki DB00045. OspA lipoprotein.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei P20273.

Polymorphism databases

DMDMi 6166019.

Proteomic databases

MaxQBi P20273.
PaxDbi P20273.
PRIDEi P20273.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000085219 ; ENSP00000085219 ; ENSG00000012124 . [P20273-1 ]
ENST00000341773 ; ENSP00000339349 ; ENSG00000012124 . [P20273-2 ]
ENST00000419549 ; ENSP00000403822 ; ENSG00000012124 .
ENST00000536635 ; ENSP00000442279 ; ENSG00000012124 . [P20273-3 ]
ENST00000544992 ; ENSP00000441237 ; ENSG00000012124 . [P20273-4 ]
ENST00000594250 ; ENSP00000469984 ; ENSG00000012124 . [P20273-2 ]
GeneIDi 933.
KEGGi hsa:933.
UCSCi uc002nzb.4. human. [P20273-2 ]
uc010edt.3. human. [P20273-1 ]

Organism-specific databases

CTDi 933.
GeneCardsi GC19P035826.
HGNCi HGNC:1643. CD22.
HPAi CAB002418.
HPA024353.
MIMi 107266. gene.
neXtProti NX_P20273.
PharmGKBi PA26201.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287433.
HOVERGENi HBG005272.
InParanoidi P20273.
KOi K06467.
OMAi PTNYTWY.
OrthoDBi EOG7VHSWK.
PhylomeDBi P20273.
TreeFami TF334827.

Miscellaneous databases

GeneWikii CD22.
GenomeRNAii 933.
NextBioi 3874.
PROi P20273.
SOURCEi Search...

Gene expression databases

ArrayExpressi P20273.
Bgeei P20273.
Genevestigatori P20273.

Family and domain databases

Gene3Di 2.60.40.10. 7 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF00047. ig. 2 hits.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
SM00408. IGc2. 4 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion."
    Stamenkovic I., Seed B.
    Nature 345:74-77(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD22-BETA).
  2. "cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions."
    Wilson G.L., Fox C.H., Fauci A.S., Kehrl J.H.
    J. Exp. Med. 173:137-146(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD22-BETA), VARIANT HIS-639.
    Tissue: Tonsil.
  3. "Genomic structure and chromosomal mapping of the human CD22 gene."
    Wilson G.L., Najfeld V., Kozlow E., Menniger J., Ward D., Kehrl J.H.
    J. Immunol. 150:5013-5024(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS CD22-ALPHA AND CD22-BETA).
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Spleen.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-137; 139-239; 241-328 AND 418-502, VARIANTS THR-34; GLU-152; LYS-203; GLY-664; CYS-669 AND ASP-745.
  8. "Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition."
    Powell L.D., Sgroi D., Sjoberg E.R., Stamenkovic I., Varki A.
    J. Biol. Chem. 268:7019-7027(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIALIC ACID-BINDING.
  9. "A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP."
    Doody G.M., Justement L.B., Delibrias C.C., Matthews R.J., Lin J., Thomas M.L., Fearon D.T.
    Science 269:242-244(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPN6.
  10. "Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22."
    Tuscano J.M., Engel P., Tedder T.F., Agarwal A., Kehrl J.H.
    Eur. J. Immunol. 26:1246-1252(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LYN; SYK AND PIK3R1/PIK3R2.
  11. "CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation."
    Law C.L., Sidorenko S.P., Chandran K.A., Zhao Z., Shen S.H., Fischer E.H., Clark E.A.
    J. Exp. Med. 183:547-560(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPN6; SYK AND PLCG1.
  12. "CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling."
    Tedder T.F., Tuscano J., Sato S., Kehrl J.H.
    Annu. Rev. Immunol. 15:481-504(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiCD22_HUMAN
AccessioniPrimary (citable) accession number: P20273
Secondary accession number(s): F5GYU4
, F5H7U3, O95699, O95701, O95702, O95703, Q01665, Q32M46, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 15, 1999
Last modified: September 3, 2014
This is version 164 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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