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P20273

- CD22_HUMAN

UniProt

P20273 - CD22_HUMAN

Protein

B-cell receptor CD22

Gene

CD22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 165 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201Sialic acidBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell adhesion Source: ProtInc

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-cell receptor CD22
    Alternative name(s):
    B-lymphocyte cell adhesion molecule
    Short name:
    BL-CAM
    Sialic acid-binding Ig-like lectin 2
    Short name:
    Siglec-2
    T-cell surface antigen Leu-14
    CD_antigen: CD22
    Gene namesi
    Name:CD22
    Synonyms:SIGLEC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:1643. CD22.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26201.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 847828B-cell receptor CD22PRO_0000014873Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi39 ↔ 167PROSITE-ProRule annotation
    Disulfide bondi44 ↔ 102PROSITE-ProRule annotation
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi161 ↔ 219PROSITE-ProRule annotation
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi265 ↔ 309PROSITE-ProRule annotation
    Disulfide bondi353 ↔ 396PROSITE-ProRule annotation
    Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi442 ↔ 484PROSITE-ProRule annotation
    Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi479 – 4791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi529 ↔ 571PROSITE-ProRule annotation
    Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi616 ↔ 659PROSITE-ProRule annotation
    Glycosylationi634 – 6341N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
    Phosphorylated on tyrosine residues by LYN.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP20273.
    PaxDbiP20273.
    PRIDEiP20273.

    PTM databases

    PhosphoSiteiP20273.

    Expressioni

    Tissue specificityi

    B-lymphocytes.

    Gene expression databases

    ArrayExpressiP20273.
    BgeeiP20273.
    GenevestigatoriP20273.

    Organism-specific databases

    HPAiCAB002418.
    HPA024353.

    Interactioni

    Subunit structurei

    Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation By similarity. May form a complex with INPP5D/SHIP, GRB2 and SHC1.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LYNP079482EBI-78277,EBI-79452
    PLCG1P191742EBI-78277,EBI-79387
    PTPN6P293504EBI-78277,EBI-78260
    SYKP434054EBI-78277,EBI-78302

    Protein-protein interaction databases

    BioGridi107371. 11 interactions.
    IntActiP20273. 7 interactions.
    MINTiMINT-3009156.

    Structurei

    3D structure databases

    ProteinModelPortaliP20273.
    SMRiP20273. Positions 36-677.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 687668ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini707 – 847141CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei688 – 70619HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 138119Ig-like V-typeAdd
    BLAST
    Domaini143 – 23593Ig-like C2-type 1Add
    BLAST
    Domaini242 – 32685Ig-like C2-type 2Add
    BLAST
    Domaini331 – 41686Ig-like C2-type 3Add
    BLAST
    Domaini419 – 50082Ig-like C2-type 4Add
    BLAST
    Domaini505 – 58278Ig-like C2-type 5Add
    BLAST
    Domaini593 – 67684Ig-like C2-type 6Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi760 – 7656ITIM motif 1
    Motifi794 – 7996ITIM motif 2
    Motifi820 – 8256ITIM motif 3
    Motifi840 – 8456ITIM motif 4

    Domaini

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287433.
    HOVERGENiHBG005272.
    InParanoidiP20273.
    KOiK06467.
    OMAiPTNYTWY.
    OrthoDBiEOG7VHSWK.
    PhylomeDBiP20273.
    TreeFamiTF334827.

    Family and domain databases

    Gene3Di2.60.40.10. 7 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF00047. ig. 2 hits.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    SM00408. IGc2. 4 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 6 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform CD22-beta (identifier: P20273-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD    50
    GDLESFILFH NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK 100
    NCTLSIHPVH LNDSGQLGLR MESKTEKWME RIHLNVSERP FPPHIQLPPE 150
    IQESQEVTLT CLLNFSCYGY PIQLQWLLEG VPMRQAAVTS TSLTIKSVFT 200
    RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH TPKLEIKVTP 250
    SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT 300
    KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE 350
    FLCMSLANPL PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN 400
    ILGTGQRGPG AELDVQYPPK KVTTVIQNPM PIREGDTVTL SCNYNSSNPS 450
    VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT TIACAACNSW CSWASPVALN 500
    VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ FFWEKNGRLL 550
    GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM 600
    SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK 650
    VQHSGAYWCQ GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI 700
    LAICGLKLQR RWKRTQSQQG LQENSSGQSF FVRNKKVRRA PLSEGPHSLG 750
    CYNPMMEDGI SYTTLRFPEM NIPRTGDAES SEMQRPPPDC DDTVTYSALH 800
    KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV DYVILKH 847
    Length:847
    Mass (Da):95,348
    Last modified:July 15, 1999 - v2
    Checksum:i38EB0BE4220ACA2D
    GO
    Isoform CD22-alpha (identifier: P20273-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         241-417: Missing.

    Show »
    Length:670
    Mass (Da):75,799
    Checksum:i04F241A74FF61471
    GO
    Isoform 3 (identifier: P20273-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         330-417: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:759
    Mass (Da):85,675
    Checksum:i18C7BFA0D4C94AE5
    GO
    Isoform 4 (identifier: P20273-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         737-751: VRRAPLSEGPHSLGC → RCRVLRDAETSPGLR
         752-847: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:751
    Mass (Da):84,480
    Checksum:i1DA8314C562A6D00
    GO
    Isoform 5 (identifier: P20273-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-3: MHL → MSL
         4-175: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:675
    Mass (Da):75,354
    Checksum:iE0969BC34AC17057
    GO

    Sequence cautioni

    The sequence CAA36988.1 differs from that shown. Reason: Frameshift at position 806.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti486 – 4861A → R in CAA42006. (PubMed:1691828)Curated
    Sequence conflicti788 – 7892PD → RT in CAA42006. (PubMed:1691828)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341A → T.1 Publication
    Corresponds to variant rs201453271 [ dbSNP | Ensembl ].
    VAR_014133
    Natural varianti152 – 1521Q → E Observed with a marginally higher frequency in patients with systemic lupus erythematosus. 1 Publication
    VAR_003913
    Natural varianti203 – 2031E → K.1 Publication
    VAR_014134
    Natural varianti551 – 5511G → R.
    Corresponds to variant rs35715143 [ dbSNP | Ensembl ].
    VAR_049903
    Natural varianti639 – 6391Y → H.1 Publication
    Corresponds to variant rs1058407 [ dbSNP | Ensembl ].
    VAR_014135
    Natural varianti664 – 6641S → G.1 Publication
    Corresponds to variant rs17719289 [ dbSNP | Ensembl ].
    VAR_003914
    Natural varianti669 – 6691R → C.1 Publication
    VAR_003915
    Natural varianti745 – 7451G → D.1 Publication
    Corresponds to variant rs10406069 [ dbSNP | Ensembl ].
    VAR_003916

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 33MHL → MSL in isoform 5. 1 PublicationVSP_054619
    Alternative sequencei4 – 175172Missing in isoform 5. 1 PublicationVSP_054620Add
    BLAST
    Alternative sequencei241 – 417177Missing in isoform CD22-alpha. CuratedVSP_002531Add
    BLAST
    Alternative sequencei330 – 41788Missing in isoform 3. 1 PublicationVSP_045363Add
    BLAST
    Alternative sequencei737 – 75115VRRAP…HSLGC → RCRVLRDAETSPGLR in isoform 4. CuratedVSP_047223Add
    BLAST
    Alternative sequencei752 – 84796Missing in isoform 4. CuratedVSP_047224Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62631 Genomic DNA. Translation: AAB06448.1.
    U62631 Genomic DNA. Translation: AAB06449.1.
    X59350 mRNA. Translation: CAA42006.1.
    X52785 mRNA. Translation: CAA36988.1. Frameshift.
    AK225625 mRNA. No translation available.
    AC002132 Genomic DNA. No translation available.
    BC109306 mRNA. Translation: AAI09307.1.
    AB012995 Genomic DNA. Translation: BAA36564.1.
    AB012996 Genomic DNA. Translation: BAA36565.1.
    AB012997 Genomic DNA. Translation: BAA36566.1.
    AB012998 Genomic DNA. Translation: BAA36567.1.
    AB012999 Genomic DNA. Translation: BAA36568.1.
    AB013000 Genomic DNA. Translation: BAA36569.1.
    AB013002 Genomic DNA. Translation: BAA36571.1.
    AB013003 Genomic DNA. Translation: BAA36572.1.
    AB013004 Genomic DNA. Translation: BAA36573.1.
    AB013006 Genomic DNA. Translation: BAA36575.1.
    CCDSiCCDS12457.1. [P20273-1]
    CCDS54247.1. [P20273-4]
    CCDS54248.1. [P20273-3]
    CCDS54249.1. [P20273-2]
    CCDS62634.1. [P20273-5]
    PIRiA35648.
    RefSeqiNP_001172028.1. NM_001185099.1. [P20273-3]
    NP_001172029.1. NM_001185100.1. [P20273-4]
    NP_001172030.1. NM_001185101.1. [P20273-2]
    NP_001265346.1. NM_001278417.1. [P20273-5]
    NP_001762.2. NM_001771.3. [P20273-1]
    UniGeneiHs.579691.

    Genome annotation databases

    EnsembliENST00000085219; ENSP00000085219; ENSG00000012124. [P20273-1]
    ENST00000341773; ENSP00000339349; ENSG00000012124. [P20273-2]
    ENST00000419549; ENSP00000403822; ENSG00000012124. [P20273-5]
    ENST00000536635; ENSP00000442279; ENSG00000012124. [P20273-3]
    ENST00000544992; ENSP00000441237; ENSG00000012124. [P20273-4]
    ENST00000594250; ENSP00000469984; ENSG00000012124. [P20273-2]
    GeneIDi933.
    KEGGihsa:933.
    UCSCiuc002nzb.4. human. [P20273-2]
    uc010edt.3. human. [P20273-1]

    Polymorphism databases

    DMDMi6166019.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Siglec-2 [3 Fc Domains]

    Functional Glycomics Gateway - Glycan Binding

    Siglec-2

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62631 Genomic DNA. Translation: AAB06448.1 .
    U62631 Genomic DNA. Translation: AAB06449.1 .
    X59350 mRNA. Translation: CAA42006.1 .
    X52785 mRNA. Translation: CAA36988.1 . Frameshift.
    AK225625 mRNA. No translation available.
    AC002132 Genomic DNA. No translation available.
    BC109306 mRNA. Translation: AAI09307.1 .
    AB012995 Genomic DNA. Translation: BAA36564.1 .
    AB012996 Genomic DNA. Translation: BAA36565.1 .
    AB012997 Genomic DNA. Translation: BAA36566.1 .
    AB012998 Genomic DNA. Translation: BAA36567.1 .
    AB012999 Genomic DNA. Translation: BAA36568.1 .
    AB013000 Genomic DNA. Translation: BAA36569.1 .
    AB013002 Genomic DNA. Translation: BAA36571.1 .
    AB013003 Genomic DNA. Translation: BAA36572.1 .
    AB013004 Genomic DNA. Translation: BAA36573.1 .
    AB013006 Genomic DNA. Translation: BAA36575.1 .
    CCDSi CCDS12457.1. [P20273-1 ]
    CCDS54247.1. [P20273-4 ]
    CCDS54248.1. [P20273-3 ]
    CCDS54249.1. [P20273-2 ]
    CCDS62634.1. [P20273-5 ]
    PIRi A35648.
    RefSeqi NP_001172028.1. NM_001185099.1. [P20273-3 ]
    NP_001172029.1. NM_001185100.1. [P20273-4 ]
    NP_001172030.1. NM_001185101.1. [P20273-2 ]
    NP_001265346.1. NM_001278417.1. [P20273-5 ]
    NP_001762.2. NM_001771.3. [P20273-1 ]
    UniGenei Hs.579691.

    3D structure databases

    ProteinModelPortali P20273.
    SMRi P20273. Positions 36-677.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107371. 11 interactions.
    IntActi P20273. 7 interactions.
    MINTi MINT-3009156.

    Chemistry

    BindingDBi P20273.
    ChEMBLi CHEMBL3218.
    DrugBanki DB00045. OspA lipoprotein.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei P20273.

    Polymorphism databases

    DMDMi 6166019.

    Proteomic databases

    MaxQBi P20273.
    PaxDbi P20273.
    PRIDEi P20273.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000085219 ; ENSP00000085219 ; ENSG00000012124 . [P20273-1 ]
    ENST00000341773 ; ENSP00000339349 ; ENSG00000012124 . [P20273-2 ]
    ENST00000419549 ; ENSP00000403822 ; ENSG00000012124 . [P20273-5 ]
    ENST00000536635 ; ENSP00000442279 ; ENSG00000012124 . [P20273-3 ]
    ENST00000544992 ; ENSP00000441237 ; ENSG00000012124 . [P20273-4 ]
    ENST00000594250 ; ENSP00000469984 ; ENSG00000012124 . [P20273-2 ]
    GeneIDi 933.
    KEGGi hsa:933.
    UCSCi uc002nzb.4. human. [P20273-2 ]
    uc010edt.3. human. [P20273-1 ]

    Organism-specific databases

    CTDi 933.
    GeneCardsi GC19P035826.
    HGNCi HGNC:1643. CD22.
    HPAi CAB002418.
    HPA024353.
    MIMi 107266. gene.
    neXtProti NX_P20273.
    PharmGKBi PA26201.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287433.
    HOVERGENi HBG005272.
    InParanoidi P20273.
    KOi K06467.
    OMAi PTNYTWY.
    OrthoDBi EOG7VHSWK.
    PhylomeDBi P20273.
    TreeFami TF334827.

    Miscellaneous databases

    GeneWikii CD22.
    GenomeRNAii 933.
    NextBioi 3874.
    PROi P20273.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20273.
    Bgeei P20273.
    Genevestigatori P20273.

    Family and domain databases

    Gene3Di 2.60.40.10. 7 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF00047. ig. 2 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    SM00408. IGc2. 4 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion."
      Stamenkovic I., Seed B.
      Nature 345:74-77(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD22-BETA).
    2. "cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions."
      Wilson G.L., Fox C.H., Fauci A.S., Kehrl J.H.
      J. Exp. Med. 173:137-146(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD22-BETA), VARIANT HIS-639.
      Tissue: Tonsil.
    3. "Genomic structure and chromosomal mapping of the human CD22 gene."
      Wilson G.L., Najfeld V., Kozlow E., Menniger J., Ward D., Kehrl J.H.
      J. Immunol. 150:5013-5024(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS CD22-ALPHA AND CD22-BETA).
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Spleen.
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-137; 139-239; 241-328 AND 418-502, VARIANTS THR-34; GLU-152; LYS-203; GLY-664; CYS-669 AND ASP-745.
    8. "Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition."
      Powell L.D., Sgroi D., Sjoberg E.R., Stamenkovic I., Varki A.
      J. Biol. Chem. 268:7019-7027(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: SIALIC ACID-BINDING.
    9. "A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP."
      Doody G.M., Justement L.B., Delibrias C.C., Matthews R.J., Lin J., Thomas M.L., Fearon D.T.
      Science 269:242-244(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PTPN6.
    10. "Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22."
      Tuscano J.M., Engel P., Tedder T.F., Agarwal A., Kehrl J.H.
      Eur. J. Immunol. 26:1246-1252(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LYN; SYK AND PIK3R1/PIK3R2.
    11. "CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation."
      Law C.L., Sidorenko S.P., Chandran K.A., Zhao Z., Shen S.H., Fischer E.H., Clark E.A.
      J. Exp. Med. 183:547-560(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PTPN6; SYK AND PLCG1.
    12. "CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling."
      Tedder T.F., Tuscano J., Sato S., Kehrl J.H.
      Annu. Rev. Immunol. 15:481-504(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiCD22_HUMAN
    AccessioniPrimary (citable) accession number: P20273
    Secondary accession number(s): F5GYU4
    , F5H7U3, O95699, O95701, O95702, O95703, Q01665, Q32M46, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 165 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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