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Protein

B-cell receptor CD22

Gene

CD22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120Sialic acidBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000012124-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell receptor CD22
Alternative name(s):
B-lymphocyte cell adhesion molecule
Short name:
BL-CAM
Sialic acid-binding Ig-like lectin 2
Short name:
Siglec-2
T-cell surface antigen Leu-14
CD_antigen: CD22
Gene namesi
Name:CD22
Synonyms:SIGLEC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1643. CD22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 687ExtracellularSequence analysisAdd BLAST668
Transmembranei688 – 706HelicalSequence analysisAdd BLAST19
Topological domaini707 – 847CytoplasmicSequence analysisAdd BLAST141

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi933.
OpenTargetsiENSG00000012124.
PharmGKBiPA26201.

Chemistry databases

ChEMBLiCHEMBL3218.
GuidetoPHARMACOLOGYi2786.

Polymorphism and mutation databases

BioMutaiCD22.
DMDMi6166019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001487320 – 847B-cell receptor CD22Add BLAST828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 167PROSITE-ProRule annotation
Disulfide bondi44 ↔ 102PROSITE-ProRule annotation
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi161 ↔ 219PROSITE-ProRule annotation
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi265 ↔ 309PROSITE-ProRule annotation
Cross-linki288Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Disulfide bondi353 ↔ 396PROSITE-ProRule annotation
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi442 ↔ 484PROSITE-ProRule annotation
Glycosylationi445N-linked (GlcNAc...)Sequence analysis1
Glycosylationi448N-linked (GlcNAc...)Sequence analysis1
Glycosylationi479N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi529 ↔ 571PROSITE-ProRule annotation
Glycosylationi574N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi616 ↔ 659PROSITE-ProRule annotation
Glycosylationi634N-linked (GlcNAc...)Sequence analysis1
Modified residuei725PhosphoserineBy similarity1
Modified residuei726PhosphoserineBy similarity1
Modified residuei729PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
Phosphorylated on tyrosine residues by LYN.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP20273.
PeptideAtlasiP20273.
PRIDEiP20273.

PTM databases

iPTMnetiP20273.
PhosphoSitePlusiP20273.

Expressioni

Tissue specificityi

B-lymphocytes.

Gene expression databases

BgeeiENSG00000012124.
ExpressionAtlasiP20273. baseline and differential.
GenevisibleiP20273. HS.

Organism-specific databases

HPAiCAB002418.
HPA024353.

Interactioni

Subunit structurei

Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LYNP079482EBI-78277,EBI-79452
PLCG1P191742EBI-78277,EBI-79387
PTPN6P293504EBI-78277,EBI-78260
SYKP434054EBI-78277,EBI-78302

Protein-protein interaction databases

BioGridi107371. 13 interactors.
IntActiP20273. 7 interactors.
MINTiMINT-3009156.
STRINGi9606.ENSP00000085219.

Chemistry databases

BindingDBiP20273.

Structurei

3D structure databases

ProteinModelPortaliP20273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 138Ig-like V-typeAdd BLAST119
Domaini143 – 235Ig-like C2-type 1Add BLAST93
Domaini242 – 326Ig-like C2-type 2Add BLAST85
Domaini331 – 416Ig-like C2-type 3Add BLAST86
Domaini419 – 500Ig-like C2-type 4Add BLAST82
Domaini505 – 582Ig-like C2-type 5Add BLAST78
Domaini593 – 676Ig-like C2-type 6Add BLAST84

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi760 – 765ITIM motif 16
Motifi794 – 799ITIM motif 26
Motifi820 – 825ITIM motif 36
Motifi840 – 845ITIM motif 46

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUGI. Eukaryota.
ENOG410YH8H. LUCA.
GeneTreeiENSGT00830000128299.
HOVERGENiHBG005272.
InParanoidiP20273.
KOiK06467.
OMAiPTNYTWY.
OrthoDBiEOG091G0FT0.
PhylomeDBiP20273.
TreeFamiTF334827.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
PROSITEiPS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform CD22-beta (identifier: P20273-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD
60 70 80 90 100
GDLESFILFH NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK
110 120 130 140 150
NCTLSIHPVH LNDSGQLGLR MESKTEKWME RIHLNVSERP FPPHIQLPPE
160 170 180 190 200
IQESQEVTLT CLLNFSCYGY PIQLQWLLEG VPMRQAAVTS TSLTIKSVFT
210 220 230 240 250
RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH TPKLEIKVTP
260 270 280 290 300
SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT
310 320 330 340 350
KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE
360 370 380 390 400
FLCMSLANPL PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN
410 420 430 440 450
ILGTGQRGPG AELDVQYPPK KVTTVIQNPM PIREGDTVTL SCNYNSSNPS
460 470 480 490 500
VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT TIACAACNSW CSWASPVALN
510 520 530 540 550
VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ FFWEKNGRLL
560 570 580 590 600
GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM
610 620 630 640 650
SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK
660 670 680 690 700
VQHSGAYWCQ GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI
710 720 730 740 750
LAICGLKLQR RWKRTQSQQG LQENSSGQSF FVRNKKVRRA PLSEGPHSLG
760 770 780 790 800
CYNPMMEDGI SYTTLRFPEM NIPRTGDAES SEMQRPPPDC DDTVTYSALH
810 820 830 840
KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV DYVILKH
Length:847
Mass (Da):95,348
Last modified:July 15, 1999 - v2
Checksum:i38EB0BE4220ACA2D
GO
Isoform CD22-alpha (identifier: P20273-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-417: Missing.

Show »
Length:670
Mass (Da):75,799
Checksum:i04F241A74FF61471
GO
Isoform 3 (identifier: P20273-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-417: Missing.

Note: No experimental confirmation available.
Show »
Length:759
Mass (Da):85,675
Checksum:i18C7BFA0D4C94AE5
GO
Isoform 4 (identifier: P20273-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     737-751: VRRAPLSEGPHSLGC → RCRVLRDAETSPGLR
     752-847: Missing.

Note: Gene prediction based on EST data.
Show »
Length:751
Mass (Da):84,480
Checksum:i1DA8314C562A6D00
GO
Isoform 5 (identifier: P20273-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MHL → MSL
     4-175: Missing.

Note: No experimental confirmation available.
Show »
Length:675
Mass (Da):75,354
Checksum:iE0969BC34AC17057
GO

Sequence cautioni

The sequence CAA36988 differs from that shown. Reason: Frameshift at position 806.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti486A → R in CAA42006 (PubMed:1691828).Curated1
Sequence conflicti788 – 789PD → RT in CAA42006 (PubMed:1691828).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01413334A → T.1 PublicationCorresponds to variant rs201453271dbSNPEnsembl.1
Natural variantiVAR_003913152Q → E Observed with a marginally higher frequency in patients with systemic lupus erythematosus. 1 PublicationCorresponds to variant rs554866571dbSNPEnsembl.1
Natural variantiVAR_014134203E → K.1 PublicationCorresponds to variant rs752024645dbSNPEnsembl.1
Natural variantiVAR_049903551G → R.Corresponds to variant rs35715143dbSNPEnsembl.1
Natural variantiVAR_014135639Y → H.1 PublicationCorresponds to variant rs1058407dbSNPEnsembl.1
Natural variantiVAR_003914664S → G.1 PublicationCorresponds to variant rs17719289dbSNPEnsembl.1
Natural variantiVAR_003915669R → C.1 PublicationCorresponds to variant rs749980313dbSNPEnsembl.1
Natural variantiVAR_003916745G → D.1 PublicationCorresponds to variant rs10406069dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0546191 – 3MHL → MSL in isoform 5. 1 Publication3
Alternative sequenceiVSP_0546204 – 175Missing in isoform 5. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_002531241 – 417Missing in isoform CD22-alpha. CuratedAdd BLAST177
Alternative sequenceiVSP_045363330 – 417Missing in isoform 3. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_047223737 – 751VRRAP…HSLGC → RCRVLRDAETSPGLR in isoform 4. CuratedAdd BLAST15
Alternative sequenceiVSP_047224752 – 847Missing in isoform 4. CuratedAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62631 Genomic DNA. Translation: AAB06448.1.
U62631 Genomic DNA. Translation: AAB06449.1.
X59350 mRNA. Translation: CAA42006.1.
X52785 mRNA. Translation: CAA36988.1. Frameshift.
AK225625 mRNA. No translation available.
AC002132 Genomic DNA. No translation available.
BC109306 mRNA. Translation: AAI09307.1.
AB012995 Genomic DNA. Translation: BAA36564.1.
AB012996 Genomic DNA. Translation: BAA36565.1.
AB012997 Genomic DNA. Translation: BAA36566.1.
AB012998 Genomic DNA. Translation: BAA36567.1.
AB012999 Genomic DNA. Translation: BAA36568.1.
AB013000 Genomic DNA. Translation: BAA36569.1.
AB013002 Genomic DNA. Translation: BAA36571.1.
AB013003 Genomic DNA. Translation: BAA36572.1.
AB013004 Genomic DNA. Translation: BAA36573.1.
AB013006 Genomic DNA. Translation: BAA36575.1.
CCDSiCCDS12457.1. [P20273-1]
CCDS54247.1. [P20273-4]
CCDS54248.1. [P20273-3]
CCDS54249.1. [P20273-2]
CCDS62634.1. [P20273-5]
PIRiA35648.
RefSeqiNP_001172028.1. NM_001185099.1. [P20273-3]
NP_001172029.1. NM_001185100.1. [P20273-4]
NP_001172030.1. NM_001185101.1. [P20273-2]
NP_001265346.1. NM_001278417.1. [P20273-5]
NP_001762.2. NM_001771.3. [P20273-1]
UniGeneiHs.579691.

Genome annotation databases

EnsembliENST00000085219; ENSP00000085219; ENSG00000012124. [P20273-1]
ENST00000341773; ENSP00000339349; ENSG00000012124. [P20273-2]
ENST00000419549; ENSP00000403822; ENSG00000012124. [P20273-5]
ENST00000536635; ENSP00000442279; ENSG00000012124. [P20273-3]
ENST00000544992; ENSP00000441237; ENSG00000012124. [P20273-4]
ENST00000594250; ENSP00000469984; ENSG00000012124. [P20273-2]
GeneIDi933.
KEGGihsa:933.
UCSCiuc002nzb.6. human. [P20273-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-2 [3 Fc Domains]

Functional Glycomics Gateway - Glycan Binding

Siglec-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62631 Genomic DNA. Translation: AAB06448.1.
U62631 Genomic DNA. Translation: AAB06449.1.
X59350 mRNA. Translation: CAA42006.1.
X52785 mRNA. Translation: CAA36988.1. Frameshift.
AK225625 mRNA. No translation available.
AC002132 Genomic DNA. No translation available.
BC109306 mRNA. Translation: AAI09307.1.
AB012995 Genomic DNA. Translation: BAA36564.1.
AB012996 Genomic DNA. Translation: BAA36565.1.
AB012997 Genomic DNA. Translation: BAA36566.1.
AB012998 Genomic DNA. Translation: BAA36567.1.
AB012999 Genomic DNA. Translation: BAA36568.1.
AB013000 Genomic DNA. Translation: BAA36569.1.
AB013002 Genomic DNA. Translation: BAA36571.1.
AB013003 Genomic DNA. Translation: BAA36572.1.
AB013004 Genomic DNA. Translation: BAA36573.1.
AB013006 Genomic DNA. Translation: BAA36575.1.
CCDSiCCDS12457.1. [P20273-1]
CCDS54247.1. [P20273-4]
CCDS54248.1. [P20273-3]
CCDS54249.1. [P20273-2]
CCDS62634.1. [P20273-5]
PIRiA35648.
RefSeqiNP_001172028.1. NM_001185099.1. [P20273-3]
NP_001172029.1. NM_001185100.1. [P20273-4]
NP_001172030.1. NM_001185101.1. [P20273-2]
NP_001265346.1. NM_001278417.1. [P20273-5]
NP_001762.2. NM_001771.3. [P20273-1]
UniGeneiHs.579691.

3D structure databases

ProteinModelPortaliP20273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107371. 13 interactors.
IntActiP20273. 7 interactors.
MINTiMINT-3009156.
STRINGi9606.ENSP00000085219.

Chemistry databases

BindingDBiP20273.
ChEMBLiCHEMBL3218.
GuidetoPHARMACOLOGYi2786.

PTM databases

iPTMnetiP20273.
PhosphoSitePlusiP20273.

Polymorphism and mutation databases

BioMutaiCD22.
DMDMi6166019.

Proteomic databases

PaxDbiP20273.
PeptideAtlasiP20273.
PRIDEiP20273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000085219; ENSP00000085219; ENSG00000012124. [P20273-1]
ENST00000341773; ENSP00000339349; ENSG00000012124. [P20273-2]
ENST00000419549; ENSP00000403822; ENSG00000012124. [P20273-5]
ENST00000536635; ENSP00000442279; ENSG00000012124. [P20273-3]
ENST00000544992; ENSP00000441237; ENSG00000012124. [P20273-4]
ENST00000594250; ENSP00000469984; ENSG00000012124. [P20273-2]
GeneIDi933.
KEGGihsa:933.
UCSCiuc002nzb.6. human. [P20273-1]

Organism-specific databases

CTDi933.
DisGeNETi933.
GeneCardsiCD22.
HGNCiHGNC:1643. CD22.
HPAiCAB002418.
HPA024353.
MIMi107266. gene.
neXtProtiNX_P20273.
OpenTargetsiENSG00000012124.
PharmGKBiPA26201.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUGI. Eukaryota.
ENOG410YH8H. LUCA.
GeneTreeiENSGT00830000128299.
HOVERGENiHBG005272.
InParanoidiP20273.
KOiK06467.
OMAiPTNYTWY.
OrthoDBiEOG091G0FT0.
PhylomeDBiP20273.
TreeFamiTF334827.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000012124-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

GeneWikiiCD22.
GenomeRNAii933.
PROiP20273.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000012124.
ExpressionAtlasiP20273. baseline and differential.
GenevisibleiP20273. HS.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
PROSITEiPS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD22_HUMAN
AccessioniPrimary (citable) accession number: P20273
Secondary accession number(s): F5GYU4
, F5H7U3, O95699, O95701, O95702, O95703, Q01665, Q32M46, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 15, 1999
Last modified: November 2, 2016
This is version 186 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.