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Protein

Homeobox protein ceh-6

Gene

ceh-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Vital for embryonic development and essential for the proper function of the excretory cell (PubMed:11171402). Required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development (PubMed:22493276).2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi281 – 34060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: WormBase

GO - Biological processi

  • cell differentiation Source: WormBase
  • excretion Source: WormBase
  • multicellular organism development Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: WormBase
  • transdifferentiation Source: WormBase
  • water homeostasis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ceh-6
Gene namesi
Name:ceh-6Imported
ORF Names:K02B12.1Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiK02B12.1; CE28045; WBGene00000431; ceh-6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • cytosol Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in defective PDA motor neuron differentiation as a result of failed Y rectal cell migration from the rectum.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Homeobox protein ceh-6PRO_0000100781Add
BLAST

Proteomic databases

PaxDbiP20268.
PRIDEiP20268.

Expressioni

Tissue specificityi

Expressed in a series of neurons in the ring ganglia, excretory cell, dividing neuroblasts in the ventral cord and rectal cells.

Gene expression databases

BgeeiWBGene00000431.

Interactioni

Subunit structurei

Interacts with egl-27, sox-2 and sem-4.1 Publication

Protein-protein interaction databases

BioGridi38073. 1 interaction.
DIPiDIP-61430N.
IntActiP20268. 4 interactions.
STRINGi6239.K02B12.1.

Structurei

3D structure databases

ProteinModelPortaliP20268.
SMRiP20268. Positions 193-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 26175POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 3127Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116303.
InParanoidiP20268.
KOiK09365.
OMAiLFPYQAV.
OrthoDBiEOG091G0U0S.
PhylomeDBiP20268.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSSSSIP SSLSASASDS EPSSLNGSGI SDQNILPNYH LHHHLINENE
60 70 80 90 100
MEAANYAQVI KPTCEAFQDW PHTPMLYQQP QLHFMLPQHD WAYPHLAQSL
110 120 130 140 150
PPPHHLTPST AAVAAATIAS QSSIINQTSV VTSTPSCQIK QEVERPEIIQ
160 170 180 190 200
RLMPPWPPAY QFSCDDSGSV SGAGGPHQPL SDISDDSEQT CPDDLEGFAK
210 220 230 240 250
QFKQRRIKLG YTQADVGVAL GTLYGNIFSQ TTICRFEALQ LSFKNMCKLK
260 270 280 290 300
PLLFKWLEEA DSTTGSPNST FEKMTGQAGR KRKKRTSIEV NVKSRLEFHF
310 320 330 340 350
QSNQKPNAQE ITQVAMELQL EKEVVRVWFC NRRQKEKRIA PNQYDAPHPM
360 370 380
ALNNGYPMTA DLFPYQAVVN HYTQQSPRQQ
Length:380
Mass (Da):42,575
Last modified:May 27, 2002 - v3
Checksum:i46890A452DF90A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286377 mRNA. Translation: AAG10298.1.
Z75711 Genomic DNA. Translation: CAB00031.2.
PIRiS05707.
T23218.
RefSeqiNP_492304.1. NM_059903.5.
UniGeneiCel.19366.

Genome annotation databases

EnsemblMetazoaiK02B12.1; K02B12.1; WBGene00000431.
GeneIDi172640.
KEGGicel:CELE_K02B12.1.
UCSCiK02B12.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286377 mRNA. Translation: AAG10298.1.
Z75711 Genomic DNA. Translation: CAB00031.2.
PIRiS05707.
T23218.
RefSeqiNP_492304.1. NM_059903.5.
UniGeneiCel.19366.

3D structure databases

ProteinModelPortaliP20268.
SMRiP20268. Positions 193-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38073. 1 interaction.
DIPiDIP-61430N.
IntActiP20268. 4 interactions.
STRINGi6239.K02B12.1.

Proteomic databases

PaxDbiP20268.
PRIDEiP20268.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK02B12.1; K02B12.1; WBGene00000431.
GeneIDi172640.
KEGGicel:CELE_K02B12.1.
UCSCiK02B12.1. c. elegans.

Organism-specific databases

CTDi172640.
WormBaseiK02B12.1; CE28045; WBGene00000431; ceh-6.

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116303.
InParanoidiP20268.
KOiK09365.
OMAiLFPYQAV.
OrthoDBiEOG091G0U0S.
PhylomeDBiP20268.

Miscellaneous databases

PROiP20268.

Gene expression databases

BgeeiWBGene00000431.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHM06_CAEEL
AccessioniPrimary (citable) accession number: P20268
Secondary accession number(s): Q9GSZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 27, 2002
Last modified: September 7, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.