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Protein

Homeobox protein ceh-6

Gene

ceh-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Vital for embryonic development and essential for the proper function of the excretory cell.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi281 – 34060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: WormBase

GO - Biological processi

  1. cell differentiation Source: WormBase
  2. excretion Source: WormBase
  3. multicellular organismal development Source: UniProtKB-KW
  4. regulation of transcription, DNA-templated Source: WormBase
  5. transdifferentiation Source: WormBase
  6. water homeostasis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ceh-6
Gene namesi
Name:ceh-6
ORF Names:K02B12.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiK02B12.1; CE28045; WBGene00000431; ceh-6.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. cytosol Source: WormBase
  3. nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Homeobox protein ceh-6PRO_0000100781Add
BLAST

Proteomic databases

PRIDEiP20268.

Expressioni

Tissue specificityi

Expressed in a series of neurons in the ring ganglia, excretory cell, dividing neuroblasts in the ventral cord and rectal cells.

Interactioni

Protein-protein interaction databases

BioGridi38073. 1 interaction.
IntActiP20268. 4 interactions.
STRINGi6239.K02B12.1.

Structurei

3D structure databases

SMRiP20268. Positions 193-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 26175POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 3127Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG261729.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116303.
InParanoidiP20268.
KOiK09365.
OMAiLFPYQAV.
OrthoDBiEOG7DJSMG.
PhylomeDBiP20268.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSSSSIP SSLSASASDS EPSSLNGSGI SDQNILPNYH LHHHLINENE
60 70 80 90 100
MEAANYAQVI KPTCEAFQDW PHTPMLYQQP QLHFMLPQHD WAYPHLAQSL
110 120 130 140 150
PPPHHLTPST AAVAAATIAS QSSIINQTSV VTSTPSCQIK QEVERPEIIQ
160 170 180 190 200
RLMPPWPPAY QFSCDDSGSV SGAGGPHQPL SDISDDSEQT CPDDLEGFAK
210 220 230 240 250
QFKQRRIKLG YTQADVGVAL GTLYGNIFSQ TTICRFEALQ LSFKNMCKLK
260 270 280 290 300
PLLFKWLEEA DSTTGSPNST FEKMTGQAGR KRKKRTSIEV NVKSRLEFHF
310 320 330 340 350
QSNQKPNAQE ITQVAMELQL EKEVVRVWFC NRRQKEKRIA PNQYDAPHPM
360 370 380
ALNNGYPMTA DLFPYQAVVN HYTQQSPRQQ
Length:380
Mass (Da):42,575
Last modified:May 27, 2002 - v3
Checksum:i46890A452DF90A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286377 mRNA. Translation: AAG10298.1.
Z75711 Genomic DNA. Translation: CAB00031.2.
PIRiS05707.
T23218.
RefSeqiNP_492304.1. NM_059903.5.
UniGeneiCel.19366.

Genome annotation databases

EnsemblMetazoaiK02B12.1; K02B12.1; WBGene00000431.
GeneIDi172640.
KEGGicel:CELE_K02B12.1.
UCSCiK02B12.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286377 mRNA. Translation: AAG10298.1.
Z75711 Genomic DNA. Translation: CAB00031.2.
PIRiS05707.
T23218.
RefSeqiNP_492304.1. NM_059903.5.
UniGeneiCel.19366.

3D structure databases

SMRiP20268. Positions 193-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38073. 1 interaction.
IntActiP20268. 4 interactions.
STRINGi6239.K02B12.1.

Proteomic databases

PRIDEiP20268.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK02B12.1; K02B12.1; WBGene00000431.
GeneIDi172640.
KEGGicel:CELE_K02B12.1.
UCSCiK02B12.1. c. elegans.

Organism-specific databases

CTDi172640.
WormBaseiK02B12.1; CE28045; WBGene00000431; ceh-6.

Phylogenomic databases

eggNOGiNOG261729.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116303.
InParanoidiP20268.
KOiK09365.
OMAiLFPYQAV.
OrthoDBiEOG7DJSMG.
PhylomeDBiP20268.

Miscellaneous databases

NextBioi876379.
PROiP20268.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6."
    Buerglin T.R., Ruvkun G.
    Development 128:779-790(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Bristol N2.
    Tissue: Embryo.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Caenorhabditis elegans has scores of homoeobox-containing genes."
    Buerglin T.R., Finney M., Coulson A., Ruvkun G.
    Nature 341:239-243(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 182-340.
    Strain: Bristol N2.

Entry informationi

Entry nameiHM06_CAEEL
AccessioniPrimary (citable) accession number: P20268
Secondary accession number(s): Q9GSZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 27, 2002
Last modified: April 29, 2015
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.