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P20268

- HM06_CAEEL

UniProt

P20268 - HM06_CAEEL

Protein

Homeobox protein ceh-6

Gene

ceh-6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (27 May 2002)
      Previous versions | rss
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    Functioni

    Vital for embryonic development and essential for the proper function of the excretory cell.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi281 – 34060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: WormBase

    GO - Biological processi

    1. cell differentiation Source: WormBase
    2. excretion Source: WormBase
    3. multicellular organismal development Source: UniProtKB-KW
    4. regulation of transcription, DNA-templated Source: WormBase
    5. transdifferentiation Source: WormBase
    6. water homeostasis Source: WormBase

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein ceh-6
    Gene namesi
    Name:ceh-6
    ORF Names:K02B12.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiK02B12.1; CE28045; WBGene00000431; ceh-6.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. cytosol Source: WormBase
    3. nucleus Source: WormBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Homeobox protein ceh-6PRO_0000100781Add
    BLAST

    Proteomic databases

    PRIDEiP20268.

    Expressioni

    Tissue specificityi

    Expressed in a series of neurons in the ring ganglia, excretory cell, dividing neuroblasts in the ventral cord and rectal cells.

    Interactioni

    Protein-protein interaction databases

    BioGridi38073. 1 interaction.
    IntActiP20268. 4 interactions.
    STRINGi6239.K02B12.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP20268.
    SMRiP20268. Positions 193-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini187 – 26175POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 3127Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261729.
    GeneTreeiENSGT00730000110809.
    HOGENOMiHOG000116303.
    InParanoidiP20268.
    KOiK09365.
    OMAiLFPYQAV.
    OrthoDBiEOG7DJSMG.
    PhylomeDBiP20268.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20268-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIPSSSSIP SSLSASASDS EPSSLNGSGI SDQNILPNYH LHHHLINENE    50
    MEAANYAQVI KPTCEAFQDW PHTPMLYQQP QLHFMLPQHD WAYPHLAQSL 100
    PPPHHLTPST AAVAAATIAS QSSIINQTSV VTSTPSCQIK QEVERPEIIQ 150
    RLMPPWPPAY QFSCDDSGSV SGAGGPHQPL SDISDDSEQT CPDDLEGFAK 200
    QFKQRRIKLG YTQADVGVAL GTLYGNIFSQ TTICRFEALQ LSFKNMCKLK 250
    PLLFKWLEEA DSTTGSPNST FEKMTGQAGR KRKKRTSIEV NVKSRLEFHF 300
    QSNQKPNAQE ITQVAMELQL EKEVVRVWFC NRRQKEKRIA PNQYDAPHPM 350
    ALNNGYPMTA DLFPYQAVVN HYTQQSPRQQ 380
    Length:380
    Mass (Da):42,575
    Last modified:May 27, 2002 - v3
    Checksum:i46890A452DF90A5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF286377 mRNA. Translation: AAG10298.1.
    Z75711 Genomic DNA. Translation: CAB00031.2.
    PIRiS05707.
    T23218.
    RefSeqiNP_492304.1. NM_059903.5.
    UniGeneiCel.19366.

    Genome annotation databases

    EnsemblMetazoaiK02B12.1; K02B12.1; WBGene00000431.
    GeneIDi172640.
    KEGGicel:CELE_K02B12.1.
    UCSCiK02B12.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF286377 mRNA. Translation: AAG10298.1 .
    Z75711 Genomic DNA. Translation: CAB00031.2 .
    PIRi S05707.
    T23218.
    RefSeqi NP_492304.1. NM_059903.5.
    UniGenei Cel.19366.

    3D structure databases

    ProteinModelPortali P20268.
    SMRi P20268. Positions 193-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 38073. 1 interaction.
    IntActi P20268. 4 interactions.
    STRINGi 6239.K02B12.1.

    Proteomic databases

    PRIDEi P20268.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K02B12.1 ; K02B12.1 ; WBGene00000431 .
    GeneIDi 172640.
    KEGGi cel:CELE_K02B12.1.
    UCSCi K02B12.1. c. elegans.

    Organism-specific databases

    CTDi 172640.
    WormBasei K02B12.1 ; CE28045 ; WBGene00000431 ; ceh-6.

    Phylogenomic databases

    eggNOGi NOG261729.
    GeneTreei ENSGT00730000110809.
    HOGENOMi HOG000116303.
    InParanoidi P20268.
    KOi K09365.
    OMAi LFPYQAV.
    OrthoDBi EOG7DJSMG.
    PhylomeDBi P20268.

    Miscellaneous databases

    NextBioi 876379.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6."
      Buerglin T.R., Ruvkun G.
      Development 128:779-790(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: Bristol N2.
      Tissue: Embryo.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    3. "Caenorhabditis elegans has scores of homoeobox-containing genes."
      Buerglin T.R., Finney M., Coulson A., Ruvkun G.
      Nature 341:239-243(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 182-340.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiHM06_CAEEL
    AccessioniPrimary (citable) accession number: P20268
    Secondary accession number(s): Q9GSZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3