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P20268 (HM06_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein ceh-6
Gene names
Name:ceh-6
ORF Names:K02B12.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Vital for embryonic development and essential for the proper function of the excretory cell. Ref.1

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in a series of neurons in the ring ganglia, excretory cell, dividing neuroblasts in the ventral cord and rectal cells.

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Homeobox protein ceh-6
PRO_0000100781

Regions

Domain187 – 26175POU-specific
DNA binding281 – 34060Homeobox
Compositional bias5 – 3127Ser-rich

Sequences

Sequence LengthMass (Da)Tools
P20268 [UniParc].

Last modified May 27, 2002. Version 3.
Checksum: 46890A452DF90A5E

FASTA38042,575
        10         20         30         40         50         60 
MLIPSSSSIP SSLSASASDS EPSSLNGSGI SDQNILPNYH LHHHLINENE MEAANYAQVI 

        70         80         90        100        110        120 
KPTCEAFQDW PHTPMLYQQP QLHFMLPQHD WAYPHLAQSL PPPHHLTPST AAVAAATIAS 

       130        140        150        160        170        180 
QSSIINQTSV VTSTPSCQIK QEVERPEIIQ RLMPPWPPAY QFSCDDSGSV SGAGGPHQPL 

       190        200        210        220        230        240 
SDISDDSEQT CPDDLEGFAK QFKQRRIKLG YTQADVGVAL GTLYGNIFSQ TTICRFEALQ 

       250        260        270        280        290        300 
LSFKNMCKLK PLLFKWLEEA DSTTGSPNST FEKMTGQAGR KRKKRTSIEV NVKSRLEFHF 

       310        320        330        340        350        360 
QSNQKPNAQE ITQVAMELQL EKEVVRVWFC NRRQKEKRIA PNQYDAPHPM ALNNGYPMTA 

       370        380 
DLFPYQAVVN HYTQQSPRQQ 

« Hide

References

« Hide 'large scale' references
[1]"Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6."
Buerglin T.R., Ruvkun G.
Development 128:779-790(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: Bristol N2.
Tissue: Embryo.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"Caenorhabditis elegans has scores of homoeobox-containing genes."
Buerglin T.R., Finney M., Coulson A., Ruvkun G.
Nature 341:239-243(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 182-340.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF286377 mRNA. Translation: AAG10298.1.
Z75711 Genomic DNA. Translation: CAB00031.2.
PIRS05707.
T23218.
RefSeqNP_492304.1. NM_059903.5.
UniGeneCel.19366.

3D structure databases

ProteinModelPortalP20268.
SMRP20268. Positions 193-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid38073. 1 interaction.
IntActP20268. 4 interactions.
STRING6239.K02B12.1.

Proteomic databases

PRIDEP20268.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaK02B12.1; K02B12.1; K02B12.1.
GeneID172640.
KEGGcel:CELE_K02B12.1.
UCSCK02B12.1. c. elegans.

Organism-specific databases

CTD172640.
WormBaseK02B12.1; CE28045; WBGene00000431; ceh-6.

Phylogenomic databases

eggNOGNOG261729.
HOGENOMHOG000116303.
InParanoidP20268.
KOK09365.
OMALFPYQAV.
OrthoDBEOG7DJSMG.
PhylomeDBP20268.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio876379.

Entry information

Entry nameHM06_CAEEL
AccessionPrimary (citable) accession number: P20268
Secondary accession number(s): Q9GSZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 27, 2002
Last modified: April 16, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase