ID PO3F1_RAT Reviewed; 451 AA. AC P20267; DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-1992, sequence version 2. DT 24-JAN-2024, entry version 165. DE RecName: Full=POU domain, class 3, transcription factor 1; DE AltName: Full=Octamer-binding protein 6; DE Short=Oct-6; DE AltName: Full=Octamer-binding transcription factor 6; DE Short=OTF-6; DE AltName: Full=POU domain transcription factor SCIP; DE AltName: Full=Tst-1; GN Name=Pou3f1; Synonyms=Oct-6, Otf-6, Otf6, Scip; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION BY INJURY. RX PubMed=1975954; DOI=10.1126/science.1975954; RA Monuki E.S., Kuhn R., Weinmaster G., Trapp B.D., Lemke G.; RT "Expression and activity of the POU transcription factor SCIP."; RL Science 249:1300-1303(1990). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 265-369. RX PubMed=2739723; DOI=10.1038/340035a0; RA He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W., RA Rosenfeld M.G.; RT "Expression of a large family of POU-domain regulatory genes in mammalian RT brain development."; RL Nature 340:35-42(1989). RN [3] RP ERRATUM OF PUBMED:2739723, AND SEQUENCE REVISION TO 320. RA He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W., RA Rosenfeld M.G.; RL Nature 340:662-662(1989). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 35-451. RX PubMed=1705013; DOI=10.1128/mcb.11.3.1739-1744.1991; RA He X., Gerrero M.R., Simmons D.M., Park R.E., Lin C.R., Swanson L.W., RA Rosenfeld M.G.; RT "Tst-1, a member of the POU domain gene family, binds the promoter of the RT gene encoding the cell surface adhesion molecule P0."; RL Mol. Cell. Biol. 11:1739-1744(1991). CC -!- FUNCTION: Transcription factor that binds to the octamer motif (5'- CC ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when CC binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By CC similarity). Acts as a transcriptional repressor of myelin-specific CC genes (PubMed:1975954). {ECO:0000250|UniProtKB:P21952, CC ECO:0000269|PubMed:1975954}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P21952}. CC -!- TISSUE SPECIFICITY: Neural tissues and testis. CC -!- INDUCTION: Transiently increased in rapidly dividing Schwann cells in CC response to sciatic nerve transection 2 days post-injury. CC {ECO:0000269|PubMed:1975954}. CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3 CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M72711; AAA42118.1; -; mRNA. DR EMBL; M63712; AAA42303.1; -; mRNA. DR PIR; A40168; A40168. DR RefSeq; NP_620193.1; NM_138838.1. DR AlphaFoldDB; P20267; -. DR SMR; P20267; -. DR GlyGen; P20267; 1 site, 1 O-linked glycan (1 site). DR PhosphoSitePlus; P20267; -. DR GeneID; 192110; -. DR KEGG; rno:192110; -. DR UCSC; RGD:619767; rat. DR AGR; RGD:619767; -. DR CTD; 5453; -. DR RGD; 619767; Pou3f1. DR InParanoid; P20267; -. DR OrthoDB; 4250502at2759; -. DR PhylomeDB; P20267; -. DR PRO; PR:P20267; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0005667; C:transcription regulator complex; ISO:RGD. DR GO; GO:0003677; F:DNA binding; ISO:RGD. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:RGD. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:MGI. DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD. DR GO; GO:0008544; P:epidermis development; ISO:RGD. DR GO; GO:0030900; P:forebrain development; ISO:RGD. DR GO; GO:0010001; P:glial cell differentiation; IDA:RGD. DR GO; GO:0030216; P:keratinocyte differentiation; ISO:RGD. DR GO; GO:0042552; P:myelination; ISO:RGD. DR GO; GO:0022011; P:myelination in peripheral nervous system; ISO:RGD. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IDA:RGD. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB. DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IDA:RGD. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0014044; P:Schwann cell development; ISO:RGD. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf. DR InterPro; IPR013847; POU. DR InterPro; IPR000327; POU_dom. DR InterPro; IPR016362; TF_POU_3. DR PANTHER; PTHR11636; POU DOMAIN; 1. DR PANTHER; PTHR11636:SF75; POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 1; 1. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF00157; Pou; 1. DR PIRSF; PIRSF002629; Transcription_factor_POU; 1. DR PRINTS; PR00028; POUDOMAIN. DR SMART; SM00389; HOX; 1. DR SMART; SM00352; POU; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00035; POU_1; 1. DR PROSITE; PS00465; POU_2; 1. DR PROSITE; PS51179; POU_3; 1. PE 2: Evidence at transcript level; KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor; KW Transcription; Transcription regulation. FT CHAIN 1..451 FT /note="POU domain, class 3, transcription factor 1" FT /id="PRO_0000100722" FT DOMAIN 247..321 FT /note="POU-specific" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530" FT DNA_BIND 339..398 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 1..21 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 69..114 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 134..154 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 186..253 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 395..451 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 437..451 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CONFLICT 423 FT /note="S -> G (in Ref. 4; AAA42118/AAA42303)" FT /evidence="ECO:0000305" SQ SEQUENCE 451 AA; 45496 MW; E32626A759125EAA CRC64; MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ KLMHHEWLGA GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGST GRADDGGGGG GFHARLVHQG AAHAGAAWAQ GGTAHHLGPA MSPSPGAGGG HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG GGAGPGLHHA LHEDGHEAQL EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS VGEHSDEDAP SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV KGALESHFLK CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA AGAGHPPMDD VYAPGELGPG GGSASPPSAP PPPPPAALHH HHHHTLPGSV Q //