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P20267 (PO3F1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 3, transcription factor 1
Alternative name(s):
Octamer-binding protein 6
Short name=Oct-6
Octamer-binding transcription factor 6
Short name=OTF-6
POU domain transcription factor SCIP
Tst-1
Gene names
Name:Pou3f1
Synonyms:Oct-6, Otf-6, Otf6, Scip
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis. Both in normal development and in response to nerve transection, SCIP expression was transiently activated only during the period of rapid cell division that separates the premyelinating and myelinating phases of Schwann cell differentiation. In cotransfection assays, scip acted as a transcriptional repressor of myelin specific genes.

Subcellular location

Nucleus.

Tissue specificity

Neural tissues and testis.

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451POU domain, class 3, transcription factor 1
PRO_0000100722

Regions

Domain247 – 32175POU-specific
DNA binding339 – 39860Homeobox

Experimental info

Sequence conflict4231S → G in AAA42118. Ref.4
Sequence conflict4231S → G in AAA42303. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P20267 [UniParc].

Last modified March 1, 1992. Version 2.
Checksum: E32626A759125EAA

FASTA45145,496
        10         20         30         40         50         60 
MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ KLMHHEWLGA 

        70         80         90        100        110        120 
GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGST GRADDGGGGG GFHARLVHQG 

       130        140        150        160        170        180 
AAHAGAAWAQ GGTAHHLGPA MSPSPGAGGG HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG 

       190        200        210        220        230        240 
GGAGPGLHHA LHEDGHEAQL EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS 

       250        260        270        280        290        300 
VGEHSDEDAP SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ 

       310        320        330        340        350        360 
LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV KGALESHFLK 

       370        380        390        400        410        420 
CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA AGAGHPPMDD VYAPGELGPG 

       430        440        450 
GGSASPPSAP PPPPPAALHH HHHHTLPGSV Q 

« Hide

References

[1]"Expression and activity of the POU transcription factor SCIP."
Monuki E.S., Kuhn R., Weinmaster G., Trapp B.D., Lemke G.
Science 249:1300-1303(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Expression of a large family of POU-domain regulatory genes in mammalian brain development."
He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W., Rosenfeld M.G.
Nature 340:35-42(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 265-369.
[3]Erratum
He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W., Rosenfeld M.G.
Nature 340:662-662(1989)
Cited for: SEQUENCE REVISION TO 320.
[4]"Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0."
He X., Gerrero M.R., Simmons D.M., Park R.E., Lin C.R., Swanson L.W., Rosenfeld M.G.
Mol. Cell. Biol. 11:1739-1744(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-451.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M72711 mRNA. Translation: AAA42118.1.
M63712 mRNA. Translation: AAA42303.1.
PIRA40168.
RefSeqNP_620193.1. NM_138838.1.
UniGeneRn.82720.

3D structure databases

ProteinModelPortalP20267.
SMRP20267. Positions 253-399.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID192110.
KEGGrno:192110.
UCSCRGD:619767. rat.

Organism-specific databases

CTD5453.
RGD619767. Pou3f1.

Phylogenomic databases

HOVERGENHBG053120.
KOK09365.
PhylomeDBP20267.

Gene expression databases

GenevestigatorP20267.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio622681.
PROP20267.

Entry information

Entry namePO3F1_RAT
AccessionPrimary (citable) accession number: P20267
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: March 1, 1992
Last modified: April 16, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families