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P20266 (PO4F1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 4, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 3A
Short name=Brain-3A
Short name=Brn-3A
Gene names
Name:Pou4f1
Synonyms:Brn-3, Brn3, Brn3a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length128 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Subcellular location

Nucleus.

Tissue specificity

Brain.

Sequence similarities

Belongs to the POU transcription factor family. Class-4 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell migration in hindbrain

Inferred from electronic annotation. Source: Ensembl

central nervous system neuron differentiation

Inferred from electronic annotation. Source: Ensembl

habenula development

Inferred from electronic annotation. Source: Ensembl

innervation

Inferred from electronic annotation. Source: Ensembl

mesoderm development

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Traceable author statement PubMed 15492043. Source: RGD

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

neuron fate specification

Inferred from electronic annotation. Source: Ensembl

peripheral nervous system neuron development

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

proprioception involved in equilibrioception

Inferred from electronic annotation. Source: Ensembl

regulation of neurogenesis

Inferred from electronic annotation. Source: Ensembl

sensory system development

Inferred from electronic annotation. Source: Ensembl

suckling behavior

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Traceable author statement PubMed 15492043. Source: RGD

trigeminal nerve development

Inferred from electronic annotation. Source: Ensembl

ventricular compact myocardium morphogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentneuron projection

Inferred from electronic annotation. Source: Ensembl

nuclear chromatin

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Traceable author statement PubMed 15492043. Source: RGD

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II distal enhancer sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Traceable author statement PubMed 15492043. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›128›128POU domain, class 4, transcription factor 1
PRO_0000100738

Regions

Domain‹1 – 60›60POU-specific
DNA binding78 – ›128›51Homeobox

Experimental info

Sequence conflict621A → P Ref.1
Non-terminal residue11
Non-terminal residue1281

Sequences

Sequence LengthMass (Da)Tools
P20266 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: 706ACDB6E12DB405

FASTA12814,233
        10         20         30         40         50         60 
RRIKLGVTQA DVGSALANLK IPGVGSLSQS TICRFESLTL SHNNMIALKP ILQAWLEEAE 

        70         80         90        100        110        120 
GAQREKMNKP ELFNGGEKKR KRTSIAAPEK RSLEAYFAVQ PRPSSEKIAA IAEKLDLKKN 


VVRVWFCN 

« Hide

References

[1]"Expression of a large family of POU-domain regulatory genes in mammalian brain development."
He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W., Rosenfeld M.G.
Nature 340:35-42(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells."
Lillycrop K.A., Budrahan V.S., Lakin N.D., Terrenghi G., Wood J.N., Polak J.M., Latchman D.S.
Nucleic Acids Res. 20:5093-5096(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-122.
[3]"Homeobox gene repertoire in adult rat dorsal root ganglia."
Vogelaar C.F., Smits S.M., Brakkee J.H., Gispen W.H., Smidt M.P., Schrama L.H., Hoekman M.F.M., Burbach J.P.H.
Neurosci. Res. Commun. 32:49-59(2003)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-123.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF390075 mRNA. Translation: AAK70502.1.
PIRS05045.
UniGeneRn.232568.

3D structure databases

ProteinModelPortalP20266.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1514701.
STRING10116.ENSRNOP00000012828.

Proteomic databases

PaxDbP20266.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:620074. rat.

Organism-specific databases

RGD620074. Pou4f1.

Phylogenomic databases

eggNOGNOG289030.
HOGENOMHOG000116305.
HOVERGENHBG053120.
InParanoidP20266.
PhylomeDBP20266.

Gene expression databases

GenevestigatorP20266.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePO4F1_RAT
AccessionPrimary (citable) accession number: P20266
Secondary accession number(s): Q91XM4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 13, 2004
Last modified: April 16, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families