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P20266

- PO4F1_RAT

UniProt

P20266 - PO4F1_RAT

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Protein

POU domain, class 4, transcription factor 1

Gene

Pou4f1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi78 – ›128›51HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: RGD
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  3. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  5. sequence-specific DNA binding transcription factor activity Source: RGD

GO - Biological processi

  1. cell migration in hindbrain Source: Ensembl
  2. central nervous system neuron differentiation Source: Ensembl
  3. habenula development Source: Ensembl
  4. innervation Source: Ensembl
  5. mesoderm development Source: Ensembl
  6. negative regulation of apoptotic process Source: RGD
  7. negative regulation of neuron apoptotic process Source: RGD
  8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. neuron fate specification Source: Ensembl
  10. peripheral nervous system neuron development Source: Ensembl
  11. positive regulation of apoptotic process Source: Ensembl
  12. proprioception involved in equilibrioception Source: Ensembl
  13. regulation of neurogenesis Source: Ensembl
  14. sensory system development Source: Ensembl
  15. spermatogenesis Source: RGD
  16. suckling behavior Source: Ensembl
  17. transcription from RNA polymerase II promoter Source: RGD
  18. trigeminal nerve development Source: Ensembl
  19. ventricular compact myocardium morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 4, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 3A
Short name:
Brain-3A
Short name:
Brn-3A
Gene namesi
Name:Pou4f1
Synonyms:Brn-3, Brn3, Brn3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620074. Pou4f1.

Subcellular locationi

GO - Cellular componenti

  1. neuron projection Source: Ensembl
  2. nuclear chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›128›128POU domain, class 4, transcription factor 1PRO_0000100738Add
BLAST

Proteomic databases

PaxDbiP20266.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

GenevestigatoriP20266.

Interactioni

Protein-protein interaction databases

MINTiMINT-1514701.
STRINGi10116.ENSRNOP00000012828.

Structurei

3D structure databases

ProteinModelPortaliP20266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 60›60POU-specificPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG289030.
HOGENOMiHOG000116305.
HOVERGENiHBG053120.
InParanoidiP20266.
PhylomeDBiP20266.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P20266-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RRIKLGVTQA DVGSALANLK IPGVGSLSQS TICRFESLTL SHNNMIALKP
60 70 80 90 100
ILQAWLEEAE GAQREKMNKP ELFNGGEKKR KRTSIAAPEK RSLEAYFAVQ
110 120
PRPSSEKIAA IAEKLDLKKN VVRVWFCN
Length:128
Mass (Da):14,233
Last modified:April 13, 2004 - v2
Checksum:i706ACDB6E12DB405
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Sequence conflicti62 – 621A → P(PubMed:2739723)Curated
Non-terminal residuei128 – 1281

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390075 mRNA. Translation: AAK70502.1.
PIRiS05045.
UniGeneiRn.232568.

Genome annotation databases

UCSCiRGD:620074. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390075 mRNA. Translation: AAK70502.1 .
PIRi S05045.
UniGenei Rn.232568.

3D structure databases

ProteinModelPortali P20266.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1514701.
STRINGi 10116.ENSRNOP00000012828.

Proteomic databases

PaxDbi P20266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620074. rat.

Organism-specific databases

RGDi 620074. Pou4f1.

Phylogenomic databases

eggNOGi NOG289030.
HOGENOMi HOG000116305.
HOVERGENi HBG053120.
InParanoidi P20266.
PhylomeDBi P20266.

Gene expression databases

Genevestigatori P20266.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of a large family of POU-domain regulatory genes in mammalian brain development."
    He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W., Rosenfeld M.G.
    Nature 340:35-42(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells."
    Lillycrop K.A., Budrahan V.S., Lakin N.D., Terrenghi G., Wood J.N., Polak J.M., Latchman D.S.
    Nucleic Acids Res. 20:5093-5096(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-122.
  3. "Homeobox gene repertoire in adult rat dorsal root ganglia."
    Vogelaar C.F., Smits S.M., Brakkee J.H., Gispen W.H., Smidt M.P., Schrama L.H., Hoekman M.F.M., Burbach J.P.H.
    Neurosci. Res. Commun. 32:49-59(2003)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-123.

Entry informationi

Entry nameiPO4F1_RAT
AccessioniPrimary (citable) accession number: P20266
Secondary accession number(s): Q91XM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 13, 2004
Last modified: October 29, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3