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P20266

- PO4F1_RAT

UniProt

P20266 - PO4F1_RAT

Protein

POU domain, class 4, transcription factor 1

Gene

Pou4f1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi78 – ›128›51HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: RGD
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    3. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding transcription factor activity Source: RGD

    GO - Biological processi

    1. cell migration in hindbrain Source: Ensembl
    2. central nervous system neuron differentiation Source: Ensembl
    3. habenula development Source: Ensembl
    4. innervation Source: Ensembl
    5. mesoderm development Source: Ensembl
    6. negative regulation of apoptotic process Source: RGD
    7. negative regulation of neuron apoptotic process Source: Ensembl
    8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. neuron fate specification Source: Ensembl
    10. peripheral nervous system neuron development Source: Ensembl
    11. positive regulation of apoptotic process Source: Ensembl
    12. proprioception involved in equilibrioception Source: Ensembl
    13. regulation of neurogenesis Source: Ensembl
    14. sensory system development Source: Ensembl
    15. suckling behavior Source: Ensembl
    16. transcription from RNA polymerase II promoter Source: RGD
    17. trigeminal nerve development Source: Ensembl
    18. ventricular compact myocardium morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 4, transcription factor 1
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 3A
    Short name:
    Brain-3A
    Short name:
    Brn-3A
    Gene namesi
    Name:Pou4f1
    Synonyms:Brn-3, Brn3, Brn3a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620074. Pou4f1.

    Subcellular locationi

    GO - Cellular componenti

    1. neuron projection Source: Ensembl
    2. nuclear chromatin Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›128›128POU domain, class 4, transcription factor 1PRO_0000100738Add
    BLAST

    Proteomic databases

    PaxDbiP20266.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    GenevestigatoriP20266.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1514701.
    STRINGi10116.ENSRNOP00000012828.

    Structurei

    3D structure databases

    ProteinModelPortaliP20266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini‹1 – 60›60POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG289030.
    HOGENOMiHOG000116305.
    HOVERGENiHBG053120.
    InParanoidiP20266.
    PhylomeDBiP20266.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P20266-1 [UniParc]FASTAAdd to Basket

    « Hide

    RRIKLGVTQA DVGSALANLK IPGVGSLSQS TICRFESLTL SHNNMIALKP    50
    ILQAWLEEAE GAQREKMNKP ELFNGGEKKR KRTSIAAPEK RSLEAYFAVQ 100
    PRPSSEKIAA IAEKLDLKKN VVRVWFCN 128
    Length:128
    Mass (Da):14,233
    Last modified:April 13, 2004 - v2
    Checksum:i706ACDB6E12DB405
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Sequence conflicti62 – 621A → P(PubMed:2739723)Curated
    Non-terminal residuei128 – 1281

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF390075 mRNA. Translation: AAK70502.1.
    PIRiS05045.
    UniGeneiRn.232568.

    Genome annotation databases

    UCSCiRGD:620074. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF390075 mRNA. Translation: AAK70502.1 .
    PIRi S05045.
    UniGenei Rn.232568.

    3D structure databases

    ProteinModelPortali P20266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1514701.
    STRINGi 10116.ENSRNOP00000012828.

    Proteomic databases

    PaxDbi P20266.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:620074. rat.

    Organism-specific databases

    RGDi 620074. Pou4f1.

    Phylogenomic databases

    eggNOGi NOG289030.
    HOGENOMi HOG000116305.
    HOVERGENi HBG053120.
    InParanoidi P20266.
    PhylomeDBi P20266.

    Gene expression databases

    Genevestigatori P20266.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of a large family of POU-domain regulatory genes in mammalian brain development."
      He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W., Rosenfeld M.G.
      Nature 340:35-42(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells."
      Lillycrop K.A., Budrahan V.S., Lakin N.D., Terrenghi G., Wood J.N., Polak J.M., Latchman D.S.
      Nucleic Acids Res. 20:5093-5096(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-122.
    3. "Homeobox gene repertoire in adult rat dorsal root ganglia."
      Vogelaar C.F., Smits S.M., Brakkee J.H., Gispen W.H., Smidt M.P., Schrama L.H., Hoekman M.F.M., Burbach J.P.H.
      Neurosci. Res. Commun. 32:49-59(2003)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-123.

    Entry informationi

    Entry nameiPO4F1_RAT
    AccessioniPrimary (citable) accession number: P20266
    Secondary accession number(s): Q91XM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3