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Protein

POU domain, class 4, transcription factor 1

Gene

Pou4f1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi78 – ›128›51HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: RGD
  • sequence-specific DNA binding transcription factor activity Source: RGD

GO - Biological processi

  • multicellular organismal development Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of neuron apoptotic process Source: RGD
  • spermatogenesis Source: RGD
  • transcription from RNA polymerase II promoter Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 4, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 3A
Short name:
Brain-3A
Short name:
Brn-3A
Gene namesi
Name:Pou4f1
Synonyms:Brn-3, Brn3, Brn3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620074. Pou4f1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›128›128POU domain, class 4, transcription factor 1PRO_0000100738Add
BLAST

Proteomic databases

PaxDbiP20266.

Expressioni

Tissue specificityi

Brain.

Interactioni

Protein-protein interaction databases

MINTiMINT-1514701.
STRINGi10116.ENSRNOP00000012828.

Structurei

3D structure databases

ProteinModelPortaliP20266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 60›60POU-specificPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG289030.
HOGENOMiHOG000116305.
HOVERGENiHBG053120.
InParanoidiP20266.
PhylomeDBiP20266.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P20266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RRIKLGVTQA DVGSALANLK IPGVGSLSQS TICRFESLTL SHNNMIALKP
60 70 80 90 100
ILQAWLEEAE GAQREKMNKP ELFNGGEKKR KRTSIAAPEK RSLEAYFAVQ
110 120
PRPSSEKIAA IAEKLDLKKN VVRVWFCN
Length:128
Mass (Da):14,233
Last modified:April 13, 2004 - v2
Checksum:i706ACDB6E12DB405
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Sequence conflicti62 – 621A → P (PubMed:2739723).Curated
Non-terminal residuei128 – 1281

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390075 mRNA. Translation: AAK70502.1.
PIRiS05045.
UniGeneiRn.232568.

Genome annotation databases

UCSCiRGD:620074. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390075 mRNA. Translation: AAK70502.1.
PIRiS05045.
UniGeneiRn.232568.

3D structure databases

ProteinModelPortaliP20266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1514701.
STRINGi10116.ENSRNOP00000012828.

Proteomic databases

PaxDbiP20266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620074. rat.

Organism-specific databases

RGDi620074. Pou4f1.

Phylogenomic databases

eggNOGiNOG289030.
HOGENOMiHOG000116305.
HOVERGENiHBG053120.
InParanoidiP20266.
PhylomeDBiP20266.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of a large family of POU-domain regulatory genes in mammalian brain development."
    He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W., Rosenfeld M.G.
    Nature 340:35-42(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells."
    Lillycrop K.A., Budrahan V.S., Lakin N.D., Terrenghi G., Wood J.N., Polak J.M., Latchman D.S.
    Nucleic Acids Res. 20:5093-5096(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-122.
  3. "Homeobox gene repertoire in adult rat dorsal root ganglia."
    Vogelaar C.F., Smits S.M., Brakkee J.H., Gispen W.H., Smidt M.P., Schrama L.H., Hoekman M.F.M., Burbach J.P.H.
    Neurosci. Res. Commun. 32:49-59(2003)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-123.

Entry informationi

Entry nameiPO4F1_RAT
AccessioniPrimary (citable) accession number: P20266
Secondary accession number(s): Q91XM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 13, 2004
Last modified: July 22, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.