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P20264

- PO3F3_HUMAN

UniProt

P20264 - PO3F3_HUMAN

Protein

POU domain, class 3, transcription factor 3

Gene

POU3F3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi406 – 46560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. central nervous system development Source: ProtInc
    2. cerebral cortex radially oriented cell migration Source: Ensembl
    3. forebrain ventricular zone progenitor cell division Source: Ensembl
    4. metanephric ascending thin limb development Source: UniProtKB
    5. metanephric DCT cell differentiation Source: UniProtKB
    6. metanephric loop of Henle development Source: UniProtKB
    7. metanephric macula densa development Source: UniProtKB
    8. metanephric thick ascending limb development Source: UniProtKB
    9. negative regulation of apoptotic process Source: UniProtKB
    10. negative regulation of transcription, DNA-templated Source: UniProtKB
    11. positive regulation of cell proliferation Source: UniProtKB
    12. positive regulation of gene expression Source: UniProtKB
    13. positive regulation of transcription, DNA-templated Source: UniProtKB
    14. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    15. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 3
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 1
    Short name:
    Brain-1
    Short name:
    Brn-1
    Octamer-binding protein 8
    Short name:
    Oct-8
    Octamer-binding transcription factor 8
    Short name:
    OTF-8
    Gene namesi
    Name:POU3F3
    Synonyms:BRN1, OTF8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:9216. POU3F3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33540.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500POU domain, class 3, transcription factor 3PRO_0000100727Add
    BLAST

    Proteomic databases

    MaxQBiP20264.
    PaxDbiP20264.
    PRIDEiP20264.

    PTM databases

    PhosphoSiteiP20264.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    BgeeiP20264.
    CleanExiHS_POU3F3.
    GenevestigatoriP20264.

    Interactioni

    Protein-protein interaction databases

    BioGridi111451. 2 interactions.
    IntActiP20264. 2 interactions.
    MINTiMINT-1410140.
    STRINGi9606.ENSP00000355001.

    Structurei

    3D structure databases

    ProteinModelPortaliP20264.
    SMRiP20264. Positions 317-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini314 – 38875POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi28 – 304277Gly-richAdd
    BLAST
    Compositional biasi81 – 204124Ala-richAdd
    BLAST
    Compositional biasi133 – 18452Pro-richAdd
    BLAST
    Compositional biasi270 – 29425His-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261729.
    HOGENOMiHOG000116303.
    HOVERGENiHBG053120.
    InParanoidiP20264.
    KOiK09365.
    OMAiAHLPSMA.
    OrthoDBiEOG7DJSMG.
    PhylomeDBiP20264.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20264-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATAASNPYL PGNSLLAAGS IVHSDAAGAG GGGGGGGGGG GGGAGGGGGG    50
    MQPGSAAVTS GAYRGDPSSV KMVQSDFMQG AMAASNGGHM LSHAHQWVTA 100
    LPHAAAAAAA AAAAAVEASS PWSGSAVGMA GSPQQPPQPP PPPPQGPDVK 150
    GGAGRDDLHA GTALHHRGPP HLGPPPPPPH QGHPGGWGAA AAAAAAAAAA 200
    AAAAHLPSMA GGQQPPPQSL LYSQPGGFTV NGMLSAPPGP GGGGGGAGGG 250
    AQSLVHPGLV RGDTPELAEH HHHHHHHAHP HPPHPHHAQG PPHHGGGGGG 300
    AGPGLNSHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL 350
    YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS TGSPTSIDKI 400
    AAQGRKRKKR TSIEVSVKGA LESHFLKCPK PSAQEITNLA DSLQLEKEVV 450
    RVWFCNRRQK EKRMTPPGIQ QQTPDDVYSQ VGTVSADTPP PHHGLQTSVQ 500
    Length:500
    Mass (Da):50,327
    Last modified:November 1, 1997 - v2
    Checksum:iE536EFFFA5212319
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti433 – 4331A → S(PubMed:2739723)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001835 Genomic DNA. Translation: BAA19459.1.
    AC018730 Genomic DNA. Translation: AAX88973.1.
    CCDSiCCDS33265.1.
    RefSeqiNP_006227.1. NM_006236.1.
    UniGeneiHs.673855.

    Genome annotation databases

    EnsembliENST00000361360; ENSP00000355001; ENSG00000198914.
    GeneIDi5455.
    KEGGihsa:5455.
    UCSCiuc010ywg.2. human.

    Polymorphism databases

    DMDMi2506534.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001835 Genomic DNA. Translation: BAA19459.1 .
    AC018730 Genomic DNA. Translation: AAX88973.1 .
    CCDSi CCDS33265.1.
    RefSeqi NP_006227.1. NM_006236.1.
    UniGenei Hs.673855.

    3D structure databases

    ProteinModelPortali P20264.
    SMRi P20264. Positions 317-466.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111451. 2 interactions.
    IntActi P20264. 2 interactions.
    MINTi MINT-1410140.
    STRINGi 9606.ENSP00000355001.

    Chemistry

    BindingDBi P20264.
    ChEMBLi CHEMBL5243.

    PTM databases

    PhosphoSitei P20264.

    Polymorphism databases

    DMDMi 2506534.

    Proteomic databases

    MaxQBi P20264.
    PaxDbi P20264.
    PRIDEi P20264.

    Protocols and materials databases

    DNASUi 5455.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361360 ; ENSP00000355001 ; ENSG00000198914 .
    GeneIDi 5455.
    KEGGi hsa:5455.
    UCSCi uc010ywg.2. human.

    Organism-specific databases

    CTDi 5455.
    GeneCardsi GC02P105471.
    HGNCi HGNC:9216. POU3F3.
    MIMi 602480. gene.
    neXtProti NX_P20264.
    PharmGKBi PA33540.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261729.
    HOGENOMi HOG000116303.
    HOVERGENi HBG053120.
    InParanoidi P20264.
    KOi K09365.
    OMAi AHLPSMA.
    OrthoDBi EOG7DJSMG.
    PhylomeDBi P20264.
    TreeFami TF316413.

    Miscellaneous databases

    GenomeRNAii 5455.
    NextBioi 21113.
    PROi P20264.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20264.
    CleanExi HS_POU3F3.
    Genevestigatori P20264.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals."
      Sumiyama K., Washio-Watanabe K., Saitou N., Hayakawa T., Ueda S.
      J. Mol. Evol. 43:170-178(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Expression of a large family of POU-domain regulatory genes in mammalian brain development."
      He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W., Rosenfeld M.G.
      Nature 340:35-42(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 332-456.
      Tissue: Brain.

    Entry informationi

    Entry nameiPO3F3_HUMAN
    AccessioniPrimary (citable) accession number: P20264
    Secondary accession number(s): P78379, Q4ZG25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3