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Protein

Lipase 1

Gene

LIP1

Organism
Candida rugosa (Yeast) (Candida cylindracea)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224Acyl-ester intermediate1
Active sitei356Charge relay system1
Active sitei464Charge relay system1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.3. 1139.

Protein family/group databases

ESTHERicanru-1lipa. Fungal_carboxylesterase_lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase 1 (EC:3.1.1.3)
Gene namesi
Name:LIP1
OrganismiCandida rugosa (Yeast) (Candida cylindracea)
Taxonomic identifieri5481 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisDiutina

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Add BLAST15
ChainiPRO_000000861916 – 549Lipase 1Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 112
Disulfide bondi283 ↔ 292
Glycosylationi329N-linked (GlcNAc...)1
Glycosylationi366N-linked (GlcNAc...)1

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

Secondary structure

1549
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 20Combined sources3
Beta strandi26 – 28Combined sources3
Beta strandi33 – 42Combined sources10
Helixi49 – 51Combined sources3
Helixi84 – 86Combined sources3
Helixi88 – 97Combined sources10
Helixi100 – 105Combined sources6
Beta strandi106 – 108Combined sources3
Beta strandi114 – 119Combined sources6
Beta strandi129 – 135Combined sources7
Turni139 – 141Combined sources3
Helixi145 – 147Combined sources3
Helixi151 – 159Combined sources9
Beta strandi165 – 169Combined sources5
Helixi174 – 178Combined sources5
Helixi182 – 187Combined sources6
Helixi192 – 207Combined sources16
Helixi208 – 211Combined sources4
Beta strandi213 – 223Combined sources11
Helixi225 – 235Combined sources11
Helixi236 – 239Combined sources4
Beta strandi246 – 248Combined sources3
Beta strandi250 – 256Combined sources7
Helixi268 – 281Combined sources14
Helixi289 – 295Combined sources7
Helixi298 – 306Combined sources9
Turni314 – 317Combined sources4
Beta strandi327 – 330Combined sources4
Helixi334 – 339Combined sources6
Beta strandi348 – 353Combined sources6
Helixi358 – 361Combined sources4
Helixi362 – 364Combined sources3
Helixi370 – 380Combined sources11
Helixi386 – 395Combined sources10
Helixi400 – 402Combined sources3
Beta strandi403 – 405Combined sources3
Turni409 – 412Combined sources4
Beta strandi414 – 417Combined sources4
Helixi418 – 429Combined sources12
Helixi431 – 440Combined sources10
Beta strandi446 – 451Combined sources6
Turni453 – 456Combined sources4
Turni458 – 460Combined sources3
Beta strandi461 – 463Combined sources3
Helixi466 – 472Combined sources7
Helixi479 – 482Combined sources4
Helixi484 – 492Combined sources9
Helixi495 – 498Combined sources4
Beta strandi512 – 514Combined sources3
Beta strandi517 – 520Combined sources4
Beta strandi525 – 528Combined sources4
Helixi534 – 541Combined sources8
Helixi544 – 547Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CRLX-ray2.06A16-549[»]
1LPMX-ray2.18A1-549[»]
1LPNX-ray2.18A1-549[»]
1LPOX-ray2.18A1-549[»]
1LPPX-ray2.18A1-549[»]
1LPSX-ray2.18A1-549[»]
1TRHX-ray2.10A16-549[»]
3RARX-ray2.19A16-549[»]
ProteinModelPortaliP20261.
SMRiP20261.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20261.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELALALSLI ASVAAAPTAT LANGDTITGL NAIINEAFLG IPFAEPPVGN
60 70 80 90 100
LRFKDPVPYS GSLDGQKFTS YGPSCMQQNP EGTYEENLPK AALDLVMQSK
110 120 130 140 150
VFEAVSPSSE DCLTINVVRP PGTKAGANLP VMLWIFGGGF EVGGTSTFPP
160 170 180 190 200
AQMITKSIAM GKPIIHVSVN YRVSSWGFLA GDEIKAEGSA NAGLKDQRLG
210 220 230 240 250
MQWVADNIAA FGGDPTKVTI FGESAGSMSV MCHILWNDGD NTYKGKPLFR
260 270 280 290 300
AGIMQSGAMV PSDAVDGIYG NEIFDLLASN AGCGSASDKL ACLRGVSSDT
310 320 330 340 350
LEDATNNTPG FLAYSSLRLS YLPRPDGVNI TDDMYALVRE GKYANIPVII
360 370 380 390 400
GDQNDEGTFF GTSSLNVTTD AQAREYFKQS FVHASDAEID TLMTAYPGDI
410 420 430 440 450
TQGSPFDTGI LNALTPQFKR ISAVLGDLGF TLARRYFLNH YTGGTKYSFL
460 470 480 490 500
SKQLSGLPVL GTFHSNDIVF QDYLLGSGSL IYNNAFIAFA TDLDPNTAGL
510 520 530 540
LVKWPEYTSS SQSGNNLMMI NALGLYTGKD NFRTAGYDAL FSNPPSFFV
Length:549
Mass (Da):58,550
Last modified:October 1, 1993 - v3
Checksum:i27A40BD318757CE0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti398G → Q.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64703 Genomic DNA. Translation: CAA45957.1.
X16712 mRNA. Translation: CAA34684.1.
PIRiS05684.
S23448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64703 Genomic DNA. Translation: CAA45957.1.
X16712 mRNA. Translation: CAA34684.1.
PIRiS05684.
S23448.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CRLX-ray2.06A16-549[»]
1LPMX-ray2.18A1-549[»]
1LPNX-ray2.18A1-549[»]
1LPOX-ray2.18A1-549[»]
1LPPX-ray2.18A1-549[»]
1LPSX-ray2.18A1-549[»]
1TRHX-ray2.10A16-549[»]
3RARX-ray2.19A16-549[»]
ProteinModelPortaliP20261.
SMRiP20261.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERicanru-1lipa. Fungal_carboxylesterase_lipase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.1.1.3. 1139.

Miscellaneous databases

EvolutionaryTraceiP20261.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIP1_CANRU
AccessioniPrimary (citable) accession number: P20261
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.