Gamma-aminobutyric acid receptor subunit alpha-4 precursor

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P20237 (GBRA4_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 108. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-4

Alternative name(s):
GABA(A) receptor subunit alpha-4

Gene names

Name:

GABRA4

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit structure	Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ion channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	central nervous system development Inferred from electronic annotation. Source: Compara gamma-aminobutyric acid signaling pathway Inferred from electronic annotation. Source: InterPro regulation of response to drug Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GABA-A receptor activity Inferred from electronic annotation. Source: InterPro chloride channel activity Inferred from electronic annotation. Source: UniProtKB-KW extracellular ligand-gated ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 35

Potential

Chain

36 – 555

520

Gamma-aminobutyric acid receptor subunit alpha-4

PRO_0000000440

Regions

Topological domain

36 – 258

223

Extracellular Probable

Transmembrane

259 – 280

Helical; Probable

Transmembrane

285 – 306

Helical; Probable

Transmembrane

318 – 340

Helical; Probable

Topological domain

341 – 524

184

Cytoplasmic Probable

Transmembrane

525 – 544

Helical; Probable

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

144

N-linked (GlcNAc...) Potential

Glycosylation

157

N-linked (GlcNAc...) Potential

Disulfide bond

172 ↔ 186

By similarity

Experimental info

Sequence conflict

308

H → PI in CAA43696. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P20237 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 03B51F1C27304DD7
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FASTA

555

61,547

        10         20         30         40         50         60 
MVSAKKVPAI AMSFGVSFAL LHFLCLAACL NESPGQNQKE EKLCPENFTR ILDSLLDGYD 

        70         80         90        100        110        120 
NRLRPGFGGP VTEVKTDIYV TSFGPVSDVE MEYTMDVFFR QTWIDKRLKY DGPIEILRLN 

       130        140        150        160        170        180 
NMMVTKVWTP DTFFRNGKKS VSHNMTAPNK LFRIMRNGTI LYTMRLTISA ECPMRLVDFP 

       190        200        210        220        230        240 
MDGHACPLKF GSYAYPKSEM IYTWTKGPEK SVEVPKESSS LVQYDLIGQT VSSETIKSIT 

       250        260        270        280        290        300 
GEYIVMTVYF HLRRKMGYFM IQTYIPCIMT VILSQVSFWI NKESVPARTV FGITTVLTMT 

       310        320        330        340        350        360 
TLSISARHSL PKVSYATAMD WFIAVCFAFV FSALIEFAAV NYFTNVQMEK AKRKTSKAPQ 

       370        380        390        400        410        420 
EISAAPVLRE KHPETPLQNT NANLSMRKRA NALVHSESDV GSRTDVGNHS SKSSTVVQGS 

       430        440        450        460        470        480 
SEATPQSYLA SSPNPFSRAN AAETISAARA IPSALPSTPS RTGYVPRQVP VGSASTQHVF 

       490        500        510        520        530        540 
GSRLQRIKTT VNSIGTSGKL SATTTPSAPP PSGSGTSKID KYARILFPVT FGAFNMVYWV 

       550 
VYLSKDTMEK SESLM

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and expression of a novel GABAA receptor alpha subunit." Ymer S., Draguhn A., Koehler M., Schofield P.R., Seeburg P.H. FEBS Lett. 258:119-122(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thalamus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X61456 mRNA. Translation: CAA43696.1. BC123424 mRNA. Translation: AAI23425.1.
IPI	IPI00689982.
PIR	S06838.
RefSeq	NP_776968.1. NM_174543.2.
UniGene	Bt.171.
3D structure databases
ProteinModelPortal	P20237.
SMR	P20237. Positions 285-344.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000022141.
Proteomic databases
PRIDE	P20237.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000022141; ENSBTAP00000022141; ENSBTAG00000016645.
GeneID	282238.
KEGG	bta:282238.
Organism-specific databases
CTD	2557.
Phylogenomic databases
eggNOG	NOG238757.
GeneTree	ENSGT00550000074441.
HOGENOM	HOG000231337.
HOVERGEN	HBG051707.
InParanoid	P20237.
KO	K05175.
OMA	THANLNM.
OrthoDB	EOG4MPHQ4.
Family and domain databases
Gene3D	2.70.170.10. 1 hit.
InterPro	IPR006028. GABAA_rcpt. IPR001390. GABAAa_rcpt. IPR005434. GABBAa4_rcpt. IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR01079. GABAARALPHA. PR01617. GABAARALPHA4. PR00253. GABAARECEPTR. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P20237.
ChEMBL	CHEMBL3140.
NextBio	20806057.

Entry information

Entry name

GBRA4_BOVIN

Accession

Primary (citable) accession number: P20237
Secondary accession number(s): Q08E47

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	April 3, 2007
Last modified:	April 3, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents