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P20236

- GBRA3_RAT

UniProt

P20236 - GBRA3_RAT

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Protein

Gamma-aminobutyric acid receptor subunit alpha-3

Gene
Gabra3, Gabra-3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. GABA-A receptor activity Source: RGD
  4. protein binding Source: IntAct

GO - Biological processi

  1. gamma-aminobutyric acid signaling pathway Source: InterPro
  2. synaptic transmission Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-3
Alternative name(s):
GABA(A) receptor subunit alpha-3
Gene namesi
Name:Gabra3
Synonyms:Gabra-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2648. Gabra3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 276248Extracellular InferredAdd
BLAST
Transmembranei277 – 29822Helical; InferredAdd
BLAST
Transmembranei304 – 32522Helical; InferredAdd
BLAST
Transmembranei338 – 35922Helical; InferredAdd
BLAST
Topological domaini360 – 45899Cytoplasmic InferredAdd
BLAST
Transmembranei459 – 48022Helical; InferredAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed predictionAdd
BLAST
Chaini29 – 493465Gamma-aminobutyric acid receptor subunit alpha-3PRO_0000000439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi176 – 1761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi191 ↔ 205 By similarity
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP20236.

Expressioni

Gene expression databases

GenevestigatoriP20236.

Interactioni

Subunit structurei

Binds UBQLN1 By similarity. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Binary interactionsi

WithEntry#Exp.IntActNotes
GphnQ03555-65EBI-5273284,EBI-5273276

Protein-protein interaction databases

IntActiP20236. 1 interaction.
MINTiMINT-8293904.
STRINGi10116.ENSRNOP00000050712.

Structurei

3D structure databases

ProteinModelPortaliP20236.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238757.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP20236.
PhylomeDBiP20236.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005433. GABBAa3_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01616. GABAARALPHA3.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20236-1 [UniParc]FASTAAdd to Basket

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MITTQMWHFY VTRVGLLLLI SILPGTTGQG ESRRQEPGDF VKQDIGGLSP    50
KHAPDIPDDS TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT 100
SFGPVSDTDM EYTIDVFFRQ TWHDERLKFD GPMKILPLNN LLASKIWTPD 150
TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL YTMRLTIHAE CPMHLEDFPM 200
DVHACPLKFG SYAYTKAEVI YSWTLGKNKS VEVAQDGSRL NQYDLLGHVV 250
GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN 300
RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FMAVCYAFVF 350
SALIEFATVN YFTKRSWAWE GKKVPEALEM KKKTPAAPTK KTSTTFNIVG 400
TTYPINLALD TEFSTISKAA AAPSASSTPT VIASPKTTYV QDSPAETKTY 450
NSVSKVDKIS RIIFPVLFAI FNLVYWATYV NRESAIKGMI RKQ 493
Length:493
Mass (Da):55,433
Last modified:February 1, 1991 - v1
Checksum:i7145AA1A00D67B53
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601V → M in AAC42031. 1 Publication
Sequence conflicti324 – 3241S → T in AAC42031. 1 Publication
Sequence conflicti409 – 4091L → K in AAC42031. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08492 Genomic DNA. Translation: AAC42031.1.
X51991 mRNA. Translation: CAA36247.1.
PIRiA34130.
UniGeneiRn.10367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08492 Genomic DNA. Translation: AAC42031.1 .
X51991 mRNA. Translation: CAA36247.1 .
PIRi A34130.
UniGenei Rn.10367.

3D structure databases

ProteinModelPortali P20236.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P20236. 1 interaction.
MINTi MINT-8293904.
STRINGi 10116.ENSRNOP00000050712.

Chemistry

BindingDBi P20236.
ChEMBLi CHEMBL2096683.
GuidetoPHARMACOLOGYi 406.

Proteomic databases

PRIDEi P20236.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 2648. Gabra3.

Phylogenomic databases

eggNOGi NOG238757.
HOGENOMi HOG000231337.
HOVERGENi HBG051707.
InParanoidi P20236.
PhylomeDBi P20236.

Miscellaneous databases

NextBioi 604953.

Gene expression databases

Genevestigatori P20236.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005433. GABBAa3_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view ]
PRINTSi PR01079. GABAARALPHA.
PR01616. GABAARALPHA3.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional expression and sites of gene transcription of a novel alpha subunit of the GABAA receptor in rat brain."
    Malherbe P., Sigel E., Baur R., Persohn E., Richards J.G., Moehler H.
    FEBS Lett. 260:261-265(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The GABAA receptor family: molecular and functional diversity."
    Seeburg P.H., Wisden W., Verdoorn T., Pritchett D., Werner P., Herb A., Lueddens H., Sprengel R., Sakmann B.
    Cold Spring Harb. Symp. Quant. Biol. 55:29-40(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Brain.

Entry informationi

Entry nameiGBRA3_RAT
AccessioniPrimary (citable) accession number: P20236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 11, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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