Gamma-aminobutyric acid receptor subunit alpha-3 precursor

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P20236 (GBRA3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-3

Alternative name(s):
GABA(A) receptor subunit alpha-3

Gene names

Name:	Gabra3
Synonyms:	Gabra-3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit structure	Binds UBQLN1 By similarity. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ionic channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gamma-aminobutyric acid signaling pathway Inferred from electronic annotation. Source: InterPro synaptic transmission Inferred from mutant phenotype. Source: RGD
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GABA-A receptor activity Inferred from direct assay Ref.1. Source: RGD chloride channel activity Inferred from electronic annotation. Source: UniProtKB-KW extracellular ligand-gated ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

Potential

Chain

29 – 493

465

Gamma-aminobutyric acid receptor subunit alpha-3

PRO_0000000439

Regions

Topological domain

29 – 276

248

Extracellular Probable

Transmembrane

277 – 298

Helical; Probable

Transmembrane

304 – 325

Helical; Probable

Transmembrane

338 – 359

Helical; Probable

Topological domain

360 – 458

Cytoplasmic Probable

Transmembrane

459 – 480

Helical; Probable

Amino acid modifications

Modified residue

434

Phosphoserine By similarity

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

163

N-linked (GlcNAc...) Potential

Glycosylation

176

N-linked (GlcNAc...) Potential

Glycosylation

228

N-linked (GlcNAc...) Potential

Disulfide bond

191 ↔ 205

By similarity

Experimental info

Sequence conflict

160

V → M in AAC42031. Ref.2

Sequence conflict

324

S → T in AAC42031. Ref.2

Sequence conflict

409

L → K in AAC42031. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P20236 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 7145AA1A00D67B53
Show »

FASTA

493

55,433

        10         20         30         40         50         60 
MITTQMWHFY VTRVGLLLLI SILPGTTGQG ESRRQEPGDF VKQDIGGLSP KHAPDIPDDS 

        70         80         90        100        110        120 
TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT SFGPVSDTDM EYTIDVFFRQ 

       130        140        150        160        170        180 
TWHDERLKFD GPMKILPLNN LLASKIWTPD TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL 

       190        200        210        220        230        240 
YTMRLTIHAE CPMHLEDFPM DVHACPLKFG SYAYTKAEVI YSWTLGKNKS VEVAQDGSRL 

       250        260        270        280        290        300 
NQYDLLGHVV GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN 

       310        320        330        340        350        360 
RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FMAVCYAFVF SALIEFATVN 

       370        380        390        400        410        420 
YFTKRSWAWE GKKVPEALEM KKKTPAAPTK KTSTTFNIVG TTYPINLALD TEFSTISKAA 

       430        440        450        460        470        480 
AAPSASSTPT VIASPKTTYV QDSPAETKTY NSVSKVDKIS RIIFPVLFAI FNLVYWATYV 

       490 
NRESAIKGMI RKQ

« Hide

References

[1]	"Functional expression and sites of gene transcription of a novel alpha subunit of the GABAA receptor in rat brain." Malherbe P., Sigel E., Baur R., Persohn E., Richards J.G., Moehler H. FEBS Lett. 260:261-265(1990) [PubMed: 2153588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The GABAA receptor family: molecular and functional diversity." Seeburg P.H., Wisden W., Verdoorn T., Pritchett D., Werner P., Herb A., Lueddens H., Sprengel R., Sakmann B. Cold Spring Harb. Symp. Quant. Biol. 55:29-40(1990) [PubMed: 1966765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08492 Genomic DNA. Translation: AAC42031.1. X51991 mRNA. Translation: CAA36247.1.
IPI	IPI00197343.
PIR	A34130.
RefSeq	NP_058765.2. NM_017069.2.
UniGene	Rn.10367.
3D structure databases
ProteinModelPortal	P20236.
ModBase	Search...
Protein-protein interaction databases
STRING	P20236.
Proteomic databases
PRIDE	P20236.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	24947.
KEGG	rno:24947.
Organism-specific databases
CTD	2556.
RGD	2648. Gabra3.
Phylogenomic databases
eggNOG	roNOG05645.
GeneTree	ENSGT00550000074441.
HOVERGEN	HBG051707.
InParanoid	P20236.
OrthoDB	EOG4X0MSC.
Gene expression databases
Genevestigator	P20236.
Family and domain databases
InterPro	IPR006028. GABAA_rcpt. IPR001390. GABAAa_rcpt. IPR005433. GABBAa3_rcpt. IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
Gene3D	G3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit.
KO	K05175.
PANTHER	PTHR18945. Neur_channel. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 2 hits. [Graphical view]
PRINTS	PR01079. GABAARALPHA. PR01616. GABAARALPHA3. PR00253. GABAARECEPTR. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	604953.

Entry information

Entry name

GBRA3_RAT

Accession

Primary (citable) accession number: P20236

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	January 25, 2012
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents