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P20236 (GBRA3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor subunit alpha-3
Alternative name(s):
GABA(A) receptor subunit alpha-3
Gene names
Name:Gabra3
Synonyms:Gabra-3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure

Binds UBQLN1 By similarity. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily. [View classification]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GphnQ03555-65EBI-5273284,EBI-5273276

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 493465Gamma-aminobutyric acid receptor subunit alpha-3
PRO_0000000439

Regions

Topological domain29 – 276248Extracellular Probable
Transmembrane277 – 29822Helical; Probable
Transmembrane304 – 32522Helical; Probable
Transmembrane338 – 35922Helical; Probable
Topological domain360 – 45899Cytoplasmic Probable
Transmembrane459 – 48022Helical; Probable

Amino acid modifications

Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation2281N-linked (GlcNAc...) Potential
Disulfide bond191 ↔ 205 By similarity

Experimental info

Sequence conflict1601V → M in AAC42031. Ref.2
Sequence conflict3241S → T in AAC42031. Ref.2
Sequence conflict4091L → K in AAC42031. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P20236 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 7145AA1A00D67B53

FASTA49355,433
        10         20         30         40         50         60 
MITTQMWHFY VTRVGLLLLI SILPGTTGQG ESRRQEPGDF VKQDIGGLSP KHAPDIPDDS 

        70         80         90        100        110        120 
TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT SFGPVSDTDM EYTIDVFFRQ 

       130        140        150        160        170        180 
TWHDERLKFD GPMKILPLNN LLASKIWTPD TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL 

       190        200        210        220        230        240 
YTMRLTIHAE CPMHLEDFPM DVHACPLKFG SYAYTKAEVI YSWTLGKNKS VEVAQDGSRL 

       250        260        270        280        290        300 
NQYDLLGHVV GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN 

       310        320        330        340        350        360 
RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FMAVCYAFVF SALIEFATVN 

       370        380        390        400        410        420 
YFTKRSWAWE GKKVPEALEM KKKTPAAPTK KTSTTFNIVG TTYPINLALD TEFSTISKAA 

       430        440        450        460        470        480 
AAPSASSTPT VIASPKTTYV QDSPAETKTY NSVSKVDKIS RIIFPVLFAI FNLVYWATYV 

       490 
NRESAIKGMI RKQ 

« Hide

References

[1]"Functional expression and sites of gene transcription of a novel alpha subunit of the GABAA receptor in rat brain."
Malherbe P., Sigel E., Baur R., Persohn E., Richards J.G., Moehler H.
FEBS Lett. 260:261-265(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"The GABAA receptor family: molecular and functional diversity."
Seeburg P.H., Wisden W., Verdoorn T., Pritchett D., Werner P., Herb A., Lueddens H., Sprengel R., Sakmann B.
Cold Spring Harb. Symp. Quant. Biol. 55:29-40(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08492 Genomic DNA. Translation: AAC42031.1.
X51991 mRNA. Translation: CAA36247.1.
PIRA34130.
UniGeneRn.10367.

3D structure databases

ProteinModelPortalP20236.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP20236. 1 interaction.
MINTMINT-8293904.
STRING10116.ENSRNOP00000050712.

Chemistry

BindingDBP20236.
ChEMBLCHEMBL2096683.
GuidetoPHARMACOLOGY406.

Proteomic databases

PRIDEP20236.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD2648. Gabra3.

Phylogenomic databases

eggNOGNOG238757.
HOGENOMHOG000231337.
HOVERGENHBG051707.
InParanoidP20236.
PhylomeDBP20236.

Gene expression databases

GenevestigatorP20236.

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005433. GABBAa3_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSPR01079. GABAARALPHA.
PR01616. GABAARALPHA3.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio604953.

Entry information

Entry nameGBRA3_RAT
AccessionPrimary (citable) accession number: P20236
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 11, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families