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P20236

- GBRA3_RAT

UniProt

P20236 - GBRA3_RAT

Protein

Gamma-aminobutyric acid receptor subunit alpha-3

Gene

Gabra3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. extracellular ligand-gated ion channel activity Source: InterPro
    3. GABA-A receptor activity Source: RGD
    4. protein binding Source: IntAct

    GO - Biological processi

    1. gamma-aminobutyric acid signaling pathway Source: InterPro
    2. synaptic transmission Source: RGD

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit alpha-3
    Alternative name(s):
    GABA(A) receptor subunit alpha-3
    Gene namesi
    Name:Gabra3
    Synonyms:Gabra-3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2648. Gabra3.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 493465Gamma-aminobutyric acid receptor subunit alpha-3PRO_0000000439Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi191 ↔ 205By similarity
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP20236.

    Expressioni

    Gene expression databases

    GenevestigatoriP20236.

    Interactioni

    Subunit structurei

    Binds UBQLN1 By similarity. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GphnQ03555-65EBI-5273284,EBI-5273276

    Protein-protein interaction databases

    IntActiP20236. 1 interaction.
    MINTiMINT-8293904.
    STRINGi10116.ENSRNOP00000050712.

    Structurei

    3D structure databases

    ProteinModelPortaliP20236.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 276248ExtracellularCuratedAdd
    BLAST
    Topological domaini360 – 45899CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei277 – 29822HelicalCuratedAdd
    BLAST
    Transmembranei304 – 32522HelicalCuratedAdd
    BLAST
    Transmembranei338 – 35922HelicalCuratedAdd
    BLAST
    Transmembranei459 – 48022HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238757.
    HOGENOMiHOG000231337.
    HOVERGENiHBG051707.
    InParanoidiP20236.
    PhylomeDBiP20236.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005433. GABBAa3_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view]
    PRINTSiPR01079. GABAARALPHA.
    PR01616. GABAARALPHA3.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20236-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITTQMWHFY VTRVGLLLLI SILPGTTGQG ESRRQEPGDF VKQDIGGLSP    50
    KHAPDIPDDS TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT 100
    SFGPVSDTDM EYTIDVFFRQ TWHDERLKFD GPMKILPLNN LLASKIWTPD 150
    TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL YTMRLTIHAE CPMHLEDFPM 200
    DVHACPLKFG SYAYTKAEVI YSWTLGKNKS VEVAQDGSRL NQYDLLGHVV 250
    GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN 300
    RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FMAVCYAFVF 350
    SALIEFATVN YFTKRSWAWE GKKVPEALEM KKKTPAAPTK KTSTTFNIVG 400
    TTYPINLALD TEFSTISKAA AAPSASSTPT VIASPKTTYV QDSPAETKTY 450
    NSVSKVDKIS RIIFPVLFAI FNLVYWATYV NRESAIKGMI RKQ 493
    Length:493
    Mass (Da):55,433
    Last modified:February 1, 1991 - v1
    Checksum:i7145AA1A00D67B53
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601V → M in AAC42031. (PubMed:1966765)Curated
    Sequence conflicti324 – 3241S → T in AAC42031. (PubMed:1966765)Curated
    Sequence conflicti409 – 4091L → K in AAC42031. (PubMed:1966765)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08492 Genomic DNA. Translation: AAC42031.1.
    X51991 mRNA. Translation: CAA36247.1.
    PIRiA34130.
    UniGeneiRn.10367.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08492 Genomic DNA. Translation: AAC42031.1 .
    X51991 mRNA. Translation: CAA36247.1 .
    PIRi A34130.
    UniGenei Rn.10367.

    3D structure databases

    ProteinModelPortali P20236.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P20236. 1 interaction.
    MINTi MINT-8293904.
    STRINGi 10116.ENSRNOP00000050712.

    Chemistry

    BindingDBi P20236.
    ChEMBLi CHEMBL2096683.
    GuidetoPHARMACOLOGYi 406.

    Proteomic databases

    PRIDEi P20236.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2648. Gabra3.

    Phylogenomic databases

    eggNOGi NOG238757.
    HOGENOMi HOG000231337.
    HOVERGENi HBG051707.
    InParanoidi P20236.
    PhylomeDBi P20236.

    Miscellaneous databases

    NextBioi 604953.

    Gene expression databases

    Genevestigatori P20236.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005433. GABBAa3_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view ]
    PRINTSi PR01079. GABAARALPHA.
    PR01616. GABAARALPHA3.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional expression and sites of gene transcription of a novel alpha subunit of the GABAA receptor in rat brain."
      Malherbe P., Sigel E., Baur R., Persohn E., Richards J.G., Moehler H.
      FEBS Lett. 260:261-265(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The GABAA receptor family: molecular and functional diversity."
      Seeburg P.H., Wisden W., Verdoorn T., Pritchett D., Werner P., Herb A., Lueddens H., Sprengel R., Sakmann B.
      Cold Spring Harb. Symp. Quant. Biol. 55:29-40(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Brain.

    Entry informationi

    Entry nameiGBRA3_RAT
    AccessioniPrimary (citable) accession number: P20236
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3