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Protein

TATA-box-binding protein

Gene

Tbp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.3 Publications

GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • core promoter binding Source: FlyBase
  • RNA polymerase III transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase III type 3 promoter sequence-specific DNA binding Source: FlyBase
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: FlyBase
  • RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly Source: FlyBase
  • TFIIA-class transcription factor binding Source: FlyBase
  • transcription factor activity, RNA polymerase III transcription factor binding Source: FlyBase
  • transcription factor binding Source: FlyBase
  • transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  • DNA-templated transcription, initiation Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • positive regulation of transcription initiation from RNA polymerase II promoter Source: BHF-UCL
  • regulation of transcription by RNA polymerase II Source: FlyBase
  • regulation of transcription by RNA polymerase III Source: FlyBase
  • RNA polymerase II transcriptional preinitiation complex assembly Source: BHF-UCL
  • snRNA transcription by RNA polymerase II Source: FlyBase
  • snRNA transcription by RNA polymerase III Source: FlyBase
  • transcription by RNA polymerase II Source: FlyBase
  • transcription by RNA polymerase III Source: FlyBase
  • transcription initiation from RNA polymerase II promoter Source: FlyBase
  • tRNA transcription by RNA polymerase III Source: FlyBase

Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-6807505 RNA polymerase II transcribes snRNA genes
R-DME-73772 RNA Polymerase I Promoter Escape
R-DME-73776 RNA Polymerase II Promoter Escape
R-DME-73777 RNA Polymerase I Chain Elongation
R-DME-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953 RNA Polymerase II Transcription Initiation
R-DME-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-DME-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene namesi
Name:Tbp
Synonyms:BTF1, TFIID
ORF Names:CG9874
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003687 Tbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539641 – 353TATA-box-binding proteinAdd BLAST353

Proteomic databases

PaxDbiP20227
PRIDEiP20227

Expressioni

Gene expression databases

BgeeiFBgn0003687
GenevisibleiP20227 DM

Interactioni

Subunit structurei

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Binds DNA as monomer. Interacts with TFIIA-L heterotrimer. Interacts with Taf1, Taf2, Taf5 and Taf12.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • TFIIA-class transcription factor binding Source: FlyBase
  • transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi63101, 29 interactors
DIPiDIP-80N
IntActiP20227, 13 interactors
STRINGi7227.FBpp0071596

Structurei

3D structure databases

ProteinModelPortaliP20227
SMRiP20227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati179 – 2551Add BLAST77
Repeati269 – 3462Add BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 61Poly-Gln8
Compositional biasi94 – 103Poly-Gln10

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3302 Eukaryota
COG2101 LUCA
GeneTreeiENSGT00410000025389
InParanoidiP20227
KOiK03120
OMAiMDQMLPS
OrthoDBiEOG091G0ENY
PhylomeDBiP20227

Family and domain databases

CDDicd04516 TBP_eukaryotes, 1 hit
Gene3Di3.30.310.10, 2 hits
HAMAPiMF_00408 TATA_bind_prot_arch, 1 hit
InterProiView protein in InterPro
IPR000814 TBP
IPR030491 TBP_CS
IPR012295 TBP_dom_sf
IPR033710 TBP_eukaryotic
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID
PROSITEiView protein in PROSITE
PS00351 TFIID, 2 hits

Sequencei

Sequence statusi: Complete.

P20227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQMLSPNFS IPSIGTPLHQ MEADQQIVAN PVYHPPAVSQ PDSLMPAPGS
60 70 80 90 100
SSVQHQQQQQ QSDASGGSGL FGHEPSLPLA HKQMQSYQPS ASYQQQQQQQ
110 120 130 140 150
QLQSQAPGGG GSTPQSMMQP QTPQSMMAHM MPMSERSVGG SGAGGGGDAL
160 170 180 190 200
SNIHQTMGPS TPMTPATPGS ADPGIVPQLQ NIVSTVNLCC KLDLKKIALH
210 220 230 240 250
ARNAEYNPKR FAAVIMRIRE PRTTALIFSS GKMVCTGAKS EDDSRLAARK
260 270 280 290 300
YARIIQKLGF PAKFLDFKIQ NMVGSCDVKF PIRLEGLVLT HCNFSSYEPE
310 320 330 340 350
LFPGLIYRMV RPRIVLLIFV SGKVVLTGAK VRQEIYDAFD KIFPILKKFK

KQS
Length:353
Mass (Da):38,451
Last modified:February 1, 1991 - v1
Checksum:i7B079BC01BAF69BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101Q → QQ (Ref. 4) Curated1
Sequence conflicti146G → A in AAA79092 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38388 mRNA Translation: AAA28926.1
M38082 mRNA Translation: AAA28931.1
U11718 Genomic DNA Translation: AAA68629.1
U35147 Genomic DNA Translation: AAA79092.1
AE013599 Genomic DNA Translation: AAF46754.1
AY069663 mRNA Translation: AAL39808.1
PIRiA35615
RefSeqiNP_523805.1, NM_079081.4
UniGeneiDm.4490

Genome annotation databases

EnsemblMetazoaiFBtr0071679; FBpp0071596; FBgn0003687
GeneIDi37476
KEGGidme:Dmel_CG9874

Similar proteinsi

Entry informationi

Entry nameiTBP_DROME
AccessioniPrimary (citable) accession number: P20227
Secondary accession number(s): Q9W2D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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