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Protein

Integrase

Gene

d335

Organism
Sulfolobus spindle-shape virus 1 (SSV1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein may encode a site-specific integrase, which is necessary for integration of the phage by site-specific recombination into a tRNA gene of the host chromosome. Essential for virus infection.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei314O-(3'-phospho-DNA)-tyrosine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Integrase (EC:2.7.7.-1 Publication, EC:3.1.-.-1 Publication)
Gene namesi
ORF Names:d335
OrganismiSulfolobus spindle-shape virus 1 (SSV1)
Taxonomic identifieri244589 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageFuselloviridaeAlphafusellovirus
Virus hostiSulfolobus solfataricus [TaxID: 2287]
Proteomesi
  • UP000000854 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975091 – 335IntegraseAdd BLAST335

Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi181 – 192Combined sources12
Helixi196 – 208Combined sources13
Helixi212 – 220Combined sources9
Helixi222 – 224Combined sources3
Beta strandi226 – 228Combined sources3
Beta strandi231 – 237Combined sources7
Beta strandi240 – 242Combined sources3
Beta strandi245 – 252Combined sources8
Helixi261 – 269Combined sources9
Helixi278 – 290Combined sources13
Helixi295 – 301Combined sources7
Beta strandi307 – 310Combined sources4
Helixi317 – 334Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UXUX-ray2.71A173-335[»]
3VCFX-ray2.70A/B174-335[»]
4DKSX-ray2.70A174-335[»]
ProteinModelPortaliP20214.
SMRiP20214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Family and domain databases

Gene3Di1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR031857. Integrase_SSV1_C.
IPR012922. ORF_D-335.
[Graphical view]
PfamiPF16795. Phage_integr_3. 1 hit.
PF07935. SSV1_ORF_D-335. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.

Sequencei

Sequence statusi: Complete.

P20214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDKTRYKY GDYILRERKG RYYVYKLEYE NGEVKERYVG PLADVVESYL
60 70 80 90 100
KMKLGVVGDT PLQADPPGFE PGTSGSGGGK EGTERRKIAL VANLRQYATD
110 120 130 140 150
GNIKAFYDYL MNERGISEKT AKDYINAISK PYKETRDAQK AYRLFARFLA
160 170 180 190 200
SRNIIHDEFA DKILKAVKVK KANADIYIPT LEEIKRTLQL AKDYSENVYF
210 220 230 240 250
IYRIALESGV RLSEILKVLK EPERDICGND VCYYPLSWTR GYKGVFYVFH
260 270 280 290 300
ITPLKRVEVT KWAIADFERR HKDAIAIKYF RKFVASKMAE LSVPLDIIDF
310 320 330
IQGRKPTRVL TQHYVSLFGI AKEQYKKYAE WLKGV
Length:335
Mass (Da):38,860
Last modified:February 1, 1991 - v1
Checksum:i5C7217C516A5112D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07234 Genomic DNA. Translation: CAA30211.1.
PIRiS03212.
RefSeqiNP_039778.1. NC_001338.1.

Genome annotation databases

GeneIDi2559644.
KEGGivg:2559644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07234 Genomic DNA. Translation: CAA30211.1.
PIRiS03212.
RefSeqiNP_039778.1. NC_001338.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UXUX-ray2.71A173-335[»]
3VCFX-ray2.70A/B174-335[»]
4DKSX-ray2.70A174-335[»]
ProteinModelPortaliP20214.
SMRiP20214.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2559644.
KEGGivg:2559644.

Family and domain databases

Gene3Di1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR031857. Integrase_SSV1_C.
IPR012922. ORF_D-335.
[Graphical view]
PfamiPF16795. Phage_integr_3. 1 hit.
PF07935. SSV1_ORF_D-335. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVINT_SSV1
AccessioniPrimary (citable) accession number: P20214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.