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P20193

- SUV37_DROME

UniProt

P20193 - SUV37_DROME

Protein

Protein suppressor of variegation 3-7

Gene

Su(var)3-7

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 4 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Dose-limiting factor in position-effect variegation, the inactivation in some cells of a gene translocated next to heterochromatin. It could play a role in chromosome condensation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri217 – 23620C2H2-type 1Add
    BLAST
    Zinc fingeri319 – 34325C2H2-type 2Add
    BLAST
    Zinc fingeri425 – 44622C2H2-type 3Add
    BLAST
    Zinc fingeri487 – 51226C2H2-type 4Add
    BLAST
    Zinc fingeri605 – 62925C2H2-type 5Add
    BLAST
    Zinc fingeri737 – 76125C2H2-type 6Add
    BLAST
    Zinc fingeri829 – 85224C2H2-type 7Add
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: FlyBase
    2. DNA binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: FlyBase

    GO - Biological processi

    1. dosage compensation by inactivation of X chromosome Source: FlyBase
    2. positive regulation of chromatin silencing at centromere Source: FlyBase

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein suppressor of variegation 3-7
    Gene namesi
    Name:Su(var)3-7
    Synonyms:Suvar(3)7
    ORF Names:CG8599
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0003598. Su(var)3-7.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. chromosome, centromeric region Source: FlyBase
    2. heterochromatin Source: FlyBase
    3. nucleus Source: FlyBase
    4. pericentric heterochromatin Source: FlyBase
    5. polytene chromosome chromocenter Source: FlyBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12501250Protein suppressor of variegation 3-7PRO_0000047060Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei165 – 1651Phosphoserine1 Publication
    Modified residuei175 – 1751Phosphoserine1 Publication
    Modified residuei176 – 1761Phosphoserine1 Publication
    Modified residuei871 – 8711Phosphoserine1 Publication
    Modified residuei873 – 8731Phosphoserine1 Publication
    Modified residuei975 – 9751Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP20193.
    PRIDEiP20193.

    Expressioni

    Gene expression databases

    BgeeiP20193.

    Interactioni

    Subunit structurei

    Interacts with Su(var)39 through the BESS domain.1 Publication

    Protein-protein interaction databases

    BioGridi66711. 9 interactions.
    IntActiP20193. 2 interactions.
    MINTiMINT-1023300.
    STRINGi7227.FBpp0082204.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini987 – 102640BESSPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi65 – 706Poly-Asp
    Compositional biasi167 – 1737Poly-Asp
    Compositional biasi670 – 6734Poly-Glu
    Compositional biasi861 – 8699Poly-Ala
    Compositional biasi1089 – 10924Poly-Asn
    Compositional biasi1194 – 11974Poly-Asn

    Sequence similaritiesi

    Contains 1 BESS domain.PROSITE-ProRule annotation
    Contains 7 C2H2-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri217 – 23620C2H2-type 1Add
    BLAST
    Zinc fingeri319 – 34325C2H2-type 2Add
    BLAST
    Zinc fingeri425 – 44622C2H2-type 3Add
    BLAST
    Zinc fingeri487 – 51226C2H2-type 4Add
    BLAST
    Zinc fingeri605 – 62925C2H2-type 5Add
    BLAST
    Zinc fingeri737 – 76125C2H2-type 6Add
    BLAST
    Zinc fingeri829 – 85224C2H2-type 7Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG288977.
    InParanoidiP20193.
    OMAiDMICSSF.
    OrthoDBiEOG7GQXTW.
    PhylomeDBiP20193.

    Family and domain databases

    InterProiIPR004210. BESS_motif.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF02944. BESS. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 2 hits.
    [Graphical view]
    PROSITEiPS51031. BESS. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20193-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRDSSMQAK NLDAQCNPDL KMASANSETL ASATHELKIM DVEGGALVDP     50
    DHIEEVETSM VIVVDDDDGD VAMVVEEDKH PMRDDPCIED IMDDEHAPLV 100
    AELQSALNNP DDKQASEDPL LEDQEREPDA MSTKTEPSSD AESSHSYHDP 150
    MGLLERIEIH DPGDSQDDDD EDDESSNGGG VDGGMRRKMP RAQRWLLWMK 200
    RWPWILHEDS DGTLAFCLYC NISINVNNRS RHIQQHNVSL SHQERECNYL 250
    AFKKSEEETR GAISDNEIKH EFGTKSYVAA MKQKRISETE AFNNFNWLRW 300
    LRWHPWLERS MPTGTIGTCR ICSVRMNVEF VYLRKRHETT KGHMEALRNL 350
    DSDKRSRKRK RSKSNSVTNS GGDEAEREKE SEPEVGPEDA QDTPVVMMNG 400
    DVDSGDDPGK WCALIPDTNP QQCRCTLCNC TMAITSFLRH CKTRAHCHML 450
    STPAEKGSSD IRGIWAVFAD MHPWLIADPE DPSIGYCSVC RKRFMYGNSE 500
    IKRKNHEKSE KHTLALASAK AGIEVGSADG RGGDNMDEEE AAASDQAQSS 550
    QTDDSEDNDD DNWSEIQKLG KGFAHKSSSE PRKATVRAGV RFYPWLCYSK 600
    DRKTQICKFC RVRFHNEAAK ARHELSARHV KLVKQFKMRQ AKLHQGTNTQ 650
    TKHNAQDDEE SQEQDEEYGE EEEDAEEDSQ SNFDLGTVQA RKTARADNKL 700
    FVKPIPATMK GKVMVWKGRF PWLSYKKNEQ RGNYAWCKLC EVSLYLPSSK 750
    WASKHQRTSR HIRLRIDRKR NGGNPLKTSN KNSGEISTVV ATASALASAE 800
    ARQKAAMAEL QAKYDWLDPD ANDENHCHCR VCDSRLPIKV FYLRQHDASR 850
    KHVENKERQR ANAAAAANAP SVSPTSTVDA ERQESGMDKE SENDMSVRSD 900
    GSTAEPLAKR SRRSMEVRRI IRALRDSMGK RQEERSQMDM ARDMICSSFD 950
    IVTRLRTLER ESVAHNESMA QAPPSVTVSP IKPPEPRHVM DLFFDSISPT 1000
    MKSLPPDLAA EGKSKIMQLV CSLELRAMQR NATTPTPATV SASSKWPSST 1050
    TVTPVKTPPA PISAPLASVD ADLHSSVVTT PHEYNNGQNN NNDKETVPKE 1100
    PVTGASSAQV TINGSAKDLP ENIRRILTSN QTQVTNRLET DSVRCVPLDK 1150
    LTTQSRTNVN GRLSQGGTSE APSTPQADLS NGNTLAMIRQ IRVNNNNSSK 1200
    ITVTNTPQMQ QPQQAQASIT SSTPIMRGGP SSNGCQITTF RTMVNHNRRP 1250
    Length:1,250
    Mass (Da):139,990
    Last modified:July 19, 2004 - v4
    Checksum:i90D0338C894D074C
    GO

    Sequence cautioni

    The sequence CAA36434.1 differs from that shown. Reason: Frameshift at positions 4 and 81.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 542IE → MQ in CAA36434. (PubMed:7708496)Curated
    Sequence conflicti265 – 2651D → S in CAA36434. (PubMed:7708496)Curated
    Sequence conflicti385 – 3851V → A in CAA36434. (PubMed:7708496)Curated
    Sequence conflicti943 – 9431D → N in CAA36434. (PubMed:7708496)Curated
    Sequence conflicti1148 – 11481L → V in CAA36434. (PubMed:7708496)Curated
    Sequence conflicti1159 – 11591V → A in CAA36434. (PubMed:7708496)Curated
    Sequence conflicti1193 – 11931V → A in CAA36434. (PubMed:7708496)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52187 mRNA. Translation: CAA36434.1. Frameshift.
    AE014297 Genomic DNA. Translation: AAF54918.2.
    PIRiS09151.
    RefSeqiNP_524342.3. NM_079618.4.
    UniGeneiDm.6402.

    Genome annotation databases

    EnsemblMetazoaiFBtr0082736; FBpp0082204; FBgn0003598.
    GeneIDi41627.
    KEGGidme:Dmel_CG8599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52187 mRNA. Translation: CAA36434.1 . Frameshift.
    AE014297 Genomic DNA. Translation: AAF54918.2 .
    PIRi S09151.
    RefSeqi NP_524342.3. NM_079618.4.
    UniGenei Dm.6402.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 66711. 9 interactions.
    IntActi P20193. 2 interactions.
    MINTi MINT-1023300.
    STRINGi 7227.FBpp0082204.

    Proteomic databases

    PaxDbi P20193.
    PRIDEi P20193.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0082736 ; FBpp0082204 ; FBgn0003598 .
    GeneIDi 41627.
    KEGGi dme:Dmel_CG8599.

    Organism-specific databases

    CTDi 41627.
    FlyBasei FBgn0003598. Su(var)3-7.

    Phylogenomic databases

    eggNOGi NOG288977.
    InParanoidi P20193.
    OMAi DMICSSF.
    OrthoDBi EOG7GQXTW.
    PhylomeDBi P20193.

    Miscellaneous databases

    ChiTaRSi Su(var)3-7. drosophila.
    GenomeRNAii 41627.
    NextBioi 824709.

    Gene expression databases

    Bgeei P20193.

    Family and domain databases

    InterProi IPR004210. BESS_motif.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF02944. BESS. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 2 hits.
    [Graphical view ]
    PROSITEi PS51031. BESS. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The modifier of position-effect variegation Suvar(3)7 of Drosophila: there are two alternative transcripts and seven scattered zinc fingers, each preceded by a tryptophan box."
      Cleard F., Matsarskaia M., Spierer P.
      Nucleic Acids Res. 23:796-802(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Erratum
      Cleard F., Matsarskaia M., Spierer P.
      Nucleic Acids Res. 23:3804-3804(1995)
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    5. "Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein."
      Reuter G., Giarre M., Farah J., Gausz J., Spierer A., Spierer P.
      Nature 344:219-223(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 336-1250.
    6. "Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing."
      Schotta G., Ebert A., Krauss V., Fischer A., Hoffmann J., Rea S., Jenuwein T., Dorn R., Reuter G.
      EMBO J. 21:1121-1131(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SU(VAR)39.
    7. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-175; SER-176; SER-871; SER-873 AND SER-975, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiSUV37_DROME
    AccessioniPrimary (citable) accession number: P20193
    Secondary accession number(s): Q9VFX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 119 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3