SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P20193

- SUV37_DROME

UniProt

P20193 - SUV37_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein suppressor of variegation 3-7

Gene
Su(var)3-7, Suvar(3)7, CG8599
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Dose-limiting factor in position-effect variegation, the inactivation in some cells of a gene translocated next to heterochromatin. It could play a role in chromosome condensation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri217 – 23620C2H2-type 1Add
BLAST
Zinc fingeri319 – 34325C2H2-type 2Add
BLAST
Zinc fingeri425 – 44622C2H2-type 3Add
BLAST
Zinc fingeri487 – 51226C2H2-type 4Add
BLAST
Zinc fingeri605 – 62925C2H2-type 5Add
BLAST
Zinc fingeri737 – 76125C2H2-type 6Add
BLAST
Zinc fingeri829 – 85224C2H2-type 7Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: FlyBase
  2. DNA binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: FlyBase

GO - Biological processi

  1. dosage compensation by inactivation of X chromosome Source: FlyBase
  2. positive regulation of chromatin silencing at centromere Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein suppressor of variegation 3-7
Gene namesi
Name:Su(var)3-7
Synonyms:Suvar(3)7
ORF Names:CG8599
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003598. Su(var)3-7.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. centromeric heterochromatin Source: FlyBase
  2. chromosome, centromeric region Source: FlyBase
  3. heterochromatin Source: FlyBase
  4. nucleus Source: FlyBase
  5. polytene chromosome chromocenter Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12501250Protein suppressor of variegation 3-7PRO_0000047060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651Phosphoserine1 Publication
Modified residuei175 – 1751Phosphoserine1 Publication
Modified residuei176 – 1761Phosphoserine1 Publication
Modified residuei871 – 8711Phosphoserine1 Publication
Modified residuei873 – 8731Phosphoserine1 Publication
Modified residuei975 – 9751Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP20193.
PRIDEiP20193.

Expressioni

Gene expression databases

BgeeiP20193.

Interactioni

Subunit structurei

Interacts with Su(var)39 through the BESS domain.1 Publication

Protein-protein interaction databases

BioGridi66711. 9 interactions.
IntActiP20193. 2 interactions.
MINTiMINT-1023300.
STRINGi7227.FBpp0082204.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini987 – 102640BESSAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi65 – 706Poly-Asp
Compositional biasi167 – 1737Poly-Asp
Compositional biasi670 – 6734Poly-Glu
Compositional biasi861 – 8699Poly-Ala
Compositional biasi1089 – 10924Poly-Asn
Compositional biasi1194 – 11974Poly-Asn

Sequence similaritiesi

Contains 1 BESS domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri217 – 23620C2H2-type 1Add
BLAST
Zinc fingeri319 – 34325C2H2-type 2Add
BLAST
Zinc fingeri425 – 44622C2H2-type 3Add
BLAST
Zinc fingeri487 – 51226C2H2-type 4Add
BLAST
Zinc fingeri605 – 62925C2H2-type 5Add
BLAST
Zinc fingeri737 – 76125C2H2-type 6Add
BLAST
Zinc fingeri829 – 85224C2H2-type 7Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG288977.
InParanoidiP20193.
OMAiDMICSSF.
OrthoDBiEOG7GQXTW.
PhylomeDBiP20193.

Family and domain databases

InterProiIPR004210. BESS_motif.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF02944. BESS. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS51031. BESS. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20193-1 [UniParc]FASTAAdd to Basket

« Hide

MDRDSSMQAK NLDAQCNPDL KMASANSETL ASATHELKIM DVEGGALVDP     50
DHIEEVETSM VIVVDDDDGD VAMVVEEDKH PMRDDPCIED IMDDEHAPLV 100
AELQSALNNP DDKQASEDPL LEDQEREPDA MSTKTEPSSD AESSHSYHDP 150
MGLLERIEIH DPGDSQDDDD EDDESSNGGG VDGGMRRKMP RAQRWLLWMK 200
RWPWILHEDS DGTLAFCLYC NISINVNNRS RHIQQHNVSL SHQERECNYL 250
AFKKSEEETR GAISDNEIKH EFGTKSYVAA MKQKRISETE AFNNFNWLRW 300
LRWHPWLERS MPTGTIGTCR ICSVRMNVEF VYLRKRHETT KGHMEALRNL 350
DSDKRSRKRK RSKSNSVTNS GGDEAEREKE SEPEVGPEDA QDTPVVMMNG 400
DVDSGDDPGK WCALIPDTNP QQCRCTLCNC TMAITSFLRH CKTRAHCHML 450
STPAEKGSSD IRGIWAVFAD MHPWLIADPE DPSIGYCSVC RKRFMYGNSE 500
IKRKNHEKSE KHTLALASAK AGIEVGSADG RGGDNMDEEE AAASDQAQSS 550
QTDDSEDNDD DNWSEIQKLG KGFAHKSSSE PRKATVRAGV RFYPWLCYSK 600
DRKTQICKFC RVRFHNEAAK ARHELSARHV KLVKQFKMRQ AKLHQGTNTQ 650
TKHNAQDDEE SQEQDEEYGE EEEDAEEDSQ SNFDLGTVQA RKTARADNKL 700
FVKPIPATMK GKVMVWKGRF PWLSYKKNEQ RGNYAWCKLC EVSLYLPSSK 750
WASKHQRTSR HIRLRIDRKR NGGNPLKTSN KNSGEISTVV ATASALASAE 800
ARQKAAMAEL QAKYDWLDPD ANDENHCHCR VCDSRLPIKV FYLRQHDASR 850
KHVENKERQR ANAAAAANAP SVSPTSTVDA ERQESGMDKE SENDMSVRSD 900
GSTAEPLAKR SRRSMEVRRI IRALRDSMGK RQEERSQMDM ARDMICSSFD 950
IVTRLRTLER ESVAHNESMA QAPPSVTVSP IKPPEPRHVM DLFFDSISPT 1000
MKSLPPDLAA EGKSKIMQLV CSLELRAMQR NATTPTPATV SASSKWPSST 1050
TVTPVKTPPA PISAPLASVD ADLHSSVVTT PHEYNNGQNN NNDKETVPKE 1100
PVTGASSAQV TINGSAKDLP ENIRRILTSN QTQVTNRLET DSVRCVPLDK 1150
LTTQSRTNVN GRLSQGGTSE APSTPQADLS NGNTLAMIRQ IRVNNNNSSK 1200
ITVTNTPQMQ QPQQAQASIT SSTPIMRGGP SSNGCQITTF RTMVNHNRRP 1250
Length:1,250
Mass (Da):139,990
Last modified:July 19, 2004 - v4
Checksum:i90D0338C894D074C
GO

Sequence cautioni

The sequence CAA36434.1 differs from that shown. Reason: Frameshift at positions 4 and 81.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 542IE → MQ in CAA36434. 1 Publication
Sequence conflicti265 – 2651D → S in CAA36434. 1 Publication
Sequence conflicti385 – 3851V → A in CAA36434. 1 Publication
Sequence conflicti943 – 9431D → N in CAA36434. 1 Publication
Sequence conflicti1148 – 11481L → V in CAA36434. 1 Publication
Sequence conflicti1159 – 11591V → A in CAA36434. 1 Publication
Sequence conflicti1193 – 11931V → A in CAA36434. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52187 mRNA. Translation: CAA36434.1. Frameshift.
AE014297 Genomic DNA. Translation: AAF54918.2.
PIRiS09151.
RefSeqiNP_524342.3. NM_079618.4.
UniGeneiDm.6402.

Genome annotation databases

EnsemblMetazoaiFBtr0082736; FBpp0082204; FBgn0003598.
GeneIDi41627.
KEGGidme:Dmel_CG8599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52187 mRNA. Translation: CAA36434.1 . Frameshift.
AE014297 Genomic DNA. Translation: AAF54918.2 .
PIRi S09151.
RefSeqi NP_524342.3. NM_079618.4.
UniGenei Dm.6402.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 66711. 9 interactions.
IntActi P20193. 2 interactions.
MINTi MINT-1023300.
STRINGi 7227.FBpp0082204.

Proteomic databases

PaxDbi P20193.
PRIDEi P20193.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0082736 ; FBpp0082204 ; FBgn0003598 .
GeneIDi 41627.
KEGGi dme:Dmel_CG8599.

Organism-specific databases

CTDi 41627.
FlyBasei FBgn0003598. Su(var)3-7.

Phylogenomic databases

eggNOGi NOG288977.
InParanoidi P20193.
OMAi DMICSSF.
OrthoDBi EOG7GQXTW.
PhylomeDBi P20193.

Miscellaneous databases

ChiTaRSi Su(var)3-7. drosophila.
GenomeRNAii 41627.
NextBioi 824709.

Gene expression databases

Bgeei P20193.

Family and domain databases

InterProi IPR004210. BESS_motif.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF02944. BESS. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 2 hits.
[Graphical view ]
PROSITEi PS51031. BESS. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The modifier of position-effect variegation Suvar(3)7 of Drosophila: there are two alternative transcripts and seven scattered zinc fingers, each preceded by a tryptophan box."
    Cleard F., Matsarskaia M., Spierer P.
    Nucleic Acids Res. 23:796-802(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Erratum
    Cleard F., Matsarskaia M., Spierer P.
    Nucleic Acids Res. 23:3804-3804(1995)
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. "Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein."
    Reuter G., Giarre M., Farah J., Gausz J., Spierer A., Spierer P.
    Nature 344:219-223(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 336-1250.
  6. "Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing."
    Schotta G., Ebert A., Krauss V., Fischer A., Hoffmann J., Rea S., Jenuwein T., Dorn R., Reuter G.
    EMBO J. 21:1121-1131(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SU(VAR)39.
  7. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-175; SER-176; SER-871; SER-873 AND SER-975, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiSUV37_DROME
AccessioniPrimary (citable) accession number: P20193
Secondary accession number(s): Q9VFX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi