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P20193 (SUV37_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein suppressor of variegation 3-7
Gene names
Name:Su(var)3-7
Synonyms:Suvar(3)7
ORF Names:CG8599
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1250 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Dose-limiting factor in position-effect variegation, the inactivation in some cells of a gene translocated next to heterochromatin. It could play a role in chromosome condensation.

Subunit structure

Interacts with Su(var)39 through the BESS domain. Ref.6

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 BESS domain.

Contains 7 C2H2-type zinc fingers.

Sequence caution

The sequence CAA36434.1 differs from that shown. Reason: Frameshift at positions 4 and 81.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12501250Protein suppressor of variegation 3-7
PRO_0000047060

Regions

Domain987 – 102640BESS
Zinc finger217 – 23620C2H2-type 1
Zinc finger319 – 34325C2H2-type 2
Zinc finger425 – 44622C2H2-type 3
Zinc finger487 – 51226C2H2-type 4
Zinc finger605 – 62925C2H2-type 5
Zinc finger737 – 76125C2H2-type 6
Zinc finger829 – 85224C2H2-type 7
Compositional bias65 – 706Poly-Asp
Compositional bias167 – 1737Poly-Asp
Compositional bias670 – 6734Poly-Glu
Compositional bias861 – 8699Poly-Ala
Compositional bias1089 – 10924Poly-Asn
Compositional bias1194 – 11974Poly-Asn

Amino acid modifications

Modified residue1651Phosphoserine Ref.7
Modified residue1751Phosphoserine Ref.7
Modified residue1761Phosphoserine Ref.7
Modified residue8711Phosphoserine Ref.7
Modified residue8731Phosphoserine Ref.7
Modified residue9751Phosphoserine Ref.7

Experimental info

Sequence conflict53 – 542IE → MQ in CAA36434. Ref.1
Sequence conflict2651D → S in CAA36434. Ref.1
Sequence conflict3851V → A in CAA36434. Ref.1
Sequence conflict9431D → N in CAA36434. Ref.1
Sequence conflict11481L → V in CAA36434. Ref.1
Sequence conflict11591V → A in CAA36434. Ref.1
Sequence conflict11931V → A in CAA36434. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P20193 [UniParc].

Last modified July 19, 2004. Version 4.
Checksum: 90D0338C894D074C

FASTA1,250139,990
        10         20         30         40         50         60 
MDRDSSMQAK NLDAQCNPDL KMASANSETL ASATHELKIM DVEGGALVDP DHIEEVETSM 

        70         80         90        100        110        120 
VIVVDDDDGD VAMVVEEDKH PMRDDPCIED IMDDEHAPLV AELQSALNNP DDKQASEDPL 

       130        140        150        160        170        180 
LEDQEREPDA MSTKTEPSSD AESSHSYHDP MGLLERIEIH DPGDSQDDDD EDDESSNGGG 

       190        200        210        220        230        240 
VDGGMRRKMP RAQRWLLWMK RWPWILHEDS DGTLAFCLYC NISINVNNRS RHIQQHNVSL 

       250        260        270        280        290        300 
SHQERECNYL AFKKSEEETR GAISDNEIKH EFGTKSYVAA MKQKRISETE AFNNFNWLRW 

       310        320        330        340        350        360 
LRWHPWLERS MPTGTIGTCR ICSVRMNVEF VYLRKRHETT KGHMEALRNL DSDKRSRKRK 

       370        380        390        400        410        420 
RSKSNSVTNS GGDEAEREKE SEPEVGPEDA QDTPVVMMNG DVDSGDDPGK WCALIPDTNP 

       430        440        450        460        470        480 
QQCRCTLCNC TMAITSFLRH CKTRAHCHML STPAEKGSSD IRGIWAVFAD MHPWLIADPE 

       490        500        510        520        530        540 
DPSIGYCSVC RKRFMYGNSE IKRKNHEKSE KHTLALASAK AGIEVGSADG RGGDNMDEEE 

       550        560        570        580        590        600 
AAASDQAQSS QTDDSEDNDD DNWSEIQKLG KGFAHKSSSE PRKATVRAGV RFYPWLCYSK 

       610        620        630        640        650        660 
DRKTQICKFC RVRFHNEAAK ARHELSARHV KLVKQFKMRQ AKLHQGTNTQ TKHNAQDDEE 

       670        680        690        700        710        720 
SQEQDEEYGE EEEDAEEDSQ SNFDLGTVQA RKTARADNKL FVKPIPATMK GKVMVWKGRF 

       730        740        750        760        770        780 
PWLSYKKNEQ RGNYAWCKLC EVSLYLPSSK WASKHQRTSR HIRLRIDRKR NGGNPLKTSN 

       790        800        810        820        830        840 
KNSGEISTVV ATASALASAE ARQKAAMAEL QAKYDWLDPD ANDENHCHCR VCDSRLPIKV 

       850        860        870        880        890        900 
FYLRQHDASR KHVENKERQR ANAAAAANAP SVSPTSTVDA ERQESGMDKE SENDMSVRSD 

       910        920        930        940        950        960 
GSTAEPLAKR SRRSMEVRRI IRALRDSMGK RQEERSQMDM ARDMICSSFD IVTRLRTLER 

       970        980        990       1000       1010       1020 
ESVAHNESMA QAPPSVTVSP IKPPEPRHVM DLFFDSISPT MKSLPPDLAA EGKSKIMQLV 

      1030       1040       1050       1060       1070       1080 
CSLELRAMQR NATTPTPATV SASSKWPSST TVTPVKTPPA PISAPLASVD ADLHSSVVTT 

      1090       1100       1110       1120       1130       1140 
PHEYNNGQNN NNDKETVPKE PVTGASSAQV TINGSAKDLP ENIRRILTSN QTQVTNRLET 

      1150       1160       1170       1180       1190       1200 
DSVRCVPLDK LTTQSRTNVN GRLSQGGTSE APSTPQADLS NGNTLAMIRQ IRVNNNNSSK 

      1210       1220       1230       1240       1250 
ITVTNTPQMQ QPQQAQASIT SSTPIMRGGP SSNGCQITTF RTMVNHNRRP 

« Hide

References

« Hide 'large scale' references
[1]"The modifier of position-effect variegation Suvar(3)7 of Drosophila: there are two alternative transcripts and seven scattered zinc fingers, each preceded by a tryptophan box."
Cleard F., Matsarskaia M., Spierer P.
Nucleic Acids Res. 23:796-802(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Erratum
Cleard F., Matsarskaia M., Spierer P.
Nucleic Acids Res. 23:3804-3804(1995)
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[5]"Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein."
Reuter G., Giarre M., Farah J., Gausz J., Spierer A., Spierer P.
Nature 344:219-223(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 336-1250.
[6]"Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing."
Schotta G., Ebert A., Krauss V., Fischer A., Hoffmann J., Rea S., Jenuwein T., Dorn R., Reuter G.
EMBO J. 21:1121-1131(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SU(VAR)39.
[7]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-175; SER-176; SER-871; SER-873 AND SER-975, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52187 mRNA. Translation: CAA36434.1. Frameshift.
AE014297 Genomic DNA. Translation: AAF54918.2.
PIRS09151.
RefSeqNP_524342.3. NM_079618.4.
UniGeneDm.6402.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid66711. 9 interactions.
IntActP20193. 2 interactions.
MINTMINT-1023300.
STRING7227.FBpp0082204.

Proteomic databases

PaxDbP20193.
PRIDEP20193.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0082736; FBpp0082204; FBgn0003598.
GeneID41627.
KEGGdme:Dmel_CG8599.

Organism-specific databases

CTD41627.
FlyBaseFBgn0003598. Su(var)3-7.

Phylogenomic databases

eggNOGNOG288977.
InParanoidP20193.
OMADMICSSF.
OrthoDBEOG7GQXTW.
PhylomeDBP20193.

Gene expression databases

BgeeP20193.

Family and domain databases

InterProIPR004210. BESS_motif.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamPF02944. BESS. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEPS51031. BESS. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSu(var)3-7. drosophila.
GenomeRNAi41627.
NextBio824709.

Entry information

Entry nameSUV37_DROME
AccessionPrimary (citable) accession number: P20193
Secondary accession number(s): Q9VFX7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase