ID   NTF3_MOUSE              Reviewed;         258 AA.
AC   P20181;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-NOV-2009, entry version 84.
DE   RecName: Full=Neurotrophin-3;
DE            Short=NT-3;
DE   AltName: Full=Neurotrophic factor;
DE   AltName: Full=HDNF;
DE   AltName: Full=Nerve growth factor 2;
DE            Short=NGF-2;
DE   Flags: Precursor;
GN   Name=Ntf3; Synonyms=Ntf-3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=90190865; PubMed=2314473; DOI=10.1038/344339a0;
RA   Hohn A., Leibrock J., Bailey K., Barde Y.-A.;
RT   "Identification and characterization of a novel member of the nerve
RT   growth factor/brain-derived neurotrophic factor family.";
RL   Nature 344:339-341(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 140-152.
RX   MEDLINE=95045576; PubMed=7957235;
RX   DOI=10.1111/j.1432-1033.1994.0995b.x;
RA   Kolbeck R., Jungbluth S., Barde Y.-A.;
RT   "Characterisation of neurotrophin dimers and monomers.";
RL   Eur. J. Biochem. 225:995-1003(1994).
CC   -!- FUNCTION: Seems to promotes the survival of visceral and
CC       proprioceptive sensory neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Brain and peripheral tissues.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; X53257; CAA37348.1; -; Genomic_DNA.
DR   EMBL; BC065785; AAH65785.1; -; mRNA.
DR   IPI; IPI00874624; -.
DR   PIR; S09155; S09155.
DR   RefSeq; NP_001157506.1; -.
DR   RefSeq; NP_001157507.1; -.
DR   RefSeq; NP_032768.1; -.
DR   UniGene; Mm.267570; -.
DR   HSSP; P20783; 1NT3.
DR   SMR; P20181; 147-254.
DR   DIP; DIP:5721N; -.
DR   STRING; P20181; -.
DR   PRIDE; P20181; -.
DR   Ensembl; ENSMUST00000050484; ENSMUSP00000052302; ENSMUSG00000049107; Mus musculus.
DR   Ensembl; ENSMUST00000112244; ENSMUSP00000107863; ENSMUSG00000049107; Mus musculus.
DR   GeneID; 18205; -.
DR   KEGG; mmu:18205; -.
DR   UCSC; uc009duz.1; mouse.
DR   CTD; 18205; -.
DR   MGI; MGI:97380; Ntf3.
DR   HOVERGEN; P20181; -.
DR   NextBio; 293582; -.
DR   ArrayExpress; P20181; -.
DR   Bgee; P20181; -.
DR   CleanEx; MM_NTF3; -.
DR   Genevestigator; P20181; -.
DR   GermOnline; ENSMUSG00000049107; Mus musculus.
DR   GO; GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; EXP:Reactome.
DR   GO; GO:0005576; C:extracellular region; EXP:Reactome.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005166; F:neurotrophin p75 receptor binding; TAS:MGI.
DR   GO; GO:0007411; P:axon guidance; IDA:MGI.
DR   GO; GO:0007420; P:brain development; IMP:MGI.
DR   GO; GO:0048484; P:enteric nervous system development; IMP:MGI.
DR   GO; GO:0008544; P:epidermis development; IMP:MGI.
DR   GO; GO:0007403; P:glial cell fate determination; IMP:MGI.
DR   GO; GO:0042490; P:mechanoreceptor differentiation; IGI:MGI.
DR   GO; GO:0021675; P:nerve development; IMP:MGI.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; IDA:MGI.
DR   GO; GO:0007422; P:peripheral nervous system development; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription from R...; IDA:MGI.
DR   GO; GO:0043523; P:regulation of neuron apoptosis; IDA:MGI.
DR   GO; GO:0051145; P:smooth muscle cell differentiation; IMP:MGI.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR020409; Neurotrophin-3_N.
DR   PANTHER; PTHR11589:SF4; Neurotrophin-3; 1.
DR   PANTHER; PTHR11589; NGF; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
DR   PRINTS; PR00268; NGF.
DR   ProDom; PD002052; NGF; 1.
DR   SMART; SM00140; NGF; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Glycoprotein; Growth factor; Secreted; Signal.
FT   SIGNAL        1     18       Potential.
FT   PROPEP       19    139
FT                                /FTId=PRO_0000019661.
FT   CHAIN       140    258       Neurotrophin-3.
FT                                /FTId=PRO_0000019662.
FT   CARBOHYD    131    131       N-linked (GlcNAc...) (Potential).
FT   DISULFID    153    218       By similarity.
FT   DISULFID    196    247       By similarity.
FT   DISULFID    206    249       By similarity.
SQ   SEQUENCE   258 AA;  29588 MW;  7180D064E8AE6042 CRC64;
     MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ
     STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM
     EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI
     KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW
     IRIDTSCVCA LSRKIGRT
//