ID   NTF3_MOUSE              Reviewed;         258 AA.
AC   P20181;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   24-JAN-2024, entry version 181.
DE   RecName: Full=Neurotrophin-3;
DE            Short=NT-3;
DE   AltName: Full=HDNF;
DE   AltName: Full=Nerve growth factor 2;
DE            Short=NGF-2;
DE   AltName: Full=Neurotrophic factor;
DE   Flags: Precursor;
GN   Name=Ntf3; Synonyms=Ntf-3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2314473; DOI=10.1038/344339a0;
RA   Hohn A., Leibrock J., Bailey K., Barde Y.-A.;
RT   "Identification and characterization of a novel member of the nerve growth
RT   factor/brain-derived neurotrophic factor family.";
RL   Nature 344:339-341(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 140-152.
RX   PubMed=7957235; DOI=10.1111/j.1432-1033.1994.0995b.x;
RA   Kolbeck R., Jungbluth S., Barde Y.-A.;
RT   "Characterisation of neurotrophin dimers and monomers.";
RL   Eur. J. Biochem. 225:995-1003(1994).
CC   -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC       sensory neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Brain and peripheral tissues.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; X53257; CAA37348.1; -; Genomic_DNA.
DR   EMBL; BC065785; AAH65785.1; -; mRNA.
DR   CCDS; CCDS20553.1; -.
DR   PIR; S09155; S09155.
DR   RefSeq; NP_001157506.1; NM_001164034.1.
DR   RefSeq; NP_001157507.1; NM_001164035.1.
DR   RefSeq; NP_032768.1; NM_008742.3.
DR   RefSeq; XP_006505779.1; XM_006505716.2.
DR   AlphaFoldDB; P20181; -.
DR   SMR; P20181; -.
DR   DIP; DIP-5721N; -.
DR   STRING; 10090.ENSMUSP00000107863; -.
DR   GlyCosmos; P20181; 1 site, No reported glycans.
DR   GlyGen; P20181; 1 site.
DR   iPTMnet; P20181; -.
DR   PhosphoSitePlus; P20181; -.
DR   PaxDb; 10090-ENSMUSP00000107863; -.
DR   Antibodypedia; 22321; 750 antibodies from 41 providers.
DR   DNASU; 18205; -.
DR   Ensembl; ENSMUST00000050484.9; ENSMUSP00000052302.8; ENSMUSG00000049107.14.
DR   GeneID; 18205; -.
DR   KEGG; mmu:18205; -.
DR   UCSC; uc012esy.1; mouse.
DR   AGR; MGI:97380; -.
DR   CTD; 4908; -.
DR   MGI; MGI:97380; Ntf3.
DR   VEuPathDB; HostDB:ENSMUSG00000049107; -.
DR   eggNOG; ENOG502R4FK; Eukaryota.
DR   GeneTree; ENSGT00390000007725; -.
DR   HOGENOM; CLU_059942_1_1_1; -.
DR   InParanoid; P20181; -.
DR   OMA; ILLYVMF; -.
DR   OrthoDB; 5399313at2759; -.
DR   PhylomeDB; P20181; -.
DR   Reactome; R-MMU-9034013; NTF3 activates NTRK3 signaling.
DR   Reactome; R-MMU-9034793; Activated NTRK3 signals through PLCG1.
DR   Reactome; R-MMU-9603381; Activated NTRK3 signals through PI3K.
DR   BioGRID-ORCS; 18205; 0 hits in 78 CRISPR screens.
DR   ChiTaRS; Nutf2; mouse.
DR   PRO; PR:P20181; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; P20181; Protein.
DR   Bgee; ENSMUSG00000049107; Expressed in external naris and 194 other cell types or tissues.
DR   ExpressionAtlas; P20181; baseline and differential.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; ISO:MGI.
DR   GO; GO:0008083; F:growth factor activity; ISO:MGI.
DR   GO; GO:0048406; F:nerve growth factor binding; ISO:MGI.
DR   GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0005166; F:neurotrophin p75 receptor binding; TAS:MGI.
DR   GO; GO:0007411; P:axon guidance; IDA:MGI.
DR   GO; GO:0007420; P:brain development; IMP:MGI.
DR   GO; GO:0048484; P:enteric nervous system development; IMP:MGI.
DR   GO; GO:0008544; P:epidermis development; IMP:MGI.
DR   GO; GO:0048699; P:generation of neurons; IGI:MGI.
DR   GO; GO:0007403; P:glial cell fate determination; IMP:MGI.
DR   GO; GO:0050930; P:induction of positive chemotaxis; ISO:MGI.
DR   GO; GO:0042490; P:mechanoreceptor differentiation; IGI:MGI.
DR   GO; GO:0007613; P:memory; IBA:GO_Central.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; ISO:MGI.
DR   GO; GO:0042552; P:myelination; ISO:MGI.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
DR   GO; GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; ISO:MGI.
DR   GO; GO:0021675; P:nerve development; IMP:MGI.
DR   GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; ISO:MGI.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; IDA:MGI.
DR   GO; GO:0051402; P:neuron apoptotic process; IMP:MGI.
DR   GO; GO:0048666; P:neuron development; IMP:MGI.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR   GO; GO:0007422; P:peripheral nervous system development; IMP:MGI.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR   GO; GO:0045687; P:positive regulation of glial cell differentiation; ISO:MGI.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:MGI.
DR   GO; GO:0002092; P:positive regulation of receptor internalization; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0042981; P:regulation of apoptotic process; ISO:MGI.
DR   GO; GO:0043523; P:regulation of neuron apoptotic process; IDA:MGI.
DR   GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR   GO; GO:0051145; P:smooth muscle cell differentiation; IMP:MGI.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISO:MGI.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR045815; NTF3_N.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR   Pfam; PF00243; NGF; 1.
DR   Pfam; PF19338; NTF3_N; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
DR   Genevisible; P20181; MM.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..139
FT                   /evidence="ECO:0000269|PubMed:7957235"
FT                   /id="PRO_0000019661"
FT   CHAIN           140..258
FT                   /note="Neurotrophin-3"
FT                   /id="PRO_0000019662"
FT   REGION          60..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        153..218
FT                   /evidence="ECO:0000250"
FT   DISULFID        196..247
FT                   /evidence="ECO:0000250"
FT   DISULFID        206..249
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   258 AA;  29588 MW;  7180D064E8AE6042 CRC64;
     MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ
     STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM
     EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI
     KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW
     IRIDTSCVCA LSRKIGRT
//