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P20181 (NTF3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotrophin-3

Short name=NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name=NGF-2
Neurotrophic factor
Gene names
Name:Ntf3
Synonyms:Ntf-3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to promote the survival of visceral and proprioceptive sensory neurons.

Subcellular location

Secreted.

Tissue specificity

Brain and peripheral tissues.

Sequence similarities

Belongs to the NGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Inferred from direct assay PubMed 15550985. Source: MGI

brain development

Inferred from mutant phenotype PubMed 10195193. Source: MGI

enteric nervous system development

Inferred from mutant phenotype PubMed 15497153. Source: MGI

epidermis development

Inferred from mutant phenotype PubMed 9736028. Source: MGI

generation of neurons

Inferred from genetic interaction PubMed 16142215. Source: MGI

glial cell fate determination

Inferred from mutant phenotype PubMed 10384880. Source: MGI

mechanoreceptor differentiation

Inferred from genetic interaction PubMed 15376326. Source: MGI

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 19915564. Source: MGI

nerve development

Inferred from mutant phenotype PubMed 7605630. Source: MGI

neuromuscular synaptic transmission

Inferred from direct assay PubMed 11978828. Source: MGI

neuron development

Inferred from mutant phenotype PubMed 8809809. Source: MGI

peripheral nervous system development

Inferred from mutant phenotype PubMed 12741988PubMed 8630254. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12741988. Source: MGI

regulation of neuron apoptotic process

Inferred from direct assay PubMed 16516892. Source: MGI

smooth muscle cell differentiation

Inferred from mutant phenotype PubMed 15497153. Source: MGI

   Cellular_componentcytoplasmic membrane-bounded vesicle

Inferred from direct assay PubMed 14715936. Source: MGI

endoplasmic reticulum lumen

Traceable author statement. Source: Reactome

extracellular region

Traceable author statement. Source: Reactome

   Molecular_functionneurotrophin p75 receptor binding

Traceable author statement PubMed 10491653. Source: MGI

protein binding

Inferred from physical interaction PubMed 11684666. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 139121
PRO_0000019661
Chain140 – 258119Neurotrophin-3
PRO_0000019662

Amino acid modifications

Glycosylation1311N-linked (GlcNAc...) Potential
Disulfide bond153 ↔ 218 By similarity
Disulfide bond196 ↔ 247 By similarity
Disulfide bond206 ↔ 249 By similarity

Sequences

Sequence LengthMass (Da)Tools
P20181 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 7180D064E8AE6042

FASTA25829,588
        10         20         30         40         50         60 
MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 

        70         80         90        100        110        120 
STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 

       130        140        150        160        170        180 
EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI 

       190        200        210        220        230        240 
KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW 

       250 
IRIDTSCVCA LSRKIGRT 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family."
Hohn A., Leibrock J., Bailey K., Barde Y.-A.
Nature 344:339-341(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[3]"Characterisation of neurotrophin dimers and monomers."
Kolbeck R., Jungbluth S., Barde Y.-A.
Eur. J. Biochem. 225:995-1003(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 140-152.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53257 Genomic DNA. Translation: CAA37348.1.
BC065785 mRNA. Translation: AAH65785.1.
CCDSCCDS20553.1.
PIRS09155.
RefSeqNP_001157506.1. NM_001164034.1.
NP_001157507.1. NM_001164035.1.
NP_032768.1. NM_008742.3.
XP_006505779.1. XM_006505716.1.
UniGeneMm.267570.

3D structure databases

ProteinModelPortalP20181.
SMRP20181. Positions 147-254.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5721N.
MINTMINT-1543682.
STRING10090.ENSMUSP00000107863.

PTM databases

PhosphoSiteP20181.

Proteomic databases

PRIDEP20181.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050484; ENSMUSP00000052302; ENSMUSG00000049107.
GeneID18205.
KEGGmmu:18205.
UCSCuc012esy.1. mouse.

Organism-specific databases

CTD4908.
MGIMGI:97380. Ntf3.

Phylogenomic databases

eggNOGNOG39844.
GeneTreeENSGT00390000007725.
HOGENOMHOG000231516.
HOVERGENHBG006494.
InParanoidP20181.
KOK04356.
PhylomeDBP20181.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

ArrayExpressP20181.
BgeeP20181.
CleanExMM_NTF3.
GenevestigatorP20181.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamPF00243. NGF. 1 hit.
[Graphical view]
PIRSFPIRSF001789. NGF. 1 hit.
PRINTSPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio293582.
PROP20181.
SOURCESearch...

Entry information

Entry nameNTF3_MOUSE
AccessionPrimary (citable) accession number: P20181
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot