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Protein

Neurotrophin-3

Gene

Ntf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  • chemoattractant activity Source: MGI
  • growth factor activity Source: MGI
  • neurotrophin p75 receptor binding Source: MGI

GO - Biological processi

  • activation of GTPase activity Source: MGI
  • activation of MAPK activity Source: MGI
  • activation of protein kinase B activity Source: MGI
  • axon guidance Source: MGI
  • brain development Source: MGI
  • enteric nervous system development Source: MGI
  • epidermis development Source: MGI
  • generation of neurons Source: MGI
  • glial cell fate determination Source: MGI
  • induction of positive chemotaxis Source: MGI
  • mechanoreceptor differentiation Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • nerve development Source: MGI
  • neuromuscular synaptic transmission Source: MGI
  • neuron development Source: MGI
  • neuron projection morphogenesis Source: GO_Central
  • peripheral nervous system development Source: MGI
  • positive chemotaxis Source: MGI
  • positive regulation of actin cytoskeleton reorganization Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of receptor internalization Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of apoptotic process Source: MGI
  • regulation of neuron apoptotic process Source: MGI
  • regulation of neuron differentiation Source: GO_Central
  • smooth muscle cell differentiation Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_289095. NRAGE signals death through JNK.
REACT_317611. NGF processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:Ntf3
Synonyms:Ntf-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:97380. Ntf3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 1391211 PublicationPRO_0000019661Add
BLAST
Chaini140 – 258119Neurotrophin-3PRO_0000019662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi153 ↔ 218By similarity
Disulfide bondi196 ↔ 247By similarity
Disulfide bondi206 ↔ 249By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP20181.

PTM databases

PhosphoSiteiP20181.

Expressioni

Tissue specificityi

Brain and peripheral tissues.

Gene expression databases

BgeeiP20181.
CleanExiMM_NTF3.
ExpressionAtlasiP20181. baseline and differential.
GenevisibleiP20181. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-5721N.
MINTiMINT-1543682.
STRINGi10090.ENSMUSP00000107863.

Structurei

3D structure databases

ProteinModelPortaliP20181.
SMRiP20181. Positions 147-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39844.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP20181.
KOiK04356.
PhylomeDBiP20181.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK
60 70 80 90 100
QMVDVKENYQ STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN
110 120 130 140 150
SPRVLLSDST PLEPPPLYLM EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY
160 170 180 190 200
SVCDSESLWV TDKSSAIDIR GHQVTVLGEI KTGNSPVKQY FYETRCKEAR
210 220 230 240 250
PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW IRIDTSCVCA

LSRKIGRT
Length:258
Mass (Da):29,588
Last modified:February 1, 1991 - v1
Checksum:i7180D064E8AE6042
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53257 Genomic DNA. Translation: CAA37348.1.
BC065785 mRNA. Translation: AAH65785.1.
CCDSiCCDS20553.1.
PIRiS09155.
RefSeqiNP_001157506.1. NM_001164034.1.
NP_001157507.1. NM_001164035.1.
NP_032768.1. NM_008742.3.
XP_006505779.1. XM_006505716.2.
UniGeneiMm.267570.

Genome annotation databases

EnsembliENSMUST00000050484; ENSMUSP00000052302; ENSMUSG00000049107.
GeneIDi18205.
KEGGimmu:18205.
UCSCiuc012esy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53257 Genomic DNA. Translation: CAA37348.1.
BC065785 mRNA. Translation: AAH65785.1.
CCDSiCCDS20553.1.
PIRiS09155.
RefSeqiNP_001157506.1. NM_001164034.1.
NP_001157507.1. NM_001164035.1.
NP_032768.1. NM_008742.3.
XP_006505779.1. XM_006505716.2.
UniGeneiMm.267570.

3D structure databases

ProteinModelPortaliP20181.
SMRiP20181. Positions 147-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5721N.
MINTiMINT-1543682.
STRINGi10090.ENSMUSP00000107863.

PTM databases

PhosphoSiteiP20181.

Proteomic databases

PRIDEiP20181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050484; ENSMUSP00000052302; ENSMUSG00000049107.
GeneIDi18205.
KEGGimmu:18205.
UCSCiuc012esy.1. mouse.

Organism-specific databases

CTDi4908.
MGIiMGI:97380. Ntf3.

Phylogenomic databases

eggNOGiNOG39844.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP20181.
KOiK04356.
PhylomeDBiP20181.

Enzyme and pathway databases

ReactomeiREACT_289095. NRAGE signals death through JNK.
REACT_317611. NGF processing.

Miscellaneous databases

NextBioi293582.
PROiP20181.
SOURCEiSearch...

Gene expression databases

BgeeiP20181.
CleanExiMM_NTF3.
ExpressionAtlasiP20181. baseline and differential.
GenevisibleiP20181. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family."
    Hohn A., Leibrock J., Bailey K., Barde Y.-A.
    Nature 344:339-341(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Characterisation of neurotrophin dimers and monomers."
    Kolbeck R., Jungbluth S., Barde Y.-A.
    Eur. J. Biochem. 225:995-1003(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 140-152.

Entry informationi

Entry nameiNTF3_MOUSE
AccessioniPrimary (citable) accession number: P20181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 24, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.