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Protein

Neurotrophin-3

Gene

Ntf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  • chemoattractant activity Source: MGI
  • growth factor activity Source: MGI
  • neurotrophin p75 receptor binding Source: MGI

GO - Biological processi

  • activation of GTPase activity Source: MGI
  • activation of MAPK activity Source: MGI
  • activation of protein kinase B activity Source: MGI
  • axon guidance Source: MGI
  • brain development Source: MGI
  • enteric nervous system development Source: MGI
  • epidermis development Source: MGI
  • generation of neurons Source: MGI
  • glial cell fate determination Source: MGI
  • induction of positive chemotaxis Source: MGI
  • mechanoreceptor differentiation Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • nerve development Source: MGI
  • neuromuscular synaptic transmission Source: MGI
  • neuron development Source: MGI
  • peripheral nervous system development Source: MGI
  • positive regulation of actin cytoskeleton reorganization Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of receptor internalization Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of apoptotic process Source: MGI
  • regulation of neuron apoptotic process Source: MGI
  • regulation of neuron differentiation Source: GO_Central
  • smooth muscle cell differentiation Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:Ntf3
Synonyms:Ntf-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:97380 Ntf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001966119 – 1391 PublicationAdd BLAST121
ChainiPRO_0000019662140 – 258Neurotrophin-3Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 218By similarity
Disulfide bondi196 ↔ 247By similarity
Disulfide bondi206 ↔ 249By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20181
PRIDEiP20181

PTM databases

iPTMnetiP20181
PhosphoSitePlusiP20181

Expressioni

Tissue specificityi

Brain and peripheral tissues.

Gene expression databases

BgeeiENSMUSG00000049107
CleanExiMM_NTF3
ExpressionAtlasiP20181 baseline and differential
GenevisibleiP20181 MM

Interactioni

GO - Molecular functioni

  • chemoattractant activity Source: MGI
  • growth factor activity Source: MGI
  • neurotrophin p75 receptor binding Source: MGI

Protein-protein interaction databases

DIPiDIP-5721N
STRINGi10090.ENSMUSP00000107863

Structurei

3D structure databases

ProteinModelPortaliP20181
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHMM Eukaryota
ENOG410XRRK LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP20181
KOiK04356
PhylomeDBiP20181

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR015578 Neurotrophin-3
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF4 PTHR11589:SF4, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01914 NEUROTROPHN3
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK
60 70 80 90 100
QMVDVKENYQ STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN
110 120 130 140 150
SPRVLLSDST PLEPPPLYLM EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY
160 170 180 190 200
SVCDSESLWV TDKSSAIDIR GHQVTVLGEI KTGNSPVKQY FYETRCKEAR
210 220 230 240 250
PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW IRIDTSCVCA

LSRKIGRT
Length:258
Mass (Da):29,588
Last modified:February 1, 1991 - v1
Checksum:i7180D064E8AE6042
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53257 Genomic DNA Translation: CAA37348.1
BC065785 mRNA Translation: AAH65785.1
CCDSiCCDS20553.1
PIRiS09155
RefSeqiNP_001157506.1, NM_001164034.1
NP_001157507.1, NM_001164035.1
NP_032768.1, NM_008742.3
XP_006505779.1, XM_006505716.2
UniGeneiMm.267570

Genome annotation databases

EnsembliENSMUST00000050484; ENSMUSP00000052302; ENSMUSG00000049107
GeneIDi18205
KEGGimmu:18205
UCSCiuc012esy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNTF3_MOUSE
AccessioniPrimary (citable) accession number: P20181
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 25, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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