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P20181

- NTF3_MOUSE

UniProt

P20181 - NTF3_MOUSE

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Protein

Neurotrophin-3

Gene

Ntf3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  1. neurotrophin p75 receptor binding Source: MGI

GO - Biological processi

  1. axon guidance Source: MGI
  2. brain development Source: MGI
  3. enteric nervous system development Source: MGI
  4. epidermis development Source: MGI
  5. generation of neurons Source: MGI
  6. glial cell fate determination Source: MGI
  7. mechanoreceptor differentiation Source: MGI
  8. negative regulation of neuron apoptotic process Source: MGI
  9. nerve development Source: MGI
  10. neuromuscular synaptic transmission Source: MGI
  11. neuron development Source: MGI
  12. peripheral nervous system development Source: MGI
  13. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  14. regulation of neuron apoptotic process Source: MGI
  15. smooth muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_206713. NGF processing.
REACT_209641. NRAGE signals death through JNK.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:Ntf3
Synonyms:Ntf-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:97380. Ntf3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: MGI
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 1391211 PublicationPRO_0000019661Add
BLAST
Chaini140 – 258119Neurotrophin-3PRO_0000019662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi153 ↔ 218By similarity
Disulfide bondi196 ↔ 247By similarity
Disulfide bondi206 ↔ 249By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP20181.

PTM databases

PhosphoSiteiP20181.

Expressioni

Tissue specificityi

Brain and peripheral tissues.

Gene expression databases

BgeeiP20181.
CleanExiMM_NTF3.
ExpressionAtlasiP20181. baseline and differential.
GenevestigatoriP20181.

Interactioni

Protein-protein interaction databases

DIPiDIP-5721N.
MINTiMINT-1543682.
STRINGi10090.ENSMUSP00000107863.

Structurei

3D structure databases

ProteinModelPortaliP20181.
SMRiP20181. Positions 147-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39844.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP20181.
KOiK04356.
PhylomeDBiP20181.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20181-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK
60 70 80 90 100
QMVDVKENYQ STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN
110 120 130 140 150
SPRVLLSDST PLEPPPLYLM EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY
160 170 180 190 200
SVCDSESLWV TDKSSAIDIR GHQVTVLGEI KTGNSPVKQY FYETRCKEAR
210 220 230 240 250
PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW IRIDTSCVCA

LSRKIGRT
Length:258
Mass (Da):29,588
Last modified:February 1, 1991 - v1
Checksum:i7180D064E8AE6042
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53257 Genomic DNA. Translation: CAA37348.1.
BC065785 mRNA. Translation: AAH65785.1.
CCDSiCCDS20553.1.
PIRiS09155.
RefSeqiNP_001157506.1. NM_001164034.1.
NP_001157507.1. NM_001164035.1.
NP_032768.1. NM_008742.3.
XP_006505779.1. XM_006505716.1.
UniGeneiMm.267570.

Genome annotation databases

EnsembliENSMUST00000050484; ENSMUSP00000052302; ENSMUSG00000049107.
GeneIDi18205.
KEGGimmu:18205.
UCSCiuc012esy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53257 Genomic DNA. Translation: CAA37348.1 .
BC065785 mRNA. Translation: AAH65785.1 .
CCDSi CCDS20553.1.
PIRi S09155.
RefSeqi NP_001157506.1. NM_001164034.1.
NP_001157507.1. NM_001164035.1.
NP_032768.1. NM_008742.3.
XP_006505779.1. XM_006505716.1.
UniGenei Mm.267570.

3D structure databases

ProteinModelPortali P20181.
SMRi P20181. Positions 147-254.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5721N.
MINTi MINT-1543682.
STRINGi 10090.ENSMUSP00000107863.

PTM databases

PhosphoSitei P20181.

Proteomic databases

PRIDEi P20181.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050484 ; ENSMUSP00000052302 ; ENSMUSG00000049107 .
GeneIDi 18205.
KEGGi mmu:18205.
UCSCi uc012esy.1. mouse.

Organism-specific databases

CTDi 4908.
MGIi MGI:97380. Ntf3.

Phylogenomic databases

eggNOGi NOG39844.
GeneTreei ENSGT00390000007725.
HOGENOMi HOG000231516.
HOVERGENi HBG006494.
InParanoidi P20181.
KOi K04356.
PhylomeDBi P20181.

Enzyme and pathway databases

Reactomei REACT_206713. NGF processing.
REACT_209641. NRAGE signals death through JNK.

Miscellaneous databases

NextBioi 293582.
PROi P20181.
SOURCEi Search...

Gene expression databases

Bgeei P20181.
CleanExi MM_NTF3.
ExpressionAtlasi P20181. baseline and differential.
Genevestigatori P20181.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view ]
PANTHERi PTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
Pfami PF00243. NGF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001789. NGF. 1 hit.
PRINTSi PR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00140. NGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family."
    Hohn A., Leibrock J., Bailey K., Barde Y.-A.
    Nature 344:339-341(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Characterisation of neurotrophin dimers and monomers."
    Kolbeck R., Jungbluth S., Barde Y.-A.
    Eur. J. Biochem. 225:995-1003(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 140-152.

Entry informationi

Entry nameiNTF3_MOUSE
AccessioniPrimary (citable) accession number: P20181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3