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P20181

- NTF3_MOUSE

UniProt

P20181 - NTF3_MOUSE

Protein

Neurotrophin-3

Gene

Ntf3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Seems to promote the survival of visceral and proprioceptive sensory neurons.

    GO - Molecular functioni

    1. neurotrophin p75 receptor binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. axon guidance Source: MGI
    2. brain development Source: MGI
    3. enteric nervous system development Source: MGI
    4. epidermis development Source: MGI
    5. generation of neurons Source: MGI
    6. glial cell fate determination Source: MGI
    7. mechanoreceptor differentiation Source: MGI
    8. negative regulation of neuron apoptotic process Source: MGI
    9. nerve development Source: MGI
    10. neuromuscular synaptic transmission Source: MGI
    11. neuron development Source: MGI
    12. peripheral nervous system development Source: MGI
    13. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    14. regulation of neuron apoptotic process Source: MGI
    15. smooth muscle cell differentiation Source: MGI

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_206713. NGF processing.
    REACT_209641. NRAGE signals death through JNK.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotrophin-3
    Short name:
    NT-3
    Alternative name(s):
    HDNF
    Nerve growth factor 2
    Short name:
    NGF-2
    Neurotrophic factor
    Gene namesi
    Name:Ntf3
    Synonyms:Ntf-3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:97380. Ntf3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: MGI
    2. endoplasmic reticulum lumen Source: Reactome
    3. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 1391211 PublicationPRO_0000019661Add
    BLAST
    Chaini140 – 258119Neurotrophin-3PRO_0000019662Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi153 ↔ 218By similarity
    Disulfide bondi196 ↔ 247By similarity
    Disulfide bondi206 ↔ 249By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP20181.

    PTM databases

    PhosphoSiteiP20181.

    Expressioni

    Tissue specificityi

    Brain and peripheral tissues.

    Gene expression databases

    ArrayExpressiP20181.
    BgeeiP20181.
    CleanExiMM_NTF3.
    GenevestigatoriP20181.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-5721N.
    MINTiMINT-1543682.
    STRINGi10090.ENSMUSP00000107863.

    Structurei

    3D structure databases

    ProteinModelPortaliP20181.
    SMRiP20181. Positions 147-254.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39844.
    GeneTreeiENSGT00390000007725.
    HOGENOMiHOG000231516.
    HOVERGENiHBG006494.
    InParanoidiP20181.
    KOiK04356.
    PhylomeDBiP20181.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR015578. Neurotrophin-3.
    [Graphical view]
    PANTHERiPTHR11589. PTHR11589. 1 hit.
    PTHR11589:SF4. PTHR11589:SF4. 1 hit.
    PfamiPF00243. NGF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001789. NGF. 1 hit.
    PRINTSiPR01914. NEUROTROPHN3.
    PR00268. NGF.
    ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00140. NGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20181-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK    50
    QMVDVKENYQ STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN 100
    SPRVLLSDST PLEPPPLYLM EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY 150
    SVCDSESLWV TDKSSAIDIR GHQVTVLGEI KTGNSPVKQY FYETRCKEAR 200
    PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW IRIDTSCVCA 250
    LSRKIGRT 258
    Length:258
    Mass (Da):29,588
    Last modified:February 1, 1991 - v1
    Checksum:i7180D064E8AE6042
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53257 Genomic DNA. Translation: CAA37348.1.
    BC065785 mRNA. Translation: AAH65785.1.
    CCDSiCCDS20553.1.
    PIRiS09155.
    RefSeqiNP_001157506.1. NM_001164034.1.
    NP_001157507.1. NM_001164035.1.
    NP_032768.1. NM_008742.3.
    XP_006505779.1. XM_006505716.1.
    UniGeneiMm.267570.

    Genome annotation databases

    EnsembliENSMUST00000050484; ENSMUSP00000052302; ENSMUSG00000049107.
    GeneIDi18205.
    KEGGimmu:18205.
    UCSCiuc012esy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53257 Genomic DNA. Translation: CAA37348.1 .
    BC065785 mRNA. Translation: AAH65785.1 .
    CCDSi CCDS20553.1.
    PIRi S09155.
    RefSeqi NP_001157506.1. NM_001164034.1.
    NP_001157507.1. NM_001164035.1.
    NP_032768.1. NM_008742.3.
    XP_006505779.1. XM_006505716.1.
    UniGenei Mm.267570.

    3D structure databases

    ProteinModelPortali P20181.
    SMRi P20181. Positions 147-254.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5721N.
    MINTi MINT-1543682.
    STRINGi 10090.ENSMUSP00000107863.

    PTM databases

    PhosphoSitei P20181.

    Proteomic databases

    PRIDEi P20181.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050484 ; ENSMUSP00000052302 ; ENSMUSG00000049107 .
    GeneIDi 18205.
    KEGGi mmu:18205.
    UCSCi uc012esy.1. mouse.

    Organism-specific databases

    CTDi 4908.
    MGIi MGI:97380. Ntf3.

    Phylogenomic databases

    eggNOGi NOG39844.
    GeneTreei ENSGT00390000007725.
    HOGENOMi HOG000231516.
    HOVERGENi HBG006494.
    InParanoidi P20181.
    KOi K04356.
    PhylomeDBi P20181.

    Enzyme and pathway databases

    Reactomei REACT_206713. NGF processing.
    REACT_209641. NRAGE signals death through JNK.

    Miscellaneous databases

    NextBioi 293582.
    PROi P20181.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20181.
    Bgeei P20181.
    CleanExi MM_NTF3.
    Genevestigatori P20181.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR015578. Neurotrophin-3.
    [Graphical view ]
    PANTHERi PTHR11589. PTHR11589. 1 hit.
    PTHR11589:SF4. PTHR11589:SF4. 1 hit.
    Pfami PF00243. NGF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001789. NGF. 1 hit.
    PRINTSi PR01914. NEUROTROPHN3.
    PR00268. NGF.
    ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00140. NGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family."
      Hohn A., Leibrock J., Bailey K., Barde Y.-A.
      Nature 344:339-341(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    3. "Characterisation of neurotrophin dimers and monomers."
      Kolbeck R., Jungbluth S., Barde Y.-A.
      Eur. J. Biochem. 225:995-1003(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 140-152.

    Entry informationi

    Entry nameiNTF3_MOUSE
    AccessioniPrimary (citable) accession number: P20181
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3