Reviewed, UniProtKB/Swiss-Prot P20181 (NTF3_MOUSE)

Names and origin

Protein names

Recommended name:
    Neurotrophin-3
      Short name=NT-3
Alternative name(s):
    Neurotrophic factor
    HDNF
    Nerve growth factor 2
      Short name=NGF-2

Gene names

Name:	Ntf3
Synonyms:	Ntf-3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Seems to promotes the survival of visceral and proprioceptive sensory neurons.
Subcellular location	Secreted.
Tissue specificity	Brain and peripheral tissues.
Sequence similarities	Belongs to the NGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	axon guidance Inferred from direct assay. Source: MGI brain development Inferred from mutant phenotype. Source: MGI enteric nervous system development Inferred from mutant phenotype. Source: MGI epidermis development Inferred from mutant phenotype. Source: MGI glial cell fate determination Inferred from mutant phenotype. Source: MGI mechanoreceptor differentiation Inferred from genetic interaction. Source: MGI nerve development Inferred from mutant phenotype. Source: MGI neuromuscular synaptic transmission Inferred from direct assay. Source: MGI peripheral nervous system development Inferred from mutant phenotype. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI regulation of neuron apoptosis Inferred from direct assay. Source: MGI smooth muscle cell differentiation Inferred from mutant phenotype. Source: MGI
Cellular component	cytoplasmic membrane-bounded vesicle Inferred from direct assay. Source: MGI endoplasmic reticulum lumen Inferred from Experiment. Source: Reactome extracellular region Ref.1 Traceable author statement. Source: MGI
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW neurotrophin p75 receptor binding Traceable author statement. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 139	121	Ref.3		PRO_0000019661
	Chain	140 – 258	119	Neurotrophin-3		PRO_0000019662
Amino acid modifications
	Glycosylation	131	1	N-linked (GlcNAc...) Potential
	Disulfide bond	153 ↔ 218		By similarity
	Disulfide bond	196 ↔ 247		By similarity
	Disulfide bond	206 ↔ 249		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P20181-1 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 7180D064E8AE6042	FASTA	258	29,588
	10 20 30 40 50 60 MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 70 80 90 100 110 120 STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 130 140 150 160 170 180 EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI 190 200 210 220 230 240 KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW 250 IRIDTSCVCA LSRKIGRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family." Hohn A., Leibrock J., Bailey K., Barde Y.-A. Nature 344:339-341(1990) [PubMed: 2314473] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
[3]	"Characterisation of neurotrophin dimers and monomers." Kolbeck R., Jungbluth S., Barde Y.-A. Eur. J. Biochem. 225:995-1003(1994) [PubMed: 7957235] [Abstract] Cited for: PROTEIN SEQUENCE OF 140-152.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X53257 Genomic DNA. Translation: CAA37348.1. BC065785 mRNA. Translation: AAH65785.1.
IPI	IPI00874624.
PIR	S09155.
RefSeq	NP_032768.1.
UniGene	Mm.267570
3D structure databases
HSSP	HSSP built from PDB template 1NT3 based on UniProtKB P20783.
SMR	P20181. Positions 147-254.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5721N.
Genome annotation databases
Ensembl	ENSMUSG00000049107. Mus musculus. [Contig view]
GeneID	18205.
KEGG	mmu:18205.
Organism-specific databases
MGI	MGI:97380. Ntf3.
Phylogenomic databases
HOVERGEN	P20181.
Gene expression databases
ArrayExpress	P20181.
Bgee	P20181.
CleanEx	MM_NTF3.
GermOnline	ENSMUSG00000049107. Mus musculus.
Family and domain databases
InterPro	IPR002072. Nerve_growth_factor-rel. IPR019846. Nerve_growth_factor_CS. IPR015578. Neurotrophin-3. [Graphical view]
PANTHER	PTHR11589:SF4. Neurotrophin-3. 1 hit. PTHR11589. NGF. 1 hit.
Pfam	PF00243. NGF. 1 hit. [Graphical view]
PIRSF	PIRSF001789. NGF. 1 hit.
PRINTS	PR00268. NGF.
ProDom	PD002052. NGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00140. NGF. 1 hit. [Graphical view]
PROSITE	PS00248. NGF_1. 1 hit. PS50270. NGF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	293582.
SOURCE	Search...

Entry information

Entry name

NTF3_MOUSE

Accession

Primary (citable) accession number: P20181

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	June 16, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)