P20181 (NTF3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurotrophin-3
Short name=NT-3

Alternative name(s):
HDNF
Nerve growth factor 2
Short name=NGF-2
Neurotrophic factor

Gene names

Name:	Ntf3
Synonyms:	Ntf-3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to promote the survival of visceral and proprioceptive sensory neurons.
Subcellular location	Secreted.
Tissue specificity	Brain and peripheral tissues.
Sequence similarities	Belongs to the NGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from direct assay PubMed 15550985. Source: MGI brain development Inferred from mutant phenotype PubMed 10195193. Source: MGI enteric nervous system development Inferred from mutant phenotype PubMed 15497153. Source: MGI epidermis development Inferred from mutant phenotype PubMed 9736028. Source: MGI glial cell fate determination Inferred from mutant phenotype PubMed 10384880. Source: MGI mechanoreceptor differentiation Inferred from genetic interaction PubMed 15376326. Source: MGI negative regulation of neuron apoptotic process Inferred from mutant phenotype PubMed 19915564. Source: MGI nerve development Inferred from mutant phenotype PubMed 7605630. Source: MGI neuromuscular synaptic transmission Inferred from direct assay PubMed 11978828. Source: MGI peripheral nervous system development Inferred from mutant phenotype PubMed 12741988PubMed 8630254. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 12741988. Source: MGI smooth muscle cell differentiation Inferred from mutant phenotype PubMed 15497153. Source: MGI
Cellular_component	cytoplasmic membrane-bounded vesicle Inferred from direct assay PubMed 14715936. Source: MGI endoplasmic reticulum lumen Traceable author statement. Source: Reactome extracellular region Traceable author statement. Source: Reactome
Molecular_function	neurotrophin p75 receptor binding Traceable author statement PubMed 10491653. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 139	121			PRO_0000019661
	Chain	140 – 258	119	Neurotrophin-3		PRO_0000019662
Amino acid modifications
	Glycosylation	131	1	N-linked (GlcNAc...) Potential
	Disulfide bond	153 ↔ 218		By similarity
	Disulfide bond	196 ↔ 247		By similarity
	Disulfide bond	206 ↔ 249		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P20181 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 7180D064E8AE6042	FASTA	258	29,588
	10 20 30 40 50 60 MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 70 80 90 100 110 120 STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 130 140 150 160 170 180 EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI 190 200 210 220 230 240 KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW 250 IRIDTSCVCA LSRKIGRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family." Hohn A., Leibrock J., Bailey K., Barde Y.-A. Nature 344:339-341(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
[3]	"Characterisation of neurotrophin dimers and monomers." Kolbeck R., Jungbluth S., Barde Y.-A. Eur. J. Biochem. 225:995-1003(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 140-152.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X53257 Genomic DNA. Translation: CAA37348.1. BC065785 mRNA. Translation: AAH65785.1.
IPI	IPI00874624.
PIR	S09155.
RefSeq	NP_001157506.1. NM_001164034.1. NP_001157507.1. NM_001164035.1. NP_032768.1. NM_008742.3.
UniGene	Mm.267570.
3D structure databases
ProteinModelPortal	P20181.
SMR	P20181. Positions 147-254.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5721N.
STRING	10090.ENSMUSP00000107863.
PTM databases
PhosphoSite	P20181.
Proteomic databases
PRIDE	P20181.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000050484; ENSMUSP00000052302; ENSMUSG00000049107.
GeneID	18205.
KEGG	mmu:18205.
Organism-specific databases
CTD	4908.
MGI	MGI:97380. Ntf3.
Phylogenomic databases
eggNOG	NOG39844.
GeneTree	ENSGT00390000007725.
HOGENOM	HOG000231516.
HOVERGEN	HBG006494.
InParanoid	P20181.
KO	K04356.
OrthoDB	EOG46HGBB.
Enzyme and pathway databases
Reactome	REACT_115202. Signal Transduction.
Gene expression databases
ArrayExpress	P20181.
Bgee	P20181.
CleanEx	MM_NTF3.
Genevestigator	P20181.
GermOnline	ENSMUSG00000049107. Mus musculus.
Family and domain databases
InterPro	IPR020408. Nerve_growth_factor-like. IPR002072. Nerve_growth_factor-rel. IPR019846. Nerve_growth_factor_CS. IPR015578. Neurotrophin-3. [Graphical view]
PANTHER	PTHR11589. PTHR11589. 1 hit. PTHR11589:SF4. PTHR11589:SF4. 1 hit.
Pfam	PF00243. NGF. 1 hit. [Graphical view]
PIRSF	PIRSF001789. NGF. 1 hit.
PRINTS	PR01914. NEUROTROPHN3. PR00268. NGF.
ProDom	PD002052. Nerve_growth_factor-rel. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00140. NGF. 1 hit. [Graphical view]
PROSITE	PS00248. NGF_1. 1 hit. PS50270. NGF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	293582.
SOURCE	Search...

Entry information

Entry name

NTF3_MOUSE

Accession

Primary (citable) accession number: P20181

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	April 3, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program