ID   RASH$RAT       STANDARD;      PRT;   189 AA.
AC   P20171;
DT   01-FEB-1991 (REL. 17, CREATED)
DT   01-FEB-1991 (REL. 17, LAST SEQUENCE UPDATE)
DT   01-FEB-1991 (REL. 17, LAST ANNOTATION UPDATE)
DE   TRANSFORMING PROTEIN P21/H-RAS-1.
OS   RATTUS NORVEGICUS (RAT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; RODENTIA.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   MEDLINE=87064453;
RA   RUTA M., WOLFORD R., DHAR R., DEFEO-JONES D., ELLIS R.W.,
RA   SCOLNICK E.M.;
RL   MOL. CELL. BIOL. 6:1706-1710(1986).
CC   -!- FUNCTION: RAS PROTEINS BIND GDP/GTP AND POSSESS INTRINSIC GTPASE
CC       ACTIVITY.
CC   -!- THE MAMMALIAN RAS GENE FAMILY CONSISTS OF THE HARVEY AND KIRSTEN
CC       RAS GENES (C-HRAS1 AND C-KRAS2), AN INACTIVE PSEUDOGENE OF
CC       EACH (C-HRAS2 AND C-KRAS1) AND THE N-RAS GENE.
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DR   EMBL; M13011; RNRASH1C.
DR   PIR; A25229; A25229.
KW   PROTO-ONCOGENE; GTP-BINDING; FARNESYLATION; LIPOPROTEIN.
FT   NP_BIND       5     22       GUANINE NUCLEOTIDE BINDING.
FT   DOMAIN       35     40       IMPLICATED IN EFFECTOR ACTIVITY.
FT   NP_BIND      59     63       GUANINE NUCLEOTIDE BINDING.
FT   DOMAIN       64     76       HYDROPHILIC, NOT REQUIRED FOR ACTIVITY.
FT   DOMAIN       93    108       HYDROPHILIC, NOT REQUIRED FOR ACTIVITY.
FT   NP_BIND     109    120       GUANINE NUCLEOTIDE BINDING.
FT   DOMAIN      124    138       HYDROPHILIC, NOT REQUIRED FOR ACTIVITY.
FT   NP_BIND     145    147       GUANINE NUCLEOTIDE BINDING.
FT   NP_BIND     152    165       GUANINE NUCLEOTIDE BINDING.
FT   DOMAIN      166    185       HYPERVARIABLE REGION.
FT   SITE         12     13       ONCOGENE ACTIVATING REGION.
FT   SITE         59     61       ONCOGENE ACTIVATING REGION.
FT   BINDING     184    184       LIPID (PALMITIC ACID).
FT   MOD_RES     186    186       FARNESYLATION.
SQ   SEQUENCE   189 AA;  21314 MW;  176948 CN;
     MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG
     QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHQYREQI KRVKDSDDVP MVLVGNKCDL
     AARTVESRQA QDLARSYGIP YIETSAKTRQ GVEDAFYTLV REIRQHKLRK LNPPDESGLG
     CMSCKCVLS
//