P20170 (TRPE_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	slr0738

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.
Sequence caution	The sequence AAA88627.1 differs from that shown. Reason: Frameshift at position 182.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Probable anthranilate synthase component 1		PRO_0000154114

Sequences

	Sequence		Length	Mass (Da)
	P20170 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: A3308E9A7B8A1FC1	FASTA	508	57,147
	10 20 30 40 50 60 MISPGFSHFT ELAQQGNFIP VYQEWVADLE TPVSAWYKVC SSQPYNFLLE SVEGGESIGR 70 80 90 100 110 120 YSFLGCDPMW VLEARGDETT QVLRNGQTET FRGNPLDILS QCLESIRPVN LPQLPPGIGG 130 140 150 160 170 180 LFGVWGYELI RWMEPRVPVY EPQPEDPPDG IWMQVDHLLI FDQVKRKIWA IAFADLRGEN 190 200 210 220 230 240 VDLETAYRNA CQRVTKLVLQ LQLPLPPEAT ALELLTKTQL EGKELNYSSN TEQEKFLEEV 250 260 270 280 290 300 AIAKDYITAG DIFQVVLSQR LSTIYRDDPF KLYRSLRLIN PSPYMAYYNF GHWQIIGSSP 310 320 330 340 350 360 EVMVKADRQL DGKLMATVRP IAGTRPRGKT HPEDEQLAEE LLNDPKEIAE HVMLVDLGRN 370 380 390 400 410 420 DLGRVCVQGS VKVNELMVIE RYSHVMHIVS NVVGELASDK TAWDLLKACF PAGTVSGAPK 430 440 450 460 470 480 IRAMEIINEL EPERRGPYSG VYGYYDFEGQ LNTAIAIRTM VVQEQPDGAH RVSVQTGAGI 490 500 VADSDPQKEY EETLNKARGL LEAIRALS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.
[2]	"Molecular cloning and sequencing of the psaD gene encoding subunit II of photosystem I from the cyanobacterium, Synechocystis sp. PCC 6803." Reilly P., Hulmes J.D., Pan Y.-C.E., Nelson N. J. Biol. Chem. 263:17658-17662(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-408.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA16689.1. J04195 Genomic DNA. Translation: AAA88626.1. Frameshift. J04195 Genomic DNA. Translation: AAA88627.1. Frameshift.
PIR	S74537.
RefSeq	NP_440009.1. NC_000911.1. YP_005650065.1. NC_017277.1. YP_007449892.1. NC_020286.1.
3D structure databases
ProteinModelPortal	P20170.
ModBase	Search...
Protein-protein interaction databases
IntAct	P20170. 1 interaction.
STRING	1148.slr0738.
Proteomic databases
PaxDb	P20170.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA16689; BAA16689; BAA16689.
GeneID	12253898. 14615533. 953222.
KEGG	syn:slr0738. syy:SYNGTS_0112.
PATRIC	23837092. VBISynSp132158_0121.
Phylogenomic databases
eggNOG	COG0147.
HOGENOM	HOG000025142.
KO	K01657.
OMA	CASSENS.
ProtClustDB	CLSK892483.
Enzyme and pathway databases
UniPathway	UPA00035; UER00040.
Family and domain databases
Gene3D	3.60.120.10. 1 hit.
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. trpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_SYNY3

Accession

Primary (citable) accession number: P20170
Secondary accession number(s): P20168

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program