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P20169 (DSPA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Drug sensory protein A

EC=2.7.13.3
Gene names
Name:dspA
Synonyms:dfr
Ordered Locus Names:sll0698
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length663 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Miscellaneous

Mutations in dspA results in resistance to herbicides difunon, diuron and calmodulin antagonists chlorpromazine and trifluoperazine.

Sequence similarities

Contains 1 HAMP domain.

Contains 1 histidine kinase domain.

Contains 1 PAS (PER-ARNT-SIM) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 663663Drug sensory protein A
PRO_0000074758

Regions

Transmembrane32 – 5221Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane199 – 21921Helical; Potential
Domain220 – 27253HAMP
Domain281 – 35171PAS
Domain429 – 656228Histidine kinase

Amino acid modifications

Modified residue4321Phosphohistidine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P20169 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 42CD7CA67E396586

FASTA66374,536
        10         20         30         40         50         60 
MGTSVSNPTA ILQTMQGFLR KWWSEFNLQT RLMAAATLVV SLLMSGLTFW AVNTIQEDAQ 

        70         80         90        100        110        120 
LVDTRFGRDV GLLLAANVAP MIADKNLTEV ARFSSRFYEN TSNIRYMIYA DPSGKIFFGI 

       130        140        150        160        170        180 
PYSEETVQNS LTLERRIELP QIDPHNFDQP FVRQHHTPNG DVTDVFIPLQ YQGKFLGVLA 

       190        200        210        220        230        240 
IGINPNPAAV NSSNLTRDVT IAVFISIWVM VILGAVFNAL TITQPIKELL LGVKNIAAGN 

       250        260        270        280        290        300 
FKQRITLPFG GELGELIVNF NEMAERLERY EAQNIEELTA EKAKLDTLVS TIADGAMLVD 

       310        320        330        340        350        360 
TNLQLLLVNP TARRLFAWEN KPIIGENLLE NLPPEITAQL TQPLRELAAD QGSLLFSPGH 

       370        380        390        400        410        420 
GPQEEEQDKT YAPEEFRISL TQPFPRTIRL MLTQVLDQNR ENLRGIVMTV QDITREVELN 

       430        440        450        460        470        480 
EAKSQFISNV SHELRTPLFN IKSFIETLSE FGEDLSEVER KEFLETANHE TDRLSRLVND 

       490        500        510        520        530        540 
VLDLSKLESS KIYQLDAVDL YQLIEQSLRS YQLNAKDKQL QLEKILDPDL PFALGNYDLL 

       550        560        570        580        590        600 
LQVMTNLIGN SFKFTKAGGK IIVRAYPLHR SNLRAEDGPG LVRVEISDTG IGIDPEDQAA 

       610        620        630        640        650        660 
IFERFYRVEN RVHTLEGTGL GLSIVKNIIA KHQSQIHLVS EVGVGTTFWF DLAVYQSMLM 


VVG 

« Hide

References

« Hide 'large scale' references
[1]"The dspA gene product of the cyanobacterium Synechocystis sp. strain PCC 6803 influences sensitivity to chemically different growth inhibitors and has amino acid similarity to histidine protein kinases."
Bartsevich V.V., Shestakov S.V.
Microbiology 141:2915-2920(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.
[3]"Molecular cloning and sequencing of the psaD gene encoding subunit II of photosystem I from the cyanobacterium, Synechocystis sp. PCC 6803."
Reilly P., Hulmes J.D., Pan Y.-C.E., Nelson N.
J. Biol. Chem. 263:17658-17662(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X72856 Genomic DNA. Translation: CAA51377.1.
BA000022 Genomic DNA. Translation: BAA16687.1.
J04195 Genomic DNA. No translation available.
PIRS74535.
RefSeqNP_440007.1. NC_000911.1.
YP_005650063.1. NC_017277.1.
YP_007449890.1. NC_020286.1.

3D structure databases

ProteinModelPortalP20169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP20169. 1 interaction.
STRING1148.sll0698.

Proteomic databases

PaxDbP20169.
PRIDEP20169.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA16687; BAA16687; BAA16687.
GeneID12253896.
14615531.
953218.
KEGGsyn:sll0698.
syy:SYNGTS_0110.
syz:MYO_11090.
PATRIC23837088. VBISynSp132158_0119.

Phylogenomic databases

eggNOGCOG0642.
HOGENOMHOG000233124.
KOK07769.
OMALFRWEGR.
OrthoDBEOG6G4VQG.
ProtClustDBCLSK892481.

Enzyme and pathway databases

BRENDA2.7.13.3. 6185.

Family and domain databases

Gene3D1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProIPR003661. EnvZ-like_dim/P.
IPR003660. HAMP_linker_domain.
IPR003594. HATPase_ATP-bd.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSPR00344. BCTRLSENSOR.
SMARTSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMSSF47384. SSF47384. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDSPA_SYNY3
AccessionPrimary (citable) accession number: P20169
Secondary accession number(s): Q55232
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families