SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P20169

- DSPA_SYNY3

UniProt

P20169 - DSPA_SYNY3

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Drug sensory protein A
Gene
dspA, dfr, sll0698
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorelay sensor kinase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
  2. response to herbicide Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Herbicide resistance, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 6185.

Names & Taxonomyi

Protein namesi
Recommended name:
Drug sensory protein A (EC:2.7.13.3)
Gene namesi
Name:dspA
Synonyms:dfr
Ordered Locus Names:sll0698
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221Helical; Reviewed prediction
Add
BLAST
Transmembranei165 – 18521Helical; Reviewed prediction
Add
BLAST
Transmembranei199 – 21921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 663663Drug sensory protein A
PRO_0000074758Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei432 – 4321Phosphohistidine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP20169.
PRIDEiP20169.

Interactioni

Protein-protein interaction databases

IntActiP20169. 1 interaction.
STRINGi1148.sll0698.

Structurei

3D structure databases

ProteinModelPortaliP20169.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 27253HAMP
Add
BLAST
Domaini281 – 35171PAS
Add
BLAST
Domaini429 – 656228Histidine kinase
Add
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0642.
HOGENOMiHOG000233124.
KOiK07769.
OMAiLFRWEGR.
OrthoDBiEOG6G4VQG.
PhylomeDBiP20169.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003660. HAMP_linker_domain.
IPR003594. HATPase_ATP-bd.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20169-1 [UniParc]FASTAAdd to Basket

« Hide

MGTSVSNPTA ILQTMQGFLR KWWSEFNLQT RLMAAATLVV SLLMSGLTFW    50
AVNTIQEDAQ LVDTRFGRDV GLLLAANVAP MIADKNLTEV ARFSSRFYEN 100
TSNIRYMIYA DPSGKIFFGI PYSEETVQNS LTLERRIELP QIDPHNFDQP 150
FVRQHHTPNG DVTDVFIPLQ YQGKFLGVLA IGINPNPAAV NSSNLTRDVT 200
IAVFISIWVM VILGAVFNAL TITQPIKELL LGVKNIAAGN FKQRITLPFG 250
GELGELIVNF NEMAERLERY EAQNIEELTA EKAKLDTLVS TIADGAMLVD 300
TNLQLLLVNP TARRLFAWEN KPIIGENLLE NLPPEITAQL TQPLRELAAD 350
QGSLLFSPGH GPQEEEQDKT YAPEEFRISL TQPFPRTIRL MLTQVLDQNR 400
ENLRGIVMTV QDITREVELN EAKSQFISNV SHELRTPLFN IKSFIETLSE 450
FGEDLSEVER KEFLETANHE TDRLSRLVND VLDLSKLESS KIYQLDAVDL 500
YQLIEQSLRS YQLNAKDKQL QLEKILDPDL PFALGNYDLL LQVMTNLIGN 550
SFKFTKAGGK IIVRAYPLHR SNLRAEDGPG LVRVEISDTG IGIDPEDQAA 600
IFERFYRVEN RVHTLEGTGL GLSIVKNIIA KHQSQIHLVS EVGVGTTFWF 650
DLAVYQSMLM VVG 663
Length:663
Mass (Da):74,536
Last modified:November 1, 1997 - v2
Checksum:i42CD7CA67E396586
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72856 Genomic DNA. Translation: CAA51377.1.
BA000022 Genomic DNA. Translation: BAA16687.1.
J04195 Genomic DNA. No translation available.
PIRiS74535.
RefSeqiNP_440007.1. NC_000911.1.
YP_005650063.1. NC_017277.1.
YP_007449890.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA16687; BAA16687; BAA16687.
GeneIDi953218.
KEGGisyn:sll0698.
syy:SYNGTS_0110.
syz:MYO_11090.
PATRICi23837088. VBISynSp132158_0119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72856 Genomic DNA. Translation: CAA51377.1 .
BA000022 Genomic DNA. Translation: BAA16687.1 .
J04195 Genomic DNA. No translation available.
PIRi S74535.
RefSeqi NP_440007.1. NC_000911.1.
YP_005650063.1. NC_017277.1.
YP_007449890.1. NC_020286.1.

3D structure databases

ProteinModelPortali P20169.
ModBasei Search...

Protein-protein interaction databases

IntActi P20169. 1 interaction.
STRINGi 1148.sll0698.

Proteomic databases

PaxDbi P20169.
PRIDEi P20169.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA16687 ; BAA16687 ; BAA16687 .
GeneIDi 953218.
KEGGi syn:sll0698.
syy:SYNGTS_0110.
syz:MYO_11090.
PATRICi 23837088. VBISynSp132158_0119.

Phylogenomic databases

eggNOGi COG0642.
HOGENOMi HOG000233124.
KOi K07769.
OMAi LFRWEGR.
OrthoDBi EOG6G4VQG.
PhylomeDBi P20169.

Enzyme and pathway databases

BRENDAi 2.7.13.3. 6185.

Family and domain databases

Gene3Di 1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProi IPR003661. EnvZ-like_dim/P.
IPR003660. HAMP_linker_domain.
IPR003594. HATPase_ATP-bd.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view ]
Pfami PF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view ]
PRINTSi PR00344. BCTRLSENSOR.
SMARTi SM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF47384. SSF47384. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The dspA gene product of the cyanobacterium Synechocystis sp. strain PCC 6803 influences sensitivity to chemically different growth inhibitors and has amino acid similarity to histidine protein kinases."
    Bartsevich V.V., Shestakov S.V.
    Microbiology 141:2915-2920(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  3. "Molecular cloning and sequencing of the psaD gene encoding subunit II of photosystem I from the cyanobacterium, Synechocystis sp. PCC 6803."
    Reilly P., Hulmes J.D., Pan Y.-C.E., Nelson N.
    J. Biol. Chem. 263:17658-17662(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.

Entry informationi

Entry nameiDSPA_SYNY3
AccessioniPrimary (citable) accession number: P20169
Secondary accession number(s): Q55232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Mutations in dspA results in resistance to herbicides difunon, diuron and calmodulin antagonists chlorpromazine and trifluoperazine.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi