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P20169

- DSPA_SYNY3

UniProt

P20169 - DSPA_SYNY3

Protein

Drug sensory protein A

Gene

dspA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorelay sensor kinase activity Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: InterPro
    2. response to herbicide Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Herbicide resistance, Two-component regulatory system

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.13.3. 6185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Drug sensory protein A (EC:2.7.13.3)
    Gene namesi
    Name:dspA
    Synonyms:dfr
    Ordered Locus Names:sll0698
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 663663Drug sensory protein APRO_0000074758Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei432 – 4321Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP20169.
    PRIDEiP20169.

    Interactioni

    Protein-protein interaction databases

    IntActiP20169. 1 interaction.
    STRINGi1148.sll0698.

    Structurei

    3D structure databases

    ProteinModelPortaliP20169.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini220 – 27253HAMPPROSITE-ProRule annotationAdd
    BLAST
    Domaini281 – 35171PASPROSITE-ProRule annotationAdd
    BLAST
    Domaini429 – 656228Histidine kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HAMP domain.PROSITE-ProRule annotation
    Contains 1 histidine kinase domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0642.
    HOGENOMiHOG000233124.
    KOiK07769.
    OMAiLFRWEGR.
    OrthoDBiEOG6G4VQG.
    PhylomeDBiP20169.

    Family and domain databases

    Gene3Di1.10.287.130. 1 hit.
    3.30.565.10. 1 hit.
    InterProiIPR003661. EnvZ-like_dim/P.
    IPR003660. HAMP_linker_domain.
    IPR003594. HATPase_ATP-bd.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    [Graphical view]
    PfamiPF00672. HAMP. 1 hit.
    PF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view]
    PRINTSiPR00344. BCTRLSENSOR.
    SMARTiSM00304. HAMP. 1 hit.
    SM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF47384. SSF47384. 1 hit.
    SSF55785. SSF55785. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEiPS50885. HAMP. 1 hit.
    PS50109. HIS_KIN. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20169-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTSVSNPTA ILQTMQGFLR KWWSEFNLQT RLMAAATLVV SLLMSGLTFW    50
    AVNTIQEDAQ LVDTRFGRDV GLLLAANVAP MIADKNLTEV ARFSSRFYEN 100
    TSNIRYMIYA DPSGKIFFGI PYSEETVQNS LTLERRIELP QIDPHNFDQP 150
    FVRQHHTPNG DVTDVFIPLQ YQGKFLGVLA IGINPNPAAV NSSNLTRDVT 200
    IAVFISIWVM VILGAVFNAL TITQPIKELL LGVKNIAAGN FKQRITLPFG 250
    GELGELIVNF NEMAERLERY EAQNIEELTA EKAKLDTLVS TIADGAMLVD 300
    TNLQLLLVNP TARRLFAWEN KPIIGENLLE NLPPEITAQL TQPLRELAAD 350
    QGSLLFSPGH GPQEEEQDKT YAPEEFRISL TQPFPRTIRL MLTQVLDQNR 400
    ENLRGIVMTV QDITREVELN EAKSQFISNV SHELRTPLFN IKSFIETLSE 450
    FGEDLSEVER KEFLETANHE TDRLSRLVND VLDLSKLESS KIYQLDAVDL 500
    YQLIEQSLRS YQLNAKDKQL QLEKILDPDL PFALGNYDLL LQVMTNLIGN 550
    SFKFTKAGGK IIVRAYPLHR SNLRAEDGPG LVRVEISDTG IGIDPEDQAA 600
    IFERFYRVEN RVHTLEGTGL GLSIVKNIIA KHQSQIHLVS EVGVGTTFWF 650
    DLAVYQSMLM VVG 663
    Length:663
    Mass (Da):74,536
    Last modified:November 1, 1997 - v2
    Checksum:i42CD7CA67E396586
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72856 Genomic DNA. Translation: CAA51377.1.
    BA000022 Genomic DNA. Translation: BAA16687.1.
    J04195 Genomic DNA. No translation available.
    PIRiS74535.
    RefSeqiNP_440007.1. NC_000911.1.
    YP_005650063.1. NC_017277.1.
    YP_007449890.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA16687; BAA16687; BAA16687.
    GeneIDi953218.
    KEGGisyn:sll0698.
    syy:SYNGTS_0110.
    syz:MYO_11090.
    PATRICi23837088. VBISynSp132158_0119.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72856 Genomic DNA. Translation: CAA51377.1 .
    BA000022 Genomic DNA. Translation: BAA16687.1 .
    J04195 Genomic DNA. No translation available.
    PIRi S74535.
    RefSeqi NP_440007.1. NC_000911.1.
    YP_005650063.1. NC_017277.1.
    YP_007449890.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P20169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P20169. 1 interaction.
    STRINGi 1148.sll0698.

    Proteomic databases

    PaxDbi P20169.
    PRIDEi P20169.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA16687 ; BAA16687 ; BAA16687 .
    GeneIDi 953218.
    KEGGi syn:sll0698.
    syy:SYNGTS_0110.
    syz:MYO_11090.
    PATRICi 23837088. VBISynSp132158_0119.

    Phylogenomic databases

    eggNOGi COG0642.
    HOGENOMi HOG000233124.
    KOi K07769.
    OMAi LFRWEGR.
    OrthoDBi EOG6G4VQG.
    PhylomeDBi P20169.

    Enzyme and pathway databases

    BRENDAi 2.7.13.3. 6185.

    Family and domain databases

    Gene3Di 1.10.287.130. 1 hit.
    3.30.565.10. 1 hit.
    InterProi IPR003661. EnvZ-like_dim/P.
    IPR003660. HAMP_linker_domain.
    IPR003594. HATPase_ATP-bd.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    [Graphical view ]
    Pfami PF00672. HAMP. 1 hit.
    PF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view ]
    PRINTSi PR00344. BCTRLSENSOR.
    SMARTi SM00304. HAMP. 1 hit.
    SM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47384. SSF47384. 1 hit.
    SSF55785. SSF55785. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEi PS50885. HAMP. 1 hit.
    PS50109. HIS_KIN. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The dspA gene product of the cyanobacterium Synechocystis sp. strain PCC 6803 influences sensitivity to chemically different growth inhibitors and has amino acid similarity to histidine protein kinases."
      Bartsevich V.V., Shestakov S.V.
      Microbiology 141:2915-2920(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.
    3. "Molecular cloning and sequencing of the psaD gene encoding subunit II of photosystem I from the cyanobacterium, Synechocystis sp. PCC 6803."
      Reilly P., Hulmes J.D., Pan Y.-C.E., Nelson N.
      J. Biol. Chem. 263:17658-17662(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.

    Entry informationi

    Entry nameiDSPA_SYNY3
    AccessioniPrimary (citable) accession number: P20169
    Secondary accession number(s): Q55232
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Mutations in dspA results in resistance to herbicides difunon, diuron and calmodulin antagonists chlorpromazine and trifluoperazine.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3