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P20167

- TRPF_BACSU

UniProt

P20167 - TRPF_BACSU

Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciBSUB:BSU22650-MONOMER.
    UniPathwayiUPA00035; UER00042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:trpF
    Ordered Locus Names:BSU22650
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU22650. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154347Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU22650.

    Structurei

    3D structure databases

    ProteinModelPortaliP20167.
    SMRiP20167. Positions 5-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpF family.Curated

    Phylogenomic databases

    HOGENOMiHOG000161598.
    KOiK01817.
    OrthoDBiEOG6N94DF.
    PhylomeDBiP20167.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P20167-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKPALKYCG IRSLKDLQLA AESQADYLGF IFAESKRKVS PEDVKKWLNQ    50
    VRVEKQVAGV FVNESIETMS RIAKSLKLDV IQLHGDEKPA DAAALRKLTG 100
    CEIWKALHHQ DNTTQEIARF KDNVDGFVID SSVKGSRGGT GVAFSWECVP 150
    EYQQAAIGKR CFIAGGVNPD SITRLLKWQP EGIDLASGIE KNGQKDQNLM 200
    RLLEERMNRY VSISE 215
    Length:215
    Mass (Da):24,041
    Last modified:July 28, 2009 - v3
    Checksum:i0153C28BA53DC9ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151K → Q in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti15 – 151K → Q in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti22 – 221E → D in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti22 – 221E → D in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti36 – 361K → Y in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti36 – 361K → Y in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti42 – 421E → Q in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti42 – 421E → Q in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti49 – 491N → S in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti49 – 491N → S in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti52 – 521R → C in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti52 – 521R → C in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti74 – 774KSLK → EDLN in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti74 – 774KSLK → EDLN in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti88 – 881K → E in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti88 – 881K → E in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti93 – 931A → D in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti93 – 931A → D in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti97 – 971K → M in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti97 – 971K → M in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti100 – 1001G → D in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti100 – 1001G → D in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti110 – 1112QD → HE in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti110 – 1112QD → HE in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti123 – 1231N → D in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti123 – 1231N → D in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti136 – 1361S → A in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti136 – 1361S → A in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti147 – 1471E → D in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti147 – 1471E → D in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti171 – 1711S → T in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti171 – 1711S → T in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti174 – 1785RLLKW → DLMKY in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti174 – 1785RLLKW → DLMKY in AAA22868. (PubMed:3924737)Curated
    Sequence conflicti181 – 1811E → A in AAA20864. (PubMed:3924737)Curated
    Sequence conflicti181 – 1811E → A in AAA22868. (PubMed:3924737)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80245 Genomic DNA. Translation: AAA20864.1.
    K01391 Genomic DNA. Translation: AAA22868.1.
    AL009126 Genomic DNA. Translation: CAB14181.3.
    PIRiD22794.
    RefSeqiNP_390146.3. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB14181; CAB14181; BSU22650.
    GeneIDi939006.
    KEGGibsu:BSU22650.
    PATRICi18976339. VBIBacSub10457_2360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80245 Genomic DNA. Translation: AAA20864.1 .
    K01391 Genomic DNA. Translation: AAA22868.1 .
    AL009126 Genomic DNA. Translation: CAB14181.3 .
    PIRi D22794.
    RefSeqi NP_390146.3. NC_000964.3.

    3D structure databases

    ProteinModelPortali P20167.
    SMRi P20167. Positions 5-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU22650.

    Protocols and materials databases

    DNASUi 939006.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB14181 ; CAB14181 ; BSU22650 .
    GeneIDi 939006.
    KEGGi bsu:BSU22650.
    PATRICi 18976339. VBIBacSub10457_2360.

    Organism-specific databases

    GenoListi BSU22650. [Micado ]

    Phylogenomic databases

    HOGENOMi HOG000161598.
    KOi K01817.
    OrthoDBi EOG6N94DF.
    PhylomeDBi P20167.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    BioCyci BSUB:BSU22650-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the Bacillus subtilis tryptophan operon."
      Henner D.J., Band L., Shimotsu H.
      Gene 34:169-177(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "Detecting and analyzing DNA sequencing errors: toward a higher quality of the Bacillus subtilis genome sequence."
      Medigue C., Rose M., Viari A., Danchin A.
      Genome Res. 9:1116-1127(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
      Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
      Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 92 AND 147.

    Entry informationi

    Entry nameiTRPF_BACSU
    AccessioniPrimary (citable) accession number: P20167
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3