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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU22650-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpF
Ordered Locus Names:BSU22650
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570 Componenti: Chromosome

Organism-specific databases

GenoListiBSU22650. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154347Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU22650.

Structurei

3D structure databases

ProteinModelPortaliP20167.
SMRiP20167. Positions 5-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

HOGENOMiHOG000161598.
InParanoidiP20167.
KOiK01817.
OMAiCEIWKAL.
OrthoDBiEOG6N94DF.
PhylomeDBiP20167.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

P20167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKPALKYCG IRSLKDLQLA AESQADYLGF IFAESKRKVS PEDVKKWLNQ
60 70 80 90 100
VRVEKQVAGV FVNESIETMS RIAKSLKLDV IQLHGDEKPA DAAALRKLTG
110 120 130 140 150
CEIWKALHHQ DNTTQEIARF KDNVDGFVID SSVKGSRGGT GVAFSWECVP
160 170 180 190 200
EYQQAAIGKR CFIAGGVNPD SITRLLKWQP EGIDLASGIE KNGQKDQNLM
210
RLLEERMNRY VSISE
Length:215
Mass (Da):24,041
Last modified:July 28, 2009 - v3
Checksum:i0153C28BA53DC9ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151K → Q in AAA20864 (PubMed:3924737).Curated
Sequence conflicti15 – 151K → Q in AAA22868 (PubMed:3924737).Curated
Sequence conflicti22 – 221E → D in AAA20864 (PubMed:3924737).Curated
Sequence conflicti22 – 221E → D in AAA22868 (PubMed:3924737).Curated
Sequence conflicti36 – 361K → Y in AAA20864 (PubMed:3924737).Curated
Sequence conflicti36 – 361K → Y in AAA22868 (PubMed:3924737).Curated
Sequence conflicti42 – 421E → Q in AAA20864 (PubMed:3924737).Curated
Sequence conflicti42 – 421E → Q in AAA22868 (PubMed:3924737).Curated
Sequence conflicti49 – 491N → S in AAA20864 (PubMed:3924737).Curated
Sequence conflicti49 – 491N → S in AAA22868 (PubMed:3924737).Curated
Sequence conflicti52 – 521R → C in AAA20864 (PubMed:3924737).Curated
Sequence conflicti52 – 521R → C in AAA22868 (PubMed:3924737).Curated
Sequence conflicti74 – 774KSLK → EDLN in AAA20864 (PubMed:3924737).Curated
Sequence conflicti74 – 774KSLK → EDLN in AAA22868 (PubMed:3924737).Curated
Sequence conflicti88 – 881K → E in AAA20864 (PubMed:3924737).Curated
Sequence conflicti88 – 881K → E in AAA22868 (PubMed:3924737).Curated
Sequence conflicti93 – 931A → D in AAA20864 (PubMed:3924737).Curated
Sequence conflicti93 – 931A → D in AAA22868 (PubMed:3924737).Curated
Sequence conflicti97 – 971K → M in AAA20864 (PubMed:3924737).Curated
Sequence conflicti97 – 971K → M in AAA22868 (PubMed:3924737).Curated
Sequence conflicti100 – 1001G → D in AAA20864 (PubMed:3924737).Curated
Sequence conflicti100 – 1001G → D in AAA22868 (PubMed:3924737).Curated
Sequence conflicti110 – 1112QD → HE in AAA20864 (PubMed:3924737).Curated
Sequence conflicti110 – 1112QD → HE in AAA22868 (PubMed:3924737).Curated
Sequence conflicti123 – 1231N → D in AAA20864 (PubMed:3924737).Curated
Sequence conflicti123 – 1231N → D in AAA22868 (PubMed:3924737).Curated
Sequence conflicti136 – 1361S → A in AAA20864 (PubMed:3924737).Curated
Sequence conflicti136 – 1361S → A in AAA22868 (PubMed:3924737).Curated
Sequence conflicti147 – 1471E → D in AAA20864 (PubMed:3924737).Curated
Sequence conflicti147 – 1471E → D in AAA22868 (PubMed:3924737).Curated
Sequence conflicti171 – 1711S → T in AAA20864 (PubMed:3924737).Curated
Sequence conflicti171 – 1711S → T in AAA22868 (PubMed:3924737).Curated
Sequence conflicti174 – 1785RLLKW → DLMKY in AAA20864 (PubMed:3924737).Curated
Sequence conflicti174 – 1785RLLKW → DLMKY in AAA22868 (PubMed:3924737).Curated
Sequence conflicti181 – 1811E → A in AAA20864 (PubMed:3924737).Curated
Sequence conflicti181 – 1811E → A in AAA22868 (PubMed:3924737).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80245 Genomic DNA. Translation: AAA20864.1.
K01391 Genomic DNA. Translation: AAA22868.1.
AL009126 Genomic DNA. Translation: CAB14181.3.
PIRiD22794.
RefSeqiNP_390146.3. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB14181; CAB14181; BSU22650.
GeneIDi939006.
KEGGibsu:BSU22650.
PATRICi18976339. VBIBacSub10457_2360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80245 Genomic DNA. Translation: AAA20864.1.
K01391 Genomic DNA. Translation: AAA22868.1.
AL009126 Genomic DNA. Translation: CAB14181.3.
PIRiD22794.
RefSeqiNP_390146.3. NC_000964.3.

3D structure databases

ProteinModelPortaliP20167.
SMRiP20167. Positions 5-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU22650.

Protocols and materials databases

DNASUi939006.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14181; CAB14181; BSU22650.
GeneIDi939006.
KEGGibsu:BSU22650.
PATRICi18976339. VBIBacSub10457_2360.

Organism-specific databases

GenoListiBSU22650. [Micado]

Phylogenomic databases

HOGENOMiHOG000161598.
InParanoidiP20167.
KOiK01817.
OMAiCEIWKAL.
OrthoDBiEOG6N94DF.
PhylomeDBiP20167.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.
BioCyciBSUB:BSU22650-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the Bacillus subtilis tryptophan operon."
    Henner D.J., Band L., Shimotsu H.
    Gene 34:169-177(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Detecting and analyzing DNA sequencing errors: toward a higher quality of the Bacillus subtilis genome sequence."
    Medigue C., Rose M., Viari A., Danchin A.
    Genome Res. 9:1116-1127(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 92 AND 147.

Entry informationi

Entry nameiTRPF_BACSU
AccessioniPrimary (citable) accession number: P20167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 28, 2009
Last modified: April 1, 2015
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.