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P20163

- HSP7D_CAEEL

UniProt

P20163 - HSP7D_CAEEL

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Protein
Heat shock 70 kDa protein D
Gene
hsp-4, hsp70d, F43E2.8
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II transcription factor binding Source: WormBase

GO - Biological processi

  1. embryo development Source: WormBase
  2. endoplasmic reticulum unfolded protein response Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_34502. ATF6-alpha activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein D
Gene namesi
Name:hsp-4
Synonyms:hsp70d
ORF Names:F43E2.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiF43E2.8a; CE07244; WBGene00002008; hsp-4.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum chaperone complex Source: WormBase
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 657640Heat shock 70 kDa protein D
PRO_0000013542Add
BLAST

Proteomic databases

PaxDbiP20163.
PRIDEiP20163.

2D gel databases

World-2DPAGE0020:P20163.

Interactioni

Protein-protein interaction databases

BioGridi39538. 5 interactions.
DIPiDIP-26704N.
IntActiP20163. 3 interactions.
MINTiMINT-1050534.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi426 – 4305
Turni431 – 4333
Beta strandi434 – 4396
Beta strandi444 – 45714
Beta strandi463 – 4719
Helixi475 – 4773
Beta strandi478 – 4869
Beta strandi499 – 5057
Beta strandi511 – 5177
Turni518 – 5203
Beta strandi523 – 5286
Beta strandi530 – 5334
Helixi537 – 54913
Helixi551 – 56010
Beta strandi565 – 5673

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OP6X-ray1.85A420-568[»]
ProteinModelPortaliP20163.
SMRiP20163. Positions 29-641.

Miscellaneous databases

EvolutionaryTraceiP20163.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi654 – 6574Prevents secretion from ER

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
GeneTreeiENSGT00750000117237.
HOGENOMiHOG000228135.
InParanoidiP20163.
OMAiERECFIG.
OrthoDBiEOG780RKX.
PhylomeDBiP20163.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20163-1 [UniParc]FASTAAdd to Basket

« Hide

MKVFSLILIA FVANAYCDEG ASTEKEEKMG TIIGIDLGTT YSCVGVFKNG    50
RVEIIANDQG NRITPSYVAF SGDQGERLIG DAAKNQLTIN PENTIFDAKR 100
LIGRFYNEKT VQQDIKHWPF KIVDKSNKPN VEVKVGSETK QFTPEEVSAM 150
VLTKMKQIAE SYLGHEVKNA VVTVPAYFND AQKQATKDAG SIAGLNVVRI 200
INEPTAAAIA YGLDKKDGER NILVFDLGGG TFDVSLLTID SGVFEVLATN 250
GDTHLGGEDF DQRVMEYFIK LYKKKSGKDL RKDNRAVQKL RREVEKAKRA 300
LSTQHQTKIE IESLFDGEDF SETLTRAKFE ELNMDLFRAT LKPVQKVLED 350
ADMKKTDVHE IVLVGGSTRI PKVQQLIKDY FNGKEPSRGI NPDEAVAYGA 400
AVQAGVIGGV ENTGDVVLLD VNPLTLGIET VGGVMTKLIG RNTVIPTKKS 450
QVFSTAADSQ SAVSIVIYEG ERPMVMDNHK LGNFDVTGIP PAPRGVPQIE 500
VTFEIDVNGI LHVSAEDKGT GNKNKLTITN DHNRLSPEDI ERMINDADKF 550
AADDQAQKEK VESRNELEAY AYQMKTQIAD KEKLGGKLTD EDKVSIESAV 600
ERAIEWLGSN QDASTEENKE QKKELESVVQ PIVSKLYSAG GQGEQASEEP 650
SEDHDEL 657
Length:657
Mass (Da):72,288
Last modified:August 16, 2004 - v2
Checksum:i0C046D3EF1B5592F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti454 – 4541S → P in AAA28076. 1 Publication
Sequence conflicti574 – 5741M → I in AAA28076. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080417 Genomic DNA. Translation: CCD63548.1.
M28528 Genomic DNA. Translation: AAA28076.1.
PIRiT34037.
RefSeqiNP_495536.1. NM_063135.6.
UniGeneiCel.38699.

Genome annotation databases

EnsemblMetazoaiF43E2.8.1; F43E2.8.1; WBGene00002008.
F43E2.8.2; F43E2.8.2; WBGene00002008.
GeneIDi174203.
KEGGicel:CELE_F43E2.8.
UCSCiF43E2.8.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080417 Genomic DNA. Translation: CCD63548.1 .
M28528 Genomic DNA. Translation: AAA28076.1 .
PIRi T34037.
RefSeqi NP_495536.1. NM_063135.6.
UniGenei Cel.38699.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2OP6 X-ray 1.85 A 420-568 [» ]
ProteinModelPortali P20163.
SMRi P20163. Positions 29-641.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 39538. 5 interactions.
DIPi DIP-26704N.
IntActi P20163. 3 interactions.
MINTi MINT-1050534.

2D gel databases

World-2DPAGE 0020:P20163.

Proteomic databases

PaxDbi P20163.
PRIDEi P20163.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F43E2.8.1 ; F43E2.8.1 ; WBGene00002008 .
F43E2.8.2 ; F43E2.8.2 ; WBGene00002008 .
GeneIDi 174203.
KEGGi cel:CELE_F43E2.8.
UCSCi F43E2.8.1. c. elegans.

Organism-specific databases

CTDi 174203.
WormBasei F43E2.8a ; CE07244 ; WBGene00002008 ; hsp-4.

Phylogenomic databases

eggNOGi COG0443.
GeneTreei ENSGT00750000117237.
HOGENOMi HOG000228135.
InParanoidi P20163.
OMAi ERECFIG.
OrthoDBi EOG780RKX.
PhylomeDBi P20163.

Enzyme and pathway databases

Reactomei REACT_34502. ATF6-alpha activates chaperone genes.

Miscellaneous databases

EvolutionaryTracei P20163.
NextBioi 882989.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Identification of a heat-shock pseudogene from Caenorhabditis elegans."
    Heschl M.F.P., Baillie D.L.
    Genome 32:190-195(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 370-657.

Entry informationi

Entry nameiHSP7D_CAEEL
AccessioniPrimary (citable) accession number: P20163
Secondary accession number(s): O02085
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi