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P20163

- HSP7D_CAEEL

UniProt

P20163 - HSP7D_CAEEL

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Protein

Heat shock 70 kDa protein D

Gene

hsp-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II transcription factor binding Source: WormBase

GO - Biological processi

  1. embryo development ending in birth or egg hatching Source: WormBase
  2. endoplasmic reticulum unfolded protein response Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_34502. ATF6-alpha activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein D
Gene namesi
Name:hsp-4
Synonyms:hsp70d
ORF Names:F43E2.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiF43E2.8a; CE07244; WBGene00002008; hsp-4.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum chaperone complex Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 657640Heat shock 70 kDa protein DPRO_0000013542Add
BLAST

Proteomic databases

PaxDbiP20163.
PRIDEiP20163.

2D gel databases

World-2DPAGE0020:P20163.

Interactioni

Protein-protein interaction databases

BioGridi39538. 5 interactions.
DIPiDIP-26704N.
IntActiP20163. 3 interactions.
MINTiMINT-1050534.

Structurei

Secondary structure

1
657
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi426 – 4305Combined sources
Turni431 – 4333Combined sources
Beta strandi434 – 4396Combined sources
Beta strandi444 – 45714Combined sources
Beta strandi463 – 4719Combined sources
Helixi475 – 4773Combined sources
Beta strandi478 – 4869Combined sources
Beta strandi499 – 5057Combined sources
Beta strandi511 – 5177Combined sources
Turni518 – 5203Combined sources
Beta strandi523 – 5286Combined sources
Beta strandi530 – 5334Combined sources
Helixi537 – 54913Combined sources
Helixi551 – 56010Combined sources
Beta strandi565 – 5673Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OP6X-ray1.85A420-568[»]
ProteinModelPortaliP20163.
SMRiP20163. Positions 29-639.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20163.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi654 – 6574Prevents secretion from ER

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
GeneTreeiENSGT00750000117237.
HOGENOMiHOG000228135.
InParanoidiP20163.
OMAiERECFIG.
OrthoDBiEOG780RKX.
PhylomeDBiP20163.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20163-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVFSLILIA FVANAYCDEG ASTEKEEKMG TIIGIDLGTT YSCVGVFKNG
60 70 80 90 100
RVEIIANDQG NRITPSYVAF SGDQGERLIG DAAKNQLTIN PENTIFDAKR
110 120 130 140 150
LIGRFYNEKT VQQDIKHWPF KIVDKSNKPN VEVKVGSETK QFTPEEVSAM
160 170 180 190 200
VLTKMKQIAE SYLGHEVKNA VVTVPAYFND AQKQATKDAG SIAGLNVVRI
210 220 230 240 250
INEPTAAAIA YGLDKKDGER NILVFDLGGG TFDVSLLTID SGVFEVLATN
260 270 280 290 300
GDTHLGGEDF DQRVMEYFIK LYKKKSGKDL RKDNRAVQKL RREVEKAKRA
310 320 330 340 350
LSTQHQTKIE IESLFDGEDF SETLTRAKFE ELNMDLFRAT LKPVQKVLED
360 370 380 390 400
ADMKKTDVHE IVLVGGSTRI PKVQQLIKDY FNGKEPSRGI NPDEAVAYGA
410 420 430 440 450
AVQAGVIGGV ENTGDVVLLD VNPLTLGIET VGGVMTKLIG RNTVIPTKKS
460 470 480 490 500
QVFSTAADSQ SAVSIVIYEG ERPMVMDNHK LGNFDVTGIP PAPRGVPQIE
510 520 530 540 550
VTFEIDVNGI LHVSAEDKGT GNKNKLTITN DHNRLSPEDI ERMINDADKF
560 570 580 590 600
AADDQAQKEK VESRNELEAY AYQMKTQIAD KEKLGGKLTD EDKVSIESAV
610 620 630 640 650
ERAIEWLGSN QDASTEENKE QKKELESVVQ PIVSKLYSAG GQGEQASEEP

SEDHDEL
Length:657
Mass (Da):72,288
Last modified:August 16, 2004 - v2
Checksum:i0C046D3EF1B5592F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti454 – 4541S → P in AAA28076. (PubMed:2744444)Curated
Sequence conflicti574 – 5741M → I in AAA28076. (PubMed:2744444)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080417 Genomic DNA. Translation: CCD63548.1.
M28528 Genomic DNA. Translation: AAA28076.1.
PIRiT34037.
RefSeqiNP_495536.1. NM_063135.6.
UniGeneiCel.38699.

Genome annotation databases

EnsemblMetazoaiF43E2.8.1; F43E2.8.1; WBGene00002008.
F43E2.8.2; F43E2.8.2; WBGene00002008.
GeneIDi174203.
KEGGicel:CELE_F43E2.8.
UCSCiF43E2.8.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080417 Genomic DNA. Translation: CCD63548.1 .
M28528 Genomic DNA. Translation: AAA28076.1 .
PIRi T34037.
RefSeqi NP_495536.1. NM_063135.6.
UniGenei Cel.38699.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2OP6 X-ray 1.85 A 420-568 [» ]
ProteinModelPortali P20163.
SMRi P20163. Positions 29-639.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 39538. 5 interactions.
DIPi DIP-26704N.
IntActi P20163. 3 interactions.
MINTi MINT-1050534.

2D gel databases

World-2DPAGE 0020:P20163.

Proteomic databases

PaxDbi P20163.
PRIDEi P20163.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F43E2.8.1 ; F43E2.8.1 ; WBGene00002008 .
F43E2.8.2 ; F43E2.8.2 ; WBGene00002008 .
GeneIDi 174203.
KEGGi cel:CELE_F43E2.8.
UCSCi F43E2.8.1. c. elegans.

Organism-specific databases

CTDi 174203.
WormBasei F43E2.8a ; CE07244 ; WBGene00002008 ; hsp-4.

Phylogenomic databases

eggNOGi COG0443.
GeneTreei ENSGT00750000117237.
HOGENOMi HOG000228135.
InParanoidi P20163.
OMAi ERECFIG.
OrthoDBi EOG780RKX.
PhylomeDBi P20163.

Enzyme and pathway databases

Reactomei REACT_34502. ATF6-alpha activates chaperone genes.

Miscellaneous databases

EvolutionaryTracei P20163.
NextBioi 882989.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Identification of a heat-shock pseudogene from Caenorhabditis elegans."
    Heschl M.F.P., Baillie D.L.
    Genome 32:190-195(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 370-657.

Entry informationi

Entry nameiHSP7D_CAEEL
AccessioniPrimary (citable) accession number: P20163
Secondary accession number(s): O02085
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 16, 2004
Last modified: November 26, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3