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P20163 (HSP7D_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock 70 kDa protein D
Gene names
Name:hsp-4
Synonyms:hsp70d
ORF Names:F43E2.8
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen.

Sequence similarities

Belongs to the heat shock protein 70 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 657640Heat shock 70 kDa protein D
PRO_0000013542

Regions

Motif654 – 6574Prevents secretion from ER

Experimental info

Sequence conflict4541S → P in AAA28076. Ref.2
Sequence conflict5741M → I in AAA28076. Ref.2

Secondary structure

........................... 657
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P20163 [UniParc].

Last modified August 16, 2004. Version 2.
Checksum: 0C046D3EF1B5592F

FASTA65772,288
        10         20         30         40         50         60 
MKVFSLILIA FVANAYCDEG ASTEKEEKMG TIIGIDLGTT YSCVGVFKNG RVEIIANDQG 

        70         80         90        100        110        120 
NRITPSYVAF SGDQGERLIG DAAKNQLTIN PENTIFDAKR LIGRFYNEKT VQQDIKHWPF 

       130        140        150        160        170        180 
KIVDKSNKPN VEVKVGSETK QFTPEEVSAM VLTKMKQIAE SYLGHEVKNA VVTVPAYFND 

       190        200        210        220        230        240 
AQKQATKDAG SIAGLNVVRI INEPTAAAIA YGLDKKDGER NILVFDLGGG TFDVSLLTID 

       250        260        270        280        290        300 
SGVFEVLATN GDTHLGGEDF DQRVMEYFIK LYKKKSGKDL RKDNRAVQKL RREVEKAKRA 

       310        320        330        340        350        360 
LSTQHQTKIE IESLFDGEDF SETLTRAKFE ELNMDLFRAT LKPVQKVLED ADMKKTDVHE 

       370        380        390        400        410        420 
IVLVGGSTRI PKVQQLIKDY FNGKEPSRGI NPDEAVAYGA AVQAGVIGGV ENTGDVVLLD 

       430        440        450        460        470        480 
VNPLTLGIET VGGVMTKLIG RNTVIPTKKS QVFSTAADSQ SAVSIVIYEG ERPMVMDNHK 

       490        500        510        520        530        540 
LGNFDVTGIP PAPRGVPQIE VTFEIDVNGI LHVSAEDKGT GNKNKLTITN DHNRLSPEDI 

       550        560        570        580        590        600 
ERMINDADKF AADDQAQKEK VESRNELEAY AYQMKTQIAD KEKLGGKLTD EDKVSIESAV 

       610        620        630        640        650 
ERAIEWLGSN QDASTEENKE QKKELESVVQ PIVSKLYSAG GQGEQASEEP SEDHDEL 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Identification of a heat-shock pseudogene from Caenorhabditis elegans."
Heschl M.F.P., Baillie D.L.
Genome 32:190-195(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 370-657.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080417 Genomic DNA. Translation: CCD63548.1.
M28528 Genomic DNA. Translation: AAA28076.1.
PIRT34037.
RefSeqNP_495536.1. NM_063135.6.
UniGeneCel.38699.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2OP6X-ray1.85A420-568[»]
ProteinModelPortalP20163.
SMRP20163. Positions 29-641.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid39538. 5 interactions.
DIPDIP-26704N.
IntActP20163. 3 interactions.
MINTMINT-1050534.

2D gel databases

World-2DPAGE0020:P20163.

Proteomic databases

PaxDbP20163.
PRIDEP20163.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF43E2.8.1; F43E2.8.1; WBGene00002008.
F43E2.8.2; F43E2.8.2; WBGene00002008.
GeneID174203.
KEGGcel:CELE_F43E2.8.
UCSCF43E2.8.1. c. elegans.

Organism-specific databases

CTD174203.
WormBaseF43E2.8a; CE07244; WBGene00002008; hsp-4.

Phylogenomic databases

eggNOGCOG0443.
GeneTreeENSGT00750000117237.
HOGENOMHOG000228135.
InParanoidP20163.
OMAERECFIG.
OrthoDBEOG780RKX.
PhylomeDBP20163.

Family and domain databases

Gene3D1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
SUPFAMSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP20163.
NextBio882989.

Entry information

Entry nameHSP7D_CAEEL
AccessionPrimary (citable) accession number: P20163
Secondary accession number(s): O02085
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase