Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P20163

- HSP7D_CAEEL

UniProt

P20163 - HSP7D_CAEEL

Protein

Heat shock 70 kDa protein D

Gene

hsp-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (16 Aug 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. RNA polymerase II transcription factor binding Source: WormBase

    GO - Biological processi

    1. embryo development ending in birth or egg hatching Source: WormBase
    2. endoplasmic reticulum unfolded protein response Source: WormBase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_34502. ATF6-alpha activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock 70 kDa protein D
    Gene namesi
    Name:hsp-4
    Synonyms:hsp70d
    ORF Names:F43E2.8
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiF43E2.8a; CE07244; WBGene00002008; hsp-4.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum chaperone complex Source: WormBase
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 657640Heat shock 70 kDa protein DPRO_0000013542Add
    BLAST

    Proteomic databases

    PaxDbiP20163.
    PRIDEiP20163.

    2D gel databases

    World-2DPAGE0020:P20163.

    Interactioni

    Protein-protein interaction databases

    BioGridi39538. 5 interactions.
    DIPiDIP-26704N.
    IntActiP20163. 3 interactions.
    MINTiMINT-1050534.

    Structurei

    Secondary structure

    1
    657
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi426 – 4305
    Turni431 – 4333
    Beta strandi434 – 4396
    Beta strandi444 – 45714
    Beta strandi463 – 4719
    Helixi475 – 4773
    Beta strandi478 – 4869
    Beta strandi499 – 5057
    Beta strandi511 – 5177
    Turni518 – 5203
    Beta strandi523 – 5286
    Beta strandi530 – 5334
    Helixi537 – 54913
    Helixi551 – 56010
    Beta strandi565 – 5673

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2OP6X-ray1.85A420-568[»]
    ProteinModelPortaliP20163.
    SMRiP20163. Positions 29-641.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP20163.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi654 – 6574Prevents secretion from ER

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    GeneTreeiENSGT00750000117237.
    HOGENOMiHOG000228135.
    InParanoidiP20163.
    OMAiERECFIG.
    OrthoDBiEOG780RKX.
    PhylomeDBiP20163.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20163-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVFSLILIA FVANAYCDEG ASTEKEEKMG TIIGIDLGTT YSCVGVFKNG    50
    RVEIIANDQG NRITPSYVAF SGDQGERLIG DAAKNQLTIN PENTIFDAKR 100
    LIGRFYNEKT VQQDIKHWPF KIVDKSNKPN VEVKVGSETK QFTPEEVSAM 150
    VLTKMKQIAE SYLGHEVKNA VVTVPAYFND AQKQATKDAG SIAGLNVVRI 200
    INEPTAAAIA YGLDKKDGER NILVFDLGGG TFDVSLLTID SGVFEVLATN 250
    GDTHLGGEDF DQRVMEYFIK LYKKKSGKDL RKDNRAVQKL RREVEKAKRA 300
    LSTQHQTKIE IESLFDGEDF SETLTRAKFE ELNMDLFRAT LKPVQKVLED 350
    ADMKKTDVHE IVLVGGSTRI PKVQQLIKDY FNGKEPSRGI NPDEAVAYGA 400
    AVQAGVIGGV ENTGDVVLLD VNPLTLGIET VGGVMTKLIG RNTVIPTKKS 450
    QVFSTAADSQ SAVSIVIYEG ERPMVMDNHK LGNFDVTGIP PAPRGVPQIE 500
    VTFEIDVNGI LHVSAEDKGT GNKNKLTITN DHNRLSPEDI ERMINDADKF 550
    AADDQAQKEK VESRNELEAY AYQMKTQIAD KEKLGGKLTD EDKVSIESAV 600
    ERAIEWLGSN QDASTEENKE QKKELESVVQ PIVSKLYSAG GQGEQASEEP 650
    SEDHDEL 657
    Length:657
    Mass (Da):72,288
    Last modified:August 16, 2004 - v2
    Checksum:i0C046D3EF1B5592F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti454 – 4541S → P in AAA28076. (PubMed:2744444)Curated
    Sequence conflicti574 – 5741M → I in AAA28076. (PubMed:2744444)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080417 Genomic DNA. Translation: CCD63548.1.
    M28528 Genomic DNA. Translation: AAA28076.1.
    PIRiT34037.
    RefSeqiNP_495536.1. NM_063135.6.
    UniGeneiCel.38699.

    Genome annotation databases

    EnsemblMetazoaiF43E2.8.1; F43E2.8.1; WBGene00002008.
    F43E2.8.2; F43E2.8.2; WBGene00002008.
    GeneIDi174203.
    KEGGicel:CELE_F43E2.8.
    UCSCiF43E2.8.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080417 Genomic DNA. Translation: CCD63548.1 .
    M28528 Genomic DNA. Translation: AAA28076.1 .
    PIRi T34037.
    RefSeqi NP_495536.1. NM_063135.6.
    UniGenei Cel.38699.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2OP6 X-ray 1.85 A 420-568 [» ]
    ProteinModelPortali P20163.
    SMRi P20163. Positions 29-641.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 39538. 5 interactions.
    DIPi DIP-26704N.
    IntActi P20163. 3 interactions.
    MINTi MINT-1050534.

    2D gel databases

    World-2DPAGE 0020:P20163.

    Proteomic databases

    PaxDbi P20163.
    PRIDEi P20163.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F43E2.8.1 ; F43E2.8.1 ; WBGene00002008 .
    F43E2.8.2 ; F43E2.8.2 ; WBGene00002008 .
    GeneIDi 174203.
    KEGGi cel:CELE_F43E2.8.
    UCSCi F43E2.8.1. c. elegans.

    Organism-specific databases

    CTDi 174203.
    WormBasei F43E2.8a ; CE07244 ; WBGene00002008 ; hsp-4.

    Phylogenomic databases

    eggNOGi COG0443.
    GeneTreei ENSGT00750000117237.
    HOGENOMi HOG000228135.
    InParanoidi P20163.
    OMAi ERECFIG.
    OrthoDBi EOG780RKX.
    PhylomeDBi P20163.

    Enzyme and pathway databases

    Reactomei REACT_34502. ATF6-alpha activates chaperone genes.

    Miscellaneous databases

    EvolutionaryTracei P20163.
    NextBioi 882989.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Identification of a heat-shock pseudogene from Caenorhabditis elegans."
      Heschl M.F.P., Baillie D.L.
      Genome 32:190-195(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 370-657.

    Entry informationi

    Entry nameiHSP7D_CAEEL
    AccessioniPrimary (citable) accession number: P20163
    Secondary accession number(s): O02085
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3