Protein lin-11 - Caenorhabditis elegans

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P20154 (LIN11_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 113. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein lin-11

Alternative name(s):
Abnormal cell lineage protein 11

Gene names

Name:	lin-11
ORF Names:	ZC247.3

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Required for asymmetric division of vulval blast cells.

Subcellular location

Nucleus.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox LIM domain Repeat
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
PTM	Isopeptide bond Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axonal fasciculation Inferred from mutant phenotype PubMed 8325236. Source: WormBase cell fate specification Inferred from mutant phenotype PubMed 11546744. Source: WormBase oviposition Inferred from mutant phenotype PubMed 12074555. Source: WormBase positive regulation of vulval development Inferred from mutant phenotype PubMed 12074555 PubMed 3996896. Source: WormBase regulation of cell differentiation Inferred from mutant phenotype PubMed 12074555. Source: WormBase regulation of cell migration Inferred from mutant phenotype PubMed 12074555. Source: WormBase
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity Ref.2. Source: WormBase zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 405

405

Protein lin-11

PRO_0000075814

Regions

Domain

68 – 124

LIM zinc-binding 1

Domain

127 – 187

LIM zinc-binding 2

DNA binding

241 – 300

Homeobox

Compositional bias

301 – 405

105

Pro-rich

Amino acid modifications

Cross-link

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) Probable

Cross-link

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) Probable

Sequences

Sequence

Length

Mass (Da)

Tools

P20154 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: F9B507780079B442
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FASTA

405

45,777

        10         20         30         40         50         60 
MHSSSSFIIT SLEEEEKKPP AHHLHQQSIE DVGSVTSSAT LLLLDSATWM MPSSTTQPHI 

        70         80         90        100        110        120 
SEISGNECAA CAQPILDRYV FTVLGKCWHQ SCLRCCDCRA PMSMTCFSRD GLILCKTDFS 

       130        140        150        160        170        180 
RRYSQRCAGC DGKLEKEDLV RRARDKVFHI RCFQCSVCQR LLDTGDQLYI MEGNRFVCQS 

       190        200        210        220        230        240 
DFQTATKTST PTSIHRPVSN GSECNSDVEE DNVDACDEVG LDDGEGDCGK DNSDDSNSAK 

       250        260        270        280        290        300 
RRGPRTTIKA KQLETLKNAF AATPKPTRHI REQLAAETGL NMRVIQVWFQ NRRSKERRMK 

       310        320        330        340        350        360 
QLRFGGYRQS RRPRRDDIVD MFPNDQQFYP PPPPSNVQFF CDPYTTSPNN PETIQMAPQF 

       370        380        390        400 
AVPTENMNMV PEPYTEQSAT PPEFNEDTFA CIYSTDLGKP TPVSW

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11." Freyd G., Kim S.K., Horvitz H.R. Nature 344:876-879(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-405. Strain: Bristol N2.
[3]	"The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain." Li P.M., Reichert J., Freyd G., Horvitz H.R., Walsh C.T. Proc. Natl. Acad. Sci. U.S.A. 88:9210-9213(1991) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF LIM DOMAIN METAL-BINDING.
[4]	"The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans." Broday L., Kolotuev I., Didier C., Bhoumik A., Gupta B.P., Sternberg P.W., Podbilewicz B., Ronai Z. Genes Dev. 18:2380-2391(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SUMOYLATION AT LYS-17 AND LYS-18.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z80221 Genomic DNA. Translation: CAB02310.1. X54355 mRNA. Translation: CAA38240.1.
PIR	T27509.
RefSeq	NP_492696.1. NM_060295.4.
3D structure databases
ProteinModelPortal	P20154.
SMR	P20154. Positions 68-188, 247-297.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.ZC247.3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZC247.3; ZC247.3; ZC247.3.
GeneID	172893.
KEGG	cel:CELE_ZC247.3.
UCSC	ZC247.3. c. elegans.
Organism-specific databases
CTD	172893.
WormBase	ZC247.3; CE15150; WBGene00003000; lin-11.
Phylogenomic databases
eggNOG	NOG257130.
GeneTree	ENSGT00700000104177.
HOGENOM	HOG000231630.
InParanoid	P20154.
KO	K09372.
OMA	NDQQFYP.
Family and domain databases
Gene3D	1.10.10.60. 1 hit. 2.10.110.10. 2 hits.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF00412. LIM. 2 hits. [Graphical view]
SMART	SM00389. HOX. 1 hit. SM00132. LIM. 2 hits. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	877423.

Entry information

Entry name

LIN11_CAEEL

Accession

Primary (citable) accession number: P20154

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents