Reviewed, UniProtKB/Swiss-Prot P20137 (GST5_CHICK)

Names and origin

Protein names	Recommended name:     Glutathione S-transferase 5     EC=2.5.1.18 Alternative name(s):     GST-CL5     GST class-sigma
Organism	Gallus gallus (Chicken)
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	28 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the GST superfamily. Sigma family. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›28	›28	Glutathione S-transferase 5		PRO_0000185921
Regions
	Domain	1 – ›28	›28	GST N-terminal
Experimental info
	Non-terminal residue	28	1

Sequences

	Sequence		Length	Mass (Da)
	P20137-1 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: DA51DC0ABD203B12	FASTA	28	3,389
	10 20 PNYKLTYFNL RGRAEISRYL FAYAGIKY

References

[1]	"Characterization of glutathione S-transferases from day-old chick livers." Chang L.-H., Chuang L.-F., Tsai C.-P., Tu C.-P.D., Tam M.F. Biochemistry 29:744-750(1990) [PubMed: 2337594] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver.

Cross-references

Sequence databases
IPI	IPI00578428.
PIR	C33948.
3D structure databases
HSSP	HSSP built from PDB template 1IYH based on UniProtKB O60760.
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALG00000010402. Gallus gallus. [Contig view]
Phylogenomic databases
HOVERGEN	P20137.
Enzyme and pathway databases
BRENDA	2.5.1.18. 4.
Family and domain databases
InterPro	IPR004045. Glutathione_S-Trfase_N. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF02798. GST_N. 1 hit. [Graphical view]
PROSITE	PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GST5_CHICK

Accession

Primary (citable) accession number: P20137

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)