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P20135

- GSTT1_CHICK

UniProt

P20135 - GSTT1_CHICK

Protein

Glutathione S-transferase theta-1

Gene

GSTT1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_222911. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase theta-1 (EC:2.5.1.18)
    Alternative name(s):
    GST class-theta
    GST-CL1
    Gene namesi
    Name:GSTT1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 15

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 261260Glutathione S-transferase theta-1PRO_0000185944Add
    BLAST

    Proteomic databases

    PaxDbiP20135.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000010240.

    Structurei

    3D structure databases

    ProteinModelPortaliP20135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 101100GST N-terminalAdd
    BLAST
    Domaini107 – 248142GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni72 – 732Glutathione bindingBy similarity
    Regioni85 – 862Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Theta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG274560.
    GeneTreeiENSGT00540000069741.
    HOGENOMiHOG000125747.
    HOVERGENiHBG051854.
    InParanoidiP20135.
    KOiK00799.
    OMAiTVKQKLM.
    OrthoDBiEOG7GTT59.
    PhylomeDBiP20135.
    TreeFamiTF325759.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20135-1 [UniParc]FASTAAdd to Basket

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    MGLELYLDLL SQPCRSIYIF ARTNNIPFEF KHVELFKDSV LGKKPAAASG    50
    AERPRTGPSN SEGDGKISLL KKVPVLKDGD FTLAECTAIL LYLSRKYNTP 100
    DHWYPSDIKK RAQVDEYLSW HHANIRANAP KTMWIKVLIP LFTGQPQPSE 150
    KLQEVMEGLS TSLKQFEERF LQDKAFIIGS EISLADLVAI VELMQPVGVG 200
    CDIFEDRPRL MEWRRRVEEA VGKELFFQAH EMILNIKELS NIQIDPQLKE 250
    HLAPVLMKML K 261
    Length:261
    Mass (Da):29,823
    Last modified:January 23, 2007 - v3
    Checksum:iF94EC305E4616803
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 174CRSI → SRAV AA sequence (PubMed:2337594)Curated
    Sequence conflicti23 – 231T → S AA sequence (PubMed:2337594)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13676 mRNA. Translation: AAA91968.1.
    PIRiS59629.
    RefSeqiNP_990696.1. NM_205365.1.
    UniGeneiGga.2437.

    Genome annotation databases

    EnsembliENSGALT00000010254; ENSGALP00000010240; ENSGALG00000006344.
    GeneIDi396322.
    KEGGigga:396322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13676 mRNA. Translation: AAA91968.1 .
    PIRi S59629.
    RefSeqi NP_990696.1. NM_205365.1.
    UniGenei Gga.2437.

    3D structure databases

    ProteinModelPortali P20135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000010240.

    Proteomic databases

    PaxDbi P20135.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000010254 ; ENSGALP00000010240 ; ENSGALG00000006344 .
    GeneIDi 396322.
    KEGGi gga:396322.

    Organism-specific databases

    CTDi 2952.

    Phylogenomic databases

    eggNOGi NOG274560.
    GeneTreei ENSGT00540000069741.
    HOGENOMi HOG000125747.
    HOVERGENi HBG051854.
    InParanoidi P20135.
    KOi K00799.
    OMAi TVKQKLM.
    OrthoDBi EOG7GTT59.
    PhylomeDBi P20135.
    TreeFami TF325759.

    Enzyme and pathway databases

    Reactomei REACT_222911. Glutathione conjugation.

    Miscellaneous databases

    NextBioi 20816370.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequencing, molecular cloning and modelling of the chick liver class-theta glutathione S-transferase CL1."
      Hsiao C.D., Martsen E.O., Lee J.Y., Tsai S.-P., Tam M.F.
      Biochem. J. 312:91-98(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Characterization of glutathione S-transferases from day-old chick livers."
      Chang L.-H., Chuang L.-F., Tsai C.-P., Tu C.-P.D., Tam M.F.
      Biochemistry 29:744-750(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-24.
      Tissue: Liver.

    Entry informationi

    Entry nameiGSTT1_CHICK
    AccessioniPrimary (citable) accession number: P20135
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3