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Protein

Glutathione S-transferase theta-1

Gene

GSTT1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-GGA-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-1 (EC:2.5.1.18)
Alternative name(s):
GST class-theta
GST-CL1
Gene namesi
Name:GSTT1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 15

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001859442 – 261Glutathione S-transferase theta-1Add BLAST260

Proteomic databases

PaxDbiP20135

Expressioni

Gene expression databases

BgeeiENSGALG00000006344

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010240

Structurei

3D structure databases

ProteinModelPortaliP20135
SMRiP20135
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 101GST N-terminalAdd BLAST100
Domaini107 – 248GST C-terminalAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 73Glutathione bindingBy similarity2
Regioni85 – 86Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
GeneTreeiENSGT00540000069741
HOGENOMiHOG000125747
HOVERGENiHBG051854
InParanoidiP20135
KOiK00799
OMAiSCNPHYD
OrthoDBiEOG091G0PCG
PhylomeDBiP20135
TreeFamiTF325759

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLELYLDLL SQPCRSIYIF ARTNNIPFEF KHVELFKDSV LGKKPAAASG
60 70 80 90 100
AERPRTGPSN SEGDGKISLL KKVPVLKDGD FTLAECTAIL LYLSRKYNTP
110 120 130 140 150
DHWYPSDIKK RAQVDEYLSW HHANIRANAP KTMWIKVLIP LFTGQPQPSE
160 170 180 190 200
KLQEVMEGLS TSLKQFEERF LQDKAFIIGS EISLADLVAI VELMQPVGVG
210 220 230 240 250
CDIFEDRPRL MEWRRRVEEA VGKELFFQAH EMILNIKELS NIQIDPQLKE
260
HLAPVLMKML K
Length:261
Mass (Da):29,823
Last modified:January 23, 2007 - v3
Checksum:iF94EC305E4616803
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14 – 17CRSI → SRAV AA sequence (PubMed:2337594).Curated4
Sequence conflicti23T → S AA sequence (PubMed:2337594).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13676 mRNA Translation: AAA91968.1
PIRiS59629
RefSeqiNP_990696.1, NM_205365.1
UniGeneiGga.2437

Genome annotation databases

EnsembliENSGALT00000010254; ENSGALP00000010240; ENSGALG00000006344
GeneIDi396322
KEGGigga:396322

Similar proteinsi

Entry informationi

Entry nameiGSTT1_CHICK
AccessioniPrimary (citable) accession number: P20135
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health