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P20135

- GSTT1_CHICK

UniProt

P20135 - GSTT1_CHICK

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Protein

Glutathione S-transferase theta-1

Gene

GSTT1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_222911. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-1 (EC:2.5.1.18)
Alternative name(s):
GST class-theta
GST-CL1
Gene namesi
Name:GSTT1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 15

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 261260Glutathione S-transferase theta-1PRO_0000185944Add
BLAST

Proteomic databases

PaxDbiP20135.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010240.

Structurei

3D structure databases

ProteinModelPortaliP20135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 101100GST N-terminalAdd
BLAST
Domaini107 – 248142GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni72 – 732Glutathione bindingBy similarity
Regioni85 – 862Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG274560.
GeneTreeiENSGT00540000069741.
HOGENOMiHOG000125747.
HOVERGENiHBG051854.
InParanoidiP20135.
KOiK00799.
OMAiTVKQKLM.
OrthoDBiEOG7GTT59.
PhylomeDBiP20135.
TreeFamiTF325759.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20135-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLELYLDLL SQPCRSIYIF ARTNNIPFEF KHVELFKDSV LGKKPAAASG
60 70 80 90 100
AERPRTGPSN SEGDGKISLL KKVPVLKDGD FTLAECTAIL LYLSRKYNTP
110 120 130 140 150
DHWYPSDIKK RAQVDEYLSW HHANIRANAP KTMWIKVLIP LFTGQPQPSE
160 170 180 190 200
KLQEVMEGLS TSLKQFEERF LQDKAFIIGS EISLADLVAI VELMQPVGVG
210 220 230 240 250
CDIFEDRPRL MEWRRRVEEA VGKELFFQAH EMILNIKELS NIQIDPQLKE
260
HLAPVLMKML K
Length:261
Mass (Da):29,823
Last modified:January 23, 2007 - v3
Checksum:iF94EC305E4616803
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 174CRSI → SRAV AA sequence (PubMed:2337594)Curated
Sequence conflicti23 – 231T → S AA sequence (PubMed:2337594)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13676 mRNA. Translation: AAA91968.1.
PIRiS59629.
RefSeqiNP_990696.1. NM_205365.1.
UniGeneiGga.2437.

Genome annotation databases

EnsembliENSGALT00000010254; ENSGALP00000010240; ENSGALG00000006344.
GeneIDi396322.
KEGGigga:396322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13676 mRNA. Translation: AAA91968.1 .
PIRi S59629.
RefSeqi NP_990696.1. NM_205365.1.
UniGenei Gga.2437.

3D structure databases

ProteinModelPortali P20135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000010240.

Proteomic databases

PaxDbi P20135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000010254 ; ENSGALP00000010240 ; ENSGALG00000006344 .
GeneIDi 396322.
KEGGi gga:396322.

Organism-specific databases

CTDi 2952.

Phylogenomic databases

eggNOGi NOG274560.
GeneTreei ENSGT00540000069741.
HOGENOMi HOG000125747.
HOVERGENi HBG051854.
InParanoidi P20135.
KOi K00799.
OMAi TVKQKLM.
OrthoDBi EOG7GTT59.
PhylomeDBi P20135.
TreeFami TF325759.

Enzyme and pathway databases

Reactomei REACT_222911. Glutathione conjugation.

Miscellaneous databases

NextBioi 20816370.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequencing, molecular cloning and modelling of the chick liver class-theta glutathione S-transferase CL1."
    Hsiao C.D., Martsen E.O., Lee J.Y., Tsai S.-P., Tam M.F.
    Biochem. J. 312:91-98(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Characterization of glutathione S-transferases from day-old chick livers."
    Chang L.-H., Chuang L.-F., Tsai C.-P., Tu C.-P.D., Tam M.F.
    Biochemistry 29:744-750(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-24.
    Tissue: Liver.

Entry informationi

Entry nameiGSTT1_CHICK
AccessioniPrimary (citable) accession number: P20135
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3