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P20135 (GSTT1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase theta-1

EC=2.5.1.18
Alternative name(s):
GST class-theta
GST-CL1
Gene names
Name:GSTT1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the GST superfamily. Theta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 261260Glutathione S-transferase theta-1
PRO_0000185944

Regions

Domain2 – 101100GST N-terminal
Domain107 – 248142GST C-terminal
Region72 – 732Glutathione binding By similarity
Region85 – 862Glutathione binding By similarity

Experimental info

Sequence conflict14 – 174CRSI → SRAV AA sequence Ref.2
Sequence conflict231T → S AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P20135 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: F94EC305E4616803

FASTA26129,823
        10         20         30         40         50         60 
MGLELYLDLL SQPCRSIYIF ARTNNIPFEF KHVELFKDSV LGKKPAAASG AERPRTGPSN 

        70         80         90        100        110        120 
SEGDGKISLL KKVPVLKDGD FTLAECTAIL LYLSRKYNTP DHWYPSDIKK RAQVDEYLSW 

       130        140        150        160        170        180 
HHANIRANAP KTMWIKVLIP LFTGQPQPSE KLQEVMEGLS TSLKQFEERF LQDKAFIIGS 

       190        200        210        220        230        240 
EISLADLVAI VELMQPVGVG CDIFEDRPRL MEWRRRVEEA VGKELFFQAH EMILNIKELS 

       250        260 
NIQIDPQLKE HLAPVLMKML K 

« Hide

References

[1]"Amino acid sequencing, molecular cloning and modelling of the chick liver class-theta glutathione S-transferase CL1."
Hsiao C.D., Martsen E.O., Lee J.Y., Tsai S.-P., Tam M.F.
Biochem. J. 312:91-98(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Characterization of glutathione S-transferases from day-old chick livers."
Chang L.-H., Chuang L.-F., Tsai C.-P., Tu C.-P.D., Tam M.F.
Biochemistry 29:744-750(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-24.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U13676 mRNA. Translation: AAA91968.1.
PIRS59629.
RefSeqNP_990696.1. NM_205365.1.
UniGeneGga.2437.

3D structure databases

ProteinModelPortalP20135.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000010240.

Proteomic databases

PaxDbP20135.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000010254; ENSGALP00000010240; ENSGALG00000006344.
GeneID396322.
KEGGgga:396322.

Organism-specific databases

CTD2952.

Phylogenomic databases

eggNOGNOG274560.
GeneTreeENSGT00540000069741.
HOGENOMHOG000125747.
HOVERGENHBG051854.
InParanoidP20135.
KOK00799.
OMATVKQKLM.
OrthoDBEOG7GTT59.
PhylomeDBP20135.
TreeFamTF325759.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816370.

Entry information

Entry nameGSTT1_CHICK
AccessionPrimary (citable) accession number: P20135
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families