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Protein

L-serine dehydratase/L-threonine deaminase

Gene

SDS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-serine = pyruvate + NH3.1 Publication
L-threonine = 2-oxobutanoate + NH3.1 Publication

Cofactori

Kineticsi

  1. KM=23 mM for serine1 Publication
  2. KM=31 mM for threonine1 Publication

    Pathwayi: gluconeogenesis

    This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
    View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

    GO - Molecular functioni

    • L-serine ammonia-lyase activity Source: UniProtKB
    • L-threonine ammonia-lyase activity Source: UniProtKB-EC
    • protein homodimerization activity Source: UniProtKB
    • pyridoxal phosphate binding Source: UniProtKB

    GO - Biological processi

    • gluconeogenesis Source: UniProtKB-UniPathway
    • L-serine catabolic process Source: UniProtKB
    • pyruvate biosynthetic process Source: UniProtKB
    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:HS05952-MONOMER.
    ZFISH:HS05952-MONOMER.
    BRENDAi4.3.1.17. 2681.
    SABIO-RKP20132.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-serine dehydratase/L-threonine deaminase (EC:4.3.1.17)
    Short name:
    SDH
    Alternative name(s):
    L-serine deaminase
    L-threonine dehydratase (EC:4.3.1.19)
    Short name:
    TDH
    Gene namesi
    Name:SDS
    Synonyms:SDH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:10691. SDS.

    Subcellular locationi

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi303C → A: Loss of enzyme activity. 1 Publication1

    Organism-specific databases

    DisGeNETi10993.
    MalaCardsiSDS.
    OpenTargetsiENSG00000135094.
    PharmGKBiPA35616.

    Chemistry databases

    DrugBankiDB00133. L-Serine.

    Polymorphism and mutation databases

    BioMutaiSDS.
    DMDMi229462819.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Initiator methionineiRemovedBy similarity
    ChainiPRO_00001855942 – 328L-serine dehydratase/L-threonine deaminaseAdd BLAST327

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei41N6-(pyridoxal phosphate)lysine1

    Proteomic databases

    PaxDbiP20132.
    PeptideAtlasiP20132.
    PRIDEiP20132.

    PTM databases

    iPTMnetiP20132.
    PhosphoSitePlusiP20132.

    Expressioni

    Gene expression databases

    BgeeiENSG00000135094.
    CleanExiHS_SDS.
    ExpressionAtlasiP20132. baseline and differential.
    GenevisibleiP20132. HS.

    Organism-specific databases

    HPAiHPA039230.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    GO - Molecular functioni

    • protein homodimerization activity Source: UniProtKB

    Protein-protein interaction databases

    STRINGi9606.ENSP00000257549.

    Structurei

    Secondary structure

    1328
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi13 – 16Combined sources4
    Helixi17 – 23Combined sources7
    Beta strandi25 – 31Combined sources7
    Helixi32 – 34Combined sources3
    Helixi36 – 38Combined sources3
    Helixi41 – 54Combined sources14
    Beta strandi59 – 62Combined sources4
    Helixi67 – 79Combined sources13
    Beta strandi83 – 88Combined sources6
    Helixi93 – 101Combined sources9
    Beta strandi105 – 109Combined sources5
    Helixi115 – 126Combined sources12
    Beta strandi130 – 133Combined sources4
    Helixi139 – 145Combined sources7
    Helixi147 – 155Combined sources9
    Beta strandi161 – 166Combined sources6
    Beta strandi168 – 170Combined sources3
    Helixi171 – 182Combined sources12
    Beta strandi190 – 195Combined sources6
    Helixi200 – 207Combined sources8
    Helixi221 – 223Combined sources3
    Helixi230 – 236Combined sources7
    Beta strandi241 – 246Combined sources6
    Helixi248 – 262Combined sources15
    Helixi268 – 278Combined sources11
    Helixi281 – 287Combined sources7
    Beta strandi297 – 302Combined sources6
    Helixi310 – 319Combined sources10

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1P5JX-ray2.50A1-328[»]
    4H27X-ray1.30A1-328[»]
    ProteinModelPortaliP20132.
    SMRiP20132.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP20132.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG1250. Eukaryota.
    COG1171. LUCA.
    GeneTreeiENSGT00550000074775.
    HOGENOMiHOG000046976.
    HOVERGENiHBG017784.
    InParanoidiP20132.
    KOiK17989.
    OMAiKKPWIET.
    OrthoDBiEOG091G0FCF.
    PhylomeDBiP20132.
    TreeFamiTF329014.

    Family and domain databases

    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR001926. TrpB-like_PLP-dep.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20132-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MMSGEPLHVK TPIRDSMALS KMAGTSVYLK MDSAQPSGSF KIRGIGHFCK
    60 70 80 90 100
    RWAKQGCAHF VCSSAGNAGM AAAYAARQLG VPATIVVPST TPALTIERLK
    110 120 130 140 150
    NEGATVKVVG ELLDEAFELA KALAKNNPGW VYIPPFDDPL IWEGHASIVK
    160 170 180 190 200
    ELKETLWEKP GAIALSVGGG GLLCGVVQGL QEVGWGDVPV IAMETFGAHS
    210 220 230 240 250
    FHAATTAGKL VSLPKITSVA KALGVKTVGA QALKLFQEHP IFSEVISDQE
    260 270 280 290 300
    AVAAIEKFVD DEKILVEPAC GAALAAVYSH VIQKLQLEGN LRTPLPSLVV
    310 320
    IVCGGSNISL AQLRALKEQL GMTNRLPK
    Length:328
    Mass (Da):34,625
    Last modified:May 5, 2009 - v2
    Checksum:iF6E9AB01D6308C83
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti89S → G in AAA36604 (PubMed:2674117).Curated1
    Sequence conflicti106V → C in AAA36604 (PubMed:2674117).Curated1
    Sequence conflicti183V → C in AAA36604 (PubMed:2674117).Curated1
    Sequence conflicti230A → S in AAA36604 (PubMed:2674117).Curated1
    Sequence conflicti270C → W in AAA36604 (PubMed:2674117).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J05037 mRNA. Translation: AAA36604.1.
    AK292760 mRNA. Translation: BAF85449.1.
    CH471054 Genomic DNA. Translation: EAW98054.1.
    CCDSiCCDS9169.1.
    PIRiA34232. DWHUT.
    RefSeqiNP_006834.2. NM_006843.2.
    UniGeneiHs.439023.

    Genome annotation databases

    EnsembliENST00000257549; ENSP00000257549; ENSG00000135094.
    GeneIDi10993.
    KEGGihsa:10993.
    UCSCiuc001tvg.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J05037 mRNA. Translation: AAA36604.1.
    AK292760 mRNA. Translation: BAF85449.1.
    CH471054 Genomic DNA. Translation: EAW98054.1.
    CCDSiCCDS9169.1.
    PIRiA34232. DWHUT.
    RefSeqiNP_006834.2. NM_006843.2.
    UniGeneiHs.439023.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1P5JX-ray2.50A1-328[»]
    4H27X-ray1.30A1-328[»]
    ProteinModelPortaliP20132.
    SMRiP20132.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi9606.ENSP00000257549.

    Chemistry databases

    DrugBankiDB00133. L-Serine.

    PTM databases

    iPTMnetiP20132.
    PhosphoSitePlusiP20132.

    Polymorphism and mutation databases

    BioMutaiSDS.
    DMDMi229462819.

    Proteomic databases

    PaxDbiP20132.
    PeptideAtlasiP20132.
    PRIDEiP20132.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000257549; ENSP00000257549; ENSG00000135094.
    GeneIDi10993.
    KEGGihsa:10993.
    UCSCiuc001tvg.4. human.

    Organism-specific databases

    CTDi10993.
    DisGeNETi10993.
    GeneCardsiSDS.
    HGNCiHGNC:10691. SDS.
    HPAiHPA039230.
    MalaCardsiSDS.
    MIMi182128. gene.
    neXtProtiNX_P20132.
    OpenTargetsiENSG00000135094.
    PharmGKBiPA35616.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1250. Eukaryota.
    COG1171. LUCA.
    GeneTreeiENSGT00550000074775.
    HOGENOMiHOG000046976.
    HOVERGENiHBG017784.
    InParanoidiP20132.
    KOiK17989.
    OMAiKKPWIET.
    OrthoDBiEOG091G0FCF.
    PhylomeDBiP20132.
    TreeFamiTF329014.

    Enzyme and pathway databases

    UniPathwayiUPA00138.
    BioCyciMetaCyc:HS05952-MONOMER.
    ZFISH:HS05952-MONOMER.
    BRENDAi4.3.1.17. 2681.
    SABIO-RKP20132.

    Miscellaneous databases

    ChiTaRSiSDS. human.
    EvolutionaryTraceiP20132.
    GenomeRNAii10993.
    PROiP20132.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000135094.
    CleanExiHS_SDS.
    ExpressionAtlasiP20132. baseline and differential.
    GenevisibleiP20132. HS.

    Family and domain databases

    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR001926. TrpB-like_PLP-dep.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiSDHL_HUMAN
    AccessioniPrimary (citable) accession number: P20132
    Secondary accession number(s): A8K9P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: May 5, 2009
    Last modified: November 2, 2016
    This is version 157 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.