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Protein

RNA replicase polyprotein

Gene
N/A
Organism
Ononis yellow mosaic virus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei711For protease activityPROSITE-ProRule annotation1
Active sitei797For protease activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi899 – 906ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiC21.001.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA replicase polyprotein (EC:2.7.7.48)
OrganismiOnonis yellow mosaic virus
Taxonomic identifieri12153 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTymoviralesTymoviridaeTymovirus
Virus hostiOnonis [TaxID: 58889]
Proteomesi
  • UP000007789 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002229361 – 1776RNA replicase polyproteinAdd BLAST1776

Structurei

3D structure databases

ProteinModelPortaliP20127.
SMRiP20127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 219Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST162
Domaini658 – 812Peptidase C21PROSITE-ProRule annotationAdd BLAST155
Domaini866 – 1026(+)RNA virus helicase ATP-bindingAdd BLAST161
Domaini1027 – 1159(+)RNA virus helicase C-terminalAdd BLAST133
Domaini1497 – 1603RdRp catalyticPROSITE-ProRule annotationAdd BLAST107

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR027351. (+)RNA_virus_helicase_core_dom.
IPR002588. Alphavirus-like_MT_dom.
IPR027417. P-loop_NTPase.
IPR008043. Peptidase_C21.
IPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
PfamiView protein in Pfam
PF05381. Peptidase_C21. 1 hit.
PF00978. RdRP_2. 1 hit.
PF01443. Viral_helicase1. 1 hit.
PF01660. Vmethyltransf. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS51743. ALPHAVIRUS_MT. 1 hit.
PS51738. PEPTIDASE_C21. 1 hit.
PS51657. PSRV_HELICASE. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.

Sequencei

Sequence statusi: Complete.

P20127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFELALNAL ASSTHKDSSL NPVLNSAVQP LQTSLQNFPW IIGKEHLPFL
60 70 80 90 100
LAAGIPTSGF GCNPHPHAVH KVIETFLLFN HWSFMATVQA SVMFMKPSKF
110 120 130 140 150
KKLASVNPNF SELVNYRLTA ADSVRYPSTS TSLPKYEIVF MHDALMYFNP
160 170 180 190 200
SQILDLFIQC PSLQRLHCSL VVPPESSFTD LSLHPNLYTY TISGNTLHYV
210 220 230 240 250
PEGHHAGSYD QPLDAISWLK LNSIHSPHLN LSVSKLESWG PVHSLLITRG
260 270 280 290 300
LPHLPSSEKQ QVSFHIPNCL PLPEATFLHQ PLRHRLVPTE VYDALFTYTR
310 320 330 340 350
AVRTLRTSDP AGFVRTHSNK PQYSWVTSRA WDNLQTYALL NAPVRPVVLF
360 370 380 390 400
DFFLSPLKKF QLFMSQHINS LVIKALPFLG LIPPLVKLTT LGFPIPSVSH
410 420 430 440 450
FQILFFTMIG PSGQFILEAF PSMLHPAISY LESCGLVPRL PPPVAQQLQT
460 470 480 490 500
MGILRKRSAF SLKTSLSTVK WPSWKITALI SALPAALSVF LKTISPLSLQ
510 520 530 540 550
SLHDGYNAHL HPSPFNLSWS LETFHVQSPS PFLPLSLTPP SPSEEIALPP
560 570 580 590 600
PIFRVPPPLP AQETPSPPAP ALVPPTQPPQ PQPWEEIIST FLSSLNASSH
610 620 630 640 650
KPSPSSAPLE SPSPIPESFE VLAEAPQHQR SINECGALNQ LPLPVPSPLQ
660 670 680 690 700
NSTNPKPPFP SSDLLSDMSC TGPVVEFETI FPAEYHMSNG SFPTRLRGHP
710 720 730 740 750
RSSAPFPQKH CLLTAVASQL SYTEHQLWEF LCDMLPDSLL TNSEVENFGL
760 770 780 790 800
STDHLTCLSY RLHFECIIHT SHSTIPYGIK KASTVIQISY IDGPPKHFKA
810 820 830 840 850
FIKLAAAAPG SNPSKSNLVR AALRFKYNDA FLPFWDAHQH TISVPHAKNL
860 870 880 890 900
ISNMKNGFDG ITSQLSGPSN KSPKMKLLEL DATIDVSFPR KCDVIHIAGF
910 920 930 940 950
PGCGKSHPIQ KLLQTPAFRH FRLSVPTNEL RSEWKRDLNL PESEVWRLCT
960 970 980 990 1000
WETALFKSSN ILVVDEIYKL PRGYLDLILL ADPSIQLVIM LGDPLQGEYH
1010 1020 1030 1040 1050
SSHPSSSNSR LESETTRLSK YIDCYCWWTY RCPKAVADLF GVKTFNSNEG
1060 1070 1080 1090 1100
FIRAVLSHPP NLPNLVNSIA TANTMQSLGH HALTISSSQG MTYSDPVTVL
1110 1120 1130 1140 1150
LDRHSLLITP QTALVALTRS RSGIYFIGSM YTASGSAGTS YMFSCALTGL
1160 1170 1180 1190 1200
PVDMMSAFPL FHTLPLIHEP IRSRRHRLVA GHTPSLHVPP SNKWPHRLHL
1210 1220 1230 1240 1250
PPHIPTSHSK DVILAHGIVA SNAPERRLTT LHLPPTRLPL HFDLESCNPS
1260 1270 1280 1290 1300
TVSTSSTSNS EVPFTHAFLG ESFEELAAHF LPAHDPDLKE VTVGDQTSQQ
1310 1320 1330 1340 1350
FPYLDQPYTL SCQPSSLLAA SHKPASDPTL LIFSISKRLR FRASSSPYAF
1360 1370 1380 1390 1400
TPNDLILGHL LYTNWCKAFG RCPNSTIPFN PALFAECICL NEYAQLSSKT
1410 1420 1430 1440 1450
QATIVSNASR SDPDWRYTVV RIFAKSQHKV NDGSIFGSWK ACQTLALMHD
1460 1470 1480 1490 1500
FVILTLGPVK KYQRIIDHYD RPNFIYTHCG KTPSELSAWS HSFLKGDAYI
1510 1520 1530 1540 1550
CNDYTSFDQS QHGEAVIFES LKMHRVGIPR HLIDLHIYLK TNVSTQFGPL
1560 1570 1580 1590 1600
TCMRLTGEPG TYDDNTDYNL AVIFSQYVIS DHPIMVSGDD SVICGHPPIN
1610 1620 1630 1640 1650
PNWPAVEKLL HLRFKTEETS LPLFCGYYVG PTGCCRNPFA LFAKLMISYD
1660 1670 1680 1690 1700
KGNLFETLPS YLYEFSIGHR LGDVVRLLFP DHLLKYYSAC WDLFCRKCTA
1710 1720 1730 1740 1750
SQKLILSFEP IPPSFFSKLA STSRWVSKVL FSDLPTKIRD MLISSSKLPS
1760 1770
YHQDPRVQYL ESELLTSFNH GRLSTN
Length:1,776
Mass (Da):198,129
Last modified:February 1, 1991 - v1
Checksum:i1C2E37B9EC3A5333
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04375 Genomic RNA. Translation: AAA46796.1.
PIRiJQ0106. RRWPYM.
RefSeqiNP_041257.1. NC_001513.1.

Genome annotation databases

GeneIDi1493968.
KEGGivg:1493968.

Similar proteinsi

Entry informationi

Entry nameiPOLR_OYMV
AccessioniPrimary (citable) accession number: P20127
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 25, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families