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Protein

Interleukin-13

Gene

Il13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses (By similarity).By similarity

GO - Biological processi

  1. cellular response to cytokine stimulus Source: MGI
  2. cellular response to mechanical stimulus Source: Ensembl
  3. immune response Source: InterPro
  4. inflammatory response Source: MGI
  5. microglial cell activation Source: Ensembl
  6. negative regulation of complement-dependent cytotoxicity Source: MGI
  7. negative regulation of endothelial cell apoptotic process Source: MGI
  8. negative regulation of NAD(P)H oxidase activity Source: Ensembl
  9. negative regulation of neuron death Source: Ensembl
  10. negative regulation of transforming growth factor beta production Source: Ensembl
  11. positive regulation of B cell proliferation Source: Ensembl
  12. positive regulation of connective tissue growth factor production Source: Ensembl
  13. positive regulation of immunoglobulin production Source: MGI
  14. positive regulation of macrophage activation Source: BHF-UCL
  15. positive regulation of mast cell degranulation Source: MGI
  16. positive regulation of pancreatic stellate cell proliferation Source: Ensembl
  17. positive regulation of protein secretion Source: Ensembl
  18. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  19. positive regulation of smooth muscle cell proliferation Source: Ensembl
  20. positive regulation of tyrosine phosphorylation of Stat6 protein Source: Ensembl
  21. regulation of proton transport Source: Ensembl
  22. response to ethanol Source: Ensembl
  23. response to lipopolysaccharide Source: Ensembl
  24. response to nicotine Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Alternative name(s):
T-cell activation protein P600
Gene namesi
Name:Il13
Synonyms:Il-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96541. Il13.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. external side of plasma membrane Source: MGI
  3. extracellular region Source: MGI
  4. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 131110Interleukin-13PRO_0000015550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi51 ↔ 79By similarity
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi67 ↔ 93By similarity
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP20109.

Expressioni

Gene expression databases

BgeeiP20109.
CleanExiMM_IL13.
GenevestigatoriP20109.

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020650.

Structurei

3D structure databases

ProteinModelPortaliP20109.
SMRiP20109. Positions 33-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42350.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP20109.
KOiK05435.
OMAiVYCAALE.
OrthoDBiEOG78SQMB.
PhylomeDBiP20109.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWVTAVLA LACLGGLAAP GPVPRSVSLP LTLKELIEEL SNITQDQTPL
60 70 80 90 100
CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT
110 120 130
VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F
Length:131
Mass (Da):14,108
Last modified:February 1, 1991 - v1
Checksum:i954F93F105713FED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23504 mRNA. Translation: AAA40149.1.
CCDSiCCDS24683.1.
PIRiE30552.
RefSeqiNP_032381.1. NM_008355.3.
UniGeneiMm.1284.

Genome annotation databases

EnsembliENSMUST00000020650; ENSMUSP00000020650; ENSMUSG00000020383.
GeneIDi16163.
KEGGimmu:16163.
UCSCiuc007iwr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23504 mRNA. Translation: AAA40149.1.
CCDSiCCDS24683.1.
PIRiE30552.
RefSeqiNP_032381.1. NM_008355.3.
UniGeneiMm.1284.

3D structure databases

ProteinModelPortaliP20109.
SMRiP20109. Positions 33-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020650.

Proteomic databases

PRIDEiP20109.

Protocols and materials databases

DNASUi16163.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020650; ENSMUSP00000020650; ENSMUSG00000020383.
GeneIDi16163.
KEGGimmu:16163.
UCSCiuc007iwr.2. mouse.

Organism-specific databases

CTDi3596.
MGIiMGI:96541. Il13.

Phylogenomic databases

eggNOGiNOG42350.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP20109.
KOiK05435.
OMAiVYCAALE.
OrthoDBiEOG78SQMB.
PhylomeDBiP20109.
TreeFamiTF336383.

Miscellaneous databases

NextBioi288991.
PROiP20109.
SOURCEiSearch...

Gene expression databases

BgeeiP20109.
CleanExiMM_IL13.
GenevestigatoriP20109.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
    Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
    J. Immunol. 142:679-687(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL13_MOUSE
AccessioniPrimary (citable) accession number: P20109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 1, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.