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P20109

- IL13_MOUSE

UniProt

P20109 - IL13_MOUSE

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Protein
Interleukin-13
Gene
Il13, Il-13
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses By similarity.

GO - Biological processi

  1. cellular response to cytokine stimulus Source: MGI
  2. cellular response to mechanical stimulus Source: Ensembl
  3. immune response Source: InterPro
  4. negative regulation of transforming growth factor beta production Source: Ensembl
  5. positive regulation of B cell proliferation Source: Ensembl
  6. positive regulation of connective tissue growth factor production Source: Ensembl
  7. positive regulation of immunoglobulin production Source: Ensembl
  8. positive regulation of macrophage activation Source: BHF-UCL
  9. positive regulation of pancreatic stellate cell proliferation Source: Ensembl
  10. positive regulation of protein secretion Source: Ensembl
  11. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  12. positive regulation of smooth muscle cell proliferation Source: Ensembl
  13. positive regulation of tyrosine phosphorylation of Stat6 protein Source: Ensembl
  14. regulation of proton transport Source: Ensembl
  15. response to ethanol Source: Ensembl
  16. response to lipopolysaccharide Source: Ensembl
  17. response to nicotine Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Alternative name(s):
T-cell activation protein P600
Gene namesi
Name:Il13
Synonyms:Il-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96541. Il13.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. external side of plasma membrane Source: MGI
  3. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 By similarity
Add
BLAST
Chaini22 – 131110Interleukin-13
PRO_0000015550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi51 ↔ 79 By similarity
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi67 ↔ 93 By similarity
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP20109.

Expressioni

Gene expression databases

BgeeiP20109.
CleanExiMM_IL13.
GenevestigatoriP20109.

Interactioni

Subunit structurei

Interacts with IL13RA2 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020650.

Structurei

3D structure databases

ProteinModelPortaliP20109.
SMRiP20109. Positions 33-131.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42350.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP20109.
KOiK05435.
OMAiQKTPLCN.
OrthoDBiEOG78SQMB.
PhylomeDBiP20109.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20109-1 [UniParc]FASTAAdd to Basket

« Hide

MALWVTAVLA LACLGGLAAP GPVPRSVSLP LTLKELIEEL SNITQDQTPL    50
CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT 100
VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F 131
Length:131
Mass (Da):14,108
Last modified:February 1, 1991 - v1
Checksum:i954F93F105713FED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23504 mRNA. Translation: AAA40149.1.
CCDSiCCDS24683.1.
PIRiE30552.
RefSeqiNP_032381.1. NM_008355.3.
UniGeneiMm.1284.

Genome annotation databases

EnsembliENSMUST00000020650; ENSMUSP00000020650; ENSMUSG00000020383.
GeneIDi16163.
KEGGimmu:16163.
UCSCiuc007iwr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23504 mRNA. Translation: AAA40149.1 .
CCDSi CCDS24683.1.
PIRi E30552.
RefSeqi NP_032381.1. NM_008355.3.
UniGenei Mm.1284.

3D structure databases

ProteinModelPortali P20109.
SMRi P20109. Positions 33-131.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000020650.

Proteomic databases

PRIDEi P20109.

Protocols and materials databases

DNASUi 16163.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020650 ; ENSMUSP00000020650 ; ENSMUSG00000020383 .
GeneIDi 16163.
KEGGi mmu:16163.
UCSCi uc007iwr.2. mouse.

Organism-specific databases

CTDi 3596.
MGIi MGI:96541. Il13.

Phylogenomic databases

eggNOGi NOG42350.
GeneTreei ENSGT00390000003225.
HOGENOMi HOG000113028.
HOVERGENi HBG006140.
InParanoidi P20109.
KOi K05435.
OMAi QKTPLCN.
OrthoDBi EOG78SQMB.
PhylomeDBi P20109.
TreeFami TF336383.

Miscellaneous databases

NextBioi 288991.
PROi P20109.
SOURCEi Search...

Gene expression databases

Bgeei P20109.
CleanExi MM_IL13.
Genevestigatori P20109.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view ]
PANTHERi PTHR11322. PTHR11322. 1 hit.
Pfami PF03487. IL13. 1 hit.
[Graphical view ]
PRINTSi PR01929. INTRLEUKIN13.
SMARTi SM00190. IL4_13. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
    Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
    J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL13_MOUSE
AccessioniPrimary (citable) accession number: P20109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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