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P20109 (IL13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-13

Short name=IL-13
Alternative name(s):
T-cell activation protein P600
Gene names
Name:Il13
Synonyms:Il-13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses By similarity.

Subunit structure

Interacts with IL13RA2 By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-4/IL-13 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to cytokine stimulus

Inferred from direct assay PubMed 19666510. Source: MGI

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

negative regulation of transforming growth factor beta production

Inferred from electronic annotation. Source: Ensembl

positive regulation of B cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of connective tissue growth factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of immunoglobulin production

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage activation

Inferred from mutant phenotype PubMed 19841166. Source: BHF-UCL

positive regulation of pancreatic stellate cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat6 protein

Inferred from electronic annotation. Source: Ensembl

regulation of proton transport

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to nicotine

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 11737071. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 18792410PubMed 19666510. Source: MGI

extracellular space

Inferred from direct assay PubMed 15240714PubMed 16275384PubMed 16949315PubMed 17082577PubMed 18997793PubMed 21460847. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 131110Interleukin-13
PRO_0000015550

Amino acid modifications

Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Potential
Disulfide bond51 ↔ 79 By similarity
Disulfide bond67 ↔ 93 By similarity

Sequences

Sequence LengthMass (Da)Tools
P20109 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 954F93F105713FED

FASTA13114,108
        10         20         30         40         50         60 
MALWVTAVLA LACLGGLAAP GPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD 

        70         80         90        100        110        120 
LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS 

       130 
YTKQLFRHGP F 

« Hide

References

[1]"A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M23504 mRNA. Translation: AAA40149.1.
PIRE30552.
RefSeqNP_032381.1. NM_008355.3.
UniGeneMm.1284.

3D structure databases

ProteinModelPortalP20109.
SMRP20109. Positions 33-131.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000020650.

Proteomic databases

PRIDEP20109.

Protocols and materials databases

DNASU16163.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020650; ENSMUSP00000020650; ENSMUSG00000020383.
GeneID16163.
KEGGmmu:16163.
UCSCuc007iwr.2. mouse.

Organism-specific databases

CTD3596.
MGIMGI:96541. Il13.

Phylogenomic databases

eggNOGNOG42350.
GeneTreeENSGT00390000003225.
HOGENOMHOG000113028.
HOVERGENHBG006140.
InParanoidP20109.
KOK05435.
OMAYCAALES.
OrthoDBEOG78SQMB.
PhylomeDBP20109.
TreeFamTF336383.

Gene expression databases

BgeeP20109.
CleanExMM_IL13.
GenevestigatorP20109.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERPTHR11322. PTHR11322. 1 hit.
PfamPF03487. IL13. 1 hit.
[Graphical view]
PRINTSPR01929. INTRLEUKIN13.
SMARTSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288991.
PROP20109.
SOURCESearch...

Entry information

Entry nameIL13_MOUSE
AccessionPrimary (citable) accession number: P20109
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot