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P20109

- IL13_MOUSE

UniProt

P20109 - IL13_MOUSE

Protein

Interleukin-13

Gene

Il13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses By similarity.By similarity

    GO - Biological processi

    1. cellular response to cytokine stimulus Source: MGI
    2. cellular response to mechanical stimulus Source: Ensembl
    3. immune response Source: InterPro
    4. negative regulation of transforming growth factor beta production Source: Ensembl
    5. positive regulation of B cell proliferation Source: Ensembl
    6. positive regulation of connective tissue growth factor production Source: Ensembl
    7. positive regulation of immunoglobulin production Source: Ensembl
    8. positive regulation of macrophage activation Source: BHF-UCL
    9. positive regulation of pancreatic stellate cell proliferation Source: Ensembl
    10. positive regulation of protein secretion Source: Ensembl
    11. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    12. positive regulation of smooth muscle cell proliferation Source: Ensembl
    13. positive regulation of tyrosine phosphorylation of Stat6 protein Source: Ensembl
    14. regulation of proton transport Source: Ensembl
    15. response to ethanol Source: Ensembl
    16. response to lipopolysaccharide Source: Ensembl
    17. response to nicotine Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-13
    Short name:
    IL-13
    Alternative name(s):
    T-cell activation protein P600
    Gene namesi
    Name:Il13
    Synonyms:Il-13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96541. Il13.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. external side of plasma membrane Source: MGI
    3. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 131110Interleukin-13PRO_0000015550Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi51 ↔ 79By similarity
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi67 ↔ 93By similarity
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP20109.

    Expressioni

    Gene expression databases

    BgeeiP20109.
    CleanExiMM_IL13.
    GenevestigatoriP20109.

    Interactioni

    Subunit structurei

    Interacts with IL13RA2.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000020650.

    Structurei

    3D structure databases

    ProteinModelPortaliP20109.
    SMRiP20109. Positions 33-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-4/IL-13 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42350.
    GeneTreeiENSGT00390000003225.
    HOGENOMiHOG000113028.
    HOVERGENiHBG006140.
    InParanoidiP20109.
    KOiK05435.
    OMAiQKTPLCN.
    OrthoDBiEOG78SQMB.
    PhylomeDBiP20109.
    TreeFamiTF336383.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020470. IL-13.
    IPR001325. IL-4/IL-13.
    IPR018096. IL-4/IL-13_CS.
    [Graphical view]
    PANTHERiPTHR11322. PTHR11322. 1 hit.
    PfamiPF03487. IL13. 1 hit.
    [Graphical view]
    PRINTSiPR01929. INTRLEUKIN13.
    SMARTiSM00190. IL4_13. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20109-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALWVTAVLA LACLGGLAAP GPVPRSVSLP LTLKELIEEL SNITQDQTPL    50
    CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT 100
    VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F 131
    Length:131
    Mass (Da):14,108
    Last modified:February 1, 1991 - v1
    Checksum:i954F93F105713FED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23504 mRNA. Translation: AAA40149.1.
    CCDSiCCDS24683.1.
    PIRiE30552.
    RefSeqiNP_032381.1. NM_008355.3.
    UniGeneiMm.1284.

    Genome annotation databases

    EnsembliENSMUST00000020650; ENSMUSP00000020650; ENSMUSG00000020383.
    GeneIDi16163.
    KEGGimmu:16163.
    UCSCiuc007iwr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23504 mRNA. Translation: AAA40149.1 .
    CCDSi CCDS24683.1.
    PIRi E30552.
    RefSeqi NP_032381.1. NM_008355.3.
    UniGenei Mm.1284.

    3D structure databases

    ProteinModelPortali P20109.
    SMRi P20109. Positions 33-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000020650.

    Proteomic databases

    PRIDEi P20109.

    Protocols and materials databases

    DNASUi 16163.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020650 ; ENSMUSP00000020650 ; ENSMUSG00000020383 .
    GeneIDi 16163.
    KEGGi mmu:16163.
    UCSCi uc007iwr.2. mouse.

    Organism-specific databases

    CTDi 3596.
    MGIi MGI:96541. Il13.

    Phylogenomic databases

    eggNOGi NOG42350.
    GeneTreei ENSGT00390000003225.
    HOGENOMi HOG000113028.
    HOVERGENi HBG006140.
    InParanoidi P20109.
    KOi K05435.
    OMAi QKTPLCN.
    OrthoDBi EOG78SQMB.
    PhylomeDBi P20109.
    TreeFami TF336383.

    Miscellaneous databases

    NextBioi 288991.
    PROi P20109.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20109.
    CleanExi MM_IL13.
    Genevestigatori P20109.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020470. IL-13.
    IPR001325. IL-4/IL-13.
    IPR018096. IL-4/IL-13_CS.
    [Graphical view ]
    PANTHERi PTHR11322. PTHR11322. 1 hit.
    Pfami PF03487. IL13. 1 hit.
    [Graphical view ]
    PRINTSi PR01929. INTRLEUKIN13.
    SMARTi SM00190. IL4_13. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00838. INTERLEUKIN_4_13. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
      Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
      J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiIL13_MOUSE
    AccessioniPrimary (citable) accession number: P20109
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3