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Protein

Saposin-C

Gene

PSAP

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.

GO - Biological processi

Keywordsi

Biological processLipid metabolism, Sphingolipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Saposin-C
Alternative name(s):
Co-beta-glucosidase
Glucosylceramidase activator
Sphingolipid activator protein 2
Short name:
SAP-2
Gene namesi
Name:PSAP
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001752391 – 81Saposin-CAdd BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 78PROSITE-ProRule annotation
Disulfide bondi8 ↔ 72PROSITE-ProRule annotation
Glycosylationi22N-linked (GlcNAc...) asparagine1
Disulfide bondi36 ↔ 47PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiENSCPOG00000001764.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001595.

Structurei

3D structure databases

ProteinModelPortaliP20097.
SMRiP20097.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 81Saposin B-typePROSITE-ProRule annotationAdd BLAST81

Phylogenomic databases

eggNOGiKOG1340. Eukaryota.
ENOG410XSI5. LUCA.
GeneTreeiENSGT00530000063434.
HOGENOMiHOG000049216.
InParanoidiP20097.

Family and domain databases

InterProiView protein in InterPro
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
PfamiView protein in Pfam
PF05184. SapB_1. 1 hit.
PF03489. SapB_2. 1 hit.
PRINTSiPR01797. SAPOSIN.
SMARTiView protein in SMART
SM00741. SapB. 1 hit.
SUPFAMiSSF47862. SSF47862. 1 hit.
PROSITEiView protein in PROSITE
PS50015. SAP_B. 1 hit.

Sequencei

Sequence statusi: Complete.

P20097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ESVTCKACEY VVKKVMELID NNRTEEKIIH ALDSVCALLP ESVSEVCQEV
60 70 80
VDTYGDSIVA LLLQEMSPEL VCSELGLCMS G
Length:81
Mass (Da):8,852
Last modified:February 1, 1991 - v1
Checksum:iE564CE1F0A292596
GO

Sequence databases

PIRiA32026.

Genome annotation databases

EnsembliENSCPOT00000026133; ENSCPOP00000021187; ENSCPOG00000001764.

Similar proteinsi

Entry informationi

Entry nameiSAP_CAVPO
AccessioniPrimary (citable) accession number: P20097
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: August 30, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome