Reviewed, UniProtKB/Swiss-Prot P20096 (IL4_RAT)

Names and origin

Protein names

Recommended name:
    Interleukin-4
      Short name=IL-4
Alternative name(s):
    B-cell stimulatory factor 1
      Short name=BSF-1
    Lymphocyte stimulatory factor 1
    B-cell IGG differentiation factor
    B-cell growth factor 1

Gene names

Name:	Il4
Synonyms:	Il-4

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-4/IL-13 family.

Ontologies

Keywords
Biological process	B-cell activation
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	B cell activation Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro inflammatory response Non-traceable author statement. Source: RGD
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Traceable author statement. Source: RGD growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW interleukin-4 receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 147	123	Interleukin-4		PRO_0000015542
Amino acid modifications
	Glycosylation	61	1	N-linked (GlcNAc...) Potential
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Glycosylation	117	1	N-linked (GlcNAc...) Potential
	Disulfide bond	47 ↔ 87		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P20096-1 [UniParc]. Last modified August 1, 1991. Version 2. Checksum: 1ED8658F6B6E1BC0	FASTA	147	16,247
	10 20 30 40 50 60 MGLSPHLAVT LFCFLICTGN GIHGCNDSPL REIINTLNQV TEKGTPCTEM FVPDVLTATR 70 80 90 100 110 120 NTTENELICR ASRVLRKFYF PRDVPPCLKN KSGVLGELRK LCRGVSGLNS LRSCTVNEST 130 140 LTTLKDFLES LKSILRGKYL QSCTSMS

References

[1]	"Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells." McKnight A.J., Barclay A.N., Mason D.W. Eur. J. Immunol. 21:1187-1194(1991) [PubMed: 1903705] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Evolutionary aspects, structure, and expression of the rat interleukin 4 gene." Richter G., Blankenstein T., Diamantstein T. Cytokine 2:221-228(1990) [PubMed: 1983334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X16058 mRNA. Translation: CAC16091.1. X53087, X53088, X53089 Genomic DNA. Translation: CAA37256.2.
IPI	IPI00195650.
PIR	ICRT4. A60237.
RefSeq	NP_958427.1.
UniGene	Rn.108255
3D structure databases
HSSP	HSSP built from PDB template 1RCB based on UniProtKB P05112.
ModBase	Search...
Protein-protein interaction databases
STRING	P20096.
Genome annotation databases
Ensembl	ENSRNOT00000010029; ENSRNOP00000010029; ENSRNOG00000007624; Rattus norvegicus. [Genome view]
GeneID	287287.
KEGG	rno:287287.
UCSC	NM_201270. rat.
Organism-specific databases
CTD	287287.
RGD	2898. Il4.
Phylogenomic databases
HOVERGEN	P20096.
OMA	ASKNTTE.
Gene expression databases
ArrayExpress	P20096.
Genevestigator	P20096.
GermOnline	ENSRNOG00000007624. Rattus norvegicus.
Family and domain databases
InterPro	IPR018096. Interleukin-4/-13_CS. IPR002354. Interleukin_4. IPR001325. Interleukin_4_13. [Graphical view]
PANTHER	PTHR11456. Interleukin_4. 1 hit.
Pfam	PF00727. IL4. 1 hit. [Graphical view]
PIRSF	PIRSF001941. Interleukin_4. 1 hit.
PRINTS	PR00431. INTERLEUKIN4.
ProDom	PD004070. Interleukin_4. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00190. IL4_13. 1 hit. [Graphical view]
PROSITE	PS00838. INTERLEUKIN_4_13. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	625805.

Entry information

Entry name

IL4_RAT

Accession

Primary (citable) accession number: P20096

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	August 1, 1991
Last modified:	November 3, 2009
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)