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Protein

FK506-binding protein 1

Gene

FPR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Miscellaneous

Binds to the immunosuppressant drug FK506 and also mediates the sensitivity to rapamycin. Rapamycin disrupts interaction with FAP1.
Present with 43300 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • FK506 binding Source: GO_Central
  • macrolide binding Source: SGD
  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

  • chaperone-mediated protein folding Source: GO_Central
  • chromatin organization Source: SGD
  • protein folding Source: SGD
  • regulation of homoserine biosynthetic process Source: SGD

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YNL135C-MONOMER.
ReactomeiR-SCE-3371568. Attenuation phase.

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein 1
Short name:
FKBP
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase (EC:5.2.1.8)
Short name:
PPIase
Rapamycin-binding protein
Gene namesi
Name:FPR1
Synonyms:FKB1, RBP1
Ordered Locus Names:YNL135C
ORF Names:N1213, N1845
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL135C.
SGDiS000005079. FPR1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi43F → Y: Reduces interaction with FAP1. 1 Publication1
Mutagenesisi44D → V: Abrogates interaction with FAP1. 1 Publication1
Mutagenesisi48D → V: Abrogates interaction with FAP1. 1 Publication1
Mutagenesisi49R → I: Abrogates interaction with FAP1. 1 Publication1
Mutagenesisi94F → V: Abrogates interaction with FAP1. 1 Publication1
Mutagenesisi106F → Y: Reduces interaction with FAP1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000753052 – 114FK506-binding protein 1Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei51PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP20081.
PRIDEiP20081.
TopDownProteomicsiP20081.

PTM databases

iPTMnetiP20081.

Interactioni

Subunit structurei

Interacts with HMO1. Interacts with FAP1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35691. 293 interactors.
DIPiDIP-1263N.
IntActiP20081. 21 interactors.
MINTiMINT-389324.

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Beta strandi10 – 15Combined sources6
Beta strandi28 – 37Combined sources10
Beta strandi42 – 46Combined sources5
Turni47 – 50Combined sources4
Beta strandi53 – 56Combined sources4
Beta strandi59 – 62Combined sources4
Helixi64 – 69Combined sources6
Helixi70 – 72Combined sources3
Beta strandi78 – 83Combined sources6
Helixi85 – 87Combined sources3
Turni88 – 92Combined sources5
Turni95 – 97Combined sources3
Beta strandi104 – 113Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YATX-ray2.50A2-114[»]
ProteinModelPortaliP20081.
SMRiP20081.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20081.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 114PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000119159.
HOGENOMiHOG000154887.
InParanoidiP20081.
KOiK09568.
OMAiVPCWTEG.
OrthoDBiEOG092C52SD.

Family and domain databases

InterProiView protein in InterPro
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVIEGNVK IDRISPGDGA TFPKTGDLVT IHYTGTLENG QKFDSSVDRG
60 70 80 90 100
SPFQCNIGVG QVIKGWDVGI PKLSVGEKAR LTIPGPYAYG PRGFPGLIPP
110
NSTLVFDVEL LKVN
Length:114
Mass (Da):12,158
Last modified:May 1, 1991 - v2
Checksum:i65C134830D300C06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46843 Genomic DNA. Translation: CAA86890.1.
M57967 Unassigned DNA. Translation: AAA03564.1.
M60877 Genomic DNA. Translation: AAA34607.1.
M63892 mRNA. Translation: AAA34962.1.
Z71411 Genomic DNA. Translation: CAA96017.1.
AY557997 Genomic DNA. Translation: AAS56323.1.
BK006947 Genomic DNA. Translation: DAA10413.1.
PIRiA37870. A33146.
RefSeqiNP_014264.1. NM_001182973.1.

Genome annotation databases

EnsemblFungiiYNL135C; YNL135C; YNL135C.
GeneIDi855587.
KEGGisce:YNL135C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46843 Genomic DNA. Translation: CAA86890.1.
M57967 Unassigned DNA. Translation: AAA03564.1.
M60877 Genomic DNA. Translation: AAA34607.1.
M63892 mRNA. Translation: AAA34962.1.
Z71411 Genomic DNA. Translation: CAA96017.1.
AY557997 Genomic DNA. Translation: AAS56323.1.
BK006947 Genomic DNA. Translation: DAA10413.1.
PIRiA37870. A33146.
RefSeqiNP_014264.1. NM_001182973.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YATX-ray2.50A2-114[»]
ProteinModelPortaliP20081.
SMRiP20081.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35691. 293 interactors.
DIPiDIP-1263N.
IntActiP20081. 21 interactors.
MINTiMINT-389324.

PTM databases

iPTMnetiP20081.

Proteomic databases

MaxQBiP20081.
PRIDEiP20081.
TopDownProteomicsiP20081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL135C; YNL135C; YNL135C.
GeneIDi855587.
KEGGisce:YNL135C.

Organism-specific databases

EuPathDBiFungiDB:YNL135C.
SGDiS000005079. FPR1.

Phylogenomic databases

GeneTreeiENSGT00760000119159.
HOGENOMiHOG000154887.
InParanoidiP20081.
KOiK09568.
OMAiVPCWTEG.
OrthoDBiEOG092C52SD.

Enzyme and pathway databases

BioCyciYEAST:YNL135C-MONOMER.
ReactomeiR-SCE-3371568. Attenuation phase.

Miscellaneous databases

EvolutionaryTraceiP20081.
PROiPR:P20081.

Family and domain databases

InterProiView protein in InterPro
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP_YEAST
AccessioniPrimary (citable) accession number: P20081
Secondary accession number(s): D6W147
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 1, 1991
Last modified: April 12, 2017
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.