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Protein

Annexin A7

Gene

ANXA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: InterPro
  • integrin binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • autophagy Source: UniProtKB
  • cell proliferation Source: Ensembl
  • cellular calcium ion homeostasis Source: Ensembl
  • cellular water homeostasis Source: Ensembl
  • epithelial cell differentiation Source: UniProtKB
  • hemostasis Source: Ensembl
  • membrane fusion Source: Ensembl
  • negative regulation of gene expression Source: UniProtKB
  • regulation of cell shape Source: Ensembl
  • response to calcium ion Source: Ensembl
  • response to organic cyclic compound Source: Ensembl
  • response to salt stress Source: Ensembl
  • social behavior Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A7
Alternative name(s):
Annexin VII
Annexin-7
Synexin
Gene namesi
Name:ANXA7
Synonyms:ANX7, SNX
ORF Names:OK/SW-cl.95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:545. ANXA7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • endoplasmic reticulum membrane Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nuclear envelope Source: Ensembl
  • nucleus Source: BHF-UCL
  • plasma membrane Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24835.

Polymorphism and mutation databases

BioMutaiANXA7.
DMDMi215274186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Annexin A7PRO_0000067499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei233 – 2331N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP20073.
PaxDbiP20073.
PRIDEiP20073.

2D gel databases

REPRODUCTION-2DPAGEIPI00002460.

PTM databases

PhosphoSiteiP20073.

Expressioni

Tissue specificityi

Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta.1 Publication

Gene expression databases

BgeeiP20073.
CleanExiHS_ANXA7.
ExpressionAtlasiP20073. baseline and differential.
GenevisibleiP20073. HS.

Organism-specific databases

HPAiCAB004312.

Interactioni

Subunit structurei

Interacts with PDCD6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRIP30626-12EBI-2338704,EBI-10816740

Protein-protein interaction databases

BioGridi106807. 115 interactions.
IntActiP20073. 115 interactions.
MINTiMINT-4999305.
STRINGi9606.ENSP00000362010.

Structurei

3D structure databases

ProteinModelPortaliP20073.
SMRiP20073. Positions 174-488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 951
Repeati10 – 1452
Repeati16 – 2053
Repeati189 – 25466Annexin 1Add
BLAST
Repeati266 – 32661Annexin 2Add
BLAST
Repeati349 – 40961Annexin 3Add
BLAST
Repeati425 – 48561Annexin 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 143143Repeat-rich regionAdd
BLAST
Regioni5 – 20163 X 5 AA tandem repeats of G-Y-P-P-XAdd
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG267770.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP20073.
KOiK17095.
OMAiFSQMYQK.
OrthoDBiEOG74XS72.
PhylomeDBiP20073.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR013286. AnnexinVII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01871. ANNEXINVII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20073-1) [UniParc]FASTAAdd to basket

Also known as: Annexin VIIb

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP
60 70 80 90 100
SSGYPGAGGY PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA
110 120 130 140 150
GFSGYPQPPS QSYGGGPAQV PLPGGFPGGQ MPSQYPGGQP TYPSQINTDS
160 170 180 190 200
FSSYPVFSPV SLDYSSEPAT VTQVTQGTIR PAANFDAIRD AEILRKAMKG
210 220 230 240 250
FGTDEQAIVD VVANRSNDQR QKIKAAFKTS YGKDLIKDLK SELSGNMEEL
260 270 280 290 300
ILALFMPPTY YDAWSLRKAM QGAGTQERVL IEILCTRTNQ EIREIVRCYQ
310 320 330 340 350
SEFGRDLEKD IRSDTSGHFE RLLVSMCQGN RDENQSINHQ MAQEDAQRLY
360 370 380 390 400
QAGEGRLGTD ESCFNMILAT RSFPQLRATM EAYSRMANRD LLSSVSREFS
410 420 430 440 450
GYVESGLKTI LQCALNRPAF FAERLYYAMK GAGTDDSTLV RIVVTRSEID
460 470 480
LVQIKQMFAQ MYQKTLGTMI AGDTSGDYRR LLLAIVGQ
Length:488
Mass (Da):52,739
Last modified:November 25, 2008 - v3
Checksum:iBFC688479D8CC2A0
GO
Isoform 2 (identifier: P20073-2) [UniParc]FASTAAdd to basket

Also known as: Annexin VIIa

The sequence of this isoform differs from the canonical sequence as follows:
     146-167: Missing.

Show »
Length:466
Mass (Da):50,316
Checksum:i09A6760729D45FCD
GO

Sequence cautioni

The sequence CAI52483.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti441 – 4411R → Q.
Corresponds to variant rs3750575 [ dbSNP | Ensembl ].
VAR_048253

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei146 – 16722Missing in isoform 2. 6 PublicationsVSP_011843Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04543 mRNA. Translation: AAA36616.1.
AB062429 mRNA. Translation: BAB93492.1.
BT007187 mRNA. Translation: AAP35851.1.
CR407686 mRNA. Translation: CAG28614.1.
AL512656, AL353731 Genomic DNA. Translation: CAI15290.1.
AL512656, AL353731 Genomic DNA. Translation: CAI15291.1.
AL353731 Genomic DNA. Translation: CAI52483.1. Sequence problems.
AL353731, AL512656 Genomic DNA. Translation: CAI52484.1.
AL353731, AL512656 Genomic DNA. Translation: CAI52485.1.
CH471083 Genomic DNA. Translation: EAW54493.1.
CH471083 Genomic DNA. Translation: EAW54494.1.
BC002632 mRNA. Translation: AAH02632.1.
CCDSiCCDS7325.1. [P20073-2]
CCDS7326.1. [P20073-1]
PIRiA54467. LUHU7.
RefSeqiNP_001147.1. NM_001156.3. [P20073-2]
NP_004025.1. NM_004034.2. [P20073-1]
UniGeneiHs.631827.

Genome annotation databases

EnsembliENST00000372919; ENSP00000362010; ENSG00000138279.
ENST00000372921; ENSP00000362012; ENSG00000138279. [P20073-2]
GeneIDi310.
KEGGihsa:310.
UCSCiuc001jtz.2. human. [P20073-1]
uc001jua.2. human. [P20073-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04543 mRNA. Translation: AAA36616.1.
AB062429 mRNA. Translation: BAB93492.1.
BT007187 mRNA. Translation: AAP35851.1.
CR407686 mRNA. Translation: CAG28614.1.
AL512656, AL353731 Genomic DNA. Translation: CAI15290.1.
AL512656, AL353731 Genomic DNA. Translation: CAI15291.1.
AL353731 Genomic DNA. Translation: CAI52483.1. Sequence problems.
AL353731, AL512656 Genomic DNA. Translation: CAI52484.1.
AL353731, AL512656 Genomic DNA. Translation: CAI52485.1.
CH471083 Genomic DNA. Translation: EAW54493.1.
CH471083 Genomic DNA. Translation: EAW54494.1.
BC002632 mRNA. Translation: AAH02632.1.
CCDSiCCDS7325.1. [P20073-2]
CCDS7326.1. [P20073-1]
PIRiA54467. LUHU7.
RefSeqiNP_001147.1. NM_001156.3. [P20073-2]
NP_004025.1. NM_004034.2. [P20073-1]
UniGeneiHs.631827.

3D structure databases

ProteinModelPortaliP20073.
SMRiP20073. Positions 174-488.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106807. 115 interactions.
IntActiP20073. 115 interactions.
MINTiMINT-4999305.
STRINGi9606.ENSP00000362010.

PTM databases

PhosphoSiteiP20073.

Polymorphism and mutation databases

BioMutaiANXA7.
DMDMi215274186.

2D gel databases

REPRODUCTION-2DPAGEIPI00002460.

Proteomic databases

MaxQBiP20073.
PaxDbiP20073.
PRIDEiP20073.

Protocols and materials databases

DNASUi310.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372919; ENSP00000362010; ENSG00000138279.
ENST00000372921; ENSP00000362012; ENSG00000138279. [P20073-2]
GeneIDi310.
KEGGihsa:310.
UCSCiuc001jtz.2. human. [P20073-1]
uc001jua.2. human. [P20073-2]

Organism-specific databases

CTDi310.
GeneCardsiGC10M075135.
HGNCiHGNC:545. ANXA7.
HPAiCAB004312.
MIMi186360. gene.
neXtProtiNX_P20073.
PharmGKBiPA24835.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG267770.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP20073.
KOiK17095.
OMAiFSQMYQK.
OrthoDBiEOG74XS72.
PhylomeDBiP20073.
TreeFamiTF105452.

Miscellaneous databases

ChiTaRSiANXA7. human.
GeneWikiiANXA7.
GenomeRNAii310.
NextBioi1253.
PROiP20073.
SOURCEiSearch...

Gene expression databases

BgeeiP20073.
CleanExiHS_ANXA7.
ExpressionAtlasiP20073. baseline and differential.
GenevisibleiP20073. HS.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR013286. AnnexinVII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01871. ANNEXINVII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Calcium channel activity of purified human synexin and structure of the human synexin gene."
    Burns A.L., Magendzo K., Shirvan A., Srivastava M., Rojas E., Alijani M.R., Pollard H.B.
    Proc. Natl. Acad. Sci. U.S.A. 86:3798-3802(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PARTIAL PROTEIN SEQUENCE.
  2. "Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10."
    Shirvan A., Srivastava M., Wang M.G., Cultraro C., Magendzo K., McBride O.W., Pollard H.B., Burns A.L.
    Biochemistry 33:6888-6901(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
    Shichijo S., Itoh K.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon adenocarcinoma.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Pancreas.
  9. "Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain."
    Magendzo K., Shirvan A., Cultraro C., Srivastava M., Pollard H.B., Burns A.L.
    J. Biol. Chem. 266:3228-3232(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 145-166 (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Fibroblast.
  10. "Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants."
    Shibata H., Suzuki H., Kakiuchi T., Inuzuka T., Yoshida H., Mizuno T., Maki M.
    J. Biol. Chem. 283:9623-9632(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDCD6.
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiANXA7_HUMAN
AccessioniPrimary (citable) accession number: P20073
Secondary accession number(s): Q5F2H3, Q5T0M6, Q5T0M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 25, 2008
Last modified: July 22, 2015
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.