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Protein

Annexin A7

Gene

ANXA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: InterPro
  • integrin binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • autophagy Source: UniProtKB
  • cell proliferation Source: Ensembl
  • cellular calcium ion homeostasis Source: Ensembl
  • cellular water homeostasis Source: Ensembl
  • epithelial cell differentiation Source: UniProtKB
  • hemostasis Source: Ensembl
  • membrane fusion Source: Ensembl
  • negative regulation of gene expression Source: UniProtKB
  • regulation of cell shape Source: Ensembl
  • response to calcium ion Source: Ensembl
  • response to organic cyclic compound Source: Ensembl
  • response to salt stress Source: Ensembl
  • social behavior Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A7
Alternative name(s):
Annexin VII
Annexin-7
Synexin
Gene namesi
Name:ANXA7
Synonyms:ANX7, SNX
ORF Names:OK/SW-cl.95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:545. ANXA7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • endoplasmic reticulum membrane Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nuclear envelope Source: Ensembl
  • nucleus Source: BHF-UCL
  • plasma membrane Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi310.
OpenTargetsiENSG00000138279.
PharmGKBiPA24835.

Polymorphism and mutation databases

BioMutaiANXA7.
DMDMi215274186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674991 – 488Annexin A7Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP20073.
MaxQBiP20073.
PaxDbiP20073.
PeptideAtlasiP20073.
PRIDEiP20073.
TopDownProteomicsiP20073-1. [P20073-1]

2D gel databases

REPRODUCTION-2DPAGEIPI00002460.

PTM databases

iPTMnetiP20073.
PhosphoSitePlusiP20073.
SwissPalmiP20073.

Expressioni

Tissue specificityi

Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta.1 Publication

Gene expression databases

BgeeiENSG00000138279.
CleanExiHS_ANXA7.
ExpressionAtlasiP20073. baseline and differential.
GenevisibleiP20073. HS.

Organism-specific databases

HPAiCAB004312.
HPA064290.

Interactioni

Subunit structurei

Interacts with PDCD6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRIP30626-12EBI-2338704,EBI-10816740

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • integrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi106807. 137 interactors.
IntActiP20073. 116 interactors.
MINTiMINT-4999305.
STRINGi9606.ENSP00000362010.

Structurei

3D structure databases

ProteinModelPortaliP20073.
SMRiP20073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 915
Repeati10 – 1425
Repeati16 – 2035
Repeati189 – 254Annexin 1Add BLAST66
Repeati266 – 326Annexin 2Add BLAST61
Repeati349 – 409Annexin 3Add BLAST61
Repeati425 – 485Annexin 4Add BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 143Repeat-rich regionAdd BLAST143
Regioni5 – 203 X 5 AA tandem repeats of G-Y-P-P-XAdd BLAST16

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP20073.
KOiK17095.
OMAiFSQMYQK.
OrthoDBiEOG091G0H6H.
PhylomeDBiP20073.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR013286. AnnexinVII.
[Graphical view]
PANTHERiPTHR10502:SF110. PTHR10502:SF110. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01871. ANNEXINVII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20073-1) [UniParc]FASTAAdd to basket
Also known as: Annexin VIIb

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP
60 70 80 90 100
SSGYPGAGGY PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA
110 120 130 140 150
GFSGYPQPPS QSYGGGPAQV PLPGGFPGGQ MPSQYPGGQP TYPSQINTDS
160 170 180 190 200
FSSYPVFSPV SLDYSSEPAT VTQVTQGTIR PAANFDAIRD AEILRKAMKG
210 220 230 240 250
FGTDEQAIVD VVANRSNDQR QKIKAAFKTS YGKDLIKDLK SELSGNMEEL
260 270 280 290 300
ILALFMPPTY YDAWSLRKAM QGAGTQERVL IEILCTRTNQ EIREIVRCYQ
310 320 330 340 350
SEFGRDLEKD IRSDTSGHFE RLLVSMCQGN RDENQSINHQ MAQEDAQRLY
360 370 380 390 400
QAGEGRLGTD ESCFNMILAT RSFPQLRATM EAYSRMANRD LLSSVSREFS
410 420 430 440 450
GYVESGLKTI LQCALNRPAF FAERLYYAMK GAGTDDSTLV RIVVTRSEID
460 470 480
LVQIKQMFAQ MYQKTLGTMI AGDTSGDYRR LLLAIVGQ
Length:488
Mass (Da):52,739
Last modified:November 25, 2008 - v3
Checksum:iBFC688479D8CC2A0
GO
Isoform 2 (identifier: P20073-2) [UniParc]FASTAAdd to basket
Also known as: Annexin VIIa

The sequence of this isoform differs from the canonical sequence as follows:
     146-167: Missing.

Show »
Length:466
Mass (Da):50,316
Checksum:i09A6760729D45FCD
GO

Sequence cautioni

The sequence CAI52483 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048253441R → Q.Corresponds to variant rs3750575dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011843146 – 167Missing in isoform 2. 6 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04543 mRNA. Translation: AAA36616.1.
AB062429 mRNA. Translation: BAB93492.1.
BT007187 mRNA. Translation: AAP35851.1.
CR407686 mRNA. Translation: CAG28614.1.
AL512656, AL353731 Genomic DNA. Translation: CAI15290.1.
AL512656, AL353731 Genomic DNA. Translation: CAI15291.1.
AL353731 Genomic DNA. Translation: CAI52483.1. Sequence problems.
AL353731, AL512656 Genomic DNA. Translation: CAI52484.1.
AL353731, AL512656 Genomic DNA. Translation: CAI52485.1.
CH471083 Genomic DNA. Translation: EAW54493.1.
CH471083 Genomic DNA. Translation: EAW54494.1.
BC002632 mRNA. Translation: AAH02632.1.
CCDSiCCDS7325.1. [P20073-2]
CCDS7326.1. [P20073-1]
PIRiA54467. LUHU7.
RefSeqiNP_001147.1. NM_001156.4. [P20073-2]
NP_004025.1. NM_004034.3. [P20073-1]
XP_016871651.1. XM_017016162.1. [P20073-1]
XP_016871652.1. XM_017016163.1. [P20073-2]
UniGeneiHs.631827.

Genome annotation databases

EnsembliENST00000372919; ENSP00000362010; ENSG00000138279. [P20073-1]
ENST00000372921; ENSP00000362012; ENSG00000138279. [P20073-2]
GeneIDi310.
KEGGihsa:310.
UCSCiuc001jtz.3. human. [P20073-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04543 mRNA. Translation: AAA36616.1.
AB062429 mRNA. Translation: BAB93492.1.
BT007187 mRNA. Translation: AAP35851.1.
CR407686 mRNA. Translation: CAG28614.1.
AL512656, AL353731 Genomic DNA. Translation: CAI15290.1.
AL512656, AL353731 Genomic DNA. Translation: CAI15291.1.
AL353731 Genomic DNA. Translation: CAI52483.1. Sequence problems.
AL353731, AL512656 Genomic DNA. Translation: CAI52484.1.
AL353731, AL512656 Genomic DNA. Translation: CAI52485.1.
CH471083 Genomic DNA. Translation: EAW54493.1.
CH471083 Genomic DNA. Translation: EAW54494.1.
BC002632 mRNA. Translation: AAH02632.1.
CCDSiCCDS7325.1. [P20073-2]
CCDS7326.1. [P20073-1]
PIRiA54467. LUHU7.
RefSeqiNP_001147.1. NM_001156.4. [P20073-2]
NP_004025.1. NM_004034.3. [P20073-1]
XP_016871651.1. XM_017016162.1. [P20073-1]
XP_016871652.1. XM_017016163.1. [P20073-2]
UniGeneiHs.631827.

3D structure databases

ProteinModelPortaliP20073.
SMRiP20073.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106807. 137 interactors.
IntActiP20073. 116 interactors.
MINTiMINT-4999305.
STRINGi9606.ENSP00000362010.

PTM databases

iPTMnetiP20073.
PhosphoSitePlusiP20073.
SwissPalmiP20073.

Polymorphism and mutation databases

BioMutaiANXA7.
DMDMi215274186.

2D gel databases

REPRODUCTION-2DPAGEIPI00002460.

Proteomic databases

EPDiP20073.
MaxQBiP20073.
PaxDbiP20073.
PeptideAtlasiP20073.
PRIDEiP20073.
TopDownProteomicsiP20073-1. [P20073-1]

Protocols and materials databases

DNASUi310.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372919; ENSP00000362010; ENSG00000138279. [P20073-1]
ENST00000372921; ENSP00000362012; ENSG00000138279. [P20073-2]
GeneIDi310.
KEGGihsa:310.
UCSCiuc001jtz.3. human. [P20073-1]

Organism-specific databases

CTDi310.
DisGeNETi310.
GeneCardsiANXA7.
HGNCiHGNC:545. ANXA7.
HPAiCAB004312.
HPA064290.
MIMi186360. gene.
neXtProtiNX_P20073.
OpenTargetsiENSG00000138279.
PharmGKBiPA24835.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP20073.
KOiK17095.
OMAiFSQMYQK.
OrthoDBiEOG091G0H6H.
PhylomeDBiP20073.
TreeFamiTF105452.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138279-MONOMER.

Miscellaneous databases

ChiTaRSiANXA7. human.
GeneWikiiANXA7.
GenomeRNAii310.
PROiP20073.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138279.
CleanExiHS_ANXA7.
ExpressionAtlasiP20073. baseline and differential.
GenevisibleiP20073. HS.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR013286. AnnexinVII.
[Graphical view]
PANTHERiPTHR10502:SF110. PTHR10502:SF110. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01871. ANNEXINVII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA7_HUMAN
AccessioniPrimary (citable) accession number: P20073
Secondary accession number(s): Q5F2H3, Q5T0M6, Q5T0M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 172 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.