SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P20073

- ANXA7_HUMAN

UniProt

P20073 - ANXA7_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Annexin A7
Gene
ANXA7, ANX7, SNX, OK/SW-cl.95
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. calcium-dependent phospholipid binding Source: UniProtKB-KW
  3. calcium-dependent protein binding Source: UniProtKB
  4. integrin binding Source: UniProt
  5. poly(A) RNA binding Source: UniProtKB
  6. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. autophagy Source: UniProt
  2. cell proliferation Source: Ensembl
  3. cellular calcium ion homeostasis Source: Ensembl
  4. cellular water homeostasis Source: Ensembl
  5. epithelial cell differentiation Source: UniProt
  6. hemostasis Source: Ensembl
  7. membrane fusion Source: Ensembl
  8. negative regulation of gene expression Source: UniProt
  9. regulation of cell shape Source: Ensembl
  10. response to calcium ion Source: Ensembl
  11. response to organic cyclic compound Source: Ensembl
  12. response to salt stress Source: Ensembl
  13. social behavior Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A7
Alternative name(s):
Annexin VII
Annexin-7
Synexin
Gene namesi
Name:ANXA7
Synonyms:ANX7, SNX
ORF Names:OK/SW-cl.95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:545. ANXA7.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endoplasmic reticulum membrane Source: BHF-UCL
  3. extracellular vesicular exosome Source: UniProt
  4. nuclear envelope Source: Ensembl
  5. nucleus Source: BHF-UCL
  6. plasma membrane Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Annexin A7
PRO_0000067499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei233 – 2331N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP20073.
PaxDbiP20073.
PRIDEiP20073.

2D gel databases

REPRODUCTION-2DPAGEiIPI00002460.

PTM databases

PhosphoSiteiP20073.

Expressioni

Tissue specificityi

Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta.1 Publication

Gene expression databases

ArrayExpressiP20073.
BgeeiP20073.
CleanExiHS_ANXA7.
GenevestigatoriP20073.

Organism-specific databases

HPAiCAB004312.

Interactioni

Subunit structurei

Interacts with PDCD6.1 Publication

Protein-protein interaction databases

BioGridi106807. 114 interactions.
IntActiP20073. 114 interactions.
MINTiMINT-4999305.
STRINGi9606.ENSP00000362010.

Structurei

3D structure databases

ProteinModelPortaliP20073.
SMRiP20073. Positions 174-488.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 951
Repeati10 – 1452
Repeati16 – 2053
Repeati189 – 25466Annexin 1
Add
BLAST
Repeati266 – 32661Annexin 2
Add
BLAST
Repeati349 – 40961Annexin 3
Add
BLAST
Repeati425 – 48561Annexin 4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 143143Repeat-rich region
Add
BLAST
Regioni5 – 20163 X 5 AA tandem repeats of G-Y-P-P-X
Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.
Contains 4 annexin repeats.

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG267770.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP20073.
KOiK17095.
OMAiFSQMYQK.
OrthoDBiEOG74XS72.
PhylomeDBiP20073.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR013286. AnnexinVII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01871. ANNEXINVII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P20073-1) [UniParc]FASTAAdd to Basket

Also known as: Annexin VIIb

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP    50
SSGYPGAGGY PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA 100
GFSGYPQPPS QSYGGGPAQV PLPGGFPGGQ MPSQYPGGQP TYPSQINTDS 150
FSSYPVFSPV SLDYSSEPAT VTQVTQGTIR PAANFDAIRD AEILRKAMKG 200
FGTDEQAIVD VVANRSNDQR QKIKAAFKTS YGKDLIKDLK SELSGNMEEL 250
ILALFMPPTY YDAWSLRKAM QGAGTQERVL IEILCTRTNQ EIREIVRCYQ 300
SEFGRDLEKD IRSDTSGHFE RLLVSMCQGN RDENQSINHQ MAQEDAQRLY 350
QAGEGRLGTD ESCFNMILAT RSFPQLRATM EAYSRMANRD LLSSVSREFS 400
GYVESGLKTI LQCALNRPAF FAERLYYAMK GAGTDDSTLV RIVVTRSEID 450
LVQIKQMFAQ MYQKTLGTMI AGDTSGDYRR LLLAIVGQ 488
Length:488
Mass (Da):52,739
Last modified:November 25, 2008 - v3
Checksum:iBFC688479D8CC2A0
GO
Isoform 2 (identifier: P20073-2) [UniParc]FASTAAdd to Basket

Also known as: Annexin VIIa

The sequence of this isoform differs from the canonical sequence as follows:
     146-167: Missing.

Show »
Length:466
Mass (Da):50,316
Checksum:i09A6760729D45FCD
GO

Sequence cautioni

The sequence CAI52483.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti441 – 4411R → Q.
Corresponds to variant rs3750575 [ dbSNP | Ensembl ].
VAR_048253

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei146 – 16722Missing in isoform 2.
VSP_011843Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04543 mRNA. Translation: AAA36616.1.
AB062429 mRNA. Translation: BAB93492.1.
BT007187 mRNA. Translation: AAP35851.1.
CR407686 mRNA. Translation: CAG28614.1.
AL512656, AL353731 Genomic DNA. Translation: CAI15290.1.
AL512656, AL353731 Genomic DNA. Translation: CAI15291.1.
AL353731 Genomic DNA. Translation: CAI52483.1. Sequence problems.
AL353731, AL512656 Genomic DNA. Translation: CAI52484.1.
AL353731, AL512656 Genomic DNA. Translation: CAI52485.1.
CH471083 Genomic DNA. Translation: EAW54493.1.
CH471083 Genomic DNA. Translation: EAW54494.1.
BC002632 mRNA. Translation: AAH02632.1.
CCDSiCCDS7325.1. [P20073-2]
CCDS7326.1. [P20073-1]
PIRiA54467. LUHU7.
RefSeqiNP_001147.1. NM_001156.3. [P20073-2]
NP_004025.1. NM_004034.2. [P20073-1]
UniGeneiHs.631827.

Genome annotation databases

EnsembliENST00000372919; ENSP00000362010; ENSG00000138279. [P20073-1]
ENST00000372921; ENSP00000362012; ENSG00000138279. [P20073-2]
GeneIDi310.
KEGGihsa:310.
UCSCiuc001jtz.2. human. [P20073-1]
uc001jua.2. human. [P20073-2]

Polymorphism databases

DMDMi215274186.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04543 mRNA. Translation: AAA36616.1 .
AB062429 mRNA. Translation: BAB93492.1 .
BT007187 mRNA. Translation: AAP35851.1 .
CR407686 mRNA. Translation: CAG28614.1 .
AL512656 , AL353731 Genomic DNA. Translation: CAI15290.1 .
AL512656 , AL353731 Genomic DNA. Translation: CAI15291.1 .
AL353731 Genomic DNA. Translation: CAI52483.1 . Sequence problems.
AL353731 , AL512656 Genomic DNA. Translation: CAI52484.1 .
AL353731 , AL512656 Genomic DNA. Translation: CAI52485.1 .
CH471083 Genomic DNA. Translation: EAW54493.1 .
CH471083 Genomic DNA. Translation: EAW54494.1 .
BC002632 mRNA. Translation: AAH02632.1 .
CCDSi CCDS7325.1. [P20073-2 ]
CCDS7326.1. [P20073-1 ]
PIRi A54467. LUHU7.
RefSeqi NP_001147.1. NM_001156.3. [P20073-2 ]
NP_004025.1. NM_004034.2. [P20073-1 ]
UniGenei Hs.631827.

3D structure databases

ProteinModelPortali P20073.
SMRi P20073. Positions 174-488.
ModBasei Search...

Protein-protein interaction databases

BioGridi 106807. 114 interactions.
IntActi P20073. 114 interactions.
MINTi MINT-4999305.
STRINGi 9606.ENSP00000362010.

PTM databases

PhosphoSitei P20073.

Polymorphism databases

DMDMi 215274186.

2D gel databases

REPRODUCTION-2DPAGEi IPI00002460.

Proteomic databases

MaxQBi P20073.
PaxDbi P20073.
PRIDEi P20073.

Protocols and materials databases

DNASUi 310.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372919 ; ENSP00000362010 ; ENSG00000138279 . [P20073-1 ]
ENST00000372921 ; ENSP00000362012 ; ENSG00000138279 . [P20073-2 ]
GeneIDi 310.
KEGGi hsa:310.
UCSCi uc001jtz.2. human. [P20073-1 ]
uc001jua.2. human. [P20073-2 ]

Organism-specific databases

CTDi 310.
GeneCardsi GC10M075135.
HGNCi HGNC:545. ANXA7.
HPAi CAB004312.
MIMi 186360. gene.
neXtProti NX_P20073.
PharmGKBi PA24835.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267770.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi P20073.
KOi K17095.
OMAi FSQMYQK.
OrthoDBi EOG74XS72.
PhylomeDBi P20073.
TreeFami TF105452.

Miscellaneous databases

ChiTaRSi ANXA7. human.
GeneWikii ANXA7.
GenomeRNAii 310.
NextBioi 1253.
PROi P20073.
SOURCEi Search...

Gene expression databases

ArrayExpressi P20073.
Bgeei P20073.
CleanExi HS_ANXA7.
Genevestigatori P20073.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR013286. AnnexinVII.
[Graphical view ]
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR01871. ANNEXINVII.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Calcium channel activity of purified human synexin and structure of the human synexin gene."
    Burns A.L., Magendzo K., Shirvan A., Srivastava M., Rojas E., Alijani M.R., Pollard H.B.
    Proc. Natl. Acad. Sci. U.S.A. 86:3798-3802(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PARTIAL PROTEIN SEQUENCE.
  2. "Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10."
    Shirvan A., Srivastava M., Wang M.G., Cultraro C., Magendzo K., McBride O.W., Pollard H.B., Burns A.L.
    Biochemistry 33:6888-6901(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
    Shichijo S., Itoh K.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon adenocarcinoma.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Pancreas.
  9. "Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain."
    Magendzo K., Shirvan A., Cultraro C., Srivastava M., Pollard H.B., Burns A.L.
    J. Biol. Chem. 266:3228-3232(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 145-166 (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Fibroblast.
  10. "Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants."
    Shibata H., Suzuki H., Kakiuchi T., Inuzuka T., Yoshida H., Mizuno T., Maki M.
    J. Biol. Chem. 283:9623-9632(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDCD6.
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiANXA7_HUMAN
AccessioniPrimary (citable) accession number: P20073
Secondary accession number(s): Q5F2H3, Q5T0M6, Q5T0M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi