P20073 (ANXA7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Annexin A7

Alternative name(s):
Annexin VII
Annexin-7
Synexin

Gene names

Name:	ANXA7
Synonyms:	ANX7, SNX
ORF Names:	OK/SW-cl.95

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
Subunit structure	Interacts with PDCD6. Ref.10
Tissue specificity	Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta. Ref.9
Domain	A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similarities	Belongs to the annexin family. Contains 4 annexin repeats.
Sequence caution	The sequence CAI52483.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Annexin Repeat
Ligand	Calcium Calcium/phospholipid-binding
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara cellular water homeostasis Inferred from electronic annotation. Source: Compara hemostasis Inferred from electronic annotation. Source: Compara regulation of cell shape Inferred from electronic annotation. Source: Compara response to salt stress Inferred from electronic annotation. Source: Compara social behavior Inferred from expression pattern PubMed 21531385. Source: UniProtKB
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara endoplasmic reticulum membrane Inferred from direct assay PubMed 10672515. Source: BHF-UCL nuclear envelope Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay PubMed 10672515. Source: BHF-UCL plasma membrane Inferred from electronic annotation. Source: Compara vesicle Inferred from electronic annotation. Source: Compara
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro calcium-dependent phospholipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P20073-1)

Also known as: Annexin VIIb;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P20073-2)

Also known as: Annexin VIIa;

The sequence of this isoform differs from the canonical sequence as follows:
     146-167: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Annexin A7		PRO_0000067499
Regions
	Repeat	5 – 9	5	1
	Repeat	10 – 14	5	2
	Repeat	16 – 20	5	3
	Repeat	189 – 254	66	Annexin 1
	Repeat	266 – 326	61	Annexin 2
	Repeat	349 – 409	61	Annexin 3
	Repeat	425 – 485	61	Annexin 4
	Region	1 – 143	143	Repeat-rich region
	Region	5 – 20	16	3 X 5 AA tandem repeats of G-Y-P-P-X
Amino acid modifications
	Modified residue	233	1	N6-acetyllysine Ref.11
Natural variations
	Alternative sequence	146 – 167	22	Missing in isoform 2.		VSP_011843
	Natural variant	441	1	R → Q. Corresponds to variant rs3750575 [ dbSNP | Ensembl ].		VAR_048253

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Annexin VIIb) [UniParc]. Last modified November 25, 2008. Version 3. Checksum: BFC688479D8CC2A0	FASTA	488	52,739
	10 20 30 40 50 60 MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP SSGYPGAGGY 70 80 90 100 110 120 PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA GFSGYPQPPS QSYGGGPAQV 130 140 150 160 170 180 PLPGGFPGGQ MPSQYPGGQP TYPSQINTDS FSSYPVFSPV SLDYSSEPAT VTQVTQGTIR 190 200 210 220 230 240 PAANFDAIRD AEILRKAMKG FGTDEQAIVD VVANRSNDQR QKIKAAFKTS YGKDLIKDLK 250 260 270 280 290 300 SELSGNMEEL ILALFMPPTY YDAWSLRKAM QGAGTQERVL IEILCTRTNQ EIREIVRCYQ 310 320 330 340 350 360 SEFGRDLEKD IRSDTSGHFE RLLVSMCQGN RDENQSINHQ MAQEDAQRLY QAGEGRLGTD 370 380 390 400 410 420 ESCFNMILAT RSFPQLRATM EAYSRMANRD LLSSVSREFS GYVESGLKTI LQCALNRPAF 430 440 450 460 470 480 FAERLYYAMK GAGTDDSTLV RIVVTRSEID LVQIKQMFAQ MYQKTLGTMI AGDTSGDYRR LLLAIVGQ
	Isoform 2 (Annexin VIIa) [UniParc]. Checksum: 09A6760729D45FCD	FASTA	466	50,316
	10 20 30 40 50 60 MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP SSGYPGAGGY 70 80 90 100 110 120 PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA GFSGYPQPPS QSYGGGPAQV 130 140 150 160 170 180 PLPGGFPGGQ MPSQYPGGQP TYPSQPATVT QVTQGTIRPA ANFDAIRDAE ILRKAMKGFG 190 200 210 220 230 240 TDEQAIVDVV ANRSNDQRQK IKAAFKTSYG KDLIKDLKSE LSGNMEELIL ALFMPPTYYD 250 260 270 280 290 300 AWSLRKAMQG AGTQERVLIE ILCTRTNQEI REIVRCYQSE FGRDLEKDIR SDTSGHFERL 310 320 330 340 350 360 LVSMCQGNRD ENQSINHQMA QEDAQRLYQA GEGRLGTDES CFNMILATRS FPQLRATMEA 370 380 390 400 410 420 YSRMANRDLL SSVSREFSGY VESGLKTILQ CALNRPAFFA ERLYYAMKGA GTDDSTLVRI 430 440 450 460 VVTRSEIDLV QIKQMFAQMY QKTLGTMIAG DTSGDYRRLL LAIVGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Calcium channel activity of purified human synexin and structure of the human synexin gene." Burns A.L., Magendzo K., Shirvan A., Srivastava M., Rojas E., Alijani M.R., Pollard H.B. Proc. Natl. Acad. Sci. U.S.A. 86:3798-3802(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PARTIAL PROTEIN SEQUENCE.
[2]	"Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10." Shirvan A., Srivastava M., Wang M.G., Cultraro C., Magendzo K., McBride O.W., Pollard H.B., Burns A.L. Biochemistry 33:6888-6901(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[3]	"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients." Shichijo S., Itoh K. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Colon adenocarcinoma.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Pancreas.
[9]	"Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain." Magendzo K., Shirvan A., Cultraro C., Srivastava M., Pollard H.B., Burns A.L. J. Biol. Chem. 266:3228-3232(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 145-166 (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Fibroblast.
[10]	"Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants." Shibata H., Suzuki H., Kakiuchi T., Inuzuka T., Yoshida H., Mizuno T., Maki M. J. Biol. Chem. 283:9623-9632(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PDCD6.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-233, MASS SPECTROMETRY.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04543 mRNA. Translation: AAA36616.1. AB062429 mRNA. Translation: BAB93492.1. BT007187 mRNA. Translation: AAP35851.1. CR407686 mRNA. Translation: CAG28614.1. AL512656, AL353731 Genomic DNA. Translation: CAI15290.1. AL512656, AL353731 Genomic DNA. Translation: CAI15291.1. AL353731 Genomic DNA. Translation: CAI52483.1. Sequence problems. AL353731, AL512656 Genomic DNA. Translation: CAI52484.1. AL353731, AL512656 Genomic DNA. Translation: CAI52485.1. CH471083 Genomic DNA. Translation: EAW54493.1. CH471083 Genomic DNA. Translation: EAW54494.1. BC002632 mRNA. Translation: AAH02632.1.
IPI	IPI00002460. IPI00021771.
PIR	LUHU7. A54467.
RefSeq	NP_001147.1. NM_001156.3. NP_004025.1. NM_004034.2.
UniGene	Hs.631827.
3D structure databases
ProteinModelPortal	P20073.
ModBase	Search...
Protein-protein interaction databases
IntAct	P20073. 16 interactions.
STRING	9606.ENSP00000362010.
PTM databases
PhosphoSite	P20073.
Polymorphism databases
DMDM	215274186.
2D gel databases
REPRODUCTION-2DPAGE	IPI00002460.
Proteomic databases
PaxDb	P20073.
PRIDE	P20073.
Protocols and materials databases
DNASU	310.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372919; ENSP00000362010; ENSG00000138279. ENST00000372921; ENSP00000362012; ENSG00000138279.
GeneID	310.
KEGG	hsa:310.
UCSC	uc001jtz.2. human. uc001jua.2. human.
Organism-specific databases
CTD	310.
GeneCards	GC10M075135.
HGNC	HGNC:545. ANXA7.
HPA	CAB004312.
MIM	186360. gene.
neXtProt	NX_P20073.
PharmGKB	PA24835.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG267770.
HOGENOM	HOG000158803.
HOVERGEN	HBG061815.
InParanoid	P20073.
OMA	QAPYPSQ.
PhylomeDB	P20073.
Gene expression databases
ArrayExpress	P20073.
Bgee	P20073.
CleanEx	HS_ANXA7.
Genevestigator	P20073.
GermOnline	ENSG00000138279. Homo sapiens.
Family and domain databases
Gene3D	1.10.220.10. 4 hits.
InterPro	IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR013286. AnnexinVII. [Graphical view]
PANTHER	PTHR10502. PTHR10502. 1 hit.
Pfam	PF00191. Annexin. 4 hits. [Graphical view]
PRINTS	PR00196. ANNEXIN. PR01871. ANNEXINVII.
SMART	SM00335. ANX. 4 hits. [Graphical view]
SUPFAM	SSF47874. Annexin. 1 hit.
PROSITE	PS00223. ANNEXIN. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ANXA7. human.
GenomeRNAi	310.
NextBio	1253.
SOURCE	Search...

Entry information

Entry name

ANXA7_HUMAN

Accession

Primary (citable) accession number: P20073
Secondary accession number(s): Q5F2H3, Q5T0M6, Q5T0M7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 138 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.