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P20073

- ANXA7_HUMAN

UniProt

P20073 - ANXA7_HUMAN

Protein

Annexin A7

Gene

ANXA7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium-dependent protein binding Source: UniProtKB
    3. calcium ion binding Source: InterPro
    4. integrin binding Source: UniProt
    5. poly(A) RNA binding Source: UniProtKB
    6. protein binding Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProt
    2. cell proliferation Source: Ensembl
    3. cellular calcium ion homeostasis Source: Ensembl
    4. cellular water homeostasis Source: Ensembl
    5. epithelial cell differentiation Source: UniProt
    6. hemostasis Source: Ensembl
    7. membrane fusion Source: Ensembl
    8. negative regulation of gene expression Source: UniProt
    9. regulation of cell shape Source: Ensembl
    10. response to calcium ion Source: Ensembl
    11. response to organic cyclic compound Source: Ensembl
    12. response to salt stress Source: Ensembl
    13. social behavior Source: UniProtKB

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A7
    Alternative name(s):
    Annexin VII
    Annexin-7
    Synexin
    Gene namesi
    Name:ANXA7
    Synonyms:ANX7, SNX
    ORF Names:OK/SW-cl.95
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:545. ANXA7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. endoplasmic reticulum membrane Source: BHF-UCL
    3. extracellular vesicular exosome Source: UniProt
    4. membrane Source: UniProtKB
    5. nuclear envelope Source: Ensembl
    6. nucleus Source: BHF-UCL
    7. plasma membrane Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24835.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Annexin A7PRO_0000067499Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei233 – 2331N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP20073.
    PaxDbiP20073.
    PRIDEiP20073.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00002460.

    PTM databases

    PhosphoSiteiP20073.

    Expressioni

    Tissue specificityi

    Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta.1 Publication

    Gene expression databases

    ArrayExpressiP20073.
    BgeeiP20073.
    CleanExiHS_ANXA7.
    GenevestigatoriP20073.

    Organism-specific databases

    HPAiCAB004312.

    Interactioni

    Subunit structurei

    Interacts with PDCD6.1 Publication

    Protein-protein interaction databases

    BioGridi106807. 114 interactions.
    IntActiP20073. 114 interactions.
    MINTiMINT-4999305.
    STRINGi9606.ENSP00000362010.

    Structurei

    3D structure databases

    ProteinModelPortaliP20073.
    SMRiP20073. Positions 174-488.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati5 – 951
    Repeati10 – 1452
    Repeati16 – 2053
    Repeati189 – 25466Annexin 1Add
    BLAST
    Repeati266 – 32661Annexin 2Add
    BLAST
    Repeati349 – 40961Annexin 3Add
    BLAST
    Repeati425 – 48561Annexin 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 143143Repeat-rich regionAdd
    BLAST
    Regioni5 – 20163 X 5 AA tandem repeats of G-Y-P-P-XAdd
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG267770.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    InParanoidiP20073.
    KOiK17095.
    OMAiFSQMYQK.
    OrthoDBiEOG74XS72.
    PhylomeDBiP20073.
    TreeFamiTF105452.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR013286. AnnexinVII.
    [Graphical view]
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR01871. ANNEXINVII.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P20073-1) [UniParc]FASTAAdd to Basket

    Also known as: Annexin VIIb

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP    50
    SSGYPGAGGY PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA 100
    GFSGYPQPPS QSYGGGPAQV PLPGGFPGGQ MPSQYPGGQP TYPSQINTDS 150
    FSSYPVFSPV SLDYSSEPAT VTQVTQGTIR PAANFDAIRD AEILRKAMKG 200
    FGTDEQAIVD VVANRSNDQR QKIKAAFKTS YGKDLIKDLK SELSGNMEEL 250
    ILALFMPPTY YDAWSLRKAM QGAGTQERVL IEILCTRTNQ EIREIVRCYQ 300
    SEFGRDLEKD IRSDTSGHFE RLLVSMCQGN RDENQSINHQ MAQEDAQRLY 350
    QAGEGRLGTD ESCFNMILAT RSFPQLRATM EAYSRMANRD LLSSVSREFS 400
    GYVESGLKTI LQCALNRPAF FAERLYYAMK GAGTDDSTLV RIVVTRSEID 450
    LVQIKQMFAQ MYQKTLGTMI AGDTSGDYRR LLLAIVGQ 488
    Length:488
    Mass (Da):52,739
    Last modified:November 25, 2008 - v3
    Checksum:iBFC688479D8CC2A0
    GO
    Isoform 2 (identifier: P20073-2) [UniParc]FASTAAdd to Basket

    Also known as: Annexin VIIa

    The sequence of this isoform differs from the canonical sequence as follows:
         146-167: Missing.

    Show »
    Length:466
    Mass (Da):50,316
    Checksum:i09A6760729D45FCD
    GO

    Sequence cautioni

    The sequence CAI52483.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti441 – 4411R → Q.
    Corresponds to variant rs3750575 [ dbSNP | Ensembl ].
    VAR_048253

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei146 – 16722Missing in isoform 2. 6 PublicationsVSP_011843Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04543 mRNA. Translation: AAA36616.1.
    AB062429 mRNA. Translation: BAB93492.1.
    BT007187 mRNA. Translation: AAP35851.1.
    CR407686 mRNA. Translation: CAG28614.1.
    AL512656, AL353731 Genomic DNA. Translation: CAI15290.1.
    AL512656, AL353731 Genomic DNA. Translation: CAI15291.1.
    AL353731 Genomic DNA. Translation: CAI52483.1. Sequence problems.
    AL353731, AL512656 Genomic DNA. Translation: CAI52484.1.
    AL353731, AL512656 Genomic DNA. Translation: CAI52485.1.
    CH471083 Genomic DNA. Translation: EAW54493.1.
    CH471083 Genomic DNA. Translation: EAW54494.1.
    BC002632 mRNA. Translation: AAH02632.1.
    CCDSiCCDS7325.1. [P20073-2]
    CCDS7326.1. [P20073-1]
    PIRiA54467. LUHU7.
    RefSeqiNP_001147.1. NM_001156.3. [P20073-2]
    NP_004025.1. NM_004034.2. [P20073-1]
    UniGeneiHs.631827.

    Genome annotation databases

    EnsembliENST00000372919; ENSP00000362010; ENSG00000138279. [P20073-1]
    ENST00000372921; ENSP00000362012; ENSG00000138279. [P20073-2]
    GeneIDi310.
    KEGGihsa:310.
    UCSCiuc001jtz.2. human. [P20073-1]
    uc001jua.2. human. [P20073-2]

    Polymorphism databases

    DMDMi215274186.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04543 mRNA. Translation: AAA36616.1 .
    AB062429 mRNA. Translation: BAB93492.1 .
    BT007187 mRNA. Translation: AAP35851.1 .
    CR407686 mRNA. Translation: CAG28614.1 .
    AL512656 , AL353731 Genomic DNA. Translation: CAI15290.1 .
    AL512656 , AL353731 Genomic DNA. Translation: CAI15291.1 .
    AL353731 Genomic DNA. Translation: CAI52483.1 . Sequence problems.
    AL353731 , AL512656 Genomic DNA. Translation: CAI52484.1 .
    AL353731 , AL512656 Genomic DNA. Translation: CAI52485.1 .
    CH471083 Genomic DNA. Translation: EAW54493.1 .
    CH471083 Genomic DNA. Translation: EAW54494.1 .
    BC002632 mRNA. Translation: AAH02632.1 .
    CCDSi CCDS7325.1. [P20073-2 ]
    CCDS7326.1. [P20073-1 ]
    PIRi A54467. LUHU7.
    RefSeqi NP_001147.1. NM_001156.3. [P20073-2 ]
    NP_004025.1. NM_004034.2. [P20073-1 ]
    UniGenei Hs.631827.

    3D structure databases

    ProteinModelPortali P20073.
    SMRi P20073. Positions 174-488.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106807. 114 interactions.
    IntActi P20073. 114 interactions.
    MINTi MINT-4999305.
    STRINGi 9606.ENSP00000362010.

    PTM databases

    PhosphoSitei P20073.

    Polymorphism databases

    DMDMi 215274186.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00002460.

    Proteomic databases

    MaxQBi P20073.
    PaxDbi P20073.
    PRIDEi P20073.

    Protocols and materials databases

    DNASUi 310.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372919 ; ENSP00000362010 ; ENSG00000138279 . [P20073-1 ]
    ENST00000372921 ; ENSP00000362012 ; ENSG00000138279 . [P20073-2 ]
    GeneIDi 310.
    KEGGi hsa:310.
    UCSCi uc001jtz.2. human. [P20073-1 ]
    uc001jua.2. human. [P20073-2 ]

    Organism-specific databases

    CTDi 310.
    GeneCardsi GC10M075135.
    HGNCi HGNC:545. ANXA7.
    HPAi CAB004312.
    MIMi 186360. gene.
    neXtProti NX_P20073.
    PharmGKBi PA24835.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267770.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    InParanoidi P20073.
    KOi K17095.
    OMAi FSQMYQK.
    OrthoDBi EOG74XS72.
    PhylomeDBi P20073.
    TreeFami TF105452.

    Miscellaneous databases

    ChiTaRSi ANXA7. human.
    GeneWikii ANXA7.
    GenomeRNAii 310.
    NextBioi 1253.
    PROi P20073.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20073.
    Bgeei P20073.
    CleanExi HS_ANXA7.
    Genevestigatori P20073.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR013286. AnnexinVII.
    [Graphical view ]
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR01871. ANNEXINVII.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Calcium channel activity of purified human synexin and structure of the human synexin gene."
      Burns A.L., Magendzo K., Shirvan A., Srivastava M., Rojas E., Alijani M.R., Pollard H.B.
      Proc. Natl. Acad. Sci. U.S.A. 86:3798-3802(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PARTIAL PROTEIN SEQUENCE.
    2. "Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10."
      Shirvan A., Srivastava M., Wang M.G., Cultraro C., Magendzo K., McBride O.W., Pollard H.B., Burns A.L.
      Biochemistry 33:6888-6901(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    3. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S., Itoh K.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon adenocarcinoma.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Pancreas.
    9. "Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain."
      Magendzo K., Shirvan A., Cultraro C., Srivastava M., Pollard H.B., Burns A.L.
      J. Biol. Chem. 266:3228-3232(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 145-166 (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Fibroblast.
    10. "Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants."
      Shibata H., Suzuki H., Kakiuchi T., Inuzuka T., Yoshida H., Mizuno T., Maki M.
      J. Biol. Chem. 283:9623-9632(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PDCD6.
    11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiANXA7_HUMAN
    AccessioniPrimary (citable) accession number: P20073
    Secondary accession number(s): Q5F2H3, Q5T0M6, Q5T0M7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 150 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3