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Protein

Annexin A7

Gene

ANXA7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: InterPro
  • identical protein binding Source: AgBase
  • integrin binding Source: Ensembl

GO - Biological processi

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A7
Alternative name(s):
Annexin VII
Annexin-7
Synexin
Gene namesi
Name:ANXA7
Synonyms:ANX7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 28

Organism-specific databases

VGNCiVGNC:25969 ANXA7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674981 – 463Annexin A7Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei208N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP20072
PeptideAtlasiP20072
PRIDEiP20072

Expressioni

Gene expression databases

BgeeiENSBTAG00000020218

Interactioni

Subunit structurei

Interacts with PDCD6.By similarity

GO - Molecular functioni

  • calcium-dependent protein binding Source: AgBase
  • identical protein binding Source: AgBase
  • integrin binding Source: Ensembl

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000046882

Structurei

3D structure databases

ProteinModelPortaliP20072
SMRiP20072
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 915
Repeati10 – 1425
Repeati16 – 2035
Repeati169 – 229Annexin 1Add BLAST61
Repeati241 – 301Annexin 2Add BLAST61
Repeati324 – 384Annexin 3Add BLAST61
Repeati400 – 460Annexin 4Add BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 140Repeat-rich regionBy similarityAdd BLAST140
Regioni5 – 203 X 5 AA tandem repeats of G-Y-P-P-XAdd BLAST16

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP20072
KOiK17095
OMAiSQMYQKT
OrthoDBiEOG091G0H6H
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR013286 ANX7
IPR034309 ANX7_chordates
PANTHERiPTHR10502:SF110 PTHR10502:SF110, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR01871 ANNEXINVII
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequencei

Sequence statusi: Complete.

P20072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPGYPPTG YPPFPGYPPT GQESSFPPPG QYPYPSGFPP MGGGAYPPAP
60 70 80 90 100
SSGYPGAGGY PAPGGYPAPG GYPGAPQPGG APSYPGGQGF GAPPGGAGFP
110 120 130 140 150
GYPQPPTQSY GGGPAQVPLP GGFPGGAMPS QYPGGQSPYP SQPAPMTQGT
160 170 180 190 200
HGTIRPAANF DAMRDAEVLR KAMKGFGTDE QAIIDVVANR SNDQRQKIKA
210 220 230 240 250
AFKTMYGKDL IKDLKSELSG NMEELILALF MPSTYYDAWS LRNAMKGAGT
260 270 280 290 300
QERVLIEILC TRTNQEIREI VRCYQSEFGR DLEKDIRSDT SGHFERLLVS
310 320 330 340 350
MCQGNRDENQ NVNHQLAQED AQRLYQAGEG RLGTDESCFN MILATRSFPQ
360 370 380 390 400
LKATMEAYSR MANRDLLNSV SREFSGNVES GLKTILQCAL NRPAFFAERL
410 420 430 440 450
YYSMKGAGTD DSTLVRIVVT RSEIDLVQIK QMFSQMYQKT LGTMIASDTS
460
GDYRKLLLAI VGQ
Length:463
Mass (Da):49,940
Last modified:April 3, 2007 - v2
Checksum:iFDD8A37D5B29C555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116141 mRNA Translation: AAI16142.1
PIRiA27695
RefSeqiNP_001069459.1, NM_001075991.1
XP_005226474.2, XM_005226417.3
UniGeneiBt.36610

Genome annotation databases

EnsembliENSBTAT00000050132; ENSBTAP00000046882; ENSBTAG00000020218
GeneIDi533360
KEGGibta:533360

Similar proteinsi

Entry informationi

Entry nameiANXA7_BOVIN
AccessioniPrimary (citable) accession number: P20072
Secondary accession number(s): Q1LZ88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health