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Protein

Annexin A7

Gene

ANXA7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: InterPro
  • identical protein binding Source: AgBase
  • integrin binding Source: Ensembl
  • RNA binding Source: Ensembl

GO - Biological processi

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A7
Alternative name(s):
Annexin VII
Annexin-7
Synexin
Gene namesi
Name:ANXA7
Synonyms:ANX7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 28

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674981 – 463Annexin A7Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei208N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP20072.
PeptideAtlasiP20072.
PRIDEiP20072.

Expressioni

Gene expression databases

BgeeiENSBTAG00000020218.

Interactioni

Subunit structurei

Interacts with PDCD6.By similarity

GO - Molecular functioni

  • calcium-dependent protein binding Source: AgBase
  • identical protein binding Source: AgBase
  • integrin binding Source: Ensembl

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000046882.

Structurei

3D structure databases

ProteinModelPortaliP20072.
SMRiP20072.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 915
Repeati10 – 1425
Repeati16 – 2035
Repeati169 – 229Annexin 1Add BLAST61
Repeati241 – 301Annexin 2Add BLAST61
Repeati324 – 384Annexin 3Add BLAST61
Repeati400 – 460Annexin 4Add BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 140Repeat-rich regionBy similarityAdd BLAST140
Regioni5 – 203 X 5 AA tandem repeats of G-Y-P-P-XAdd BLAST16

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP20072.
KOiK17095.
OMAiSQMYQKT.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiView protein in InterPro
IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR013286. ANX7.
IPR034309. ANX7_chordates.
PANTHERiPTHR10502:SF135. PTHR10502:SF135. 1 hit.
PfamiView protein in Pfam
PF00191. Annexin. 4 hits.
PRINTSiPR00196. ANNEXIN.
PR01871. ANNEXINVII.
SMARTiView protein in SMART
SM00335. ANX. 4 hits.
PROSITEiView protein in PROSITE
PS00223. ANNEXIN. 4 hits.

Sequencei

Sequence statusi: Complete.

P20072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPGYPPTG YPPFPGYPPT GQESSFPPPG QYPYPSGFPP MGGGAYPPAP
60 70 80 90 100
SSGYPGAGGY PAPGGYPAPG GYPGAPQPGG APSYPGGQGF GAPPGGAGFP
110 120 130 140 150
GYPQPPTQSY GGGPAQVPLP GGFPGGAMPS QYPGGQSPYP SQPAPMTQGT
160 170 180 190 200
HGTIRPAANF DAMRDAEVLR KAMKGFGTDE QAIIDVVANR SNDQRQKIKA
210 220 230 240 250
AFKTMYGKDL IKDLKSELSG NMEELILALF MPSTYYDAWS LRNAMKGAGT
260 270 280 290 300
QERVLIEILC TRTNQEIREI VRCYQSEFGR DLEKDIRSDT SGHFERLLVS
310 320 330 340 350
MCQGNRDENQ NVNHQLAQED AQRLYQAGEG RLGTDESCFN MILATRSFPQ
360 370 380 390 400
LKATMEAYSR MANRDLLNSV SREFSGNVES GLKTILQCAL NRPAFFAERL
410 420 430 440 450
YYSMKGAGTD DSTLVRIVVT RSEIDLVQIK QMFSQMYQKT LGTMIASDTS
460
GDYRKLLLAI VGQ
Length:463
Mass (Da):49,940
Last modified:April 3, 2007 - v2
Checksum:iFDD8A37D5B29C555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116141 mRNA. Translation: AAI16142.1.
PIRiA27695.
RefSeqiNP_001069459.1. NM_001075991.1.
XP_005226474.2. XM_005226417.3.
UniGeneiBt.36610.

Genome annotation databases

EnsembliENSBTAT00000050132; ENSBTAP00000046882; ENSBTAG00000020218.
GeneIDi533360.
KEGGibta:533360.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiANXA7_BOVIN
AccessioniPrimary (citable) accession number: P20072
Secondary accession number(s): Q1LZ88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 3, 2007
Last modified: June 7, 2017
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families