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Protein

Annexin A7

Gene

ANXA7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: InterPro
  • identical protein binding Source: AgBase
  • poly(A) RNA binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A7
Alternative name(s):
Annexin VII
Annexin-7
Synexin
Gene namesi
Name:ANXA7
Synonyms:ANX7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 28

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Annexin A7PRO_0000067498Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei208 – 2081N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP20072.
PeptideAtlasiP20072.
PRIDEiP20072.

Expressioni

Gene expression databases

BgeeiENSBTAG00000020218.

Interactioni

Subunit structurei

Interacts with PDCD6.By similarity

GO - Molecular functioni

  • calcium-dependent protein binding Source: AgBase
  • identical protein binding Source: AgBase

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000046882.

Structurei

3D structure databases

ProteinModelPortaliP20072.
SMRiP20072. Positions 151-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 951
Repeati10 – 1452
Repeati16 – 2053
Repeati169 – 22961Annexin 1Add
BLAST
Repeati241 – 30161Annexin 2Add
BLAST
Repeati324 – 38461Annexin 3Add
BLAST
Repeati400 – 46061Annexin 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 140140Repeat-rich regionBy similarityAdd
BLAST
Regioni5 – 20163 X 5 AA tandem repeats of G-Y-P-P-XAdd
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP20072.
KOiK17095.
OMAiFSQMYQK.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR013286. AnnexinVII.
[Graphical view]
PANTHERiPTHR10502:SF110. PTHR10502:SF110. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01871. ANNEXINVII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPGYPPTG YPPFPGYPPT GQESSFPPPG QYPYPSGFPP MGGGAYPPAP
60 70 80 90 100
SSGYPGAGGY PAPGGYPAPG GYPGAPQPGG APSYPGGQGF GAPPGGAGFP
110 120 130 140 150
GYPQPPTQSY GGGPAQVPLP GGFPGGAMPS QYPGGQSPYP SQPAPMTQGT
160 170 180 190 200
HGTIRPAANF DAMRDAEVLR KAMKGFGTDE QAIIDVVANR SNDQRQKIKA
210 220 230 240 250
AFKTMYGKDL IKDLKSELSG NMEELILALF MPSTYYDAWS LRNAMKGAGT
260 270 280 290 300
QERVLIEILC TRTNQEIREI VRCYQSEFGR DLEKDIRSDT SGHFERLLVS
310 320 330 340 350
MCQGNRDENQ NVNHQLAQED AQRLYQAGEG RLGTDESCFN MILATRSFPQ
360 370 380 390 400
LKATMEAYSR MANRDLLNSV SREFSGNVES GLKTILQCAL NRPAFFAERL
410 420 430 440 450
YYSMKGAGTD DSTLVRIVVT RSEIDLVQIK QMFSQMYQKT LGTMIASDTS
460
GDYRKLLLAI VGQ
Length:463
Mass (Da):49,940
Last modified:April 3, 2007 - v2
Checksum:iFDD8A37D5B29C555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116141 mRNA. Translation: AAI16142.1.
PIRiA27695.
RefSeqiNP_001069459.1. NM_001075991.1.
XP_005226474.2. XM_005226417.3.
UniGeneiBt.36610.

Genome annotation databases

EnsembliENSBTAT00000050132; ENSBTAP00000046882; ENSBTAG00000020218.
GeneIDi533360.
KEGGibta:533360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116141 mRNA. Translation: AAI16142.1.
PIRiA27695.
RefSeqiNP_001069459.1. NM_001075991.1.
XP_005226474.2. XM_005226417.3.
UniGeneiBt.36610.

3D structure databases

ProteinModelPortaliP20072.
SMRiP20072. Positions 151-463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000046882.

Proteomic databases

PaxDbiP20072.
PeptideAtlasiP20072.
PRIDEiP20072.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000050132; ENSBTAP00000046882; ENSBTAG00000020218.
GeneIDi533360.
KEGGibta:533360.

Organism-specific databases

CTDi310.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP20072.
KOiK17095.
OMAiFSQMYQK.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Gene expression databases

BgeeiENSBTAG00000020218.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR013286. AnnexinVII.
[Graphical view]
PANTHERiPTHR10502:SF110. PTHR10502:SF110. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01871. ANNEXINVII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA7_BOVIN
AccessioniPrimary (citable) accession number: P20072
Secondary accession number(s): Q1LZ88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.