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Protein

Mitochondrial-processing peptidase subunit alpha

Gene

Pmpca

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The mitochondrial processing protease (MPP-I) cleaves presequences from mitochondrial protein precursors. Most MPP-I cleavage sites follow an arginine at position -2.1 Publication

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

GO - Molecular functioni

  • endopeptidase activity Source: RGD
  • metalloendopeptidase activity Source: GO_Central
  • zinc ion binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease

Protein family/group databases

MEROPSiM16.971

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial-processing peptidase subunit alpha (EC:3.4.24.64)
Alternative name(s):
Alpha-MPP
P-55
Gene namesi
Name:Pmpca
Synonyms:Mppa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727897 Pmpca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32Mitochondrion1 PublicationAdd BLAST32
ChainiPRO_000002676933 – 524Mitochondrial-processing peptidase subunit alphaAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63N6-succinyllysineBy similarity1

Proteomic databases

PRIDEiP20069

PTM databases

CarbonylDBiP20069
iPTMnetiP20069
PhosphoSitePlusiP20069

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.

Protein-protein interaction databases

IntActiP20069, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP20069
SMRiP20069
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000206848
HOVERGENiHBG106890
InParanoidiP20069
PhylomeDBiP20069

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
IPR037715 PMPCA
PANTHERiPTHR11851:SF183 PTHR11851:SF183, 1 hit
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAVWAAAR LLRGSAALCA RPKFGSPAHR RFSSGATYPN IPLSSPLPGV
60 70 80 90 100
PKPIFATVDG QEKFETKVTT LDNGLRVASQ NKFGQFCTLG ILINSGSRYE
110 120 130 140 150
AKYLSGIAHF LEKLAFSSTA RFDSKDEILL TLEKHGGICD CQTSRDTTMY
160 170 180 190 200
AVSADSKGLD TVVGLLADVV LHPRLTDEEI EMTRMAVQFE LEDLNMRPDP
210 220 230 240 250
EPLLTEMIHE AAFRENTVGL HRFCPVENIG KIDREVLHSY LKNYYTPDRM
260 270 280 290 300
VLAGVGVEHE HLVECARKYL LGVQPAWGAP GAVWMLTAQW HSTRGGSSRW
310 320 330 340 350
RETCQMSALR PPRFQSSHIY GGARELLLLE EDFIPFAVLN MMMGGGGSFS
360 370 380 390 400
AGGPGKGMFS RLYLNVLNRH HWMYNATSYH HSYEDTGLLC IHASADPRQV
410 420 430 440 450
REMVEIITKE FILMGRTVDL VELERAKTQL MSMLMMNLES RPVIFEDVGR
460 470 480 490 500
QVLATHSRKL PHELCTLIRN VKPEDIKRVA SKMLRGKPAV AALGDLTDLP
510 520
TYEHIQAALS SRDGRLPRTY RLFR
Length:524
Mass (Da):58,608
Last modified:February 1, 1991 - v1
Checksum:i8BF08FBC9FF09DB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57728 mRNA Translation: AAA41632.1
PIRiA36205
UniGeneiRn.11175

Genome annotation databases

UCSCiRGD:727897 rat

Similar proteinsi

Entry informationi

Entry nameiMPPA_RAT
AccessioniPrimary (citable) accession number: P20069
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health