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Protein

Mitochondrial-processing peptidase subunit alpha

Gene

Pmpca

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The mitochondrial processing protease (MPP-I) cleaves presequences from mitochondrial protein precursors. Most MPP-I cleavage sites follow an arginine at position -2.1 Publication

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

GO - Molecular functioni

  • endopeptidase activity Source: RGD
  • metalloendopeptidase activity Source: GO_Central
  • zinc ion binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Protein family/group databases

MEROPSiM16.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial-processing peptidase subunit alpha (EC:3.4.24.64)
Alternative name(s):
Alpha-MPP
P-55
Gene namesi
Name:Pmpca
Synonyms:Mppa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727897. Pmpca.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrial matrix Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32Mitochondrion1 PublicationAdd BLAST32
ChainiPRO_000002676933 – 524Mitochondrial-processing peptidase subunit alphaAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63N6-succinyllysineBy similarity1

Proteomic databases

PRIDEiP20069.

PTM databases

iPTMnetiP20069.
PhosphoSitePlusiP20069.

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.

Protein-protein interaction databases

IntActiP20069. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP20069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000206848.
HOVERGENiHBG106890.
InParanoidiP20069.
PhylomeDBiP20069.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAVWAAAR LLRGSAALCA RPKFGSPAHR RFSSGATYPN IPLSSPLPGV
60 70 80 90 100
PKPIFATVDG QEKFETKVTT LDNGLRVASQ NKFGQFCTLG ILINSGSRYE
110 120 130 140 150
AKYLSGIAHF LEKLAFSSTA RFDSKDEILL TLEKHGGICD CQTSRDTTMY
160 170 180 190 200
AVSADSKGLD TVVGLLADVV LHPRLTDEEI EMTRMAVQFE LEDLNMRPDP
210 220 230 240 250
EPLLTEMIHE AAFRENTVGL HRFCPVENIG KIDREVLHSY LKNYYTPDRM
260 270 280 290 300
VLAGVGVEHE HLVECARKYL LGVQPAWGAP GAVWMLTAQW HSTRGGSSRW
310 320 330 340 350
RETCQMSALR PPRFQSSHIY GGARELLLLE EDFIPFAVLN MMMGGGGSFS
360 370 380 390 400
AGGPGKGMFS RLYLNVLNRH HWMYNATSYH HSYEDTGLLC IHASADPRQV
410 420 430 440 450
REMVEIITKE FILMGRTVDL VELERAKTQL MSMLMMNLES RPVIFEDVGR
460 470 480 490 500
QVLATHSRKL PHELCTLIRN VKPEDIKRVA SKMLRGKPAV AALGDLTDLP
510 520
TYEHIQAALS SRDGRLPRTY RLFR
Length:524
Mass (Da):58,608
Last modified:February 1, 1991 - v1
Checksum:i8BF08FBC9FF09DB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57728 mRNA. Translation: AAA41632.1.
PIRiA36205.
UniGeneiRn.11175.

Genome annotation databases

UCSCiRGD:727897. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57728 mRNA. Translation: AAA41632.1.
PIRiA36205.
UniGeneiRn.11175.

3D structure databases

ProteinModelPortaliP20069.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP20069. 1 interactor.

Protein family/group databases

MEROPSiM16.971.

PTM databases

iPTMnetiP20069.
PhosphoSitePlusiP20069.

Proteomic databases

PRIDEiP20069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:727897. rat.

Organism-specific databases

RGDi727897. Pmpca.

Phylogenomic databases

HOGENOMiHOG000206848.
HOVERGENiHBG106890.
InParanoidiP20069.
PhylomeDBiP20069.

Miscellaneous databases

PROiP20069.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPPA_RAT
AccessioniPrimary (citable) accession number: P20069
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.