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Protein

Neurotensin/neuromedin N

Gene

Nts

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

GO - Biological processi

  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to lithium ion Source: RGD
  • cellular response to nerve growth factor stimulus Source: RGD
  • digestive tract development Source: RGD
  • hyperosmotic response Source: RGD
  • liver development Source: RGD
  • regulation of blood vessel size Source: UniProtKB-KW
  • response to amphetamine Source: RGD
  • response to antipsychotic drug Source: RGD
  • response to axon injury Source: RGD
  • response to cocaine Source: RGD
  • response to corticosterone Source: RGD
  • response to estradiol Source: RGD
  • response to mineralocorticoid Source: RGD
  • visual learning Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin/neuromedin N
Cleaved into the following 4 chains:
Alternative name(s):
NmN-125
Neuromedin N
Short name:
NN
Short name:
NmN
Neurotensin
Short name:
NT
Gene namesi
Name:Nts
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621612. Nts.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • extracellular region Source: UniProtKB-SubCell
  • neuronal cell body Source: RGD
  • transport vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 147125Large neuromedin NPRO_0000019530Add
BLAST
Peptidei142 – 1476Neuromedin NPRO_0000019531
Peptidei150 – 16213NeurotensinPRO_0000019532Add
BLAST
Peptidei165 – 1695Tail peptideSequence analysisPRO_0000019533

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei150 – 1501Pyrrolidone carboxylic acidBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP20068.

Interactioni

Subunit structurei

Interacts with NTSR1. Interacts with SORT1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005706.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZEVX-ray3.00C/D157-162[»]
4BUOX-ray2.75C/D157-162[»]
4BV0X-ray3.10C/D157-162[»]
4BWBX-ray3.57C/D157-162[»]
4XEEX-ray2.90B157-162[»]
4XESX-ray2.60B157-162[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neurotensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDE. Eukaryota.
ENOG410YV74. LUCA.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiP20068.
PhylomeDBiP20068.

Family and domain databases

InterProiIPR008055. NeurotensiN.
[Graphical view]
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSiPR01668. NEUROTENSIN.
ProDomiPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGMNLQLVC LTLLAFSSWS LCSDSEEDVR ALEADLLTNM HASKVSKGSP
60 70 80 90 100
PSWKMTLLNV CSLINNLNSA AEEAGEMRDD DLVAKRKLPL VLDDFSLEAL
110 120 130 140 150
LTVFQLQKIC RSRAFQHWEI IQEDILDHGN EKTEKEEVIK RKIPYILKRQ
160
LYENKPRRPY ILKRASYYY
Length:169
Mass (Da):19,564
Last modified:February 1, 1991 - v1
Checksum:i91CF0CF68C3D3C91
GO

Sequence cautioni

The sequence AAA41712.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21187, M21218 Genomic DNA. Translation: AAA41712.1. Different initiation.
PIRiA28146.
UniGeneiRn.60814.

Genome annotation databases

UCSCiRGD:621612. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21187, M21218 Genomic DNA. Translation: AAA41712.1. Different initiation.
PIRiA28146.
UniGeneiRn.60814.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZEVX-ray3.00C/D157-162[»]
4BUOX-ray2.75C/D157-162[»]
4BV0X-ray3.10C/D157-162[»]
4BWBX-ray3.57C/D157-162[»]
4XEEX-ray2.90B157-162[»]
4XESX-ray2.60B157-162[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005706.

Proteomic databases

PaxDbiP20068.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621612. rat.

Organism-specific databases

RGDi621612. Nts.

Phylogenomic databases

eggNOGiENOG410IKDE. Eukaryota.
ENOG410YV74. LUCA.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiP20068.
PhylomeDBiP20068.

Miscellaneous databases

PROiP20068.

Family and domain databases

InterProiIPR008055. NeurotensiN.
[Graphical view]
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSiPR01668. NEUROTENSIN.
ProDomiPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences."
    Kislauskis E., Bullock B., McNeil S., Dobner P.R.
    J. Biol. Chem. 263:4963-4968(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Immunological and biochemical characterization of processing products from the neurotensin/neuromedin N precursor in the rat medullary thyroid carcinoma 6-23 cell line."
    Bidard J.-N., de Nadai F., Rovere C., Moinier D., Laur J., Martinez J., Cuber J.-C., Kitabgi P.
    Biochem. J. 291:225-233(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-42, PROTEOLYTIC PROCESSING.
  3. "Biosynthesis and posttranslational processing of the neurotensin/neuromedin N precursor in the rat medullary thyroid carcinoma 6-23 cell line. Effect of dexamethasone."
    de Nadai F., Rovere C., Bidard J.-N., Laur J., Martinez J., Cuber J.-C., Kitabgi P.
    Endocrinology 132:1614-1620(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING.

Entry informationi

Entry nameiNEUT_RAT
AccessioniPrimary (citable) accession number: P20068
Secondary accession number(s): Q9QV80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.