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Protein

Neurotensin/neuromedin N

Gene

Nts

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

GO - Molecular functioni

GO - Biological processi

  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to lithium ion Source: RGD
  • cellular response to nerve growth factor stimulus Source: RGD
  • digestive tract development Source: RGD
  • hyperosmotic response Source: RGD
  • liver development Source: RGD
  • regulation of blood vessel size Source: UniProtKB-KW
  • response to amphetamine Source: RGD
  • response to antipsychotic drug Source: RGD
  • response to axon injury Source: RGD
  • response to cocaine Source: RGD
  • response to corticosterone Source: RGD
  • response to estradiol Source: RGD
  • response to mineralocorticoid Source: RGD
  • visual learning Source: RGD

Keywordsi

Molecular functionVasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin/neuromedin N
Cleaved into the following 4 chains:
Alternative name(s):
NmN-125
Neuromedin N
Short name:
NN
Short name:
NmN
Neurotensin
Short name:
NT
Gene namesi
Name:Nts
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621612. Nts.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001953023 – 147Large neuromedin NAdd BLAST125
PeptideiPRO_0000019531142 – 147Neuromedin N6
PeptideiPRO_0000019532150 – 162NeurotensinAdd BLAST13
PeptideiPRO_0000019533165 – 169Tail peptideSequence analysis5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei150Pyrrolidone carboxylic acidBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP20068.

Interactioni

Subunit structurei

Interacts with NTSR1. Interacts with SORT1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005706.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZEVX-ray3.00C/D157-162[»]
4BUOX-ray2.75C/D157-162[»]
4BV0X-ray3.10C/D157-162[»]
4BWBX-ray3.57C/D157-162[»]
4XEEX-ray2.90B157-162[»]
4XESX-ray2.60B157-162[»]
5T04X-ray3.30B157-162[»]
SMRiP20068.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neurotensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDE. Eukaryota.
ENOG410YV74. LUCA.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiP20068.
PhylomeDBiP20068.

Family and domain databases

InterProiView protein in InterPro
IPR008055. NeurotensiN.
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiView protein in Pfam
PF07421. Pro-NT_NN. 1 hit.
PRINTSiPR01668. NEUROTENSIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016590. NeurotensiN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGMNLQLVC LTLLAFSSWS LCSDSEEDVR ALEADLLTNM HASKVSKGSP
60 70 80 90 100
PSWKMTLLNV CSLINNLNSA AEEAGEMRDD DLVAKRKLPL VLDDFSLEAL
110 120 130 140 150
LTVFQLQKIC RSRAFQHWEI IQEDILDHGN EKTEKEEVIK RKIPYILKRQ
160
LYENKPRRPY ILKRASYYY
Length:169
Mass (Da):19,564
Last modified:February 1, 1991 - v1
Checksum:i91CF0CF68C3D3C91
GO

Sequence cautioni

The sequence AAA41712 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21187, M21218 Genomic DNA. Translation: AAA41712.1. Different initiation.
PIRiA28146.
UniGeneiRn.60814.

Genome annotation databases

UCSCiRGD:621612. rat.

Similar proteinsi

Entry informationi

Entry nameiNEUT_RAT
AccessioniPrimary (citable) accession number: P20068
Secondary accession number(s): Q9QV80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families