UniProtKB - P20065 (TYB4_MOUSE)
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Protein
Thymosin beta-4
Gene
Tmsb4x
Organism
Mus musculus (Mouse)
Status
Functioni
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.By similarity
GO - Molecular functioni
- actin monomer binding Source: InterPro
GO - Biological processi
- actin filament organization Source: InterPro
- osteoblast differentiation Source: Ensembl
- positive regulation of smooth muscle cell differentiation Source: DFLAT
- positive regulation of smooth muscle cell migration Source: DFLAT
- positive regulation of transcription, DNA-templated Source: DFLAT
- regulation of cell migration Source: MGI
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Thymosin beta-4Short name: T beta 4 Cleaved into the following chain: Alternative name(s): Seraspenide |
Gene namesi | Name:Tmsb4x Synonyms:Ptmb4, Tmsb4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99510 Tmsb4x |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000045923 | 1 – 50 | Thymosin beta-4Add BLAST | 50 | |
PeptideiPRO_0000034297 | 8 – 11 | Hematopoietic system regulatory peptideBy similarity | 4 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphoserineBy similarity | 1 | |
Modified residuei | 10 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 18 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 18 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 29 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 32 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 37 | PhosphoserineBy similarity | 1 | |
Modified residuei | 38 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 40 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 45 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P20065 |
PaxDbi | P20065 |
PeptideAtlasi | P20065 |
PRIDEi | P20065 |
PTM databases
iPTMneti | P20065 |
PhosphoSitePlusi | P20065 |
Expressioni
Tissue specificityi
Originally found in thymus but it is widely distributed in many tissues.
Gene expression databases
Bgeei | ENSMUSG00000049775 |
CleanExi | MM_TMSB4X |
ExpressionAtlasi | P20065 baseline and differential |
Genevisiblei | P20065 MM |
Interactioni
Subunit structurei
Interacts with SERPINB1. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity).By similarity
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
STAB2 | Q8WWQ8 | 3 | EBI-7946048,EBI-7945957 | From Homo sapiens. |
GO - Molecular functioni
- actin monomer binding Source: InterPro
Protein-protein interaction databases
BioGridi | 2024719 interactors. |
CORUMi | P20065 |
ELMi | P20065 |
IntActi | P20065 1 interactor. |
MINTi | P20065 |
STRINGi | 10090.ENSMUSP00000107795 |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1T44 | X-ray | 2.00 | G | 28-46 | [»] | |
3M3N | X-ray | 7.00 | W | 26-50 | [»] | |
ProteinModelPortali | P20065 | |||||
SMRi | P20065 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P20065 |
Family & Domainsi
Sequence similaritiesi
Belongs to the thymosin beta family.Curated
Phylogenomic databases
eggNOGi | KOG4794 Eukaryota ENOG410Y3I4 LUCA |
GeneTreei | ENSGT00390000007040 |
HOGENOMi | HOG000231370 |
HOVERGENi | HBG012534 |
InParanoidi | P20065 |
KOi | K05764 |
OMAi | SKETIGQ |
OrthoDBi | EOG091G1AVI |
PhylomeDBi | P20065 |
Family and domain databases
Gene3Di | 1.20.5.5201 hit |
InterProi | View protein in InterPro IPR001152 Beta-thymosin IPR038386 Beta-thymosin_sf |
PANTHERi | PTHR12021 PTHR12021, 1 hit |
Pfami | View protein in Pfam PF01290 Thymosin, 1 hit |
PIRSFi | PIRSF001828 Thymosin_beta, 1 hit |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD005116 Thymosin_b4, 1 hit |
SMARTi | View protein in SMART SM00152 THY, 1 hit |
PROSITEi | View protein in PROSITE PS00500 THYMOSIN_B4, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform Long (identifier: P20065-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MLLPATMSDK PDMAEIEKFD KSKLKKTETQ EKNPLPSKET IEQEKQAGES
Isoform Short (identifier: P20065-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-6: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006424 | 1 – 6 | Missing in isoform Short. Curated | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16053 mRNA Translation: CAA34187.1 X16053 mRNA Translation: CAA34188.1 U38967 Genomic DNA Translation: AAC52490.1 |
CCDSi | CCDS30529.1 [P20065-2] |
PIRi | A37217 |
RefSeqi | NP_067253.1, NM_021278.2 [P20065-2] XP_006528822.1, XM_006528759.1 [P20065-2] |
UniGenei | Mm.142729 Mm.490263 |
Genome annotation databases
Ensembli | ENSMUST00000112172; ENSMUSP00000107795; ENSMUSG00000049775 [P20065-2] ENSMUST00000112175; ENSMUSP00000107797; ENSMUSG00000049775 [P20065-1] ENSMUST00000112176; ENSMUSP00000107798; ENSMUSG00000049775 [P20065-1] |
GeneIDi | 19241 |
KEGGi | mmu:19241 |
UCSCi | uc009uwx.1 mouse [P20065-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | TYB4_MOUSE | |
Accessioni | P20065Primary (citable) accession number: P20065 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | April 25, 2018 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |