P20061A8KAC5Q8WV77TCO1_HUMANTranscobalamin-1TC-1HaptocorrinHCProtein RTranscobalamin ITC ITCITCN1TC1Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoStructure of the cDNA encoding transcobalamin I, a neutrophil granule protein.NUCLEOTIDE SEQUENCE [MRNA]TISSUE SPECIFICITYComplete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Human chromosome 11 DNA sequence and analysis including novel gene identification.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-216Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-216 AND ASN-369Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin.X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) IN COMPLEX WITH CYANOCOBALAMINDISULFIDE BONDSCOBALAMIN-BINDING SITESGLYCOSYLATION AT ASN-216; ASN-316; ASN-337; ASN-343; ASN-349; ASN-354 AND ASN-369Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.P20061Q8WXH2false3SecretedProduced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.Contains about 30% carbohydrates.Belongs to the eukaryotic cobalamin transport proteins family.3D-structureCobaltCobalt transportDisulfide bondGlycoproteinIon transportReference proteomeSecretedSignalTransportcyanocob(III)alamincyanocob(III)alamincyanocob(III)alamincyanocob(III)alamincyanocob(III)alamincyanocob(III)alamincyanocob(III)alamincyanocob(III)alaminRHDYITMRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY
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