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P20061

- TCO1_HUMAN

UniProt

P20061 - TCO1_HUMAN

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Protein

Transcobalamin-1

Gene
TCN1, TC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei240 – 2401Cobalamin
Binding sitei243 – 2431Cobalamin
Binding sitei289 – 2891Cobalamin
Binding sitei433 – 4331Cobalamin

GO - Molecular functioni

  1. cobalamin binding Source: RefGenome

GO - Biological processi

  1. cobalamin metabolic process Source: RefGenome
  2. cobalamin transport Source: ProtInc
  3. cobalt ion transport Source: UniProtKB-KW
  4. small molecule metabolic process Source: Reactome
  5. vitamin metabolic process Source: Reactome
  6. water-soluble vitamin metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cobalt transport, Ion transport, Transport

Keywords - Ligandi

Cobalt

Enzyme and pathway databases

ReactomeiREACT_163862. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcobalamin-1
Short name:
TC-1
Alternative name(s):
Haptocorrin
Short name:
HC
Protein R
Transcobalamin I
Short name:
TC I
Short name:
TCI
Gene namesi
Name:TCN1
Synonyms:TC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:11652. TCN1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 433410Transcobalamin-1PRO_0000005561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 2651 Publication
Disulfide bondi105 ↔ 3081 Publication
Disulfide bondi155 ↔ 1971 Publication
Glycosylationi160 – 1601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi216 – 2161N-linked (GlcNAc...)3 Publications
Glycosylationi316 – 3161N-linked (GlcNAc...)1 Publication
Glycosylationi337 – 3371N-linked (GlcNAc...)1 Publication
Glycosylationi343 – 3431N-linked (GlcNAc...)1 Publication
Glycosylationi349 – 3491N-linked (GlcNAc...)1 Publication
Glycosylationi354 – 3541N-linked (GlcNAc...)1 Publication
Glycosylationi369 – 3691N-linked (GlcNAc...)2 Publications
Disulfide bondi388 ↔ 3931 Publication

Post-translational modificationi

Contains about 30% carbohydrates.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20061.
PRIDEiP20061.

PTM databases

PhosphoSiteiP20061.

Expressioni

Tissue specificityi

Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.1 Publication

Gene expression databases

BgeeiP20061.
CleanExiHS_TCN1.
GenevestigatoriP20061.

Organism-specific databases

HPAiHPA041631.

Interactioni

Protein-protein interaction databases

BioGridi112807. 2 interactions.
IntActiP20061. 1 interaction.
STRINGi9606.ENSP00000257264.

Structurei

Secondary structure

1
433
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 367
Helixi37 – 459
Helixi46 – 483
Beta strandi50 – 523
Helixi55 – 639
Helixi69 – 8517
Turni87 – 893
Helixi92 – 10211
Helixi108 – 1103
Helixi111 – 1155
Helixi118 – 13518
Turni136 – 1383
Helixi144 – 15613
Helixi163 – 1697
Helixi175 – 1773
Helixi185 – 20319
Helixi213 – 22917
Beta strandi238 – 2403
Turni241 – 2433
Helixi244 – 2529
Helixi255 – 2573
Turni260 – 2623
Helixi265 – 27713
Turni278 – 2814
Helixi284 – 29411
Helixi299 – 3013
Beta strandi333 – 35321
Helixi358 – 36811
Helixi370 – 3734
Beta strandi375 – 3795
Beta strandi381 – 3899
Turni396 – 3994
Beta strandi400 – 4067
Turni415 – 4173
Beta strandi426 – 4327

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CKVmodel-Y24-433[»]
4KKIX-ray2.35A1-433[»]
4KKJX-ray3.00A1-433[»]
ProteinModelPortaliP20061.
SMRiP20061. Positions 24-433.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 310287Globular N-terminal alpha domainAdd
BLAST
Regioni142 – 1465Cobalamin binding
Regioni182 – 1865Cobalamin binding
Regioni311 – 33222Flexible linkerAdd
BLAST
Regioni333 – 433101Globular C-terminal beta domainAdd
BLAST
Regioni402 – 4043Cobalamin binding

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG79743.
HOGENOMiHOG000013214.
HOVERGENiHBG094393.
InParanoidiP20061.
OMAiENLEVRW.
OrthoDBiEOG771277.
PhylomeDBiP20061.
TreeFamiTF333092.

Family and domain databases

InterProiIPR002157. Cbl-bd_transpt_euk.
IPR027954. DUF4430.
[Graphical view]
PANTHERiPTHR10559. PTHR10559. 1 hit.
PfamiPF01122. Cobalamin_bind. 1 hit.
PF14478. DUF4430. 1 hit.
[Graphical view]
PROSITEiPS00468. COBALAMIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20061-1 [UniParc]FASTAAdd to Basket

« Hide

MRQSHQLPLV GLLLFSFIPS QLCEICEVSE ENYIRLKPLL NTMIQSNYNR    50
GTSAVNVVLS LKLVGIQIQT LMQKMIQQIK YNVKSRLSDV SSGELALIIL 100
ALGVCRNAEE NLIYDYHLID KLENKFQAEI ENMEAHNGTP LTNYYQLSLD 150
VLALCLFNGN YSTAEVVNHF TPENKNYYFG SQFSVDTGAM AVLALTCVKK 200
SLINGQIKAD EGSLKNISIY TKSLVEKILS EKKENGLIGN TFSTGEAMQA 250
LFVSSDYYNE NDWNCQQTLN TVLTEISQGA FSNPNAAAQV LPALMGKTFL 300
DINKDSSCVS ASGNFNISAD EPITVTPPDS QSYISVNYSV RINETYFTNV 350
TVLNGSVFLS VMEKAQKMND TIFGFTMEER SWGPYITCIQ GLCANNNDRT 400
YWELLSGGEP LSQGAGSYVV RNGENLEVRW SKY 433
Length:433
Mass (Da):48,207
Last modified:May 1, 2007 - v2
Checksum:iCF1052BE3DBA929A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351R → H.
Corresponds to variant rs34528912 [ dbSNP | Ensembl ].
VAR_031923
Natural varianti301 – 3011D → Y.
Corresponds to variant rs34324219 [ dbSNP | Ensembl ].
VAR_031924

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191I → T in AAA61058. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05068 mRNA. Translation: AAA61058.1.
AK292990 mRNA. Translation: BAF85679.1.
AP002347 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73861.1.
CCDSiCCDS7978.1.
PIRiA34227.
RefSeqiNP_001053.2. NM_001062.3.
UniGeneiHs.2012.

Genome annotation databases

EnsembliENST00000257264; ENSP00000257264; ENSG00000134827.
GeneIDi6947.
KEGGihsa:6947.
UCSCiuc001noj.2. human.

Polymorphism databases

DMDMi146345530.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05068 mRNA. Translation: AAA61058.1 .
AK292990 mRNA. Translation: BAF85679.1 .
AP002347 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73861.1 .
CCDSi CCDS7978.1.
PIRi A34227.
RefSeqi NP_001053.2. NM_001062.3.
UniGenei Hs.2012.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CKV model - Y 24-433 [» ]
4KKI X-ray 2.35 A 1-433 [» ]
4KKJ X-ray 3.00 A 1-433 [» ]
ProteinModelPortali P20061.
SMRi P20061. Positions 24-433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112807. 2 interactions.
IntActi P20061. 1 interaction.
STRINGi 9606.ENSP00000257264.

Chemistry

DrugBanki DB00115. Cyanocobalamin.
DB00200. Hydroxocobalamin.

PTM databases

PhosphoSitei P20061.

Polymorphism databases

DMDMi 146345530.

Proteomic databases

PaxDbi P20061.
PRIDEi P20061.

Protocols and materials databases

DNASUi 6947.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257264 ; ENSP00000257264 ; ENSG00000134827 .
GeneIDi 6947.
KEGGi hsa:6947.
UCSCi uc001noj.2. human.

Organism-specific databases

CTDi 6947.
GeneCardsi GC11M059620.
H-InvDB HIX0009662.
HGNCi HGNC:11652. TCN1.
HPAi HPA041631.
MIMi 189905. gene.
neXtProti NX_P20061.
PharmGKBi PA36403.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79743.
HOGENOMi HOG000013214.
HOVERGENi HBG094393.
InParanoidi P20061.
OMAi ENLEVRW.
OrthoDBi EOG771277.
PhylomeDBi P20061.
TreeFami TF333092.

Enzyme and pathway databases

Reactomei REACT_163862. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Miscellaneous databases

GeneWikii Haptocorrin.
GenomeRNAii 6947.
NextBioi 27199.
PROi P20061.
SOURCEi Search...

Gene expression databases

Bgeei P20061.
CleanExi HS_TCN1.
Genevestigatori P20061.

Family and domain databases

InterProi IPR002157. Cbl-bd_transpt_euk.
IPR027954. DUF4430.
[Graphical view ]
PANTHERi PTHR10559. PTHR10559. 1 hit.
Pfami PF01122. Cobalamin_bind. 1 hit.
PF14478. DUF4430. 1 hit.
[Graphical view ]
PROSITEi PS00468. COBALAMIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the cDNA encoding transcobalamin I, a neutrophil granule protein."
    Johnston J., Bollekens J., Allen R.H., Berliner N.
    J. Biol. Chem. 264:15754-15757(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-216.
    Tissue: Plasma.
  6. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-216 AND ASN-369.
    Tissue: Saliva.
  7. "Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin."
    Furger E., Frei D.C., Schibli R., Fischer E., Prota A.E.
    J. Biol. Chem. 288:25466-25476(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) IN COMPLEX WITH CYANOCOBALAMIN, DISULFIDE BONDS, COBALAMIN-BINDING SITES, GLYCOSYLATION AT ASN-216; ASN-316; ASN-337; ASN-343; ASN-349; ASN-354 AND ASN-369.

Entry informationi

Entry nameiTCO1_HUMAN
AccessioniPrimary (citable) accession number: P20061
Secondary accession number(s): A8KAC5, Q8WV77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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