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Protein

Transcobalamin-1

Gene

TCN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei240Cobalamin1
Binding sitei243Cobalamin1
Binding sitei289Cobalamin1
Binding sitei433Cobalamin1

GO - Molecular functioni

GO - Biological processi

  • cobalamin metabolic process Source: Reactome
  • cobalamin transport Source: ProtInc
  • cobalt ion transport Source: UniProtKB-KW
  • neutrophil degranulation Source: Reactome

Keywordsi

Biological processCobalt transport, Ion transport, Transport
LigandCobalt

Enzyme and pathway databases

ReactomeiR-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcobalamin-1
Short name:
TC-1
Alternative name(s):
Haptocorrin
Short name:
HC
Protein R
Transcobalamin I
Short name:
TC I
Short name:
TCI
Gene namesi
Name:TCN1
Synonyms:TC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000134827.7
HGNCiHGNC:11652 TCN1
MIMi189905 gene
neXtProtiNX_P20061

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6947
OpenTargetsiENSG00000134827
PharmGKBiPA36403

Chemistry databases

DrugBankiDB00115 Cyanocobalamin
DB00200 Hydroxocobalamin

Polymorphism and mutation databases

BioMutaiTCN1
DMDMi146345530

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000000556124 – 433Transcobalamin-1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 2651 Publication
Disulfide bondi105 ↔ 3081 Publication
Disulfide bondi155 ↔ 1971 Publication
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi216N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi316N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi337N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi343N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi349N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi354N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi369N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi388 ↔ 3931 Publication

Post-translational modificationi

Contains about 30% carbohydrates.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP20061
PaxDbiP20061
PeptideAtlasiP20061
PRIDEiP20061

PTM databases

iPTMnetiP20061
PhosphoSitePlusiP20061

Expressioni

Tissue specificityi

Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.1 Publication

Gene expression databases

BgeeiENSG00000134827
CleanExiHS_TCN1
GenevisibleiP20061 HS

Interactioni

Protein-protein interaction databases

BioGridi1128073 interactors.
IntActiP20061 1 interactor.
STRINGi9606.ENSP00000257264

Structurei

Secondary structure

1433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 36Combined sources7
Helixi37 – 45Combined sources9
Helixi46 – 48Combined sources3
Beta strandi50 – 52Combined sources3
Helixi55 – 63Combined sources9
Helixi69 – 85Combined sources17
Turni87 – 89Combined sources3
Helixi92 – 102Combined sources11
Helixi108 – 110Combined sources3
Helixi111 – 115Combined sources5
Helixi118 – 135Combined sources18
Turni136 – 138Combined sources3
Helixi144 – 156Combined sources13
Helixi163 – 169Combined sources7
Helixi175 – 177Combined sources3
Helixi185 – 203Combined sources19
Helixi213 – 229Combined sources17
Beta strandi238 – 240Combined sources3
Turni241 – 243Combined sources3
Helixi244 – 252Combined sources9
Helixi255 – 257Combined sources3
Turni260 – 262Combined sources3
Helixi265 – 277Combined sources13
Turni278 – 281Combined sources4
Helixi284 – 294Combined sources11
Helixi299 – 301Combined sources3
Beta strandi333 – 353Combined sources21
Helixi358 – 368Combined sources11
Helixi370 – 373Combined sources4
Beta strandi375 – 379Combined sources5
Beta strandi381 – 389Combined sources9
Turni396 – 399Combined sources4
Beta strandi400 – 406Combined sources7
Turni415 – 417Combined sources3
Beta strandi426 – 432Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CKVmodel-Y24-433[»]
4KKIX-ray2.35A1-433[»]
4KKJX-ray3.00A1-433[»]
ProteinModelPortaliP20061
SMRiP20061
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 310Globular N-terminal alpha domainAdd BLAST287
Regioni142 – 146Cobalamin binding5
Regioni182 – 186Cobalamin binding5
Regioni311 – 332Flexible linkerAdd BLAST22
Regioni333 – 433Globular C-terminal beta domainAdd BLAST101
Regioni402 – 404Cobalamin binding3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVBN Eukaryota
ENOG410XSU1 LUCA
GeneTreeiENSGT00530000063370
HOGENOMiHOG000013214
HOVERGENiHBG094393
InParanoidiP20061
OMAiSWGPYIT
OrthoDBiEOG091G095C
PhylomeDBiP20061
TreeFamiTF333092

Family and domain databases

InterProiView protein in InterPro
IPR002157 Cbl-bd_prot
IPR027954 DUF4430
PfamiView protein in Pfam
PF01122 Cobalamin_bind, 1 hit
PF14478 DUF4430, 1 hit
PROSITEiView protein in PROSITE
PS00468 COBALAMIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQSHQLPLV GLLLFSFIPS QLCEICEVSE ENYIRLKPLL NTMIQSNYNR
60 70 80 90 100
GTSAVNVVLS LKLVGIQIQT LMQKMIQQIK YNVKSRLSDV SSGELALIIL
110 120 130 140 150
ALGVCRNAEE NLIYDYHLID KLENKFQAEI ENMEAHNGTP LTNYYQLSLD
160 170 180 190 200
VLALCLFNGN YSTAEVVNHF TPENKNYYFG SQFSVDTGAM AVLALTCVKK
210 220 230 240 250
SLINGQIKAD EGSLKNISIY TKSLVEKILS EKKENGLIGN TFSTGEAMQA
260 270 280 290 300
LFVSSDYYNE NDWNCQQTLN TVLTEISQGA FSNPNAAAQV LPALMGKTFL
310 320 330 340 350
DINKDSSCVS ASGNFNISAD EPITVTPPDS QSYISVNYSV RINETYFTNV
360 370 380 390 400
TVLNGSVFLS VMEKAQKMND TIFGFTMEER SWGPYITCIQ GLCANNNDRT
410 420 430
YWELLSGGEP LSQGAGSYVV RNGENLEVRW SKY
Length:433
Mass (Da):48,207
Last modified:May 1, 2007 - v2
Checksum:iCF1052BE3DBA929A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119I → T in AAA61058 (PubMed:2777761).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03192335R → H. Corresponds to variant dbSNP:rs34528912Ensembl.1
Natural variantiVAR_031924301D → Y. Corresponds to variant dbSNP:rs34324219Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05068 mRNA Translation: AAA61058.1
AK292990 mRNA Translation: BAF85679.1
AP002347 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73861.1
CCDSiCCDS7978.1
PIRiA34227
RefSeqiNP_001053.2, NM_001062.3
UniGeneiHs.2012

Genome annotation databases

EnsembliENST00000257264; ENSP00000257264; ENSG00000134827
GeneIDi6947
KEGGihsa:6947
UCSCiuc001noj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCO1_HUMAN
AccessioniPrimary (citable) accession number: P20061
Secondary accession number(s): A8KAC5, Q8WV77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 1, 2007
Last modified: February 28, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome