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Protein

Beta-hexosaminidase subunit beta

Gene

Hexb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei334Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • astrocyte cell migration Source: UniProtKB
  • cellular calcium ion homeostasis Source: MGI
  • cellular protein metabolic process Source: MGI
  • ganglioside catabolic process Source: MGI
  • glycosaminoglycan metabolic process Source: MGI
  • glycosphingolipid metabolic process Source: MGI
  • lipid storage Source: MGI
  • locomotory behavior Source: MGI
  • lysosome organization Source: MGI
  • male courtship behavior Source: MGI
  • myelination Source: MGI
  • neuromuscular process Source: MGI
  • neuromuscular process controlling balance Source: MGI
  • oligosaccharide catabolic process Source: MGI
  • oogenesis Source: MGI
  • penetration of zona pellucida Source: MGI
  • phospholipid biosynthetic process Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • regulation of cellular metabolic process Source: MGI
  • sensory perception of sound Source: MGI
  • sexual reproduction Source: MGI
  • single fertilization Source: MGI
  • skeletal system development Source: MGI

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-2022857. Keratan sulfate degradation.
R-MMU-2024101. CS/DS degradation.
R-MMU-2160916. Hyaluronan uptake and degradation.
R-MMU-6798695. Neutrophil degranulation.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase subunit beta (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase subunit beta
Short name:
Hexosaminidase subunit B
N-acetyl-beta-glucosaminidase subunit beta
Gene namesi
Name:Hexb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:96074. Hexb.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001200632 – 536Beta-hexosaminidase subunit betaAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi70 ↔ 116By similarity
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi288 ↔ 339By similarity
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi513 ↔ 530By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP20060.
PaxDbiP20060.
PeptideAtlasiP20060.
PRIDEiP20060.

PTM databases

PhosphoSitePlusiP20060.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021665.
CleanExiMM_HEXB.
ExpressionAtlasiP20060. baseline and differential.
GenevisibleiP20060. MM.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

IntActiP20060. 1 interactor.
MINTiMINT-4097385.
STRINGi10090.ENSMUSP00000022169.

Structurei

3D structure databases

ProteinModelPortaliP20060.
SMRiP20060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2499. Eukaryota.
COG3525. LUCA.
GeneTreeiENSGT00390000008107.
HOGENOMiHOG000157972.
HOVERGENiHBG005961.
InParanoidiP20060.
KOiK12373.
OMAiGHDVVMC.
OrthoDBiEOG091G04NA.
PhylomeDBiP20060.
TreeFamiTF313036.

Family and domain databases

InterProiView protein in InterPro
IPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
PfamiView protein in Pfam
PF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQSPRSAPG LLLLQALVSL VSLALVAPAR LQPALWPFPR SVQMFPRLLY
60 70 80 90 100
ISAEDFSIDH SPNSTAGPSC SLLQEAFRRY YNYVFGFYKR HHGPARFRAE
110 120 130 140 150
PQLQKLLVSI TLESECESFP SLSSDETYSL LVQEPVAVLK ANSVWGALRG
160 170 180 190 200
LETFSQLVYQ DSFGTFTINE SSIADSPRFP HRGILIDTSR HFLPVKTILK
210 220 230 240 250
TLDAMAFNKF NVLHWHIVDD QSFPYQSTTF PELSNKGSYS LSHVYTPNDV
260 270 280 290 300
RMVLEYARLR GIRVIPEFDT PGHTQSWGKG QKNLLTPCYN QKTKTQVFGP
310 320 330 340 350
VDPTVNTTYA FFNTFFKEIS SVFPDQFIHL GGDEVEFQCW ASNPNIQGFM
360 370 380 390 400
KRKGFGSDFR RLESFYIKKI LEIISSLKKN SIVWQEVFDD KVELQPGTVV
410 420 430 440 450
EVWKSEHYSY ELKQVTGSGF PAILSAPWYL DLISYGQDWK NYYKVEPLNF
460 470 480 490 500
EGSEKQKQLV IGGEACLWGE FVDATNLTPR LWPRASAVGE RLWSPKTVTD
510 520 530
LENAYKRLAV HRCRMVSRGI AAQPLYTGYC NYENKI
Length:536
Mass (Da):61,116
Last modified:February 1, 1996 - v2
Checksum:i579BBEEE9CB508BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00964 mRNA. Translation: CAA68781.1.
U07633 mRNA. Translation: AAA18776.1.
U07049
, U07036, U07037, U07038, U07039, U07040, U07041, U07042, U07043, U07044, U07045, U07046, U07047, U07048 Genomic DNA. Translation: AAA74738.1.
U07742
, U07722, U07723, U07724, U07725, U07726, U07727, U07728, U07737, U07738, U07739, U07740, U07741 Genomic DNA. Translation: AAB60667.1.
CCDSiCCDS26709.1.
PIRiB54745.
RefSeqiNP_034552.1. NM_010422.2.
UniGeneiMm.27816.

Genome annotation databases

EnsembliENSMUST00000022169; ENSMUSP00000022169; ENSMUSG00000021665.
GeneIDi15212.
KEGGimmu:15212.
UCSCiuc007roc.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiHEXB_MOUSE
AccessioniPrimary (citable) accession number: P20060
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: September 27, 2017
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families