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Protein

Meiosis-specific protein HOP1

Gene

HOP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable constituent of the synaptonemal complex during meiosis. May interact with RED1.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri348 – 36417Add
BLAST

GO - Molecular functioni

  • four-way junction DNA binding Source: SGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • meiotic recombination checkpoint Source: SGD
  • synapsis Source: SGD
  • synaptonemal complex assembly Source: SGD
Complete GO annotation...

Keywords - Biological processi

Meiosis

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31339-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis-specific protein HOP1
Gene namesi
Name:HOP1
Ordered Locus Names:YIL072W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL072W.
SGDiS000001334. HOP1.

Subcellular locationi

GO - Cellular componenti

  • condensed nuclear chromosome Source: SGD
  • lateral element Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Meiosis-specific protein HOP1PRO_0000126123Add
BLAST

Proteomic databases

PeptideAtlasiP20050.

PTM databases

iPTMnetiP20050.

Expressioni

Developmental stagei

Meiosis-specific.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RED1P142913EBI-3768303,EBI-14909

Protein-protein interaction databases

BioGridi34920. 45 interactions.
DIPiDIP-2371N.
IntActiP20050. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP20050.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 250231HORMAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HORMA domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri348 – 36417Add
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000018130.
HOGENOMiHOG000112928.
InParanoidiP20050.
KOiK12778.
OMAiMRRFIII.
OrthoDBiEOG7F252H.

Family and domain databases

Gene3Di3.30.900.10. 1 hit.
InterProiIPR016573. Hop1.
IPR003511. HORMA_dom.
[Graphical view]
PfamiPF02301. HORMA. 1 hit.
[Graphical view]
PIRSFiPIRSF010751. HOP1_fungi. 1 hit.
SUPFAMiSSF56019. SSF56019. 1 hit.
PROSITEiPS50815. HORMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKQLVKPK TETKTEITTE QSQKLLQTML TMSFGCLAFL RGLFPDDIFV
60 70 80 90 100
DQRFVPEKVE KNYNKQNTSQ NNSIKIKTLI RGKSAQADLL LDWLEKGVFK
110 120 130 140 150
SIRLKCLKAL SLGIFLEDPT DLLENYIFSF DYDEENNVNI NVNLSGNKKG
160 170 180 190 200
SKNADPENET ISLLDSRRMV QQLMRRFIII TQSLEPLPQK KFLTMRLMFN
210 220 230 240 250
DNVDEDYQPE LFKDATFDKR ATLKVPTNLD NDAIDVGTLN TKHHKVALSV
260 270 280 290 300
LSAATSSMEK AGNTNFIRVD PFDLILQQQE ENKLEESVPT KPQNFVTSQT
310 320 330 340 350
TNVLGNLLNS SQASIQPTQF VSNNPVTGIC SCECGLEVPK AATVLKTCKS
360 370 380 390 400
CRKTLHGICY GNFLHSSIEK CFTCIFGPSL DTKWSKFQDL MMIRKVFRFL
410 420 430 440 450
VRKKKGFPAS ITELIDSFIN VEDQNNEVKE RVAFALFVFF LDETLCLDNG
460 470 480 490 500
GKPSQTIRYV TSSVLVDVKG IVIPNTRKQL NVNHEYKWHF TTSSPKAESF
510 520 530 540 550
YQEVLPNSRK QVESWLQDIT NLRKVYSEAL SPSSTLQELD LNSSLPTQDP
560 570 580 590 600
IISGQKRRRY DLDEYLEEDK SSVVNDTIKA KDFDESVPAK IRKISVSKKT

LKSNW
Length:605
Mass (Da):68,876
Last modified:February 1, 1994 - v2
Checksum:i9ED6EA30BE41B166
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti595 – 5951S → N in allele HOP1-628; TS.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04877 Genomic DNA. Translation: AAA34682.1.
Z38060 Genomic DNA. Translation: CAA86151.1.
Z37997 Genomic DNA. Translation: CAA86098.1.
BK006942 Genomic DNA. Translation: DAA08478.1.
PIRiA34691.
RefSeqiNP_012193.3. NM_001179422.3.

Genome annotation databases

EnsemblFungiiYIL072W; YIL072W; YIL072W.
GeneIDi854738.
KEGGisce:YIL072W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04877 Genomic DNA. Translation: AAA34682.1.
Z38060 Genomic DNA. Translation: CAA86151.1.
Z37997 Genomic DNA. Translation: CAA86098.1.
BK006942 Genomic DNA. Translation: DAA08478.1.
PIRiA34691.
RefSeqiNP_012193.3. NM_001179422.3.

3D structure databases

ProteinModelPortaliP20050.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34920. 45 interactions.
DIPiDIP-2371N.
IntActiP20050. 1 interaction.

PTM databases

iPTMnetiP20050.

Proteomic databases

PeptideAtlasiP20050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL072W; YIL072W; YIL072W.
GeneIDi854738.
KEGGisce:YIL072W.

Organism-specific databases

EuPathDBiFungiDB:YIL072W.
SGDiS000001334. HOP1.

Phylogenomic databases

GeneTreeiENSGT00390000018130.
HOGENOMiHOG000112928.
InParanoidiP20050.
KOiK12778.
OMAiMRRFIII.
OrthoDBiEOG7F252H.

Enzyme and pathway databases

BioCyciYEAST:G3O-31339-MONOMER.

Miscellaneous databases

NextBioi977446.
PROiP20050.

Family and domain databases

Gene3Di3.30.900.10. 1 hit.
InterProiIPR016573. Hop1.
IPR003511. HORMA_dom.
[Graphical view]
PfamiPF02301. HORMA. 1 hit.
[Graphical view]
PIRSFiPIRSF010751. HOP1_fungi. 1 hit.
SUPFAMiSSF56019. SSF56019. 1 hit.
PROSITEiPS50815. HORMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The HOP1 gene encodes a meiosis-specific component of yeast chromosomes."
    Hollingsworth N.M., Goetsch L., Byers B.
    Cell 61:73-84(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 7234.
  2. "A conditional allele of the Saccharomyces cerevisiae HOP1 gene is suppressed by overexpression of two other meiosis-specific genes: RED1 and REC104."
    Hollingsworth N.M., Johnson A.D.
    Genetics 133:785-797(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiHOP1_YEAST
AccessioniPrimary (citable) accession number: P20050
Secondary accession number(s): D6VVL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1994
Last modified: May 11, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.