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Protein

Prephenate dehydrogenase [NADP(+)]

Gene

TYR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 2180 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH.

Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. Prephenate dehydrogenase [NADP(+)] (TYR1)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 43NADPSequence analysisAdd BLAST30

GO - Molecular functioni

  • NAD+ binding Source: GO_Central
  • prephenate dehydrogenase (NAD+) activity Source: SGD
  • prephenate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  • oxidation-reduction process Source: GO_Central
  • tyrosine biosynthetic process Source: GO_Central
  • tyrosine metabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyciYEAST:YBR166C-MONOMER
UniPathwayiUPA00122; UER00962

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase [NADP(+)] (EC:1.3.1.13)
Short name:
PRDH
Gene namesi
Name:TYR1
Ordered Locus Names:YBR166C
ORF Names:YBR1218
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR166C
SGDiS000000370 TYR1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001192081 – 452Prephenate dehydrogenase [NADP(+)]Add BLAST452

Proteomic databases

MaxQBiP20049
PaxDbiP20049
PRIDEiP20049

Expressioni

Inductioni

Presence of Phe represses the TYR1 gene expression.

Interactioni

Protein-protein interaction databases

BioGridi32866, 101 interactors
DIPiDIP-4627N
IntActiP20049, 12 interactors
MINTiP20049
STRINGi4932.YBR166C

Structurei

3D structure databases

ProteinModelPortaliP20049
SMRiP20049
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 297Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST284

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000163305
InParanoidiP20049
KOiK00211
OMAiYIIYSVE
OrthoDBiEOG092C2OAE

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR003099 Prephen_DH
IPR012385 Prephenate_DH_fun
PfamiView protein in Pfam
PF02153 PDH, 1 hit
PIRSFiPIRSF036510 PDH_fung, 1 hit
SUPFAMiSSF48179 SSF48179, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS51176 PDH_ADH, 1 hit

Sequencei

Sequence statusi: Complete.

P20049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSEDKIEQW KATKVIGIIG LGDMGLLYAN KFTDAGWGVI CCDREEYYDE
60 70 80 90 100
LKEKYASAKF ELVKNGHLVS RQSDYIIYSV EASNISKIVA TYGPSSKVGT
110 120 130 140 150
IVGGQTSCKL PEIEAFEKYL PKDCDIITVH SLHGPKVNTE GQPLVIINHR
160 170 180 190 200
SQYPESFEFV NSVMACLKSK QVYLTYEEHD KITADTQAVT HAAFLSMGSA
210 220 230 240 250
WAKIKIYPWT LGVNKWYGGL ENVKVNISLR IYSNKWHVYA GLAITNPSAH
260 270 280 290 300
QQILQYATSA TELFSLMIDN KEQELTDRLL KAKQFVFGKH TGLLLLDDTI
310 320 330 340 350
LEKYSLSKSS IGNSNNCKPV PNSHLSLLAI VDSWFQLGID PYDHMICSTP
360 370 380 390 400
LFRIFLGVSE YLFLKPGLLE QTIDAAIHDK SFIKDDLEFV ISAREWSSVV
410 420 430 440 450
SFANFDIYKK QFQSVQKFFE PMLPEANLIG NEMIKTILSH SSDRSAAEKR

NT
Length:452
Mass (Da):50,923
Last modified:October 1, 1994 - v2
Checksum:iD483B93ABBC8F8F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38G → S (PubMed:2697638).Curated1
Sequence conflicti204 – 211IKIYPWTL → DKDSSLDS (PubMed:2697638).Curated8
Sequence conflicti312 – 313GN → SD (PubMed:2697638).Curated2
Sequence conflicti433 – 452MIKTI…EKRNT → DDKNHSESF (PubMed:2697638).CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36035 Genomic DNA Translation: CAA85127.1
BK006936 Genomic DNA Translation: DAA07282.1
PIRiS46037
RefSeqiNP_009725.1, NM_001178514.1

Genome annotation databases

EnsemblFungiiYBR166C; YBR166C; YBR166C
GeneIDi852464
KEGGisce:YBR166C

Similar proteinsi

Entry informationi

Entry nameiTYR1_YEAST
AccessioniPrimary (citable) accession number: P20049
Secondary accession number(s): D6VQG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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