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Protein

Dolichol kinase

Gene

SEC59

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. It is required for spore germination. Has an essential role in cellular metabolism.

Catalytic activityi

CTP + dolichol = CDP + dolichyl phosphate.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • dolichol kinase activity Source: SGD

GO - Biological processi

  • dolichyl monophosphate biosynthetic process Source: SGD
  • protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:YMR013C-MONOMER.
YEAST:YMR013C-MONOMER.
BRENDAi2.7.1.108. 984.
ReactomeiR-SCE-446199. Synthesis of Dolichyl-phosphate.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichol kinase (EC:2.7.1.108)
Gene namesi
Name:SEC59
Ordered Locus Names:YMR013C
ORF Names:YM8270.17C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR013C.
SGDiS000004615. SEC59.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 88LumenalSequence analysisAdd BLAST20
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 118CytoplasmicSequence analysis9
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 151LumenalSequence analysisAdd BLAST12
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 181CytoplasmicSequence analysis9
Transmembranei182 – 203HelicalSequence analysisAdd BLAST22
Topological domaini204 – 223LumenalSequence analysisAdd BLAST20
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 253CytoplasmicSequence analysis9
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 294LumenalSequence analysisAdd BLAST20
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 326CytoplasmicSequence analysisAdd BLAST11
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 349LumenalSequence analysis2
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 394CytoplasmicSequence analysisAdd BLAST24
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 417LumenalSequence analysis2
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 449CytoplasmicSequence analysisAdd BLAST11
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 472LumenalSequence analysis2
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 519CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976621 – 519Dolichol kinaseAdd BLAST519

Proteomic databases

MaxQBiP20048.
PRIDEiP20048.

Interactioni

Protein-protein interaction databases

BioGridi35183. 31 interactors.
DIPiDIP-8198N.

Structurei

3D structure databases

ProteinModelPortaliP20048.
SMRiP20048.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polyprenol kinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000004067.
HOGENOMiHOG000141906.
InParanoidiP20048.
KOiK00902.
OMAiNTSRKIW.
OrthoDBiEOG092C0M6T.

Family and domain databases

InterProiIPR032974. Polypren_kinase.
[Graphical view]
PANTHERiPTHR13205. PTHR13205. 1 hit.

Sequencei

Sequence statusi: Complete.

P20048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAIIPHASF TTIKLTQKTE GSQMPTEEIC KINMRTRKFD VGGNSRDFEC
60 70 80 90 100
FYSNFVQTVI LLGTFFYCVE RLQPWSIVTA DISYKQIFVN VFVVCLIMVG
110 120 130 140 150
LIFTKYWQHG YKSLPKFDTI YSLYLPFMVS LLFDTSSTVI NTILILSVLN
160 170 180 190 200
SYRWRTQLVV IILQLCLIFF NFEAGDRLKN IISIVINSLL SLILKYIGQL
210 220 230 240 250
KSLDNIDSNL FSILLTNILY VSEAGTVHFR ILKGIILALT TIISINYVLK
260 270 280 290 300
KVMHFKPFML SISFAIGLPL FANTFIHLED GENPLLWLVK YILESTIRQK
310 320 330 340 350
ILFAWSSILI LSIPSILIEK DSLSLNTSRK LWHFIIFLLI IPSFQMDSNF
360 370 380 390 400
VKIALSGTIP VFLSIEYIRF QNLPPLGSAI ELQLRRFADD RDHSGPLIIS
410 420 430 440 450
YLYLLFGIST PLLMNNSPMG LIGLGIGDSL ASIIGKRYGR IRWKGTQKTL
460 470 480 490 500
EGTLAFIVTS FIVCLVLLRF DKAAIFNHLT TLQLLTLCTL SGVLEGNSVL
510
NDNILIPAFM MICEKLITL
Length:519
Mass (Da):58,906
Last modified:February 1, 1991 - v1
Checksum:i2C75B6F175BBFF06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25779 Genomic DNA. Translation: AAA35033.1.
Z48613 Genomic DNA. Translation: CAA88530.1.
AY692829 Genomic DNA. Translation: AAT92848.1.
BK006946 Genomic DNA. Translation: DAA09911.1.
PIRiJQ0124.
RefSeqiNP_013726.1. NM_001182509.1.

Genome annotation databases

EnsemblFungiiYMR013C; YMR013C; YMR013C.
GeneIDi855026.
KEGGisce:YMR013C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25779 Genomic DNA. Translation: AAA35033.1.
Z48613 Genomic DNA. Translation: CAA88530.1.
AY692829 Genomic DNA. Translation: AAT92848.1.
BK006946 Genomic DNA. Translation: DAA09911.1.
PIRiJQ0124.
RefSeqiNP_013726.1. NM_001182509.1.

3D structure databases

ProteinModelPortaliP20048.
SMRiP20048.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35183. 31 interactors.
DIPiDIP-8198N.

Proteomic databases

MaxQBiP20048.
PRIDEiP20048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR013C; YMR013C; YMR013C.
GeneIDi855026.
KEGGisce:YMR013C.

Organism-specific databases

EuPathDBiFungiDB:YMR013C.
SGDiS000004615. SEC59.

Phylogenomic databases

GeneTreeiENSGT00390000004067.
HOGENOMiHOG000141906.
InParanoidiP20048.
KOiK00902.
OMAiNTSRKIW.
OrthoDBiEOG092C0M6T.

Enzyme and pathway databases

UniPathwayiUPA00378.
BioCyciMetaCyc:YMR013C-MONOMER.
YEAST:YMR013C-MONOMER.
BRENDAi2.7.1.108. 984.
ReactomeiR-SCE-446199. Synthesis of Dolichyl-phosphate.

Miscellaneous databases

PROiP20048.

Family and domain databases

InterProiIPR032974. Polypren_kinase.
[Graphical view]
PANTHERiPTHR13205. PTHR13205. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSEC59_YEAST
AccessioniPrimary (citable) accession number: P20048
Secondary accession number(s): D6VZI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.