P20036 (DPA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class II histocompatibility antigen, DP alpha 1 chain

Alternative name(s):
DP(W3)
DP(W4)
HLA-SB alpha chain
MHC class II DP3-alpha
MHC class II DPA1

Gene names

Name:	HLA-DPA1
Synonyms:	HLA-DP1A, HLASB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
Subunit structure	Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus › trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Polymorphism	The following alleles of DPA1 are known: DPA1*01:03, DPA1*01:04, DPA1*01:05, DPA1*01:06, DPA1*01:07, DPA1*01:08, DPA1*01:09, DPA1*01:10, DPA1*02:01, DPA1*02:02, DPA1*02:03, DPA1*02:04, DPA1*03:01, DPA1*03:02, DPA1*03:03, DPA1*04:01 The sequence shown is that of DPA1*01:03.
Sequence similarities	Belongs to the MHC class II family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Sequence caution	The sequence AAC64233.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAD42927.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Immunity
Cellular component	Cell membrane Endoplasmic reticulum Endosome Golgi apparatus Lysosome MHC II Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell costimulation Traceable author statement. Source: Reactome T cell receptor signaling pathway Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class II Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular_component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class II protein complex Inferred from electronic annotation. Source: UniProtKB-KW clathrin-coated endocytic vesicle membrane Traceable author statement. Source: Reactome endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to plasma membrane Non-traceable author statement Ref.3. Source: UniProtKB lysosomal membrane Traceable author statement. Source: Reactome trans-Golgi network membrane Traceable author statement. Source: Reactome
Molecular_function	MHC class II receptor activity Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

28

Chain

29 – 260

232

HLA class II histocompatibility antigen, DP alpha 1 chain

PRO_0000018967

Regions

Topological domain

29 – 222

194

Extracellular Potential

Transmembrane

223 – 245

23

Helical; Potential

Topological domain

246 – 260

15

Cytoplasmic Potential

Domain

118 – 210

93

Ig-like C1-type

Region

29 – 115

87

Alpha-1

Region

116 – 209

94

Alpha-2

Region

210 – 222

13

Connecting peptide

Amino acid modifications

Glycosylation

109

1

N-linked (GlcNAc...) Potential

Glycosylation

149

1

N-linked (GlcNAc...) Ref.29

Disulfide bond

138 ↔ 194

By similarity

Natural variations

Natural variant

42

1

A → M in allele DPA1*02:02, allele DPA1*02:04, allele DPA1*03:01, allele DPA1*03:02 and allele DPA1*03:03; requires 2 nucleotide substitutions.

VAR_058832

Natural variant

42

1

A → T.
Corresponds to variant rs1126533 [ dbSNP | Ensembl ].

VAR_047683

Natural variant

42

1

A → V.
Corresponds to variant rs1126534 [ dbSNP | Ensembl ].

VAR_047684

Natural variant

49

1

P → T in allele DPA1*04:01.
Corresponds to variant rs2308907 [ dbSNP | Ensembl ].

VAR_058833

Natural variant

54

1

M → T in allele DPA1*01:09.
Corresponds to variant rs1042175 [ dbSNP | Ensembl ].

VAR_058834

Natural variant

59

1

E → D in allele DPA1*01:04, allele DPA1*01:08, allele DPA1*03:03 and allele DPA1*04:01.
Corresponds to variant rs2308910 [ dbSNP | Ensembl ].

VAR_058835

Natural variant

62

1

M → K.
Corresponds to variant rs2308912 [ dbSNP | Ensembl ].

VAR_058836

Natural variant

62

1

M → L.
Corresponds to variant rs2308911 [ dbSNP | Ensembl ].

VAR_047685

Natural variant

62

1

M → Q in allele DPA1*01:06, allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*02:04; requires 2 nucleotide substitutions.
Corresponds to variant rs36013091 [ dbSNP | Ensembl ].

VAR_058850

Natural variant

74

1

W → C in allele DPA1*01:10.
Corresponds to variant rs72558171 [ dbSNP | Ensembl ].

VAR_058837

Natural variant

81

1

Q → R in allele DPA1*01:08, allele DPA1*02:01, allele DPA1*02:02, allele DPA1*02:03, allele DPA1*02:04 and allele DPA1*04:01.
Corresponds to variant rs1042178 [ dbSNP | Ensembl ].

VAR_047686

Natural variant

82

1

A → T in allele DPA1*01:07.
Corresponds to variant rs41543112 [ dbSNP | Ensembl ].

VAR_058838

Natural variant

97

1

L → S in allele DPA1*03:01 and allele DPA1*03:03.
Corresponds to variant rs2308917 [ dbSNP | Ensembl ].

VAR_047687

Natural variant

100

1

N → D in allele DPA1*02:04.
Corresponds to variant rs61759929 [ dbSNP | Ensembl ].

VAR_058839

Natural variant

103

1

T → I in allele DPA1*04:01.
Corresponds to variant rs41559316 [ dbSNP | Ensembl ].

VAR_058840

Natural variant

104

1

L → A in allele DPA1*04:01; requires 2 nucleotide substitutions.

VAR_058841

Natural variant

114

1

T → A in allele DPA1*01:05, allele DPA1*02:01, allele DPA1*02:02, allele DPA1*02:03, allele DPA1*02:04 and allele DPA1*04:01.
Corresponds to variant rs1126542 [ dbSNP | Ensembl ].

VAR_047688

Natural variant

127

1

P → A in allele DPA1*04:01.
Corresponds to variant rs41562016 [ dbSNP | Ensembl ].

VAR_058842

Natural variant

142

1

K → R in allele DPA1*02:01 and allele DPA1*02:02.
Corresponds to variant rs1042190 [ dbSNP | Ensembl ].

VAR_047689

Natural variant

158

1

L → P in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01.
Corresponds to variant rs2308930 [ dbSNP | Ensembl ].

VAR_058843

Natural variant

191

1

F → V in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01.
Corresponds to variant rs1042308 [ dbSNP | Ensembl ].

VAR_047690

Natural variant

221

1

T → A in allele DPA1*04:01.

VAR_058844

Natural variant

259

1

T → P in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01.
Corresponds to variant rs1126769 [ dbSNP | Ensembl ].

VAR_058845

Experimental info

Sequence conflict

237

1

I → F in CAA25143. Ref.7

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

260

Helix Strand Turn

Details...

Beta strand

35 – 49

15

Beta strand

51 – 57

7

Beta strand

60 – 66

7

Turn

67 – 70

4

Beta strand

71 – 76

6

Helix

77 – 80

4

Helix

87 – 106

20

Turn

107 – 110

4

Beta strand

119 – 126

8

Beta strand

134 – 145

12

Beta strand

149 – 154

6

Beta strand

163 – 165

3

Beta strand

176 – 184

9

Beta strand

192 – 197

6

Beta strand

205 – 209

5

Sequences

	Sequence		Length	Mass (Da)
	P20036 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 826174E963A8CB42	FASTA	260	29,381
	10 20 30 40 50 60 MRPEDRMFHI RAVILRALSL AFLLSLRGAG AIKADHVSTY AAFVQTHRPT GEFMFEFDED 70 80 90 100 110 120 EMFYVDLDKK ETVWHLEEFG QAFSFEAQGG LANIAILNNN LNTLIQRSNH TQATNDPPEV 130 140 150 160 170 180 TVFPKEPVEL GQPNTLICHI DKFFPPVLNV TWLCNGELVT EGVAESLFLP RTDYSFHKFH 190 200 210 220 230 240 YLTFVPSAED FYDCRVEHWG LDQPLLKHWE AQEPIQMPET TETVLCALGL VLGLVGIIVG 250 260 TVLIIKSLRS GHDPRAQGTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene." Lawrance S.K., Das H.K., Pan J., Weissman S.M. Nucleic Acids Res. 13:7515-7528(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPA1*01:03).
[2]	"Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes." Gustafsson K., Widmark E., Jonsson A.-K., Servenius B., Sachs D.H., Larhammar D., Rask L., Peterson P.A. J. Biol. Chem. 262:8778-8786(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPA1*01:03).
[3]	"Epitope recognition by a DP alpha chain-specific monoclonal antibody (DP11.1) is influenced by the interaction between the DP alpha chain and its polymorphic DP beta chain partner." Young J.A., Lindsay J., Bodmer J.G., Trowsdale J. Hum. Immunol. 23:37-44(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPA1*01:03).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DPA1*01:03).
[6]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes." Auffray C., Lillie J.W., Arnot D., Grossberger D., Kappes D., Strominger J.L. Nature 308:327-333(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-260 (ALLELE DPA1*01:03).
[8]	"A novel DPA1 allele (DPA1*0203) composed of known epitopes." Muntau B., Thye T., Pirmez C., Horstmann R.D. Tissue Antigens 49:668-669(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-115 (ALLELE DPA1*02:03).
[9]	"Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302." Steiner L.L., Cavalli A., Zimmerman P.A., Boatin B.A., Titanji V.P., Bradley J.E., Lucius R., Nutman T.B., Begovich A.B. Tissue Antigens 51:653-657(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-115 (ALLELE DPA1*03:02).
[10]	"Sequencing-based typing reveals new insight in HLA-DPA1 polymorphism." Rozemuller E.H., Bouwens A.G., van Oort E., Versluis L.F., Marsh S.G., Bodmer J.G., Tilanus M.G. Tissue Antigens 45:57-62(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-116 AND 211-260 (ALLELE DPA1*01:04), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-229 (ALLELE DPA1*02:01), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-116 AND 211-260 (ALLELE DPA1*02:02), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-115 AND 211-260 (ALLELES DPA1*03:01 AND DPA1*401).
[11]	"A new HLA-DPA1 allele, DPA1*02016, identified in African-American population." McDaniel D.O., Nguyen C., McDaniel L.S. Tissue Antigens 56:197-198(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DPA1*02:01).
[12]	"High-resolution sequence-based DPA1 typing identified two novel DPA1 alleles, DPA1*010303 and DPA1*0303, from a Kenyan population." Luo M., Bamforth J., Gill K., Cohen C., Brunham R.C., Plummer F.A. Tissue Antigens 65:120-122(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*03:03).
[13]	"Identification of a novel DPA1 allele, DPA1*010602, in an East African population." Peterson T.A., Luo M., Mao X., Brunham R.C., Plummer F.A. Hum. Immunol. 69:885-886(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:06).
[14]	"Description of two novel HLA-DPA1 alleles: DPA1*0110 and DPA1*010304." Lee K.W. Tissue Antigens 71:575-577(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELES DPA1*01:03 AND DPA1*01:10).
[15]	"A novel HLA-DPA1*0204 allele was identified in a Chinese individual." Zhao H., Dai W.-J., He Y.-M., Zhu F.-M., Yan L.-X. Tissue Antigens 71:577-578(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*02:04).
[16]	Steiner L., Begovich A., Suraj V. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:06).
[17]	"One new DPA1 Allele." Grams S.E., Begovich A., Mangaccat J. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:08).
[18]	"Novel human HLA-DPA1 allele identified in potential bone marrow donors." Bassinger S., Wu J., Williams T.M. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:09).
[19]	"DPA1 polymorphism in Polynesians." Varney M.D., Gavrilidis A., Abbott W. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-115 (ALLELE DPA1*01:07).
[20]	"DPA1*0105, a novel DPA1 variant in a negrois population." May J., Krestchmer C., Schnittger L., Striecker R., Kremoner P.G., Meyer C.G. Tissue Antigens 48:593-594(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-115 (ALLELE DPA1*01:05).
[21]	"Exon 2, 3, and 4 polymorphism of HLA-DPA1." Rozemuller E.H., Versluis L.F., Bouwens A.G., Tilanus M.G. Immunogenetics 41:53-53(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 117-210 (ALLELES DPA1*01:04; DPA1*02:02; DPA1*03:01 AND DPA1*04:01).
[22]	"Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes." Trowsdale J., Lee J., Carey J., Grosveld F., Bodmer J., Bodmer W. Proc. Natl. Acad. Sci. U.S.A. 80:1972-1976(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-209 (ALLELE DPA1*01:03).
[23]	"Invariant chain structure and MHC class II function." Cresswell P. Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[24]	"Presentation of antigens by MHC class II molecules: getting the most out of them." Villadangos J.A. Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[25]	"MHC class II molecules on the move for successful antigen presentation." Rocha N., Neefjes J. EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[26]	"Autophagy in MHC class II presentation: sampling from within." Menendez-Benito V., Neefjes J. Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[27]	"MHC class II transport at a glance." Berger A.C., Roche P.A. J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[28]	"CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract." Beswick E.J., Reyes V.E. World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[29]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-149, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X03100 Genomic DNA. Translation: CAA26887.1.
M27487 mRNA. Translation: AAA63220.1.
AK292709 mRNA. Translation: BAF85398.1.
AL645931 Genomic DNA. No translation available.
AL805913 Genomic DNA. Translation: CAI18549.1.
BX120009, BX005422 Genomic DNA. Translation: CAM25981.1.
BX005422, BX120009 Genomic DNA. Translation: CAM26119.1.
CR759829, CR762479 Genomic DNA. Translation: CAQ07261.1.
CR759795 Genomic DNA. Translation: CAQ07433.1.
CR847849 Genomic DNA. Translation: CAQ07485.1.
CR759904 Genomic DNA. Translation: CAQ09865.1.
CR762479, CR759829 Genomic DNA. Translation: CAQ10344.1.
CH471081 Genomic DNA. Translation: EAX03669.1.
X00457 mRNA. Translation: CAA25143.1.
Z48473 Genomic DNA. No translation available.
AF013767 Genomic DNA. Translation: AAC64233.1. Sequence problems.
X78199 Genomic DNA. No translation available.
X82393 Genomic DNA. No translation available.
X82394 Genomic DNA. No translation available.
X78198 Genomic DNA. No translation available.
X82391 Genomic DNA. No translation available.
X79475 Genomic DNA. No translation available.
X79477 Genomic DNA. No translation available.
X79479 Genomic DNA. No translation available.
X79481 Genomic DNA. No translation available.
AF165160 Genomic DNA. Translation: AAD47826.1.
AY618553 Genomic DNA. Translation: AAT92097.1.
EU729350 Genomic DNA. Translation: ACH88749.1.
DQ274060 Genomic DNA. Translation: ABB88406.1.
DQ274061 Genomic DNA. Translation: ABB88407.1.
EU304462 Genomic DNA. Translation: ABY27081.1.
U87556 Genomic DNA. Translation: AAB97110.1.
AF346471 Genomic DNA. Translation: AAK27152.1.
AY650051 Genomic DNA. Translation: AAT67468.1.
AF076284 Genomic DNA. Translation: AAD42927.1. Sequence problems.
X96984 Genomic DNA. No translation available.
X80482 Genomic DNA. No translation available.
X81347 Genomic DNA. No translation available.
X81348 Genomic DNA. No translation available.
K00514 Genomic DNA. Translation: AAA59786.1.

IPI

IPI00021711.

PIR

HLHUSB. A29313.

RefSeq

NP_001229453.1. NM_001242524.1.
NP_001229454.1. NM_001242525.1.
NP_291032.2. NM_033554.3.

UniGene

Hs.347270.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3LQZ	X-ray	3.25	A	32-212	[»]

ProteinModelPortal

P20036.

ModBase

Search...

Protein-protein interaction databases

IntAct

P20036. 4 interactions.

MINT

MINT-1488672.

PTM databases

PhosphoSite

P20036.

Polymorphism databases

DMDM

122204.

Proteomic databases

PaxDb

P20036.

PRIDE

P20036.

Protocols and materials databases

DNASU

3113.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000374808; ENSP00000363941; ENSG00000168384.
ENST00000383224; ENSP00000372711; ENSG00000206291.
ENST00000415247; ENSP00000405838; ENSG00000224103.
ENST00000419277; ENSP00000393566; ENSG00000231389.
ENST00000422504; ENSP00000406250; ENSG00000228163.
ENST00000428995; ENSP00000402872; ENSG00000231389.
ENST00000443117; ENSP00000397587; ENSG00000235844.
ENST00000454805; ENSP00000397139; ENSG00000229685.
ENST00000515317; ENSP00000427429; ENSG00000236177.
ENST00000549300; ENSP00000449627; ENSG00000229685.
ENST00000550456; ENSP00000446736; ENSG00000236177.
ENST00000550806; ENSP00000449242; ENSG00000228163.
ENST00000551196; ENSP00000448034; ENSG00000235844.
ENST00000551933; ENSP00000448097; ENSG00000206291.
ENST00000552158; ENSP00000447713; ENSG00000168384.

GeneID

3113.

KEGG

hsa:3113.

UCSC

uc003ocs.2. human.

Organism-specific databases

CTD

3113.

GeneCards

GC06M033032.

HGNC

HGNC:4938. HLA-DPA1.

HPA

HPA017967.

MIM

142880. gene.

neXtProt

NX_P20036.

PharmGKB

PA35062.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG235591.

HOVERGEN

HBG006862.

InParanoid

P20036.

KO

K06752.

OMA

LNVTWLC.

OrthoDB

EOG45X7XB.

PhylomeDB

P20036.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P20036.

Bgee

P20036.

CleanEx

HS_HLA-DPA1.

Genevestigator

P20036.

GermOnline

ENSG00000168384. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.10.320.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

HLA-DPA1. human.

EvolutionaryTrace

P20036.

GenomeRNAi

3113.

NextBio

12353.

SOURCE

Search...

Entry information

Entry name

DPA1_HUMAN

Accession

Primary (citable) accession number: P20036
Secondary accession number(s): A9YWH7 , B9UKH4, O19722, O46883, P01905, P79554, Q2Q060, Q2Q061, Q5EY03, Q5STP1, Q6DQK4, Q9BCQ1, Q9TPX3, Q9XS10

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	February 1, 1991
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.