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P20036 (DPA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class II histocompatibility antigen, DP alpha 1 chain
Alternative name(s):
DP(W3)
DP(W4)
HLA-SB alpha chain
MHC class II DP3-alpha
MHC class II DPA1
Gene names
Name:HLA-DPA1
Synonyms:HLA-DP1A, HLASB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Subunit structure

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Polymorphism

The following alleles of DPA1 are known: DPA1*01:03, DPA1*01:04, DPA1*01:05, DPA1*01:06, DPA1*01:07, DPA1*01:08, DPA1*01:09, DPA1*01:10, DPA1*02:01, DPA1*02:02, DPA1*02:03, DPA1*02:04, DPA1*03:01, DPA1*03:02, DPA1*03:03, DPA1*04:01 The sequence shown is that of DPA1*01:03.

Sequence similarities

Belongs to the MHC class II family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence caution

The sequence AAC64233.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAD42927.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processImmunity
   Cellular componentCell membrane
Endoplasmic reticulum
Endosome
Golgi apparatus
Lysosome
Membrane
MHC II
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell costimulation

Traceable author statement. Source: Reactome

T cell receptor signaling pathway

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class II

Traceable author statement. Source: Reactome

cellular response to interferon-gamma

Inferred from direct assay PubMed 8568247. Source: UniProtKB

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

immune response

Non-traceable author statement Ref.3. Source: UniProtKB

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi membrane

Traceable author statement. Source: Reactome

MHC class II protein complex

Inferred from electronic annotation. Source: UniProtKB-KW

clathrin-coated endocytic vesicle membrane

Traceable author statement. Source: Reactome

endocytic vesicle membrane

Traceable author statement. Source: Reactome

endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

integral component of plasma membrane

Non-traceable author statement Ref.3. Source: UniProtKB

lysosomal membrane

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

trans-Golgi network membrane

Traceable author statement. Source: Reactome

transport vesicle membrane

Traceable author statement. Source: Reactome

   Molecular_functionMHC class II receptor activity

Non-traceable author statement Ref.3. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828
Chain29 – 260232HLA class II histocompatibility antigen, DP alpha 1 chain
PRO_0000018967

Regions

Topological domain29 – 222194Extracellular Potential
Transmembrane223 – 24523Helical; Potential
Topological domain246 – 26015Cytoplasmic Potential
Domain118 – 21093Ig-like C1-type
Region29 – 11587Alpha-1
Region116 – 20994Alpha-2
Region210 – 22213Connecting peptide

Amino acid modifications

Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation1491N-linked (GlcNAc...) Ref.29
Disulfide bond138 ↔ 194 By similarity

Natural variations

Natural variant421A → M in allele DPA1*02:02, allele DPA1*02:04, allele DPA1*03:01, allele DPA1*03:02 and allele DPA1*03:03; requires 2 nucleotide substitutions.
VAR_058832
Natural variant421A → T.
Corresponds to variant rs1126533 [ dbSNP | Ensembl ].
VAR_047683
Natural variant421A → V.
Corresponds to variant rs1126534 [ dbSNP | Ensembl ].
VAR_047684
Natural variant491P → T in allele DPA1*04:01.
Corresponds to variant rs2308907 [ dbSNP | Ensembl ].
VAR_058833
Natural variant541M → T in allele DPA1*01:09.
Corresponds to variant rs1042175 [ dbSNP | Ensembl ].
VAR_058834
Natural variant591E → D in allele DPA1*01:04, allele DPA1*01:08, allele DPA1*03:03 and allele DPA1*04:01.
Corresponds to variant rs2308910 [ dbSNP | Ensembl ].
VAR_058835
Natural variant621M → K.
Corresponds to variant rs2308912 [ dbSNP | Ensembl ].
VAR_058836
Natural variant621M → L.
Corresponds to variant rs2308911 [ dbSNP | Ensembl ].
VAR_047685
Natural variant621M → Q in allele DPA1*01:06, allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*02:04; requires 2 nucleotide substitutions.
Corresponds to variant rs36013091 [ dbSNP | Ensembl ].
VAR_058850
Natural variant741W → C in allele DPA1*01:10.
Corresponds to variant rs72558171 [ dbSNP | Ensembl ].
VAR_058837
Natural variant811Q → R in allele DPA1*01:08, allele DPA1*02:01, allele DPA1*02:02, allele DPA1*02:03, allele DPA1*02:04 and allele DPA1*04:01.
Corresponds to variant rs1042178 [ dbSNP | Ensembl ].
VAR_047686
Natural variant821A → T in allele DPA1*01:07.
Corresponds to variant rs41543112 [ dbSNP | Ensembl ].
VAR_058838
Natural variant971L → S in allele DPA1*03:01 and allele DPA1*03:03.
Corresponds to variant rs2308917 [ dbSNP | Ensembl ].
VAR_047687
Natural variant1001N → D in allele DPA1*02:04.
Corresponds to variant rs61759929 [ dbSNP | Ensembl ].
VAR_058839
Natural variant1031T → I in allele DPA1*04:01.
Corresponds to variant rs41559316 [ dbSNP | Ensembl ].
VAR_058840
Natural variant1041L → A in allele DPA1*04:01; requires 2 nucleotide substitutions.
VAR_058841
Natural variant1141T → A in allele DPA1*01:05, allele DPA1*02:01, allele DPA1*02:02, allele DPA1*02:03, allele DPA1*02:04 and allele DPA1*04:01.
Corresponds to variant rs1126542 [ dbSNP | Ensembl ].
VAR_047688
Natural variant1271P → A in allele DPA1*04:01.
Corresponds to variant rs41562016 [ dbSNP | Ensembl ].
VAR_058842
Natural variant1421K → R in allele DPA1*02:01 and allele DPA1*02:02.
Corresponds to variant rs1042190 [ dbSNP | Ensembl ].
VAR_047689
Natural variant1581L → P in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01.
Corresponds to variant rs2308930 [ dbSNP | Ensembl ].
VAR_058843
Natural variant1911F → V in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01.
Corresponds to variant rs1042308 [ dbSNP | Ensembl ].
VAR_047690
Natural variant2211T → A in allele DPA1*04:01.
VAR_058844
Natural variant2591T → P in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01.
Corresponds to variant rs1126769 [ dbSNP | Ensembl ].
VAR_058845

Experimental info

Sequence conflict2371I → F in CAA25143. Ref.7

Secondary structure

........................... 260
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P20036 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 826174E963A8CB42

FASTA26029,381
        10         20         30         40         50         60 
MRPEDRMFHI RAVILRALSL AFLLSLRGAG AIKADHVSTY AAFVQTHRPT GEFMFEFDED 

        70         80         90        100        110        120 
EMFYVDLDKK ETVWHLEEFG QAFSFEAQGG LANIAILNNN LNTLIQRSNH TQATNDPPEV 

       130        140        150        160        170        180 
TVFPKEPVEL GQPNTLICHI DKFFPPVLNV TWLCNGELVT EGVAESLFLP RTDYSFHKFH 

       190        200        210        220        230        240 
YLTFVPSAED FYDCRVEHWG LDQPLLKHWE AQEPIQMPET TETVLCALGL VLGLVGIIVG 

       250        260 
TVLIIKSLRS GHDPRAQGTL 

« Hide

References

« Hide 'large scale' references
[1]"The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene."
Lawrance S.K., Das H.K., Pan J., Weissman S.M.
Nucleic Acids Res. 13:7515-7528(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPA1*01:03).
[2]"Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes."
Gustafsson K., Widmark E., Jonsson A.-K., Servenius B., Sachs D.H., Larhammar D., Rask L., Peterson P.A.
J. Biol. Chem. 262:8778-8786(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPA1*01:03).
[3]"Epitope recognition by a DP alpha chain-specific monoclonal antibody (DP11.1) is influenced by the interaction between the DP alpha chain and its polymorphic DP beta chain partner."
Young J.A., Lindsay J., Bodmer J.G., Trowsdale J.
Hum. Immunol. 23:37-44(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPA1*01:03).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DPA1*01:03).
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes."
Auffray C., Lillie J.W., Arnot D., Grossberger D., Kappes D., Strominger J.L.
Nature 308:327-333(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-260 (ALLELE DPA1*01:03).
[8]"A novel DPA1 allele (DPA1*0203) composed of known epitopes."
Muntau B., Thye T., Pirmez C., Horstmann R.D.
Tissue Antigens 49:668-669(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-115 (ALLELE DPA1*02:03).
[9]"Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302."
Steiner L.L., Cavalli A., Zimmerman P.A., Boatin B.A., Titanji V.P., Bradley J.E., Lucius R., Nutman T.B., Begovich A.B.
Tissue Antigens 51:653-657(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-115 (ALLELE DPA1*03:02).
[10]"Sequencing-based typing reveals new insight in HLA-DPA1 polymorphism."
Rozemuller E.H., Bouwens A.G., van Oort E., Versluis L.F., Marsh S.G., Bodmer J.G., Tilanus M.G.
Tissue Antigens 45:57-62(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-116 AND 211-260 (ALLELE DPA1*01:04), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-229 (ALLELE DPA1*02:01), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-116 AND 211-260 (ALLELE DPA1*02:02), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-115 AND 211-260 (ALLELES DPA1*03:01 AND DPA1*401).
[11]"A new HLA-DPA1 allele, DPA1*02016, identified in African-American population."
McDaniel D.O., Nguyen C., McDaniel L.S.
Tissue Antigens 56:197-198(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DPA1*02:01).
[12]"High-resolution sequence-based DPA1 typing identified two novel DPA1 alleles, DPA1*010303 and DPA1*0303, from a Kenyan population."
Luo M., Bamforth J., Gill K., Cohen C., Brunham R.C., Plummer F.A.
Tissue Antigens 65:120-122(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*03:03).
[13]"Identification of a novel DPA1 allele, DPA1*010602, in an East African population."
Peterson T.A., Luo M., Mao X., Brunham R.C., Plummer F.A.
Hum. Immunol. 69:885-886(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:06).
[14]"Description of two novel HLA-DPA1 alleles: DPA1*0110 and DPA1*010304."
Lee K.W.
Tissue Antigens 71:575-577(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELES DPA1*01:03 AND DPA1*01:10).
[15]"A novel HLA-DPA1*0204 allele was identified in a Chinese individual."
Zhao H., Dai W.-J., He Y.-M., Zhu F.-M., Yan L.-X.
Tissue Antigens 71:577-578(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*02:04).
[16]Steiner L., Begovich A., Suraj V.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:06).
[17]"One new DPA1 Allele."
Grams S.E., Begovich A., Mangaccat J.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:08).
[18]"Novel human HLA-DPA1 allele identified in potential bone marrow donors."
Bassinger S., Wu J., Williams T.M.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:09).
[19]"DPA1 polymorphism in Polynesians."
Varney M.D., Gavrilidis A., Abbott W.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-115 (ALLELE DPA1*01:07).
[20]"DPA1*0105, a novel DPA1 variant in a negrois population."
May J., Krestchmer C., Schnittger L., Striecker R., Kremoner P.G., Meyer C.G.
Tissue Antigens 48:593-594(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-115 (ALLELE DPA1*01:05).
[21]"Exon 2, 3, and 4 polymorphism of HLA-DPA1."
Rozemuller E.H., Versluis L.F., Bouwens A.G., Tilanus M.G.
Immunogenetics 41:53-53(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 117-210 (ALLELES DPA1*01:04; DPA1*02:02; DPA1*03:01 AND DPA1*04:01).
[22]"Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes."
Trowsdale J., Lee J., Carey J., Grosveld F., Bodmer J., Bodmer W.
Proc. Natl. Acad. Sci. U.S.A. 80:1972-1976(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-209 (ALLELE DPA1*01:03).
[23]"Invariant chain structure and MHC class II function."
Cresswell P.
Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[24]"Presentation of antigens by MHC class II molecules: getting the most out of them."
Villadangos J.A.
Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[25]"MHC class II molecules on the move for successful antigen presentation."
Rocha N., Neefjes J.
EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[26]"Autophagy in MHC class II presentation: sampling from within."
Menendez-Benito V., Neefjes J.
Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[27]"MHC class II transport at a glance."
Berger A.C., Roche P.A.
J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[28]"CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
Beswick E.J., Reyes V.E.
World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[29]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-149.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X03100 Genomic DNA. Translation: CAA26887.1.
M27487 mRNA. Translation: AAA63220.1.
AK292709 mRNA. Translation: BAF85398.1.
AL645931 Genomic DNA. No translation available.
AL805913 Genomic DNA. Translation: CAI18549.1.
BX120009, BX005422 Genomic DNA. Translation: CAM25981.1.
BX005422, BX120009 Genomic DNA. Translation: CAM26119.1.
CR759829, CR762479 Genomic DNA. Translation: CAQ07261.1.
CR759795 Genomic DNA. Translation: CAQ07433.1.
CR847849 Genomic DNA. Translation: CAQ07485.1.
CR759904 Genomic DNA. Translation: CAQ09865.1.
CR762479, CR759829 Genomic DNA. Translation: CAQ10344.1.
CH471081 Genomic DNA. Translation: EAX03669.1.
X00457 mRNA. Translation: CAA25143.1.
Z48473 Genomic DNA. No translation available.
AF013767 Genomic DNA. Translation: AAC64233.1. Sequence problems.
X78199 Genomic DNA. No translation available.
X82393 Genomic DNA. No translation available.
X82394 Genomic DNA. No translation available.
X78198 Genomic DNA. No translation available.
X82391 Genomic DNA. No translation available.
X79475 Genomic DNA. No translation available.
X79477 Genomic DNA. No translation available.
X79479 Genomic DNA. No translation available.
X79481 Genomic DNA. No translation available.
AF165160 Genomic DNA. Translation: AAD47826.1.
AY618553 Genomic DNA. Translation: AAT92097.1.
EU729350 Genomic DNA. Translation: ACH88749.1.
DQ274060 Genomic DNA. Translation: ABB88406.1.
DQ274061 Genomic DNA. Translation: ABB88407.1.
EU304462 Genomic DNA. Translation: ABY27081.1.
U87556 Genomic DNA. Translation: AAB97110.1.
AF346471 Genomic DNA. Translation: AAK27152.1.
AY650051 Genomic DNA. Translation: AAT67468.1.
AF076284 Genomic DNA. Translation: AAD42927.1. Sequence problems.
X96984 Genomic DNA. No translation available.
X80482 Genomic DNA. No translation available.
X81347 Genomic DNA. No translation available.
X81348 Genomic DNA. No translation available.
K00514 Genomic DNA. Translation: AAA59786.1.
PIRHLHUSB. A29313.
RefSeqNP_001229453.1. NM_001242524.1.
NP_001229454.1. NM_001242525.1.
NP_291032.2. NM_033554.3.
UniGeneHs.347270.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3LQZX-ray3.25A32-212[»]
ProteinModelPortalP20036.
SMRP20036. Positions 32-212.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109358. 1 interaction.
IntActP20036. 4 interactions.
MINTMINT-1488672.

PTM databases

PhosphoSiteP20036.

Polymorphism databases

DMDM122204.

Proteomic databases

PaxDbP20036.
PRIDEP20036.

Protocols and materials databases

DNASU3113.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374808; ENSP00000363941; ENSG00000168384.
ENST00000383224; ENSP00000372711; ENSG00000206291.
ENST00000415247; ENSP00000405838; ENSG00000224103.
ENST00000419277; ENSP00000393566; ENSG00000231389.
ENST00000422504; ENSP00000406250; ENSG00000228163.
ENST00000428995; ENSP00000402872; ENSG00000231389.
ENST00000443117; ENSP00000397587; ENSG00000235844.
ENST00000454805; ENSP00000397139; ENSG00000229685.
ENST00000515317; ENSP00000427429; ENSG00000236177.
ENST00000549300; ENSP00000449627; ENSG00000229685.
ENST00000550456; ENSP00000446736; ENSG00000236177.
ENST00000550806; ENSP00000449242; ENSG00000228163.
ENST00000551196; ENSP00000448034; ENSG00000235844.
ENST00000551933; ENSP00000448097; ENSG00000206291.
ENST00000552158; ENSP00000447713; ENSG00000168384.
GeneID3113.
KEGGhsa:3113.
UCSCuc003ocs.2. human.

Organism-specific databases

CTD3113.
GeneCardsGC06M033032.
GC06Mi33015.
GC06Mj32954.
GC06Mk33010.
GC06Ml33186.
GC06Mm33065.
GC06Mn32961.
GC06Mo33171.
HGNCHGNC:4938. HLA-DPA1.
HPAHPA017967.
MIM142880. gene.
neXtProtNX_P20036.
PharmGKBPA35062.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG235591.
HOVERGENHBG006862.
InParanoidP20036.
KOK06752.
OMAAFSFEAQ.
PhylomeDBP20036.
TreeFamTF333797.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressP20036.
BgeeP20036.
CleanExHS_HLA-DPA1.
GenevestigatorP20036.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-DPA1. human.
EvolutionaryTraceP20036.
GenomeRNAi3113.
NextBio12353.
PROP20036.
SOURCESearch...

Entry information

Entry nameDPA1_HUMAN
AccessionPrimary (citable) accession number: P20036
Secondary accession number(s): A9YWH7 expand/collapse secondary AC list , B9UKH4, O19722, O46883, P01905, P79554, Q2Q060, Q2Q061, Q5EY03, Q5STP1, Q6DQK4, Q9BCQ1, Q9TPX3, Q9XS10
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM