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P20036

- DPA1_HUMAN

UniProt

P20036 - DPA1_HUMAN

Protein

HLA class II histocompatibility antigen, DP alpha 1 chain

Gene

HLA-DPA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

    GO - Molecular functioni

    1. MHC class II receptor activity Source: UniProtKB
    2. peptide antigen binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProt
    2. cellular response to interferon-gamma Source: UniProtKB
    3. cytokine-mediated signaling pathway Source: Reactome
    4. immune response Source: UniProtKB
    5. interferon-gamma-mediated signaling pathway Source: Reactome
    6. positive regulation of interferon-gamma production Source: UniProt
    7. positive regulation of T cell activation Source: UniProt
    8. positive regulation of T cell proliferation Source: UniProt
    9. T cell costimulation Source: Reactome
    10. T cell receptor signaling pathway Source: Reactome

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class II histocompatibility antigen, DP alpha 1 chain
    Alternative name(s):
    DP(W3)
    DP(W4)
    HLA-SB alpha chain
    MHC class II DP3-alpha
    MHC class II DPA1
    Gene namesi
    Name:HLA-DPA1
    Synonyms:HLA-DP1A, HLASB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4938. HLA-DPA1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. clathrin-coated endocytic vesicle membrane Source: Reactome
    3. endocytic vesicle membrane Source: Reactome
    4. endosome membrane Source: UniProtKB-SubCell
    5. ER to Golgi transport vesicle membrane Source: Reactome
    6. Golgi membrane Source: Reactome
    7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    8. integral component of plasma membrane Source: UniProtKB
    9. lysosomal membrane Source: Reactome
    10. MHC class II protein complex Source: UniProt
    11. plasma membrane Source: Reactome
    12. trans-Golgi network membrane Source: Reactome
    13. transport vesicle membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35062.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Add
    BLAST
    Chaini29 – 260232HLA class II histocompatibility antigen, DP alpha 1 chainPRO_0000018967Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi138 ↔ 194PROSITE-ProRule annotation
    Glycosylationi149 – 1491N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP20036.
    PaxDbiP20036.
    PRIDEiP20036.

    PTM databases

    PhosphoSiteiP20036.

    Expressioni

    Gene expression databases

    ArrayExpressiP20036.
    BgeeiP20036.
    CleanExiHS_HLA-DPA1.
    GenevestigatoriP20036.

    Organism-specific databases

    HPAiHPA017967.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

    Protein-protein interaction databases

    BioGridi109358. 1 interaction.
    IntActiP20036. 4 interactions.
    MINTiMINT-1488672.

    Structurei

    Secondary structure

    1
    260
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi35 – 4915
    Beta strandi51 – 577
    Beta strandi60 – 667
    Turni67 – 704
    Beta strandi71 – 766
    Helixi77 – 804
    Helixi87 – 10620
    Turni107 – 1104
    Beta strandi119 – 1268
    Beta strandi134 – 14512
    Beta strandi149 – 1546
    Beta strandi163 – 1653
    Beta strandi176 – 1849
    Beta strandi192 – 1976
    Beta strandi205 – 2095

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LQZX-ray3.25A32-212[»]
    ProteinModelPortaliP20036.
    SMRiP20036. Positions 32-212.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP20036.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 222194ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini246 – 26015CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei223 – 24523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini118 – 21093Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni29 – 11587Alpha-1Add
    BLAST
    Regioni116 – 20994Alpha-2Add
    BLAST
    Regioni210 – 22213Connecting peptideAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class II family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG235591.
    HOVERGENiHBG006862.
    InParanoidiP20036.
    KOiK06752.
    OMAiWGISTIV.
    PhylomeDBiP20036.
    TreeFamiTF333797.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20036-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPEDRMFHI RAVILRALSL AFLLSLRGAG AIKADHVSTY AAFVQTHRPT    50
    GEFMFEFDED EMFYVDLDKK ETVWHLEEFG QAFSFEAQGG LANIAILNNN 100
    LNTLIQRSNH TQATNDPPEV TVFPKEPVEL GQPNTLICHI DKFFPPVLNV 150
    TWLCNGELVT EGVAESLFLP RTDYSFHKFH YLTFVPSAED FYDCRVEHWG 200
    LDQPLLKHWE AQEPIQMPET TETVLCALGL VLGLVGIIVG TVLIIKSLRS 250
    GHDPRAQGTL 260
    Length:260
    Mass (Da):29,381
    Last modified:February 1, 1991 - v1
    Checksum:i826174E963A8CB42
    GO

    Sequence cautioni

    The sequence AAC64233.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AAD42927.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti237 – 2371I → F in CAA25143. (PubMed:6584734)Curated

    Polymorphismi

    The following alleles of DPA1 are known: DPA1*01:03, DPA1*01:04, DPA1*01:05, DPA1*01:06, DPA1*01:07, DPA1*01:08, DPA1*01:09, DPA1*01:10, DPA1*02:01, DPA1*02:02, DPA1*02:03, DPA1*02:04, DPA1*03:01, DPA1*03:02, DPA1*03:03, DPA1*04:01 The sequence shown is that of DPA1*01:03.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421A → M in allele DPA1*02:02, allele DPA1*02:04, allele DPA1*03:01, allele DPA1*03:02 and allele DPA1*03:03; requires 2 nucleotide substitutions.
    VAR_058832
    Natural varianti42 – 421A → T.
    Corresponds to variant rs1126533 [ dbSNP | Ensembl ].
    VAR_047683
    Natural varianti42 – 421A → V.
    Corresponds to variant rs1126534 [ dbSNP | Ensembl ].
    VAR_047684
    Natural varianti49 – 491P → T in allele DPA1*04:01.
    Corresponds to variant rs2308907 [ dbSNP | Ensembl ].
    VAR_058833
    Natural varianti54 – 541M → T in allele DPA1*01:09.
    Corresponds to variant rs1042175 [ dbSNP | Ensembl ].
    VAR_058834
    Natural varianti59 – 591E → D in allele DPA1*01:04, allele DPA1*01:08, allele DPA1*03:03 and allele DPA1*04:01.
    Corresponds to variant rs2308910 [ dbSNP | Ensembl ].
    VAR_058835
    Natural varianti62 – 621M → K.
    Corresponds to variant rs2308912 [ dbSNP | Ensembl ].
    VAR_058836
    Natural varianti62 – 621M → L.
    Corresponds to variant rs2308911 [ dbSNP | Ensembl ].
    VAR_047685
    Natural varianti62 – 621M → Q in allele DPA1*01:06, allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*02:04; requires 2 nucleotide substitutions.
    Corresponds to variant rs36013091 [ dbSNP | Ensembl ].
    VAR_058850
    Natural varianti74 – 741W → C in allele DPA1*01:10.
    Corresponds to variant rs72558171 [ dbSNP | Ensembl ].
    VAR_058837
    Natural varianti81 – 811Q → R in allele DPA1*01:08, allele DPA1*02:01, allele DPA1*02:02, allele DPA1*02:03, allele DPA1*02:04 and allele DPA1*04:01.
    Corresponds to variant rs1042178 [ dbSNP | Ensembl ].
    VAR_047686
    Natural varianti82 – 821A → T in allele DPA1*01:07.
    Corresponds to variant rs41543112 [ dbSNP | Ensembl ].
    VAR_058838
    Natural varianti97 – 971L → S in allele DPA1*03:01 and allele DPA1*03:03.
    Corresponds to variant rs2308917 [ dbSNP | Ensembl ].
    VAR_047687
    Natural varianti100 – 1001N → D in allele DPA1*02:04.
    Corresponds to variant rs61759929 [ dbSNP | Ensembl ].
    VAR_058839
    Natural varianti103 – 1031T → I in allele DPA1*04:01.
    Corresponds to variant rs41559316 [ dbSNP | Ensembl ].
    VAR_058840
    Natural varianti104 – 1041L → A in allele DPA1*04:01; requires 2 nucleotide substitutions.
    VAR_058841
    Natural varianti114 – 1141T → A in allele DPA1*01:05, allele DPA1*02:01, allele DPA1*02:02, allele DPA1*02:03, allele DPA1*02:04 and allele DPA1*04:01.
    Corresponds to variant rs1126542 [ dbSNP | Ensembl ].
    VAR_047688
    Natural varianti127 – 1271P → A in allele DPA1*04:01.
    Corresponds to variant rs41562016 [ dbSNP | Ensembl ].
    VAR_058842
    Natural varianti142 – 1421K → R in allele DPA1*02:01 and allele DPA1*02:02.
    Corresponds to variant rs1042190 [ dbSNP | Ensembl ].
    VAR_047689
    Natural varianti158 – 1581L → P in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01.
    Corresponds to variant rs2308930 [ dbSNP | Ensembl ].
    VAR_058843
    Natural varianti191 – 1911F → V in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01.
    Corresponds to variant rs1042308 [ dbSNP | Ensembl ].
    VAR_047690
    Natural varianti221 – 2211T → A in allele DPA1*04:01.
    VAR_058844
    Natural varianti259 – 2591T → P in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01.
    Corresponds to variant rs1126769 [ dbSNP | Ensembl ].
    VAR_058845

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03100 Genomic DNA. Translation: CAA26887.1.
    M27487 mRNA. Translation: AAA63220.1.
    AK292709 mRNA. Translation: BAF85398.1.
    AL645931 Genomic DNA. No translation available.
    AL805913 Genomic DNA. Translation: CAI18549.1.
    BX120009, BX005422 Genomic DNA. Translation: CAM25981.1.
    BX005422, BX120009 Genomic DNA. Translation: CAM26119.1.
    CR759829, CR762479 Genomic DNA. Translation: CAQ07261.1.
    CR759795 Genomic DNA. Translation: CAQ07433.1.
    CR847849 Genomic DNA. Translation: CAQ07485.1.
    CR759904 Genomic DNA. Translation: CAQ09865.1.
    CR762479, CR759829 Genomic DNA. Translation: CAQ10344.1.
    CH471081 Genomic DNA. Translation: EAX03669.1.
    X00457 mRNA. Translation: CAA25143.1.
    Z48473 Genomic DNA. No translation available.
    AF013767 Genomic DNA. Translation: AAC64233.1. Sequence problems.
    X78199 Genomic DNA. No translation available.
    X82393 Genomic DNA. No translation available.
    X82394 Genomic DNA. No translation available.
    X78198 Genomic DNA. No translation available.
    X82391 Genomic DNA. No translation available.
    X79475 Genomic DNA. No translation available.
    X79477 Genomic DNA. No translation available.
    X79479 Genomic DNA. No translation available.
    X79481 Genomic DNA. No translation available.
    AF165160 Genomic DNA. Translation: AAD47826.1.
    AY618553 Genomic DNA. Translation: AAT92097.1.
    EU729350 Genomic DNA. Translation: ACH88749.1.
    DQ274060 Genomic DNA. Translation: ABB88406.1.
    DQ274061 Genomic DNA. Translation: ABB88407.1.
    EU304462 Genomic DNA. Translation: ABY27081.1.
    U87556 Genomic DNA. Translation: AAB97110.1.
    AF346471 Genomic DNA. Translation: AAK27152.1.
    AY650051 Genomic DNA. Translation: AAT67468.1.
    AF076284 Genomic DNA. Translation: AAD42927.1. Sequence problems.
    X96984 Genomic DNA. No translation available.
    X80482 Genomic DNA. No translation available.
    X81347 Genomic DNA. No translation available.
    X81348 Genomic DNA. No translation available.
    K00514 Genomic DNA. Translation: AAA59786.1.
    CCDSiCCDS4764.1.
    PIRiA29313. HLHUSB.
    RefSeqiNP_001229453.1. NM_001242524.1.
    NP_001229454.1. NM_001242525.1.
    NP_291032.2. NM_033554.3.
    UniGeneiHs.347270.

    Genome annotation databases

    EnsembliENST00000374808; ENSP00000363941; ENSG00000168384.
    ENST00000383224; ENSP00000372711; ENSG00000206291.
    ENST00000415247; ENSP00000405838; ENSG00000224103.
    ENST00000419277; ENSP00000393566; ENSG00000231389.
    ENST00000422504; ENSP00000406250; ENSG00000228163.
    ENST00000443117; ENSP00000397587; ENSG00000235844.
    ENST00000454805; ENSP00000397139; ENSG00000229685.
    ENST00000515317; ENSP00000427429; ENSG00000236177.
    GeneIDi3113.
    KEGGihsa:3113.
    UCSCiuc003ocs.2. human.

    Polymorphism databases

    DMDMi122204.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03100 Genomic DNA. Translation: CAA26887.1 .
    M27487 mRNA. Translation: AAA63220.1 .
    AK292709 mRNA. Translation: BAF85398.1 .
    AL645931 Genomic DNA. No translation available.
    AL805913 Genomic DNA. Translation: CAI18549.1 .
    BX120009 , BX005422 Genomic DNA. Translation: CAM25981.1 .
    BX005422 , BX120009 Genomic DNA. Translation: CAM26119.1 .
    CR759829 , CR762479 Genomic DNA. Translation: CAQ07261.1 .
    CR759795 Genomic DNA. Translation: CAQ07433.1 .
    CR847849 Genomic DNA. Translation: CAQ07485.1 .
    CR759904 Genomic DNA. Translation: CAQ09865.1 .
    CR762479 , CR759829 Genomic DNA. Translation: CAQ10344.1 .
    CH471081 Genomic DNA. Translation: EAX03669.1 .
    X00457 mRNA. Translation: CAA25143.1 .
    Z48473 Genomic DNA. No translation available.
    AF013767 Genomic DNA. Translation: AAC64233.1 . Sequence problems.
    X78199 Genomic DNA. No translation available.
    X82393 Genomic DNA. No translation available.
    X82394 Genomic DNA. No translation available.
    X78198 Genomic DNA. No translation available.
    X82391 Genomic DNA. No translation available.
    X79475 Genomic DNA. No translation available.
    X79477 Genomic DNA. No translation available.
    X79479 Genomic DNA. No translation available.
    X79481 Genomic DNA. No translation available.
    AF165160 Genomic DNA. Translation: AAD47826.1 .
    AY618553 Genomic DNA. Translation: AAT92097.1 .
    EU729350 Genomic DNA. Translation: ACH88749.1 .
    DQ274060 Genomic DNA. Translation: ABB88406.1 .
    DQ274061 Genomic DNA. Translation: ABB88407.1 .
    EU304462 Genomic DNA. Translation: ABY27081.1 .
    U87556 Genomic DNA. Translation: AAB97110.1 .
    AF346471 Genomic DNA. Translation: AAK27152.1 .
    AY650051 Genomic DNA. Translation: AAT67468.1 .
    AF076284 Genomic DNA. Translation: AAD42927.1 . Sequence problems.
    X96984 Genomic DNA. No translation available.
    X80482 Genomic DNA. No translation available.
    X81347 Genomic DNA. No translation available.
    X81348 Genomic DNA. No translation available.
    K00514 Genomic DNA. Translation: AAA59786.1 .
    CCDSi CCDS4764.1.
    PIRi A29313. HLHUSB.
    RefSeqi NP_001229453.1. NM_001242524.1.
    NP_001229454.1. NM_001242525.1.
    NP_291032.2. NM_033554.3.
    UniGenei Hs.347270.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LQZ X-ray 3.25 A 32-212 [» ]
    ProteinModelPortali P20036.
    SMRi P20036. Positions 32-212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109358. 1 interaction.
    IntActi P20036. 4 interactions.
    MINTi MINT-1488672.

    PTM databases

    PhosphoSitei P20036.

    Polymorphism databases

    DMDMi 122204.

    Proteomic databases

    MaxQBi P20036.
    PaxDbi P20036.
    PRIDEi P20036.

    Protocols and materials databases

    DNASUi 3113.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374808 ; ENSP00000363941 ; ENSG00000168384 .
    ENST00000383224 ; ENSP00000372711 ; ENSG00000206291 .
    ENST00000415247 ; ENSP00000405838 ; ENSG00000224103 .
    ENST00000419277 ; ENSP00000393566 ; ENSG00000231389 .
    ENST00000422504 ; ENSP00000406250 ; ENSG00000228163 .
    ENST00000443117 ; ENSP00000397587 ; ENSG00000235844 .
    ENST00000454805 ; ENSP00000397139 ; ENSG00000229685 .
    ENST00000515317 ; ENSP00000427429 ; ENSG00000236177 .
    GeneIDi 3113.
    KEGGi hsa:3113.
    UCSCi uc003ocs.2. human.

    Organism-specific databases

    CTDi 3113.
    GeneCardsi GC06M033032.
    GC06Mi33015.
    GC06Mj32954.
    GC06Mk33010.
    GC06Ml33186.
    GC06Mm33065.
    GC06Mn32961.
    GC06Mo33171.
    HGNCi HGNC:4938. HLA-DPA1.
    HPAi HPA017967.
    MIMi 142880. gene.
    neXtProti NX_P20036.
    PharmGKBi PA35062.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235591.
    HOVERGENi HBG006862.
    InParanoidi P20036.
    KOi K06752.
    OMAi WGISTIV.
    PhylomeDBi P20036.
    TreeFami TF333797.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Miscellaneous databases

    ChiTaRSi HLA-DPA1. human.
    EvolutionaryTracei P20036.
    GenomeRNAii 3113.
    NextBioi 12353.
    PROi P20036.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20036.
    Bgeei P20036.
    CleanExi HS_HLA-DPA1.
    Genevestigatori P20036.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene."
      Lawrance S.K., Das H.K., Pan J., Weissman S.M.
      Nucleic Acids Res. 13:7515-7528(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPA1*01:03).
    2. "Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes."
      Gustafsson K., Widmark E., Jonsson A.-K., Servenius B., Sachs D.H., Larhammar D., Rask L., Peterson P.A.
      J. Biol. Chem. 262:8778-8786(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPA1*01:03).
    3. "Epitope recognition by a DP alpha chain-specific monoclonal antibody (DP11.1) is influenced by the interaction between the DP alpha chain and its polymorphic DP beta chain partner."
      Young J.A., Lindsay J., Bodmer J.G., Trowsdale J.
      Hum. Immunol. 23:37-44(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPA1*01:03).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DPA1*01:03).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes."
      Auffray C., Lillie J.W., Arnot D., Grossberger D., Kappes D., Strominger J.L.
      Nature 308:327-333(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-260 (ALLELE DPA1*01:03).
    8. "A novel DPA1 allele (DPA1*0203) composed of known epitopes."
      Muntau B., Thye T., Pirmez C., Horstmann R.D.
      Tissue Antigens 49:668-669(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-115 (ALLELE DPA1*02:03).
    9. "Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302."
      Steiner L.L., Cavalli A., Zimmerman P.A., Boatin B.A., Titanji V.P., Bradley J.E., Lucius R., Nutman T.B., Begovich A.B.
      Tissue Antigens 51:653-657(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-115 (ALLELE DPA1*03:02).
    10. "Sequencing-based typing reveals new insight in HLA-DPA1 polymorphism."
      Rozemuller E.H., Bouwens A.G., van Oort E., Versluis L.F., Marsh S.G., Bodmer J.G., Tilanus M.G.
      Tissue Antigens 45:57-62(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-116 AND 211-260 (ALLELE DPA1*01:04), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-229 (ALLELE DPA1*02:01), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-116 AND 211-260 (ALLELE DPA1*02:02), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-115 AND 211-260 (ALLELES DPA1*03:01 AND DPA1*401).
    11. "A new HLA-DPA1 allele, DPA1*02016, identified in African-American population."
      McDaniel D.O., Nguyen C., McDaniel L.S.
      Tissue Antigens 56:197-198(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DPA1*02:01).
    12. "High-resolution sequence-based DPA1 typing identified two novel DPA1 alleles, DPA1*010303 and DPA1*0303, from a Kenyan population."
      Luo M., Bamforth J., Gill K., Cohen C., Brunham R.C., Plummer F.A.
      Tissue Antigens 65:120-122(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*03:03).
    13. "Identification of a novel DPA1 allele, DPA1*010602, in an East African population."
      Peterson T.A., Luo M., Mao X., Brunham R.C., Plummer F.A.
      Hum. Immunol. 69:885-886(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:06).
    14. "Description of two novel HLA-DPA1 alleles: DPA1*0110 and DPA1*010304."
      Lee K.W.
      Tissue Antigens 71:575-577(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELES DPA1*01:03 AND DPA1*01:10).
    15. "A novel HLA-DPA1*0204 allele was identified in a Chinese individual."
      Zhao H., Dai W.-J., He Y.-M., Zhu F.-M., Yan L.-X.
      Tissue Antigens 71:577-578(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*02:04).
    16. Steiner L., Begovich A., Suraj V.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:06).
    17. "One new DPA1 Allele."
      Grams S.E., Begovich A., Mangaccat J.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:08).
    18. "Novel human HLA-DPA1 allele identified in potential bone marrow donors."
      Bassinger S., Wu J., Williams T.M.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DPA1*01:09).
    19. "DPA1 polymorphism in Polynesians."
      Varney M.D., Gavrilidis A., Abbott W.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-115 (ALLELE DPA1*01:07).
    20. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-115 (ALLELE DPA1*01:05).
    21. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 117-210 (ALLELES DPA1*01:04; DPA1*02:02; DPA1*03:01 AND DPA1*04:01).
    22. "Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes."
      Trowsdale J., Lee J., Carey J., Grosveld F., Bodmer J., Bodmer W.
      Proc. Natl. Acad. Sci. U.S.A. 80:1972-1976(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-209 (ALLELE DPA1*01:03).
    23. "Invariant chain structure and MHC class II function."
      Cresswell P.
      Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    24. "Presentation of antigens by MHC class II molecules: getting the most out of them."
      Villadangos J.A.
      Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    25. "MHC class II molecules on the move for successful antigen presentation."
      Rocha N., Neefjes J.
      EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    26. "Autophagy in MHC class II presentation: sampling from within."
      Menendez-Benito V., Neefjes J.
      Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    27. "MHC class II transport at a glance."
      Berger A.C., Roche P.A.
      J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    28. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
      Beswick E.J., Reyes V.E.
      World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    29. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-149.
      Tissue: Liver.

    Entry informationi

    Entry nameiDPA1_HUMAN
    AccessioniPrimary (citable) accession number: P20036
    Secondary accession number(s): A9YWH7
    , B9UKH4, O19722, O46883, P01905, P79554, Q2Q060, Q2Q061, Q5EY03, Q5STP1, Q6DQK4, Q9BCQ1, Q9TPX3, Q9XS10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3