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Protein

HLA class II histocompatibility antigen, DP alpha 1 chain

Gene

HLA-DPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functioni

  • MHC class II receptor activity Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
  • cellular response to interferon-gamma Source: UniProtKB
  • immune response Source: UniProtKB
  • interferon-gamma-mediated signaling pathway Source: Reactome
  • positive regulation of interferon-gamma production Source: UniProtKB
  • positive regulation of T cell activation Source: UniProtKB
  • positive regulation of T cell proliferation Source: UniProtKB
  • T cell costimulation Source: Reactome
  • T cell receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168384-MONOMER.
ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DP alpha 1 chain
Alternative name(s):
DP(W3)
DP(W4)
HLA-SB alpha chain
MHC class II DP3-alpha
MHC class II DPA1
Gene namesi
Name:HLA-DPA1
Synonyms:HLA-DP1A, HLASB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4938. HLA-DPA1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 222ExtracellularSequence analysisAdd BLAST194
Transmembranei223 – 245HelicalSequence analysisAdd BLAST23
Topological domaini246 – 260CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

DisGeNETi3113.
OpenTargetsiENSG00000168384.
ENSG00000206291.
ENSG00000224103.
ENSG00000228163.
ENSG00000229685.
ENSG00000231389.
ENSG00000235844.
ENSG00000236177.
PharmGKBiPA35062.

Polymorphism and mutation databases

BioMutaiHLA-DPA1.
DMDMi122204.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
ChainiPRO_000001896729 – 260HLA class II histocompatibility antigen, DP alpha 1 chainAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi138 ↔ 194PROSITE-ProRule annotation
Glycosylationi149N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP20036.
PaxDbiP20036.
PeptideAtlasiP20036.
PRIDEiP20036.

PTM databases

iPTMnetiP20036.
PhosphoSitePlusiP20036.

Expressioni

Gene expression databases

BgeeiENSG00000168384.
CleanExiHS_HLA-DPA1.
ExpressionAtlasiP20036. baseline and differential.
GenevisibleiP20036. HS.

Organism-specific databases

HPAiHPA017967.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Protein-protein interaction databases

BioGridi109358. 92 interactors.
IntActiP20036. 4 interactors.
MINTiMINT-1488672.

Structurei

Secondary structure

1260
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 49Combined sources15
Beta strandi51 – 57Combined sources7
Beta strandi60 – 66Combined sources7
Turni67 – 70Combined sources4
Beta strandi71 – 76Combined sources6
Helixi77 – 82Combined sources6
Helixi87 – 107Combined sources21
Beta strandi119 – 126Combined sources8
Beta strandi134 – 146Combined sources13
Beta strandi149 – 154Combined sources6
Beta strandi157 – 159Combined sources3
Beta strandi161 – 165Combined sources5
Beta strandi176 – 184Combined sources9
Beta strandi191 – 197Combined sources7
Beta strandi201 – 203Combined sources3
Beta strandi205 – 210Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LQZX-ray3.25A32-212[»]
4P4KX-ray2.80A/E32-214[»]
4P4RX-ray3.00A/C32-214[»]
4P57X-ray2.60A/C32-214[»]
4P5KX-ray2.59A/D32-214[»]
4P5MX-ray1.70A/C/E/G32-214[»]
ProteinModelPortaliP20036.
SMRiP20036.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20036.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 210Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 115Alpha-1Add BLAST87
Regioni116 – 209Alpha-2Add BLAST94
Regioni210 – 222Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
GeneTreeiENSGT00760000118970.
HOVERGENiHBG006862.
InParanoidiP20036.
KOiK06752.
OMAiPRTDYSF.
OrthoDBiEOG091G0IC9.
PhylomeDBiP20036.
TreeFamiTF333797.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20036-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPEDRMFHI RAVILRALSL AFLLSLRGAG AIKADHVSTY AAFVQTHRPT
60 70 80 90 100
GEFMFEFDED EMFYVDLDKK ETVWHLEEFG QAFSFEAQGG LANIAILNNN
110 120 130 140 150
LNTLIQRSNH TQATNDPPEV TVFPKEPVEL GQPNTLICHI DKFFPPVLNV
160 170 180 190 200
TWLCNGELVT EGVAESLFLP RTDYSFHKFH YLTFVPSAED FYDCRVEHWG
210 220 230 240 250
LDQPLLKHWE AQEPIQMPET TETVLCALGL VLGLVGIIVG TVLIIKSLRS
260
GHDPRAQGTL
Length:260
Mass (Da):29,381
Last modified:February 1, 1991 - v1
Checksum:i826174E963A8CB42
GO

Sequence cautioni

The sequence AAC64233 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAD42927 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237I → F in CAA25143 (PubMed:6584734).Curated1

Polymorphismi

The following alleles of DPA1 are known: DPA1*01:03, DPA1*01:04, DPA1*01:05, DPA1*01:06, DPA1*01:07, DPA1*01:08, DPA1*01:09, DPA1*01:10, DPA1*02:01, DPA1*02:02, DPA1*02:03, DPA1*02:04, DPA1*03:01, DPA1*03:02, DPA1*03:03, DPA1*04:01 The sequence shown is that of DPA1*01:03.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05883242A → M in allele DPA1*02:02, allele DPA1*02:04, allele DPA1*03:01, allele DPA1*03:02 and allele DPA1*03:03; requires 2 nucleotide substitutions. Corresponds to variant rs386699859dbSNPEnsembl.1
Natural variantiVAR_04768342A → T.Corresponds to variant rs1126533dbSNPEnsembl.1
Natural variantiVAR_04768442A → V.Corresponds to variant rs1126534dbSNPEnsembl.1
Natural variantiVAR_05883349P → T in allele DPA1*04:01. Corresponds to variant rs2308907dbSNPEnsembl.1
Natural variantiVAR_05883454M → T in allele DPA1*01:09. Corresponds to variant rs1042175dbSNPEnsembl.1
Natural variantiVAR_05883559E → D in allele DPA1*01:04, allele DPA1*01:08, allele DPA1*03:03 and allele DPA1*04:01. Corresponds to variant rs2308910dbSNPEnsembl.1
Natural variantiVAR_05883662M → K.Corresponds to variant rs2308912dbSNPEnsembl.1
Natural variantiVAR_04768562M → L.Corresponds to variant rs2308911dbSNPEnsembl.1
Natural variantiVAR_05885062M → Q in allele DPA1*01:06, allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*02:04; requires 2 nucleotide substitutions. Corresponds to variant rs36013091dbSNPEnsembl.1
Natural variantiVAR_05883774W → C in allele DPA1*01:10. Corresponds to variant rs72558171dbSNPEnsembl.1
Natural variantiVAR_04768681Q → R in allele DPA1*01:08, allele DPA1*02:01, allele DPA1*02:02, allele DPA1*02:03, allele DPA1*02:04 and allele DPA1*04:01. Corresponds to variant rs1042178dbSNPEnsembl.1
Natural variantiVAR_05883882A → T in allele DPA1*01:07. Corresponds to variant rs41543112dbSNPEnsembl.1
Natural variantiVAR_04768797L → S in allele DPA1*03:01 and allele DPA1*03:03. Corresponds to variant rs2308917dbSNPEnsembl.1
Natural variantiVAR_058839100N → D in allele DPA1*02:04. Corresponds to variant rs61759929dbSNPEnsembl.1
Natural variantiVAR_058840103T → I in allele DPA1*04:01. Corresponds to variant rs41559316dbSNPEnsembl.1
Natural variantiVAR_058841104L → A in allele DPA1*04:01; requires 2 nucleotide substitutions. 1
Natural variantiVAR_047688114T → A in allele DPA1*01:05, allele DPA1*02:01, allele DPA1*02:02, allele DPA1*02:03, allele DPA1*02:04 and allele DPA1*04:01. Corresponds to variant rs1126542dbSNPEnsembl.1
Natural variantiVAR_058842127P → A in allele DPA1*04:01. Corresponds to variant rs41562016dbSNPEnsembl.1
Natural variantiVAR_047689142K → R in allele DPA1*02:01 and allele DPA1*02:02. Corresponds to variant rs1042190dbSNPEnsembl.1
Natural variantiVAR_058843158L → P in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01. Corresponds to variant rs2308930dbSNPEnsembl.1
Natural variantiVAR_047690191F → V in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01. Corresponds to variant rs1042308dbSNPEnsembl.1
Natural variantiVAR_058844221T → A in allele DPA1*04:01. Corresponds to variant rs17509489dbSNPEnsembl.1
Natural variantiVAR_058845259T → P in allele DPA1*02:01, allele DPA1*02:02 and allele DPA1*04:01. Corresponds to variant rs1126769dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03100 Genomic DNA. Translation: CAA26887.1.
M27487 mRNA. Translation: AAA63220.1.
AK292709 mRNA. Translation: BAF85398.1.
AL645931 Genomic DNA. No translation available.
AL805913 Genomic DNA. Translation: CAI18549.1.
BX120009, BX005422 Genomic DNA. Translation: CAM25981.1.
BX005422, BX120009 Genomic DNA. Translation: CAM26119.1.
CR759829, CR762479 Genomic DNA. Translation: CAQ07261.1.
CR759795 Genomic DNA. Translation: CAQ07433.1.
CR847849 Genomic DNA. Translation: CAQ07485.1.
CR759904 Genomic DNA. Translation: CAQ09865.1.
CR762479, CR759829 Genomic DNA. Translation: CAQ10344.1.
CH471081 Genomic DNA. Translation: EAX03669.1.
X00457 mRNA. Translation: CAA25143.1.
Z48473 Genomic DNA. No translation available.
AF013767 Genomic DNA. Translation: AAC64233.1. Sequence problems.
X78199 Genomic DNA. No translation available.
X82393 Genomic DNA. No translation available.
X82394 Genomic DNA. No translation available.
X78198 Genomic DNA. No translation available.
X82391 Genomic DNA. No translation available.
X79475 Genomic DNA. No translation available.
X79477 Genomic DNA. No translation available.
X79479 Genomic DNA. No translation available.
X79481 Genomic DNA. No translation available.
AF165160 Genomic DNA. Translation: AAD47826.1.
AY618553 Genomic DNA. Translation: AAT92097.1.
EU729350 Genomic DNA. Translation: ACH88749.1.
DQ274060 Genomic DNA. Translation: ABB88406.1.
DQ274061 Genomic DNA. Translation: ABB88407.1.
EU304462 Genomic DNA. Translation: ABY27081.1.
U87556 Genomic DNA. Translation: AAB97110.1.
AF346471 Genomic DNA. Translation: AAK27152.1.
AY650051 Genomic DNA. Translation: AAT67468.1.
AF076284 Genomic DNA. Translation: AAD42927.1. Sequence problems.
X96984 Genomic DNA. No translation available.
X80482 Genomic DNA. No translation available.
X81347 Genomic DNA. No translation available.
X81348 Genomic DNA. No translation available.
K00514 Genomic DNA. Translation: AAA59786.1.
CCDSiCCDS4764.1.
PIRiA29313. HLHUSB.
RefSeqiNP_001229453.1. NM_001242524.1.
NP_001229454.1. NM_001242525.1.
NP_291032.2. NM_033554.3.
UniGeneiHs.347270.

Genome annotation databases

EnsembliENST00000374808; ENSP00000363941; ENSG00000168384.
ENST00000383224; ENSP00000372711; ENSG00000206291.
ENST00000415247; ENSP00000405838; ENSG00000224103.
ENST00000419277; ENSP00000393566; ENSG00000231389.
ENST00000422504; ENSP00000406250; ENSG00000228163.
ENST00000443117; ENSP00000397587; ENSG00000235844.
ENST00000454805; ENSP00000397139; ENSG00000229685.
ENST00000515317; ENSP00000427429; ENSG00000236177.
GeneIDi3113.
KEGGihsa:3113.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03100 Genomic DNA. Translation: CAA26887.1.
M27487 mRNA. Translation: AAA63220.1.
AK292709 mRNA. Translation: BAF85398.1.
AL645931 Genomic DNA. No translation available.
AL805913 Genomic DNA. Translation: CAI18549.1.
BX120009, BX005422 Genomic DNA. Translation: CAM25981.1.
BX005422, BX120009 Genomic DNA. Translation: CAM26119.1.
CR759829, CR762479 Genomic DNA. Translation: CAQ07261.1.
CR759795 Genomic DNA. Translation: CAQ07433.1.
CR847849 Genomic DNA. Translation: CAQ07485.1.
CR759904 Genomic DNA. Translation: CAQ09865.1.
CR762479, CR759829 Genomic DNA. Translation: CAQ10344.1.
CH471081 Genomic DNA. Translation: EAX03669.1.
X00457 mRNA. Translation: CAA25143.1.
Z48473 Genomic DNA. No translation available.
AF013767 Genomic DNA. Translation: AAC64233.1. Sequence problems.
X78199 Genomic DNA. No translation available.
X82393 Genomic DNA. No translation available.
X82394 Genomic DNA. No translation available.
X78198 Genomic DNA. No translation available.
X82391 Genomic DNA. No translation available.
X79475 Genomic DNA. No translation available.
X79477 Genomic DNA. No translation available.
X79479 Genomic DNA. No translation available.
X79481 Genomic DNA. No translation available.
AF165160 Genomic DNA. Translation: AAD47826.1.
AY618553 Genomic DNA. Translation: AAT92097.1.
EU729350 Genomic DNA. Translation: ACH88749.1.
DQ274060 Genomic DNA. Translation: ABB88406.1.
DQ274061 Genomic DNA. Translation: ABB88407.1.
EU304462 Genomic DNA. Translation: ABY27081.1.
U87556 Genomic DNA. Translation: AAB97110.1.
AF346471 Genomic DNA. Translation: AAK27152.1.
AY650051 Genomic DNA. Translation: AAT67468.1.
AF076284 Genomic DNA. Translation: AAD42927.1. Sequence problems.
X96984 Genomic DNA. No translation available.
X80482 Genomic DNA. No translation available.
X81347 Genomic DNA. No translation available.
X81348 Genomic DNA. No translation available.
K00514 Genomic DNA. Translation: AAA59786.1.
CCDSiCCDS4764.1.
PIRiA29313. HLHUSB.
RefSeqiNP_001229453.1. NM_001242524.1.
NP_001229454.1. NM_001242525.1.
NP_291032.2. NM_033554.3.
UniGeneiHs.347270.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LQZX-ray3.25A32-212[»]
4P4KX-ray2.80A/E32-214[»]
4P4RX-ray3.00A/C32-214[»]
4P57X-ray2.60A/C32-214[»]
4P5KX-ray2.59A/D32-214[»]
4P5MX-ray1.70A/C/E/G32-214[»]
ProteinModelPortaliP20036.
SMRiP20036.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109358. 92 interactors.
IntActiP20036. 4 interactors.
MINTiMINT-1488672.

PTM databases

iPTMnetiP20036.
PhosphoSitePlusiP20036.

Polymorphism and mutation databases

BioMutaiHLA-DPA1.
DMDMi122204.

Proteomic databases

EPDiP20036.
PaxDbiP20036.
PeptideAtlasiP20036.
PRIDEiP20036.

Protocols and materials databases

DNASUi3113.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374808; ENSP00000363941; ENSG00000168384.
ENST00000383224; ENSP00000372711; ENSG00000206291.
ENST00000415247; ENSP00000405838; ENSG00000224103.
ENST00000419277; ENSP00000393566; ENSG00000231389.
ENST00000422504; ENSP00000406250; ENSG00000228163.
ENST00000443117; ENSP00000397587; ENSG00000235844.
ENST00000454805; ENSP00000397139; ENSG00000229685.
ENST00000515317; ENSP00000427429; ENSG00000236177.
GeneIDi3113.
KEGGihsa:3113.

Organism-specific databases

CTDi3113.
DisGeNETi3113.
GeneCardsiHLA-DPA1.
HGNCiHGNC:4938. HLA-DPA1.
HPAiHPA017967.
MIMi142880. gene.
neXtProtiNX_P20036.
OpenTargetsiENSG00000168384.
ENSG00000206291.
ENSG00000224103.
ENSG00000228163.
ENSG00000229685.
ENSG00000231389.
ENSG00000235844.
ENSG00000236177.
PharmGKBiPA35062.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
GeneTreeiENSGT00760000118970.
HOVERGENiHBG006862.
InParanoidiP20036.
KOiK06752.
OMAiPRTDYSF.
OrthoDBiEOG091G0IC9.
PhylomeDBiP20036.
TreeFamiTF333797.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168384-MONOMER.
ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSiHLA-DPA1. human.
EvolutionaryTraceiP20036.
GenomeRNAii3113.
PROiP20036.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168384.
CleanExiHS_HLA-DPA1.
ExpressionAtlasiP20036. baseline and differential.
GenevisibleiP20036. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPA1_HUMAN
AccessioniPrimary (citable) accession number: P20036
Secondary accession number(s): A9YWH7
, B9UKH4, O19722, O46883, P01905, P79554, Q2Q060, Q2Q061, Q5EY03, Q5STP1, Q6DQK4, Q9BCQ1, Q9TPX3, Q9XS10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.