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P20020

- AT2B1_HUMAN

UniProt

P20020 - AT2B1_HUMAN

Protein

Plasma membrane calcium-transporting ATPase 1

Gene

ATP2B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 161 (01 Oct 2014)
      Sequence version 3 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

    Catalytic activityi

    ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei475 – 47514-aspartylphosphate intermediate
    Metal bindingi797 – 7971MagnesiumBy similarity
    Metal bindingi801 – 8011MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium-transporting ATPase activity Source: ProtInc
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. ion transmembrane transport Source: Reactome
    3. transmembrane transport Source: Reactome
    4. transport Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_23765. Reduction of cytosolic Ca++ levels.
    REACT_25149. Ion transport by P-type ATPases.

    Protein family/group databases

    TCDBi3.A.3.2.25. the p-type atpase (p-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasma membrane calcium-transporting ATPase 1 (EC:3.6.3.8)
    Short name:
    PMCA1
    Alternative name(s):
    Plasma membrane calcium ATPase isoform 1
    Plasma membrane calcium pump isoform 1
    Gene namesi
    Name:ATP2B1
    Synonyms:PMCA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:814. ATP2B1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25107.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 12581257Plasma membrane calcium-transporting ATPase 1PRO_0000046209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycine1 Publication
    Modified residuei17 – 171Phosphoserine1 Publication
    Modified residuei1116 – 11161Phosphothreonine; by PKC
    Modified residuei1193 – 11931Phosphoserine4 Publications
    Modified residuei1203 – 12031Phosphothreonine2 Publications
    Modified residuei1216 – 12161Phosphoserine; by PKA2 Publications
    Modified residuei1220 – 12201Phosphoserine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP20020.
    PaxDbiP20020.
    PRIDEiP20020.

    PTM databases

    PhosphoSiteiP20020.

    Expressioni

    Tissue specificityi

    Isoform B is ubiquitously expressed. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small intestine and liver.

    Gene expression databases

    ArrayExpressiP20020.
    BgeeiP20020.
    CleanExiHS_ATP2B1.
    GenevestigatoriP20020.

    Organism-specific databases

    HPAiCAB005605.
    HPA011166.
    HPA012945.

    Interactioni

    Subunit structurei

    Interacts with PDZD11. Interacts with SLC35G1 and STIM1.2 Publications

    Protein-protein interaction databases

    BioGridi106980. 8 interactions.
    IntActiP20020. 5 interactions.
    MINTiMINT-5004114.
    STRINGi9606.ENSP00000261173.

    Structurei

    3D structure databases

    ProteinModelPortaliP20020.
    SMRiP20020. Positions 66-946, 1100-1126.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 9796CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini119 – 15436ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini176 – 366191CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini387 – 41933ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini438 – 852415CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini873 – 88210ExtracellularSequence Analysis
    Topological domaini904 – 92320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini947 – 96418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini987 – 100519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1028 – 103710ExtracellularSequence Analysis
    Topological domaini1060 – 1258199CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei367 – 38620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei420 – 43718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei853 – 87220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei883 – 90321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei924 – 94623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei965 – 98622HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1006 – 102722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1038 – 105922HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1100 – 111718Calmodulin-binding subdomain AAdd
    BLAST
    Regioni1118 – 112710Calmodulin-binding subdomain B

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi296 – 2994Poly-Glu

    Domaini

    The calmodulin-binding subdomain B is different in the different splice variants and shows pH dependent calmodulin binding properties in isoforms A, C, D and E.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOVERGENiHBG061286.
    KOiK05850.
    OMAiNNSVAYG.
    OrthoDBiEOG7SN8BN.
    PhylomeDBiP20020.
    TreeFamiTF300330.

    Family and domain databases

    Gene3Di1.20.1110.10. 1 hit.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR022141. ATP_Ca_trans_C.
    IPR006408. ATPase_P-typ_Ca-transp_plasma.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF12424. ATP_Ca_trans_C. 2 hits.
    PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform D (identifier: P20020-1) [UniParc]FASTAAdd to Basket

    Also known as: CIV

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ     50
    ESYGDVYGIC TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ 100
    LVWEALQDVT LIILEIAAIV SLGLSFYQPP EGDNALCGEV SVGEEEGEGE 150
    TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ FRGLQSRIEQ EQKFTVIRGG 200
    QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE SSLTGESDHV 250
    KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 300
    KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK 350
    KANLPKKEKS VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ 400
    KRPWLAECTP IYIQYFVKFF IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM 450
    MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA YINEKHYKKV 500
    PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH VGNKTECALL 550
    GLLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSYRIFS 600
    KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL 650
    AFRDFPAGEP EPEWDNENDI VTGLTCIAVV GIEDPVRPEV PDAIKKCQRA 700
    GITVRMVTGD NINTARAIAT KCGILHPGED FLCLEGKDFN RRIRNEKGEI 750
    EQERIDKIWP KLRVLARSSP TDKHTLVKGI IDSTVSDQRQ VVAVTGDGTN 800
    DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK AVMWGRNVYD 850
    SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 900
    ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG 950
    EKFFDIDSGR NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF 1000
    EGIFNNAIFC TIVLGTFVVQ IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG 1050
    TLLWGQLIST IPTSRLKFLK EAGHGTQKEE IPEEELAEDV EEIDHAEREL 1100
    RRGQILWFRG LNRIQTQMDV VNAFQSGSSI QGALRRQPSI ASQHHDVTNI 1150
    STPTHIRVVN AFRSSLYEGL EKPESRSSIH NFMTHPEFRI EDSEPHIPLI 1200
    DDTDAEDDAP TKRNSSPPPS PNKNNNAVDS GIHLTIEMNK SATSSSPGSP 1250
    LHSLETSL 1258
    Length:1,258
    Mass (Da):138,755
    Last modified:June 1, 2001 - v3
    Checksum:i7037112747FC9B0A
    GO
    Isoform A (identifier: P20020-2) [UniParc]FASTAAdd to Basket

    Also known as: CII

    The sequence of this isoform differs from the canonical sequence as follows:
         1156-1258: IRVVNAFRSS...SPLHSLETSL → VVFSSSTASTTVGYSSGECIS

    Show »
    Length:1,176
    Mass (Da):129,516
    Checksum:i5672202C16491703
    GO
    Isoform B (identifier: P20020-3) [UniParc]FASTAAdd to Basket

    Also known as: CI

    The sequence of this isoform differs from the canonical sequence as follows:
         1118-1155: Missing.

    Show »
    Length:1,220
    Mass (Da):134,685
    Checksum:i7E75C19B1A501423
    GO
    Isoform C (identifier: P20020-4) [UniParc]FASTAAdd to Basket

    Also known as: CIII

    The sequence of this isoform differs from the canonical sequence as follows:
         1147-1155: Missing.

    Show »
    Length:1,249
    Mass (Da):137,804
    Checksum:i8F56F132BE096587
    GO
    Isoform E (identifier: P20020-5) [UniParc]FASTAAdd to Basket

    Also known as: CV

    The sequence of this isoform differs from the canonical sequence as follows:
         1156-1258: IRVVNAFRSS...SPLHSLETSL → VVFSSSTASTTVGFEW

    Show »
    Length:1,171
    Mass (Da):129,152
    Checksum:i9FC9B1AA3B32B384
    GO
    Isoform K (identifier: P20020-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1021-1056: Missing.
         1118-1155: Missing.

    Show »
    Length:1,184
    Mass (Da):130,617
    Checksum:iB1FB3E7116D2FDA2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti259 – 2624LLLS → MSAT in AAA36000. (PubMed:8386431)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti267 – 2671M → R Rare polymorphism. 1 Publication
    VAR_000698

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1021 – 105636Missing in isoform K. CuratedVSP_000372Add
    BLAST
    Alternative sequencei1118 – 115538Missing in isoform B and isoform K. 2 PublicationsVSP_000373Add
    BLAST
    Alternative sequencei1147 – 11559Missing in isoform C. CuratedVSP_000374
    Alternative sequencei1156 – 1258103IRVVN…LETSL → VVFSSSTASTTVGYSSGECI S in isoform A. CuratedVSP_000375Add
    BLAST
    Alternative sequencei1156 – 1258103IRVVN…LETSL → VVFSSSTASTTVGFEW in isoform E. CuratedVSP_000376Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04027 mRNA. Translation: AAA74511.1.
    M95541 mRNA. Translation: AAA35999.1.
    M95542 mRNA. Translation: AAA36000.1.
    L14561 Genomic DNA. Translation: AAD09924.1.
    L14561 Genomic DNA. Translation: AAD09925.1.
    M25824 Genomic DNA. Translation: AAA58383.1.
    M25824 Genomic DNA. Translation: AAA58382.1.
    M25824 Genomic DNA. Translation: AAA58381.1.
    S49852 mRNA. Translation: AAB24324.1.
    U15686 mRNA. Translation: AAA60983.1.
    U15687 mRNA. Translation: AAA60984.1.
    CCDSiCCDS41817.1. [P20020-2]
    CCDS9035.1. [P20020-3]
    PIRiA30802.
    E49570.
    I55491.
    I70165.
    RefSeqiNP_001001323.1. NM_001001323.1. [P20020-2]
    NP_001673.2. NM_001682.2. [P20020-3]
    XP_005268976.1. XM_005268919.1. [P20020-4]
    UniGeneiHs.506276.

    Genome annotation databases

    EnsembliENST00000261173; ENSP00000261173; ENSG00000070961. [P20020-3]
    ENST00000359142; ENSP00000352054; ENSG00000070961. [P20020-2]
    ENST00000428670; ENSP00000392043; ENSG00000070961. [P20020-3]
    GeneIDi490.
    KEGGihsa:490.
    UCSCiuc001tbf.3. human. [P20020-6]
    uc001tbg.3. human. [P20020-2]
    uc001tbh.3. human. [P20020-3]

    Polymorphism databases

    DMDMi14286104.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04027 mRNA. Translation: AAA74511.1 .
    M95541 mRNA. Translation: AAA35999.1 .
    M95542 mRNA. Translation: AAA36000.1 .
    L14561 Genomic DNA. Translation: AAD09924.1 .
    L14561 Genomic DNA. Translation: AAD09925.1 .
    M25824 Genomic DNA. Translation: AAA58383.1 .
    M25824 Genomic DNA. Translation: AAA58382.1 .
    M25824 Genomic DNA. Translation: AAA58381.1 .
    S49852 mRNA. Translation: AAB24324.1 .
    U15686 mRNA. Translation: AAA60983.1 .
    U15687 mRNA. Translation: AAA60984.1 .
    CCDSi CCDS41817.1. [P20020-2 ]
    CCDS9035.1. [P20020-3 ]
    PIRi A30802.
    E49570.
    I55491.
    I70165.
    RefSeqi NP_001001323.1. NM_001001323.1. [P20020-2 ]
    NP_001673.2. NM_001682.2. [P20020-3 ]
    XP_005268976.1. XM_005268919.1. [P20020-4 ]
    UniGenei Hs.506276.

    3D structure databases

    ProteinModelPortali P20020.
    SMRi P20020. Positions 66-946, 1100-1126.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106980. 8 interactions.
    IntActi P20020. 5 interactions.
    MINTi MINT-5004114.
    STRINGi 9606.ENSP00000261173.

    Protein family/group databases

    TCDBi 3.A.3.2.25. the p-type atpase (p-atpase) superfamily.

    PTM databases

    PhosphoSitei P20020.

    Polymorphism databases

    DMDMi 14286104.

    Proteomic databases

    MaxQBi P20020.
    PaxDbi P20020.
    PRIDEi P20020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261173 ; ENSP00000261173 ; ENSG00000070961 . [P20020-3 ]
    ENST00000359142 ; ENSP00000352054 ; ENSG00000070961 . [P20020-2 ]
    ENST00000428670 ; ENSP00000392043 ; ENSG00000070961 . [P20020-3 ]
    GeneIDi 490.
    KEGGi hsa:490.
    UCSCi uc001tbf.3. human. [P20020-6 ]
    uc001tbg.3. human. [P20020-2 ]
    uc001tbh.3. human. [P20020-3 ]

    Organism-specific databases

    CTDi 490.
    GeneCardsi GC12M089981.
    HGNCi HGNC:814. ATP2B1.
    HPAi CAB005605.
    HPA011166.
    HPA012945.
    MIMi 108731. gene.
    neXtProti NX_P20020.
    PharmGKBi PA25107.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0474.
    HOVERGENi HBG061286.
    KOi K05850.
    OMAi NNSVAYG.
    OrthoDBi EOG7SN8BN.
    PhylomeDBi P20020.
    TreeFami TF300330.

    Enzyme and pathway databases

    Reactomei REACT_23765. Reduction of cytosolic Ca++ levels.
    REACT_25149. Ion transport by P-type ATPases.

    Miscellaneous databases

    GeneWikii ATP2B1.
    GenomeRNAii 490.
    NextBioi 2053.
    PROi P20020.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20020.
    Bgeei P20020.
    CleanExi HS_ATP2B1.
    Genevestigatori P20020.

    Family and domain databases

    Gene3Di 1.20.1110.10. 1 hit.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR022141. ATP_Ca_trans_C.
    IPR006408. ATPase_P-typ_Ca-transp_plasma.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF12424. ATP_Ca_trans_C. 2 hits.
    PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01517. ATPase-IIB_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete primary structure of a human plasma membrane Ca2+ pump."
      Verma A.K., Filoteo A.G., Stanford D.R., Wieben E.D., Penniston J.T., Strehler E.E., Fischer R., Heim R., Vogel G., Mathews S., Strehler-Page M.-A., James P., Vorherr T.E., Krebs J., Carafoli E.
      J. Biol. Chem. 263:14152-14159(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
      Tissue: Erythrocyte.
    2. "Molecular cloning of a plasma membrane calcium pump from human osteoblasts."
      Kumar R., Haugen J.D., Penniston J.T.
      J. Bone Miner. Res. 8:505-513(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
      Tissue: Osteoblast.
    3. "Structure of the gene encoding the human plasma membrane calcium pump isoform 1."
      Hilfiker H., Strehler-Page M.-A., Stauffer T.P., Carafoli E., Strehler E.E.
      J. Biol. Chem. 268:19717-19725(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B).
      Tissue: Leukocyte.
    4. Strehler E.E., Strehler-Page M.-A.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. "mRNAs for plasma membrane calcium pump isoforms differing in their regulatory domain are generated by alternative splicing that involves two internal donor sites in a single exon."
      Strehler E.E., Strehler-Page M.-A., Vogel G., Carafoli E.
      Proc. Natl. Acad. Sci. U.S.A. 86:6908-6912(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A; C AND D).
      Tissue: Fetal skeletal muscle.
    6. "Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane Ca2+ pump."
      Kessler F., Falchetto R., Heim R., Meili R., Vorherr T.E., Strehler E.E., Carafoli E.
      Biochemistry 31:11785-11792(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
      Tissue: Fetal brain.
    7. "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes."
      Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E.
      J. Biol. Chem. 268:25993-26003(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND E).
      Tissue: Brain cortex.
    8. Erratum
      Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E.
      J. Biol. Chem. 269:32022-32022(1994) [PubMed] [Europe PMC] [Abstract]
    9. "Human and rat intestinal plasma membrane calcium pump isoforms."
      Howard A., Legon S., Walters J.R.
      Am. J. Physiol. 265:G917-G925(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM K).
      Tissue: Small intestine mucosa.
    10. "Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump."
      James P.H., Pruschy M., Vorherr T.E., Penniston J.T., Carafoli E.
      Biochemistry 28:4253-4258(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY CAMP KINASE.
    11. "Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes."
      Wang K.K.W., Wright L.C., Machan C.L., Allen B.G., Conigrave A.D., Roufogalis B.D.
      J. Biol. Chem. 266:9078-9085(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY PROTEIN KINASE C.
    12. "Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants."
      Goellner G.M., DeMarco S.J., Strehler E.E.
      Ann. N. Y. Acad. Sci. 986:461-471(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PDZD11.
    13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1193 AND SER-1220, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-1193; THR-1203; SER-1216 AND SER-1220, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1193 AND THR-1203, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters."
      Krapivinsky G., Krapivinsky L., Stotz S.C., Manasian Y., Clapham D.E.
      Proc. Natl. Acad. Sci. U.S.A. 108:19234-19239(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SLC35G1 AND STIM1.
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1193; SER-1216 AND SER-1220, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique."
      Benkwitz C., Kubsisch C., Kraft K., Neyses L.
      J. Mol. Med. 75:62-66(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ARG-267.

    Entry informationi

    Entry nameiAT2B1_HUMAN
    AccessioniPrimary (citable) accession number: P20020
    Secondary accession number(s): Q12992
    , Q12993, Q13819, Q13820, Q13821, Q16504, Q93082
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 161 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3