Plasma membrane calcium-transporting ATPase 1

Preferred order of sections

Names and origin

Protein names

Recommended name:
Plasma membrane calcium-transporting ATPase 1
Short name=PMCA1
EC=3.6.3.8

Alternative name(s):
Plasma membrane calcium ATPase isoform 1
Plasma membrane calcium pump isoform 1

Gene names

Name:	ATP2B1
Synonyms:	PMCA1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1258 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Catalytic activity	ATP + H₂O + Ca²⁺[side 1] = ADP + phosphate + Ca²⁺[side 2].
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Isoform B is ubiquitously expressed. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small intestine and liver.
Domain	The calmodulin-binding subdomain B is different in the different splice variants and shows pH dependent calmodulin binding properties in isoforms A, C, D and E.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Calcium Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro platelet activation Traceable author statement. Source: Reactome
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Traceable author statement. Source: ProtInc calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform D (identifier: P20020-1) Also known as: CIV; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: P20020-2) Also known as: CII; The sequence of this isoform differs from the canonical sequence as follows: 1156-1258: IRVVNAFRSS...SPLHSLETSL → VVFSSSTASTTVGYSSGECIS

Isoform B (identifier: P20020-3) Also known as: CI; The sequence of this isoform differs from the canonical sequence as follows: 1118-1155: Missing.

Isoform C (identifier: P20020-4) Also known as: CIII; The sequence of this isoform differs from the canonical sequence as follows: 1147-1155: Missing.

Isoform E (identifier: P20020-5) Also known as: CV; The sequence of this isoform differs from the canonical sequence as follows: 1156-1258: IRVVNAFRSS...SPLHSLETSL → VVFSSSTASTTVGFEW

Isoform K (identifier: P20020-6) The sequence of this isoform differs from the canonical sequence as follows: 1021-1056: Missing. 1118-1155: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1258

1258

Plasma membrane calcium-transporting ATPase 1

PRO_0000046209

Regions

Topological domain

1 – 97

97

Cytoplasmic Potential

Transmembrane

98 – 118

21

Helical; Potential

Topological domain

119 – 154

36

Extracellular Potential

Transmembrane

155 – 175

21

Helical; Potential

Topological domain

176 – 366

191

Cytoplasmic Potential

Transmembrane

367 – 386

20

Helical; Potential

Topological domain

387 – 419

33

Extracellular Potential

Transmembrane

420 – 437

18

Helical; Potential

Topological domain

438 – 852

415

Cytoplasmic Potential

Transmembrane

853 – 872

20

Helical; Potential

Topological domain

873 – 882

10

Extracellular Potential

Transmembrane

883 – 903

21

Helical; Potential

Topological domain

904 – 923

20

Cytoplasmic Potential

Transmembrane

924 – 946

23

Helical; Potential

Topological domain

947 – 964

18

Extracellular Potential

Transmembrane

965 – 986

22

Helical; Potential

Topological domain

987 – 1005

19

Cytoplasmic Potential

Transmembrane

1006 – 1027

22

Helical; Potential

Topological domain

1028 – 1037

10

Extracellular Potential

Transmembrane

1038 – 1059

22

Helical; Potential

Topological domain

1060 – 1258

199

Cytoplasmic Potential

Region

1100 – 1117

18

Calmodulin-binding subdomain A

Region

1118 – 1127

10

Calmodulin-binding subdomain B

Compositional bias

296 – 299

4

Poly-Glu

Sites

Active site

475

1

4-aspartylphosphate intermediate

Metal binding

797

1

Magnesium By similarity

Metal binding

801

1

Magnesium By similarity

Amino acid modifications

Modified residue

17

1

Phosphoserine Ref.13

Modified residue

1116

1

Phosphothreonine; by PKC

Modified residue

1193

1

Phosphoserine Ref.12 Ref.13

Modified residue

1203

1

Phosphothreonine Ref.13

Modified residue

1216

1

Phosphoserine; by PKA Ref.12 Ref.13

Modified residue

1220

1

Phosphoserine Ref.12 Ref.13

Modified residue

1246

1

Phosphoserine Ref.13

Modified residue

1249

1

Phosphoserine Ref.13

Modified residue

1253

1

Phosphoserine Ref.13

Modified residue

1256

1

Phosphothreonine Ref.13

Modified residue

1257

1

Phosphoserine Ref.13

Natural variations

Alternative sequence

1021 – 1056

36

Missing in isoform K.

VSP_000372

Alternative sequence

1118 – 1155

38

Missing in isoform B and isoform K.

VSP_000373

Alternative sequence

1147 – 1155

9

Missing in isoform C.

VSP_000374

Alternative sequence

1156 – 1258

103

IRVVN…LETSL → VVFSSSTASTTVGYSSGECI S in isoform A.

VSP_000375

Alternative sequence

1156 – 1258

103

IRVVN…LETSL → VVFSSSTASTTVGFEW in isoform E.

VSP_000376

Natural variant

267

1

M → R Rare polymorphism. Ref.14

VAR_000698

Experimental info

Sequence conflict

259 – 262

4

LLLS → MSAT in AAA36000. Ref.2

Sequences

Sequence		Length	Mass (Da)
Isoform D (CIV) [UniParc]. Last modified June 1, 2001. Version 3. Checksum: 7037112747FC9B0A Show »	FASTA	1,258	138,755
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GLLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSYRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDI VTGLTCIAVV GIEDPVRPEV PDAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSDQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 1090 1100 1110 1120 1130 1140 IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQMDV VNAFQSGSSI QGALRRQPSI 1150 1160 1170 1180 1190 1200 ASQHHDVTNI STPTHIRVVN AFRSSLYEGL EKPESRSSIH NFMTHPEFRI EDSEPHIPLI 1210 1220 1230 1240 1250 DDTDAEDDAP TKRNSSPPPS PNKNNNAVDS GIHLTIEMNK SATSSSPGSP LHSLETSL « Hide
Isoform A (CII) [UniParc]. Checksum: 5672202C16491703 Show »	FASTA	1,176	129,516
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GLLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSYRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDI VTGLTCIAVV GIEDPVRPEV PDAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSDQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 1090 1100 1110 1120 1130 1140 IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQMDV VNAFQSGSSI QGALRRQPSI 1150 1160 1170 ASQHHDVTNI STPTHVVFSS STASTTVGYS SGECIS « Hide
Isoform B (CI) [UniParc]. Checksum: 7E75C19B1A501423 Show »	FASTA	1,220	134,685
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GLLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSYRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDI VTGLTCIAVV GIEDPVRPEV PDAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSDQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 1090 1100 1110 1120 1130 1140 IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQIRV VNAFRSSLYE GLEKPESRSS 1150 1160 1170 1180 1190 1200 IHNFMTHPEF RIEDSEPHIP LIDDTDAEDD APTKRNSSPP PSPNKNNNAV DSGIHLTIEM 1210 1220 NKSATSSSPG SPLHSLETSL « Hide
Isoform C (CIII) [UniParc]. Checksum: 8F56F132BE096587 Show »	FASTA	1,249	137,804
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GLLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSYRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDI VTGLTCIAVV GIEDPVRPEV PDAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSDQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 1090 1100 1110 1120 1130 1140 IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQMDV VNAFQSGSSI QGALRRQPSI 1150 1160 1170 1180 1190 1200 ASQHHDIRVV NAFRSSLYEG LEKPESRSSI HNFMTHPEFR IEDSEPHIPL IDDTDAEDDA 1210 1220 1230 1240 PTKRNSSPPP SPNKNNNAVD SGIHLTIEMN KSATSSSPGS PLHSLETSL « Hide
Isoform E (CV) [UniParc]. Checksum: 9FC9B1AA3B32B384 Show »	FASTA	1,171	129,152
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GLLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSYRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDI VTGLTCIAVV GIEDPVRPEV PDAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSDQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 1090 1100 1110 1120 1130 1140 IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQMDV VNAFQSGSSI QGALRRQPSI 1150 1160 1170 ASQHHDVTNI STPTHVVFSS STASTTVGFE W « Hide
Isoform K [UniParc]. Checksum: B1FB3E7116D2FDA2 Show »	FASTA	1,184	130,617
10 20 30 40 50 60 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC 70 80 90 100 110 120 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 130 140 150 160 170 180 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 190 200 210 220 230 240 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 250 260 270 280 290 300 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 310 320 330 340 350 360 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 370 380 390 400 410 420 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 430 440 450 460 470 480 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 490 500 510 520 530 540 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 550 560 570 580 590 600 VGNKTECALL GLLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSYRIFS 610 620 630 640 650 660 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 670 680 690 700 710 720 EPEWDNENDI VTGLTCIAVV GIEDPVRPEV PDAIKKCQRA GITVRMVTGD NINTARAIAT 730 740 750 760 770 780 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 790 800 810 820 830 840 IDSTVSDQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 850 860 870 880 890 900 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 910 920 930 940 950 960 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 970 980 990 1000 1010 1020 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1030 1040 1050 1060 1070 1080 LISTIPTSRL KFLKEAGHGT QKEEIPEEEL AEDVEEIDHA ERELRRGQIL WFRGLNRIQT 1090 1100 1110 1120 1130 1140 QIRVVNAFRS SLYEGLEKPE SRSSIHNFMT HPEFRIEDSE PHIPLIDDTD AEDDAPTKRN 1150 1160 1170 1180 SSPPPSPNKN NNAVDSGIHL TIEMNKSATS SSPGSPLHSL ETSL « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete primary structure of a human plasma membrane Ca2+ pump." Verma A.K., Filoteo A.G., Stanford D.R., Wieben E.D., Penniston J.T., Strehler E.E., Fischer R., Heim R., Vogel G., Mathews S., Strehler-Page M.-A., James P., Vorherr T.E., Krebs J., Carafoli E. J. Biol. Chem. 263:14152-14159(1988) [PubMed: 2844759] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). Tissue: Erythrocyte.
[2]	"Molecular cloning of a plasma membrane calcium pump from human osteoblasts." Kumar R., Haugen J.D., Penniston J.T. J. Bone Miner. Res. 8:505-513(1993) [PubMed: 8386431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). Tissue: Osteoblast.
[3]	"Structure of the gene encoding the human plasma membrane calcium pump isoform 1." Hilfiker H., Strehler-Page M.-A., Stauffer T.P., Carafoli E., Strehler E.E. J. Biol. Chem. 268:19717-19725(1993) [PubMed: 8396145] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B). Tissue: Leukocyte.
[4]	Strehler E.E., Strehler-Page M.-A. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	"mRNAs for plasma membrane calcium pump isoforms differing in their regulatory domain are generated by alternative splicing that involves two internal donor sites in a single exon." Strehler E.E., Strehler-Page M.-A., Vogel G., Carafoli E. Proc. Natl. Acad. Sci. U.S.A. 86:6908-6912(1989) [PubMed: 2528729] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A; C AND D). Tissue: Fetal skeletal muscle.
[6]	"Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane Ca2+ pump." Kessler F., Falchetto R., Heim R., Meili R., Vorherr T.E., Strehler E.E., Carafoli E. Biochemistry 31:11785-11792(1992) [PubMed: 1332771] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). Tissue: Fetal brain.
[7]	"Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes." Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E. J. Biol. Chem. 268:25993-26003(1993) [PubMed: 8245032] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND E). Tissue: Brain cortex.
[8]	Erratum Stauffer T.P., Hilfiker H., Carafoli E., Strehler E.E. J. Biol. Chem. 269:32022-32022(1994) [PubMed: 7989379] [Abstract]
[9]	"Human and rat intestinal plasma membrane calcium pump isoforms." Howard A., Legon S., Walters J.R. Am. J. Physiol. 265:G917-G925(1993) [PubMed: 7694502] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM K). Tissue: Small intestine mucosa.
[10]	"Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump." James P.H., Pruschy M., Vorherr T.E., Penniston J.T., Carafoli E. Biochemistry 28:4253-4258(1989) [PubMed: 2548572] [Abstract] Cited for: PHOSPHORYLATION BY CAMP KINASE.
[11]	"Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes." Wang K.K.W., Wright L.C., Machan C.L., Allen B.G., Conigrave A.D., Roufogalis B.D. J. Biol. Chem. 266:9078-9085(1991) [PubMed: 1827443] [Abstract] Cited for: PHOSPHORYLATION BY PROTEIN KINASE C.
[12]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1193; SER-1216 AND SER-1220, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-1193; THR-1203; SER-1216; SER-1220; SER-1246; SER-1249; SER-1253; THR-1256 AND SER-1257, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique." Benkwitz C., Kubsisch C., Kraft K., Neyses L. J. Mol. Med. 75:62-66(1997) [PubMed: 9020386] [Abstract] Cited for: VARIANT ARG-267.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04027 mRNA. Translation: AAA74511.1. M95541 mRNA. Translation: AAA35999.1. M95542 mRNA. Translation: AAA36000.1. L14561 Genomic DNA. Translation: AAD09924.1. L14561 Genomic DNA. Translation: AAD09925.1. M25824 Genomic DNA. Translation: AAA58383.1. M25824 Genomic DNA. Translation: AAA58382.1. M25824 Genomic DNA. Translation: AAA58381.1. S49852 mRNA. Translation: AAB24324.1. U15686 mRNA. Translation: AAA60983.1. U15687 mRNA. Translation: AAA60984.1.
IPI	IPI00021695. IPI00216526. IPI00216527. IPI00216528. IPI00216529. IPI00216530.
PIR	A30802. E49570. I55491. I70165.
RefSeq	NP_001001323.1. NM_001001323.1. NP_001673.2. NM_001682.2.
UniGene	Hs.506276.
3D structure databases
ProteinModelPortal	P20020.
SMR	P20020. Positions 180-294, 771-828, 1100-1126.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-5004114.
STRING	P20020.
Protein family/group databases
TCDB	3.A.3.2.25. P-type ATPase (P-ATPase) superfamily.
PTM databases
PhosphoSite	P20020.
Polymorphism databases
DMDM	14286104.
Proteomic databases
PRIDE	P20020.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000428670; ENSP00000392043; ENSG00000070961.
GeneID	490.
KEGG	hsa:490.
UCSC	uc001tbg.1. human. uc001tbh.1. human.
Organism-specific databases
CTD	490.
GeneCards	GC12M089916.
HGNC	HGNC:814. ATP2B1.
HPA	CAB005605. HPA011166. HPA012945.
MIM	108731. gene.
neXtProt	NX_P20020.
PharmGKB	PA25107.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG061286.
OMA	VYGICTR.
OrthoDB	EOG4KPT93.
PhylomeDB	P20020.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	P20020.
Bgee	P20020.
CleanEx	HS_ATP2B1.
Genevestigator	P20020.
GermOnline	ENSG00000070961. Homo sapiens.
Family and domain databases
InterPro	IPR022141. ATP_Ca_trans_C. IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 1 hit.
KO	K05850.
Pfam	PF12424. ATP_Ca_trans_C. 2 hits. PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	2053.
SOURCE	Search...

Entry information

Entry name

AT2B1_HUMAN

Accession

Primary (citable) accession number: P20020
Secondary accession number(s): Q12992

Q93082

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 134 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents