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P20014 (ACEA_CANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate lyase

Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL1
OrganismCandida tropicalis (Yeast)
Taxonomic identifier5482 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer.

Subcellular location

Peroxisome.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Isocitrate lyase
PRO_0000068786

Regions

Motif548 – 5503Microbody targeting signal Potential

Sites

Active site2101 Probable

Sequences

Sequence LengthMass (Da)Tools
P20014 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: BA86F18169B5AC0C

FASTA55061,577
        10         20         30         40         50         60 
MAYTKIDINQ EEADFQKEVA EIKKWWSEPR WRKTKRIYSA EDIAKKRGTL KIAYPSSQQS 

        70         80         90        100        110        120 
DKLFKLLEKH DAEKSVSFTF GALDPIHVAQ MAKYLDSIYV SGWQCSSTAS TSNEPSPDLA 

       130        140        150        160        170        180 
DYPMDTVPNK VEHLWFAQLF HDRKQREERL NMTKEERANT PYIDFLRPII ADADTGHGGI 

       190        200        210        220        230        240 
TAIIKLTKLF IERGAAGIHI EDQAPGTKKC GHMAGKVLVP VQEHINRLVA IRASADIFGS 

       250        260        270        280        290        300 
NLLAVARTDS EAATLITSTI DHRDHYFIIG ATNPESGDLA ALMAEAEAKG IYGDELARIE 

       310        320        330        340        350        360 
TEWTKKAGLK LFHEAVIDEI KAGNYSNKEA LIKKFTDKVN PLSHTSHKEA KKLAKELTGK 

       370        380        390        400        410        420 
DIYFNWDVAR AREGYYRYQG GTQCAVMRGR AFAPYADLIW MESALPDYNQ AKEFADGVKA 

       430        440        450        460        470        480 
AVPDQWLAYN LSPSFNWNKA MPADEQETYI KRLGQLGYVW QFITLAGLHT TALAVDDFAN 

       490        500        510        520        530        540 
QYSQIGMRAY GQTVQQPEIE KGVEVVKHQK WSGANYIDGL LRMVSGGVTS TAAMGAGVTE 

       550 
DQFKETKAKV 

« Hide

References

[1]"Peroxisomal isocitrate lyase of the n-alkane-assimilating yeast Candida tropicalis: gene analysis and characterization."
Atomi H., Ueda M., Hikida M., Hishida T., Teranishi Y., Tanaka A.
J. Biochem. 107:262-266(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00703 Genomic DNA. Translation: BAA00611.1.
PIRWZCKI. JX0105.

3D structure databases

ProteinModelPortalP20014.
SMRP20014. Positions 8-527.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_CANTR
AccessionPrimary (citable) accession number: P20014
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways