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Protein

Ligninase C

Gene
N/A
Organism
Trametes versicolor (White-rot fungus) (Coriolus versicolor)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Depolymerization of lignin. Catalyzes the C(alpha)-C(beta) cleavage of the propyl side chains of lignin.

Catalytic activityi

1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 3,4-dimethoxybenzaldehyde + 2-methoxyphenol + glycolaldehyde + H2O.
2 (3,4-dimethoxyphenyl)methanol + H2O2 = 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O.

Cofactori

Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Pathwayi: lignin degradation

This protein is involved in the pathway lignin degradation, which is part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the pathway lignin degradation and in Secondary metabolite metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei70 – 701Transition state stabilizerPROSITE-ProRule annotation
Active sitei74 – 741Proton acceptorPROSITE-ProRule annotation
Metal bindingi75 – 751Calcium 1PROSITE-ProRule annotation
Metal bindingi93 – 931Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi95 – 951Calcium 1PROSITE-ProRule annotation
Metal bindingi97 – 971Calcium 1PROSITE-ProRule annotation
Metal bindingi205 – 2051Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi206 – 2061Calcium 2PROSITE-ProRule annotation
Metal bindingi223 – 2231Calcium 2PROSITE-ProRule annotation
Metal bindingi225 – 2251Calcium 2PROSITE-ProRule annotation
Metal bindingi228 – 2281Calcium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi230 – 2301Calcium 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide, Lignin degradation

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00892.

Protein family/group databases

CAZyiAA2. Auxiliary Activities 2.
mycoCLAPiLPO2C_TRAVE.
PeroxiBasei2420. TvLiP12_PRL572.

Names & Taxonomyi

Protein namesi
Recommended name:
Ligninase C (EC:1.11.1.14)
Alternative name(s):
Diarylpropane peroxidase
Lignin peroxidase
OrganismiTrametes versicolor (White-rot fungus) (Coriolus versicolor)
Taxonomic identifieri5325 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 372346Ligninase CPRO_0000023777Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Ligninases are expressed during secondary metabolism, and are triggered by nutrient limitation.

Structurei

3D structure databases

ProteinModelPortaliP20013.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Ligninase subfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR001621. Ligninase.
IPR024589. Ligninase_C.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF11895. DUF3415. 1 hit.
PF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00462. LIGNINASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFKSLLSFV SVIGALQGAN AALTRRVACP DGVNTATNAA CCQLFAVRED
60 70 80 90 100
LQQNLFHGGL CTAEAHESLR LTFHDAIAIS PALEAQGIFG GGGADGSIAI
110 120 130 140 150
FPEIETNFHP NIGLDEIIEL QKPFIARHNI SVADFIQFAG AIGASNCAGA
160 170 180 190 200
PQLAAFVGRK DATQPAPDGL VPEPFHTPDQ IFDRLADASQ GEFDPILTVW
210 220 230 240 250
LLTAHTVAAA NDVDPTKSGL PFDSTPELWD TQFFLETQLR GTSFPGSGGN
260 270 280 290 300
QGEVESPLAG EMRLQSDHTI ARDSRTACEW QSFVDNQPKA QQMFQFVFHD
310 320 330 340 350
LSIFGQDINT LVDCTEVVPI PADPQGHTHF PAGLSNADIE QACAETPFPT
360 370
FPTDPGPKTA VAPVPKPPAA RK
Length:372
Mass (Da):39,625
Last modified:June 1, 1994 - v2
Checksum:i9F7A06AABAA9B25A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64993 Genomic DNA. Translation: AAA34049.1.
PIRiS32581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64993 Genomic DNA. Translation: AAA34049.1.
PIRiS32581.

3D structure databases

ProteinModelPortaliP20013.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiAA2. Auxiliary Activities 2.
mycoCLAPiLPO2C_TRAVE.
PeroxiBasei2420. TvLiP12_PRL572.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00892.

Family and domain databases

InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR001621. Ligninase.
IPR024589. Ligninase_C.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF11895. DUF3415. 1 hit.
PF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00462. LIGNINASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIGC_TRAVE
AccessioniPrimary (citable) accession number: P20013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.