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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
70 kDa antigen
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:ML2496
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000784932 – 620Chaperone protein DnaKAdd BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175Phosphothreonine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP19993.

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2496.

Structurei

3D structure databases

ProteinModelPortaliP19993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04043.
OMAiFYSAKRF.
OrthoDBiPOG091H01UE.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAVGIDLG TTNSVVSVLE GGDPVVVANS EGSRTTPSTV AFARNGEVLV
60 70 80 90 100
GQPAKNQAVT NVDRTIRSVK RHMGSDWSIE IDGKKYTAQE ISARVLMKLK
110 120 130 140 150
RDAEAYLGED ITDAVITTPA YFNDAQRQAT KEAGQIAGLN VLRIVNEPTA
160 170 180 190 200
AALAYGLDKG EREQTILVFD LGGGTFDVSL LEIGEGVVEV RATSGDNHLG
210 220 230 240 250
GDDWDDRIVN WLVDKFKGTS GIDLTKDKMA MQRLREAAEK AKIELSSSQS
260 270 280 290 300
TSVNLPYITV DSDKNPLFLD EQLIRAEFQR ITQDLLDRTR QPFQSVVKDA
310 320 330 340 350
GISVSEIDHV VLVGGSTRMP AVTDLVKELT GGKEPNKGVN PDEVVAVGAA
360 370 380 390 400
LQAGVLKGEV KDVLLLDVTP LSLGIETKGG VMTKLIERNT TIPTKRSETF
410 420 430 440 450
TTADDNQPSV QIQVYQGERE IASHNKLLGS FELTGIPPAP RGVPQIEVTF
460 470 480 490 500
DIDANGIVHV TAKDKGTGKE NTIKIQEGSG LSKEEIDRMV KDAEAHAEED
510 520 530 540 550
RKRREEADVR NQAETLVYQT EKFVKEQRET ENGSRVPEDT LNKVEAAVAE
560 570 580 590 600
AKTALGGTDI SAIKSAMEKL GQDSQALGQA IYEATQAASK VGGEASAPGG
610 620
SNSTDDVVDA EVVDDERESK
Length:620
Mass (Da):66,679
Last modified:January 23, 2007 - v5
Checksum:iAFE89A7CD3B80D98
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti370P → PP in AAA25362 (PubMed:2051024).Curated1
Sequence conflicti608 – 619VDAEV…DERES → LTRRWSTTNGSP (PubMed:2051024).CuratedAdd BLAST12
Sequence conflicti608 – 619VDAEV…DERES → LTRRWSTTNGSP (PubMed:2491836).CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95576 Genomic DNA. Translation: AAA25362.1.
AL583925 Genomic DNA. Translation: CAC32013.1.
PIRiE87221.
RefSeqiNP_302613.1. NC_002677.1.
WP_010908932.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC32013; CAC32013; CAC32013.
GeneIDi908588.
KEGGimle:ML2496.
PATRICi18059753. VBIMycLep78757_4791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95576 Genomic DNA. Translation: AAA25362.1.
AL583925 Genomic DNA. Translation: CAC32013.1.
PIRiE87221.
RefSeqiNP_302613.1. NC_002677.1.
WP_010908932.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP19993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2496.

PTM databases

iPTMnetiP19993.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC32013; CAC32013; CAC32013.
GeneIDi908588.
KEGGimle:ML2496.
PATRICi18059753. VBIMycLep78757_4791.

Organism-specific databases

LepromaiML2496.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04043.
OMAiFYSAKRF.
OrthoDBiPOG091H01UE.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_MYCLE
AccessioniPrimary (citable) accession number: P19993
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 122 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.