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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-2741-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
70 kDa antigen
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:ML2496
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2496

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000784932 – 620Chaperone protein DnaKAdd BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175Phosphothreonine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP19993

PTM databases

iPTMnetiP19993

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi272631.ML2496

Structurei

3D structure databases

ProteinModelPortaliP19993
SMRiP19993
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG Bacteria
COG0443 LUCA
HOGENOMiHOG000228136
KOiK04043
OMAiISIKRHM
OrthoDBiPOG091H01UE

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
HAMAPiMF_00332 DnaK, 1 hit
InterProiView protein in InterPro
IPR012725 Chaperone_DnaK
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 2 hits
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
TIGRFAMsiTIGR02350 prok_dnaK, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAVGIDLG TTNSVVSVLE GGDPVVVANS EGSRTTPSTV AFARNGEVLV
60 70 80 90 100
GQPAKNQAVT NVDRTIRSVK RHMGSDWSIE IDGKKYTAQE ISARVLMKLK
110 120 130 140 150
RDAEAYLGED ITDAVITTPA YFNDAQRQAT KEAGQIAGLN VLRIVNEPTA
160 170 180 190 200
AALAYGLDKG EREQTILVFD LGGGTFDVSL LEIGEGVVEV RATSGDNHLG
210 220 230 240 250
GDDWDDRIVN WLVDKFKGTS GIDLTKDKMA MQRLREAAEK AKIELSSSQS
260 270 280 290 300
TSVNLPYITV DSDKNPLFLD EQLIRAEFQR ITQDLLDRTR QPFQSVVKDA
310 320 330 340 350
GISVSEIDHV VLVGGSTRMP AVTDLVKELT GGKEPNKGVN PDEVVAVGAA
360 370 380 390 400
LQAGVLKGEV KDVLLLDVTP LSLGIETKGG VMTKLIERNT TIPTKRSETF
410 420 430 440 450
TTADDNQPSV QIQVYQGERE IASHNKLLGS FELTGIPPAP RGVPQIEVTF
460 470 480 490 500
DIDANGIVHV TAKDKGTGKE NTIKIQEGSG LSKEEIDRMV KDAEAHAEED
510 520 530 540 550
RKRREEADVR NQAETLVYQT EKFVKEQRET ENGSRVPEDT LNKVEAAVAE
560 570 580 590 600
AKTALGGTDI SAIKSAMEKL GQDSQALGQA IYEATQAASK VGGEASAPGG
610 620
SNSTDDVVDA EVVDDERESK
Length:620
Mass (Da):66,679
Last modified:January 23, 2007 - v5
Checksum:iAFE89A7CD3B80D98
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti370P → PP in AAA25362 (PubMed:2051024).Curated1
Sequence conflicti608 – 619VDAEV…DERES → LTRRWSTTNGSP (PubMed:2051024).CuratedAdd BLAST12
Sequence conflicti608 – 619VDAEV…DERES → LTRRWSTTNGSP (PubMed:2491836).CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95576 Genomic DNA Translation: AAA25362.1
AL583925 Genomic DNA Translation: CAC32013.1
PIRiE87221
RefSeqiNP_302613.1, NC_002677.1
WP_010908932.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC32013; CAC32013; CAC32013
GeneIDi908588
KEGGimle:ML2496
PATRICifig|272631.5.peg.4791

Similar proteinsi

Entry informationi

Entry nameiDNAK_MYCLE
AccessioniPrimary (citable) accession number: P19993
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 130 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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