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P19976

- FRI1_SOYBN

UniProt

P19976 - FRI1_SOYBN

Protein

Ferritin-1, chloroplastic

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 4 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi100 – 1001Iron 1PROSITE-ProRule annotation
    Metal bindingi135 – 1351Iron 1PROSITE-ProRule annotation
    Metal bindingi135 – 1351Iron 2PROSITE-ProRule annotation
    Metal bindingi138 – 1381Iron 1PROSITE-ProRule annotation
    Metal bindingi184 – 1841Iron 2PROSITE-ProRule annotation
    Metal bindingi218 – 2181Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin-1, chloroplastic (EC:1.16.3.1)
    Alternative name(s):
    SFerH-1
    SOF-35
    OrganismiGlycine max (Soybean) (Glycine hispida)
    Taxonomic identifieri3847 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
    ProteomesiUP000008827: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4949Chloroplast1 PublicationAdd
    BLAST
    Chaini50 – 250201Ferritin-1, chloroplasticPRO_0000008864Add
    BLAST

    Expressioni

    Tissue specificityi

    Leaf > hypocotyl.

    Gene expression databases

    GenevestigatoriP19976.

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

    Structurei

    3D structure databases

    ProteinModelPortaliP19976.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini83 – 236154Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 8233Extension peptide (EP)Add
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    KOiK00522.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19976-1 [UniParc]FASTAAdd to Basket

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    MALAPSKVST FSGFSPKPSV GGAQKNPTCS VSLSFLNEKL GSRNLRVCAS    50
    TVPLTGVIFE PFEEVKKSEL AVPTAPQVSL ARQNYADECE SAINEQINVE 100
    YNASYVYHSL FAYFDRDNVA LKGFAKFFKE SSEEEREHAE KLMKYQNTRG 150
    GRVVLHPIKN APSEFEHVEK GDALYAMELA LSLEKLVNEK LLNVHSVADR 200
    NNDPQMADFI ESEFLSEQVE SIKKISEYVA QLRRVGKGHG VWHFDQRLLD 250
    Length:250
    Mass (Da):28,051
    Last modified:December 1, 1992 - v4
    Checksum:i3A48F00B33D7CBA9
    GO

    Sequence cautioni

    The sequence AAA33958.1 differs from that shown. Reason: Contaminating sequence. Vector contamination.
    The sequence AAA34016.1 differs from that shown. Reason: Contaminating sequence. Vector contamination.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti161 – 1611A → V in AAA33958. (PubMed:2211706)Curated
    Sequence conflicti161 – 1611A → V in AAA34016. (PubMed:2211706)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58336 mRNA. Translation: AAA33958.1. Sequence problems.
    M72894 mRNA. Translation: AAA34016.1. Sequence problems.
    M64337 mRNA. Translation: AAA33959.1.
    PIRiA40992.
    RefSeqiNP_001238501.1. NM_001251572.1.
    UniGeneiGma.1089.

    Genome annotation databases

    GeneIDi547824.
    KEGGigmx:547824.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58336 mRNA. Translation: AAA33958.1 . Sequence problems.
    M72894 mRNA. Translation: AAA34016.1 . Sequence problems.
    M64337 mRNA. Translation: AAA33959.1 .
    PIRi A40992.
    RefSeqi NP_001238501.1. NM_001251572.1.
    UniGenei Gma.1089.

    3D structure databases

    ProteinModelPortali P19976.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 547824.
    KEGGi gmx:547824.

    Phylogenomic databases

    KOi K00522.

    Gene expression databases

    Genevestigatori P19976.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ferritin gene transcription is regulated by iron in soybean cell cultures."
      Lescure A.-M., Proudhon D., Pesey H., Ragland M., Theil E.C., Briat J.-F.
      Proc. Natl. Acad. Sci. U.S.A. 88:8222-8226(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Evidence for conservation of ferritin sequences among plants and animals and for a transit peptide in soybean."
      Ragland M., Briat J.-F., Gagnon J., Laulhere J.-P., Massenet O., Theil E.C.
      J. Biol. Chem. 265:18339-18344(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-189.
      Tissue: Hypocotyl.
    3. "Purification and characterization of an iron-induced ferritin from soybean (Glycine max) cell suspensions."
      Lescure A.-M., Massenet O., Briat J.-F.
      Biochem. J. 272:147-150(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 50-63.
      Strain: cv. Mandarin.
      Tissue: Seed.

    Entry informationi

    Entry nameiFRI1_SOYBN
    AccessioniPrimary (citable) accession number: P19976
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 105 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Multiple cleavage sites may occur in the extension peptide yielding several smaller (26.5 kDa) ferritins subunits.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3