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Protein

Ferritin-1, chloroplastic

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Miscellaneous

Multiple cleavage sites may occur in the extension peptide yielding several smaller (26.5 kDa) ferritins subunits.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi100Iron 1PROSITE-ProRule annotation1
Metal bindingi135Iron 1PROSITE-ProRule annotation1
Metal bindingi135Iron 2PROSITE-ProRule annotation1
Metal bindingi138Iron 1PROSITE-ProRule annotation1
Metal bindingi184Iron 2PROSITE-ProRule annotation1
Metal bindingi218Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-1, chloroplastic (EC:1.16.3.1)
Alternative name(s):
SFerH-1
SOF-35
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49Chloroplast1 PublicationAdd BLAST49
ChainiPRO_000000886450 – 250Ferritin-1, chloroplasticAdd BLAST201

Proteomic databases

PRIDEiP19976.

Expressioni

Tissue specificityi

Leaf > hypocotyl.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Structurei

3D structure databases

ProteinModelPortaliP19976.
SMRiP19976.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 236Ferritin-like diironPROSITE-ProRule annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 82Extension peptide (EP)Add BLAST33

Sequence similaritiesi

Belongs to the ferritin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IU15. Eukaryota.
ENOG4111TFW. LUCA.
KOiK00522.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiView protein in InterPro
IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiView protein in Pfam
PF00210. Ferritin. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiView protein in PROSITE
PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19976-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAPSKVST FSGFSPKPSV GGAQKNPTCS VSLSFLNEKL GSRNLRVCAS
60 70 80 90 100
TVPLTGVIFE PFEEVKKSEL AVPTAPQVSL ARQNYADECE SAINEQINVE
110 120 130 140 150
YNASYVYHSL FAYFDRDNVA LKGFAKFFKE SSEEEREHAE KLMKYQNTRG
160 170 180 190 200
GRVVLHPIKN APSEFEHVEK GDALYAMELA LSLEKLVNEK LLNVHSVADR
210 220 230 240 250
NNDPQMADFI ESEFLSEQVE SIKKISEYVA QLRRVGKGHG VWHFDQRLLD
Length:250
Mass (Da):28,051
Last modified:December 1, 1992 - v4
Checksum:i3A48F00B33D7CBA9
GO

Sequence cautioni

The sequence AAA33958 differs from that shown. Contaminating sequence. Vector contamination.Curated
The sequence AAA34016 differs from that shown. Contaminating sequence. Vector contamination.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161A → V in AAA33958 (PubMed:2211706).Curated1
Sequence conflicti161A → V in AAA34016 (PubMed:2211706).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58336 mRNA. Translation: AAA33958.1. Sequence problems.
M72894 mRNA. Translation: AAA34016.1. Sequence problems.
M64337 mRNA. Translation: AAA33959.1.
PIRiA40992.
RefSeqiNP_001238501.1. NM_001251572.1.
UniGeneiGma.1089.

Genome annotation databases

GeneIDi547824.
KEGGigmx:547824.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFRI1_SOYBN
AccessioniPrimary (citable) accession number: P19976
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 1, 1992
Last modified: July 5, 2017
This is version 114 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families