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P19976

- FRI1_SOYBN

UniProt

P19976 - FRI1_SOYBN

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Protein

Ferritin-1, chloroplastic

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi100 – 1001Iron 1PROSITE-ProRule annotation
Metal bindingi135 – 1351Iron 1PROSITE-ProRule annotation
Metal bindingi135 – 1351Iron 2PROSITE-ProRule annotation
Metal bindingi138 – 1381Iron 1PROSITE-ProRule annotation
Metal bindingi184 – 1841Iron 2PROSITE-ProRule annotation
Metal bindingi218 – 2181Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-1, chloroplastic (EC:1.16.3.1)
Alternative name(s):
SFerH-1
SOF-35
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4949Chloroplast1 PublicationAdd
BLAST
Chaini50 – 250201Ferritin-1, chloroplasticPRO_0000008864Add
BLAST

Expressioni

Tissue specificityi

Leaf > hypocotyl.

Gene expression databases

GenevestigatoriP19976.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Structurei

3D structure databases

ProteinModelPortaliP19976.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 236154Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 8233Extension peptide (EP)Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

KOiK00522.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19976-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALAPSKVST FSGFSPKPSV GGAQKNPTCS VSLSFLNEKL GSRNLRVCAS
60 70 80 90 100
TVPLTGVIFE PFEEVKKSEL AVPTAPQVSL ARQNYADECE SAINEQINVE
110 120 130 140 150
YNASYVYHSL FAYFDRDNVA LKGFAKFFKE SSEEEREHAE KLMKYQNTRG
160 170 180 190 200
GRVVLHPIKN APSEFEHVEK GDALYAMELA LSLEKLVNEK LLNVHSVADR
210 220 230 240 250
NNDPQMADFI ESEFLSEQVE SIKKISEYVA QLRRVGKGHG VWHFDQRLLD
Length:250
Mass (Da):28,051
Last modified:December 1, 1992 - v4
Checksum:i3A48F00B33D7CBA9
GO

Sequence cautioni

The sequence AAA33958.1 differs from that shown. Reason: Contaminating sequence. Vector contamination.Curated
The sequence AAA34016.1 differs from that shown. Reason: Contaminating sequence. Vector contamination.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611A → V in AAA33958. (PubMed:2211706)Curated
Sequence conflicti161 – 1611A → V in AAA34016. (PubMed:2211706)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58336 mRNA. Translation: AAA33958.1. Sequence problems.
M72894 mRNA. Translation: AAA34016.1. Sequence problems.
M64337 mRNA. Translation: AAA33959.1.
PIRiA40992.
RefSeqiNP_001238501.1. NM_001251572.1.
UniGeneiGma.1089.

Genome annotation databases

GeneIDi547824.
KEGGigmx:547824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58336 mRNA. Translation: AAA33958.1 . Sequence problems.
M72894 mRNA. Translation: AAA34016.1 . Sequence problems.
M64337 mRNA. Translation: AAA33959.1 .
PIRi A40992.
RefSeqi NP_001238501.1. NM_001251572.1.
UniGenei Gma.1089.

3D structure databases

ProteinModelPortali P19976.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 547824.
KEGGi gmx:547824.

Phylogenomic databases

KOi K00522.

Gene expression databases

Genevestigatori P19976.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ferritin gene transcription is regulated by iron in soybean cell cultures."
    Lescure A.-M., Proudhon D., Pesey H., Ragland M., Theil E.C., Briat J.-F.
    Proc. Natl. Acad. Sci. U.S.A. 88:8222-8226(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Evidence for conservation of ferritin sequences among plants and animals and for a transit peptide in soybean."
    Ragland M., Briat J.-F., Gagnon J., Laulhere J.-P., Massenet O., Theil E.C.
    J. Biol. Chem. 265:18339-18344(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-189.
    Tissue: Hypocotyl.
  3. "Purification and characterization of an iron-induced ferritin from soybean (Glycine max) cell suspensions."
    Lescure A.-M., Massenet O., Briat J.-F.
    Biochem. J. 272:147-150(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 50-63.
    Strain: cv. Mandarin.
    Tissue: Seed.

Entry informationi

Entry nameiFRI1_SOYBN
AccessioniPrimary (citable) accession number: P19976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 1, 1992
Last modified: October 29, 2014
This is version 106 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Multiple cleavage sites may occur in the extension peptide yielding several smaller (26.5 kDa) ferritins subunits.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3